Details of the Target

General Information of Target

Target ID LDTP17105
Target Name UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (UAP1L1)
Gene Name UAP1L1
Gene ID 91373
Synonyms
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; EC 2.7.7.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVAFEDVSVSFSQEEWALLAPSQKKLYRDVMQETFKNLASIGEKWEDPNVEDQHKNQG
RNLRSHTGERLCEGKEGSQCAENFSPNLSVTKKTAGVKPYECTICGKAFMRLSSLTRHMR
SHTGYELFEKPYKCKECEKAFSYLKSFQRHERSHTGEKPYKCKQCGKTFIYHQPFQRHER
THIGEKPYECKQCGKALSCSSSLRVHERIHTGEKPYECKQCGKAFSCSSSIRVHERTHTG
EKPYACKECGKAFISHTSVLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPY
KCKQCGKAFRCSTSIQIHERIHTGEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKE
CGKAFSRISYFRIHERTHTGEKPYECKKCGKTFNYPLDLKIHKRNHTGEKPYECKECAKT
FISLENFRRHMITHTGDGPYKCRDCGKVFIFPSALRTHERTHTGEKPYECKQCGKAFSCS
SYIRIHKRTHTGEKPYECKECGKAFIYPTSFQGHMRMHTGEKPYKCKECGKAFSLHSSFQ
RHTRIHNYEKPLECKQCGKAFSVSTSLKKHMRMHNR
Target Bioclass
Enzyme
Family
UDPGP type 1 family
Uniprot ID
Q3KQV9
Ensemble ID
ENST00000360271.3
HGNC ID
HGNC:28082

