Details of the Target

General Information of Target

Target ID LDTP17590
Target Name Archaemetzincin-2 (AMZ2)
Gene Name AMZ2
Gene ID 51321
Synonyms
Archaemetzincin-2; EC 3.4.-.-; Archeobacterial metalloproteinase-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANL
RAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQE
DLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKY
RENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVG
KTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFM
SQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLL
ITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFH
SCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQW
RALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQ
EFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIAREL
EDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFE
VDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICS
TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG
NSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV
TRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHL
NLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLG
ENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNEL
DTDGVKMLCKALKKSTCRLQKLG
Target Bioclass
Enzyme
Family
Peptidase M54 family
Function Probable zinc metalloprotease.
Uniprot ID
Q86W34
Ensemble ID
ENST00000359783.8
HGNC ID
HGNC:28041

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(9.42)  LDD0204  [1]
IA-alkyne
 Probe Info  		C253(0.00); C35(0.00); C190(0.00)  LDD0161  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C289(0.75)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C289(1.06); C292(1.04)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C289(1.11); C292(1.17)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C289(1.25); C292(1.55)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C289(0.91); C292(1.20)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C289(1.02); C292(1.36)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C289(0.95); C292(1.06)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C289(1.19); C292(1.39)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C289(1.63); C292(1.43)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C289(1.04); C292(1.23)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C289(0.90); C292(1.04)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C289(0.96); C292(1.05)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C289(1.09); C292(1.06)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C289(1.27); C292(1.70)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C289(1.04); C292(0.99)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C289(0.92); C292(1.11)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C289(0.85); C292(0.85)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C289(0.82); C292(1.16)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C289(0.78); C292(0.95)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C289(0.92); C292(0.96)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C289(0.79); C292(0.96)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C289(0.92); C292(0.96)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C289(0.82); C292(1.13)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C289(1.02); C292(1.11)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C289(0.97); C292(0.97)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C289(0.83); C292(1.03)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C289(0.94); C292(1.01)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C289(0.81); C292(1.08)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C289(0.85); C292(1.16)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C289(0.97); C292(0.97)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C289(1.05); C292(0.98)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C289(0.87); C292(0.87)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C289(1.26); C292(1.26)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C289(1.26); C292(1.26)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C289(1.17); C292(1.17)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C289(1.16); C292(1.16)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C289(1.11); C292(1.11)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C289(1.26); C292(1.26)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C289(1.10); C292(1.10)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C289(1.31); C292(1.31)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C289(1.02); C292(1.02)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C289(1.20); C292(1.20)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C289(1.06); C292(1.06)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C289(1.19); C292(1.19)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C289(1.20); C292(1.44)  LDD0857  [4]
 LDCM0260  AC140 HCT 116 C289(1.19); C292(1.19)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C289(1.26); C292(1.26)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C289(1.17); C292(1.17)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C289(0.72); C292(0.72)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C289(0.74); C292(0.74)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C289(0.88); C292(0.88)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C289(0.97); C292(0.97)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C289(0.99); C292(0.99)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C289(1.31); C292(1.31)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C289(0.99); C292(0.99)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C289(0.92); C292(1.09)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C289(0.76); C292(0.76)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C289(0.76); C292(0.76)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C289(0.85); C292(0.85)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C289(0.78); C292(0.78)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C289(0.91); C292(0.91)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C289(0.70); C292(0.70)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C289(0.81); C292(0.81)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C289(0.71); C292(0.71)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C289(0.70); C292(0.51)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C289(0.79); C292(0.69)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C289(0.82); C292(0.65)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C289(0.84)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C289(0.92); C292(0.87)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C289(0.78); C292(0.76)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C289(0.80); C292(0.83)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C289(0.84); C292(0.89)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C289(1.06); C292(0.89)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C289(1.33); C292(1.33)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C289(1.24); C292(1.24)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C289(1.11); C292(1.11)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C289(1.75); C292(1.75)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C289(1.07); C292(1.07)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C289(1.05)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C289(0.91); C292(0.91)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C289(1.17); C292(1.17)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C289(1.22); C292(1.22)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C289(0.92); C292(0.92)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C289(0.91); C292(0.91)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C298(0.92)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C298(1.05)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C298(1.03)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C298(0.98)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C298(1.10)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C289(1.55)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C298(0.95)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C298(0.91)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C298(1.13)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C298(0.91)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C298(1.04)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C298(1.03)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C289(0.88)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C289(0.91)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C289(0.80)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C289(0.96)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C289(0.82)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C289(0.68)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C289(0.60)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C289(0.61)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C289(0.68)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C289(0.54)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C289(0.65)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C289(0.83)  LDD0917  [4]
 LDCM0320  AC57 HCT 116 C289(0.58); C292(0.58)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C289(0.56); C292(0.56)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C289(0.56); C292(0.56)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C289(1.13); C292(1.05)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C289(0.48); C292(0.48)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C289(0.47); C292(0.47)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C289(0.50); C292(0.50)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C289(0.46); C292(0.46)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C289(0.59); C292(0.59)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C289(0.61); C292(0.61)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C289(0.60); C292(0.60)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C289(0.50); C292(0.50)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C289(0.92); C292(0.92)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C289(0.87); C292(0.87)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C289(1.00); C292(1.14)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C289(1.37); C292(1.37)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C289(1.08); C292(1.08)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C289(0.90); C292(0.90)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C289(1.10); C292(1.10)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C289(1.50); C292(1.50)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C289(0.99); C292(0.99)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C289(0.89); C292(0.89)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C289(1.20); C292(1.20)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C289(0.81); C292(0.81)