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.G275S .
BXPC3 SNV: p.R21C .
CAL33 SNV: p.R200H .
CCK81 Deletion: p.E88RfsTer16 .
HCT116 SNV: p.E4G DBIA    Probe Info 
IGROV1 SNV: p.E248G .
LNCaP clone FGC SNV: p.T169N DBIA    Probe Info 
MOLT4 SNV: p.I493T .
PFSK1 SNV: p.V79M DBIA    Probe Info 
SKMEL5 SNV: p.P470S DBIA    Probe Info 
TE4 SNV: p.A343V .
YSCCC SNV: p.G126V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K125(1.06); K342(10.00); K353(7.99); K360(10.00)  LDD0277  [1]
IPM
 Probe Info  		C231(0.00); C57(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y123(15.45); Y139(25.35)  LDD3495  [3]
m-APA
 Probe Info  		12.73  LDD0403  [4]
BTD
 Probe Info  		C278(0.91)  LDD2089  [5]
DBIA
 Probe Info  		C332(0.99)  LDD0533  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C57(0.00); C254(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C161(0.00); C254(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C161(0.00); C254(0.00); C231(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C50(0.00); C161(0.00); C296(0.00); C332(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
W1
 Probe Info  		C57(0.00); C332(0.00)  LDD0236  [2]
NAIA_5
 Probe Info  		C50(0.00); C57(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C57(0.94)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C278(0.98)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C332(0.77); C57(0.77)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C332(0.99)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C332(0.91)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C332(0.99)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C332(1.07)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C332(0.94)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C332(1.00)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C332(1.02)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C332(0.95)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C332(0.92)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C332(0.91)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C332(0.74); C57(0.74)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C332(1.02)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C332(0.97)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C332(1.10)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C332(0.78)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C332(0.81)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C332(0.79)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C332(0.86)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C332(1.08)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C332(0.84)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C332(0.89)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C332(0.93); C57(0.93)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C332(0.99)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C332(0.85)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C332(0.82)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C332(0.88)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C332(0.89)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C332(0.87)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C332(0.86)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C332(1.03)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C332(0.78)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C332(0.72)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C332(0.61)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C332(0.84)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C332(1.25)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C332(0.68)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C332(0.62)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C332(0.64)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C332(0.84)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C332(1.02)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C332(0.65)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C332(0.71)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C332(0.75); C57(0.75)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C332(0.73)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C332(0.63)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C332(0.96)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C332(1.03)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C332(1.11)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C332(1.41)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C332(1.08)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C332(1.08)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C332(1.07)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C332(1.03)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C332(0.65); C57(0.65)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C332(1.18)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C332(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C332(1.05)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C332(1.05)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C332(1.12)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C332(1.24)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C332(1.21)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C332(0.82)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C332(0.87)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C332(0.73)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C332(0.84)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C278(1.05)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C332(0.97)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C332(1.02)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C332(1.34)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C332(0.56)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C332(0.89)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C332(1.05)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C332(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C332(0.95)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C332(0.88)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C332(0.88)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C278(0.87)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C332(1.00)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C332(0.92)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C332(0.99)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C332(1.17)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C332(0.95)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C278(0.99)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C278(1.02)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C278(1.04)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C278(0.89)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C278(0.89)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C278(0.81)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C278(0.97)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C278(0.92)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C278(0.86)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C278(1.03)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C278(0.90)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C278(0.98)  LDD0905  [6]
 LDCM0308  AC46 PaTu 8988t C161(1.65); C231(0.75); C271(1.05); C278(1.05)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C161(0.93); C231(0.67); C271(0.88); C278(0.88)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C161(0.85); C231(0.64); C271(0.53); C278(0.53)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C161(0.76); C231(0.59); C271(0.59); C278(0.59)  LDD1190  [6]
 LDCM0312  AC5 HEK-293T C278(0.85)  LDD0910  [6]
 LDCM0313  AC50 PaTu 8988t C161(0.70); C231(0.66); C271(0.55); C278(0.55)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C161(0.99); C231(0.89); C271(0.88); C278(0.88)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C161(0.72); C231(0.64); C271(0.53); C278(0.53)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C161(0.68); C231(0.51); C271(0.47); C278(0.47)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C161(0.62); C231(0.38); C271(0.36); C278(0.36)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C161(0.97); C231(0.67); C271(0.79); C278(0.79)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C161(0.92); C231(0.68); C271(0.65); C278(0.65)  LDD1198  [6]
 LDCM0320  AC57 HCT 116 C332(1.28)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C332(0.78)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C332(1.03)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C332(1.34); C57(1.34)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C332(0.95)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C332(1.03)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C332(1.00)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C332(1.01)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C332(1.23)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C332(1.11)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C332(1.29)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C332(1.10)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C332(1.04)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C332(1.02)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C332(0.73); C57(0.73)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C332(1.15)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C332(0.97)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C332(1.24)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C332(1.10)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C332(1.10)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C332(1.12)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C332(0.92)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C332(1.13)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C332(1.00)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C332(1.28)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C332(1.02); C57(1.02)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C332(1.00)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C332(0.95)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C332(1.19)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C278(0.92)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C278(1.00)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C278(0.85)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C278(0.80)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C278(0.77)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C278(0.99)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C278(1.03)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C278(0.89)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C278(0.90)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C278(0.77)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C278(1.03)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C278(1.01)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C278(1.07)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C278(0.98)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C278(1.04)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C332(1.06)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C332(0.92)  LDD0683  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C278(0.96)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C332(1.05); C57(1.05)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C332(0.80); C57(0.80)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C332(0.86); C57(0.86)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 12.73  LDD0403  [4]
 LDCM0498  BS-3668 MDA-MB-231 C278(0.84)  LDD2091  [5]
 LDCM0367  CL1 PaTu 8988t C161(0.80); C271(0.88); C278(0.88); C332(0.95)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C161(0.69); C271(0.29); C278(0.29); C332(0.93)  LDD1247  [6]
 LDCM0369  CL100 HEK-293T C278(1.10)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C332(1.23); C57(1.23)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C332(0.79); C57(0.79)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C332(0.79); C57(0.79)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C332(0.93); C57(0.93)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C332(1.06)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C332(0.65)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C332(0.82)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C332(0.60)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C332(1.13)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C161(0.65); C271(0.74); C278(0.74); C332(0.92)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C332(0.78)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C332(0.66)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C332(1.09)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C332(0.95)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C332(0.99)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C332(1.07)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C332(1.04)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C278(1.12)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C278(1.13)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C278(1.08)  LDD0987  [6]
 LDCM0390  CL12 PaTu 8988t C161(0.71); C271(0.51); C278(0.51); C332(0.99)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C278(0.92)  LDD0989  [6]
 LDCM0392  CL121 PaTu 8988t C161(1.15); C231(0.90); C271(0.70); C278(0.70)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C161(1.16); C231(1.27); C271(0.70); C278(0.70)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C161(0.68); C231(0.45); C271(0.48); C278(0.48)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C161(0.75); C231(0.61); C271(0.54); C278(0.54)  LDD1274  [6]
 LDCM0396  CL125 HCT 116 C332(0.91)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C332(0.91)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C332(0.94)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C332(0.99)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C161(1.20); C271(0.25); C278(0.25); C332(0.99)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C161(0.93); C271(0.33); C278(0.33); C332(1.02)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C161(0.58); C271(0.43); C278(0.43); C332(1.10)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C278(0.79); C332(0.91)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C278(0.74); C332(0.84)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C278(0.92); C332(0.97)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C278(0.80); C332(0.84)  LDD1004  [6]
 LDCM0407  CL2 PaTu 8988t C161(0.67); C271(0.50); C278(0.50); C332(0.98)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C278(0.74); C332(1.08)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C278(0.87); C332(1.00)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C278(0.94); C332(1.16)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C278(1.17); C332(1.43)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C278(0.91); C332(1.05)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C278(0.95); C332(0.85)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C278(0.99); C332(0.95)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C278(0.88); C332(0.88)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C278(0.98); C332(0.88)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C278(0.90); C332(1.15)  LDD1015  [6]
 LDCM0418  CL3 PaTu 8988t C161(0.85); C271(0.34); C278(0.34); C332(0.97)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C278(1.00); C332(1.24)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C332(0.82)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C332(0.74)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C332(0.77)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C332(0.84)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C332(0.97)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C332(1.06)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C332(1.04)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C332(0.89)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C161(1.12); C271(0.43); C278(0.43); C332(0.95)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C332(0.92)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C332(0.84)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C332(1.21)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C332(0.73)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C332(1.00)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C332(0.87)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C278(1.33); C332(1.14); C57(1.14)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C278(1.29); C332(0.74); C57(0.74)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C278(1.17); C332(1.14); C57(1.14)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C278(1.39); C332(0.78); C57(0.78)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C161(0.77); C271(0.26); C278(0.26); C332(0.94)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C278(1.57); C332(0.69); C57(0.69)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C278(1.42); C332(0.82); C57(0.82)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C278(1.23); C332(0.82); C57(0.82)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C278(1.31); C332(0.79); C57(0.79)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C278(1.44); C332(0.78); C57(0.78)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C278(1.44); C332(0.95); C57(0.95)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C278(1.15); C332(0.73); C57(0.73)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C278(1.07); C332(0.67); C57(0.67)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C278(1.14); C332(0.71); C57(0.71)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C278(1.48); C332(0.77); C57(0.77)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C161(0.80); C271(0.35); C278(0.35); C332(1.00)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C278(1.29); C332(0.83); C57(0.83)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C278(1.26); C332(1.08); C57(0.91)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C278(1.07); C332(0.96); C57(0.73)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C278(1.23); C332(1.01); C57(0.60)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C278(1.17); C332(0.98); C57(0.69)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C278(1.10); C332(0.90); C57(0.79)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C278(1.15); C332(1.26); C57(0.97)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C278(1.05); C332(0.87); C57(0.63)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C278(1.33); C332(0.96); C57(0.74)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C278(1.28); C332(0.90); C57(0.76)  LDD1059  [6]
 LDCM0462  CL7 PaTu 8988t C161(0.73); C271(0.29); C278(0.29); C332(0.99)  LDD1341  [6]
 LDCM0463  CL70 HEK-293T C278(1.03); C332(1.04); C57(0.87)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C278(1.03); C332(1.10); C57(0.69)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C278(0.99); C332(0.90); C57(0.65)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C278(1.11); C332(0.85); C57(0.63)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C278(1.66); C332(1.25); C57(0.64)  LDD1065  [6]
 LDCM0469  CL76 PaTu 8988t C332(0.71)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C332(0.87)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C332(1.00)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C332(0.80)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C161(0.77); C271(0.30); C278(0.30); C332(0.84)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C332(0.76)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C332(0.76)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C332(0.83)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C332(0.74)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C332(0.85)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C332(0.98)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C332(0.85)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C332(0.77)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C332(0.99)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C332(0.73)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C161(0.75); C271(0.29); C278(0.29); C332(0.91)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C332(0.76)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C278(0.92)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C278(1.06)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C278(1.13)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C278(0.96)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C278(1.24)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C278(0.93)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C278(0.95)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C278(0.99)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C278(0.92)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C57(1.00); C254(0.95); C296(1.40); C332(1.10)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C57(5.50); C332(2.95)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C278(1.32); C332(0.77); C57(0.53)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C332(1.07)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C57(0.94); C231(1.25); C254(0.92); C296(1.00)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C57(1.00); C231(1.19); C254(0.98); C296(1.01)  LDD1497  [10]
 LDCM0024  KB05 G361 C332(1.36); C278(2.71)  LDD3311  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C278(0.46)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C278(0.91)  LDD2089  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C57(1.06)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C57(0.83)  LDD2107  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C57(0.51)  LDD2115  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C278(0.97)  LDD2120  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C57(1.05)  LDD2127  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C57(0.98)  LDD2137  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C278(0.40)  LDD2150  [5]

References

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Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840