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C289(0.92); C292(0.92)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C289(0.89); C292(0.99)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C289(0.86); C292(0.86)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C289(0.83); C292(0.83)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C289(1.05); C292(1.05)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C289(0.88); C292(0.88)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C289(0.94); C292(0.94)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C289(1.09); C292(1.09)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C289(1.05); C292(1.05)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C289(1.01); C292(1.01)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C289(1.04); C292(1.04)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C289(0.96); C292(0.96)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C289(0.99); C292(0.99)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C289(1.09); C292(1.09)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C289(1.04); C292(1.04)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C289(0.92); C292(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C289(1.20); C292(1.20)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C289(1.10); C292(1.10)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C289(1.21); C292(1.21)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C289(0.97); C292(0.97)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C289(1.09); C292(1.05)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C289(0.83); C292(1.05)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C289(0.91); C292(0.89)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C289(1.13); C292(1.24)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C289(1.07); C292(1.36)  LDD0873  [4]
 LDCM0102  BDHI 8 Jurkat C115(9.42)  LDD0204  [1]
 LDCM0367  CL1 HEK-293T C289(1.02); C292(1.02)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C289(0.82); C292(0.82)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C289(0.94)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C289(0.84); C292(0.97)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C289(0.77); C292(0.82)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C289(0.99); C292(1.12)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C289(1.17); C292(1.14)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C289(0.88); C292(0.81)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C289(0.90); C292(0.79)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C289(0.84); C292(0.75)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C289(0.89); C292(0.60)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C289(0.94); C292(0.84)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C289(0.97); C292(0.97)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C289(0.75); C292(0.63)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C289(0.84); C292(0.90)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C289(0.94); C292(0.94)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C289(0.91); C292(0.91)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C289(0.84); C292(0.84)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C289(0.83); C292(0.83)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C289(0.98); C292(0.98)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C298(0.98)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C298(1.11); C115(1.22)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C298(0.86)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C289(0.92); C292(0.92)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C298(1.02); C115(0.95)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C289(0.68)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C289(0.98)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C289(0.97)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C289(0.72)  LDD0993  [4]
 LDCM0396  CL125 HCT 116 C289(0.88); C292(0.88)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C289(0.81); C292(0.81)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C289(0.67); C292(0.67)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C289(0.63); C292(0.63)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C289(1.26); C292(1.26)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C289(0.86); C292(0.86)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C289(0.83); C292(0.83)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C298(0.80); C115(0.78)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C298(0.86)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C298(0.88)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C298(0.78)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C289(0.98); C292(0.98)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C298(0.85)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C298(0.86)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C298(0.84)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C298(0.79)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C298(0.77)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C298(0.97)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C298(0.94); C115(1.06)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C298(0.86)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C298(0.89); C115(0.76)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C298(0.75)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C289(1.05); C292(1.05)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C298(1.04)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C289(0.89)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C289(0.75)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C289(0.88)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C289(0.70)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C289(0.69)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C289(0.68)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C289(0.66)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C289(0.61)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C289(0.92); C292(0.92)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C289(0.72)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C289(0.51)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C289(0.62)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C289(0.56)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C289(0.66)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C289(0.65)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C289(1.07)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C289(0.90)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C289(1.07)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C289(0.79)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C289(1.07); C292(1.07)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C289(0.91)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C289(0.87)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C289(1.17)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C289(0.94)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C289(0.93)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C289(1.07)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C289(1.18)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C289(0.98)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C289(1.04)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C289(0.95)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C289(0.95); C292(0.95)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C289(1.01)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C289(0.98); C292(0.98)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C289(0.96); C292(0.96)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C289(0.80); C292(0.80)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C289(0.94); C292(0.94)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C289(0.89); C292(0.89)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C289(0.85); C292(0.85)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C289(0.80); C292(0.80)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C289(0.66); C292(0.66)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C289(0.79); C292(0.79)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C289(1.26); C292(1.26)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C289(0.84); C292(0.84)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C289(0.74); C292(0.74)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C289(0.95); C292(0.95)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C289(0.76); C292(0.76)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C289(0.72); C292(0.72)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C289(0.75); C292(0.75)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C289(0.77); C292(0.77)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C289(0.91); C292(0.91)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C289(0.85); C292(0.85)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C289(1.27); C292(0.89)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C289(1.00); C292(1.00)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C289(0.92); C292(0.92)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C289(1.01); C292(1.01)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C289(0.81); C292(0.81)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C289(0.74); C292(0.74)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C289(0.61); C292(0.61)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C289(0.59); C292(0.59)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C289(0.54); C292(0.54)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C289(0.62); C292(0.62)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C289(0.80); C292(0.80)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C289(1.09); C292(0.92)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C289(0.65); C292(0.65)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C289(1.09)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C289(0.60)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C289(0.64)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C289(0.91)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C289(0.63)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C289(1.16)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C289(1.10)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C289(1.03)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C289(0.95)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C298(0.77)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C289(0.76); C292(0.76)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C289(0.77)  LDD1025  [4]
 LDCM0022  KB02 HEK-293T C298(1.00)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C115(27.51)  LDD0209  [1]
 LDCM0024  KB05 MKN45 C298(1.00)  LDD3332  [6]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840