Details of the Target

General Information of Target

Target ID LDTP16181
Target Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP2)
Gene Name PDP2
Gene ID 57546
Synonyms
KIAA1348; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; PDP 2; EC 3.1.3.43; Pyruvate dehydrogenase phosphatase catalytic subunit 2; PDPC 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLQDSTLSREGKPEGEIMAAVFFSVGRLSPEVTQPDEDLHLQAEETQLVKESVTFKDVA
IDFTLEEWRLMDPTQRNLHKDVMLENYRNLVSLGLAVSKPDMISHLENGKGPWVTVREIS
RIPYPDMEPKPATKKATRTKAISEDLSQEAILEKLTENGLWDSRMEGLWKWNDRILRLQN
NQENHLSQRIIPLKKTPTSQRGFRFESILIPEPGIATEELHSRCQTQEENFTENLNLITD
THLGKIICKEMKGSKAIRQTSELTLGKKSNNKEKPYKCSTCEKAFHYRSLLIQHQRTHTK
EKPYECNECGKTFSQPSYLSQHKKIHTGEKPYKCNECGKAFIASSSLMVHQRIHTKEKPY
QCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGEKPYKCDD
CGKAFRNKSYLSVHQKTHTEEKPYQCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKA
YRSNSSLIVHIRTHTGEKPYECNECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINY
SCLTVHHRMHTGEKPYKCTECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLT
VHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYKCYDCGKSFRTKSYLIVHQR
THTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTG
EKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPY
TCKECGKGCITLSQLTLHQRIHTGERPYKCEECGKAFRTNSDFTVHLRMHTGEKPYKCNE
CGKAFRSSSSLTVHQRIHQRETQLI
Target Bioclass
Enzyme
Family
PP2C family
Subcellular location
Mitochondrion matrix
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17.
Uniprot ID
Q9P2J9
Ensemble ID
ENST00000311765.4
HGNC ID
HGNC:30263

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C345(1.68)  LDD1702  [1]
DBIA
 Probe Info  		C345(0.72)  LDD0532  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C345(0.93)  LDD1507  [4]
 LDCM0215  AC10 HCT 116 C345(0.72)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C345(0.58)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C345(0.73)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C345(0.81)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C345(1.54)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C345(0.84)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C345(1.22)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C345(1.64)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C345(0.92)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C345(0.74)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C345(0.86)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C345(1.03)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C345(1.33)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C345(0.89)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C345(0.87)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C345(0.83)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C345(0.94)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C345(1.01)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C345(1.69)  LDD0579  [2]
 LDCM0263  AC143 PaTu 8988t C345(0.62)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C345(0.70)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C345(0.62)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C345(0.52)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C345(0.61)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C345(0.43)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C345(0.41)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C345(0.70)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C345(0.55)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C345(0.45)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C345(0.36)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C345(0.44)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C345(0.41)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C345(0.45)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C345(0.45)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C345(0.73)  LDD2169  [2]
 LDCM0276  AC17 HEK-293T C345(0.75)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C302(0.80); C345(1.07)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C302(0.96); C345(0.95)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C302(1.40); C345(0.92)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C302(0.99); C345(0.87)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C302(1.03); C345(1.03)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C302(0.99)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C302(1.07); C345(0.80)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C345(1.09)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C345(0.95)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C345(0.83)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C345(0.88)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C345(0.69)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C345(0.78)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C345(0.74)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C345(0.77)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C345(0.90)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C345(0.85)  LDD0612  [2]
 LDCM0297  AC36 HEK-293T C302(1.01); C345(0.95)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C302(0.91); C345(0.88)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C302(0.92); C345(1.09)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C302(1.06)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C302(1.05); C345(1.00)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C302(0.94); C345(0.80)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C345(0.71)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C302(0.84); C345(0.97)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C302(1.21); C345(0.96)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C302(1.14); C345(0.91)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C302(0.82); C345(0.96)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C302(1.06)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C302(1.07); C345(0.88)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C345(0.83)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C302(1.01); C345(0.94)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C302(1.02); C345(0.99)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C302(0.93); C345(1.00)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C302(1.20); C345(0.89)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C302(0.85); C345(1.05)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C302(0.93)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C302(1.09); C345(0.82)  LDD1558  [4]
 LDCM0320  AC57 HCT 116 C345(0.44)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C345(0.39)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C345(0.35)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C345(0.79)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C345(0.45)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C345(0.56)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C345(0.39)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C345(0.42)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C345(0.44)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C345(0.48)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C345(0.46)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C345(0.47)  LDD0648  [2]
 LDCM0332  AC68 PaTu 8988t C345(2.17)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C345(1.32)  LDD1212  [2]
 LDCM0334  AC7 HCT 116 C345(0.99)  LDD0651  [2]
 LDCM0335  AC70 PaTu 8988t C345(1.47)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C345(1.74)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C345(2.95)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C345(2.28)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C345(2.28)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C345(1.57)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C345(1.85)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C345(1.56)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C345(1.99)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C345(1.46)  LDD1223  [2]
 LDCM0345  AC8 HCT 116 C345(0.75)  LDD0662  [2]
 LDCM0346  AC80 PaTu 8988t C345(2.63)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C345(1.92)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C345(2.14)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C345(1.14)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C345(1.10)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C345(1.35)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C345(1.21)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C345(1.59)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C345(1.54)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C345(1.39)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C345(2.32)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C345(1.47)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C345(1.06)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C345(2.79)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C345(1.79)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C345(1.04)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C345(3.55)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C345(1.92)  LDD1243  [2]
 LDCM0248  AKOS034007472 HCT 116 C345(1.16)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C345(0.70)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C345(0.39)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C345(1.36)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C345(0.93)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C302(0.91); C345(0.88)  LDD1573  [4]
 LDCM0370  CL101 HCT 116 C345(0.52)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C345(0.77)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C345(0.96)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C345(0.98)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C302(0.96); C345(1.25)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C302(1.04); C345(1.16)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C302(1.19); C345(1.08)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C302(0.94); C345(1.01)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C302(0.44); C345(1.65)  LDD1582  [4]
 LDCM0379  CL11 HCT 116 C345(0.70)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C302(0.94); C345(1.17)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C302(0.92); C345(0.93)  LDD1585  [4]
 LDCM0382  CL112 HCT 116 C345(1.07)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C345(0.77)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C345(0.69)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C345(0.90)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C345(1.12)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C302(1.42); C345(1.12)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C302(1.05); C345(1.12)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C302(1.03); C345(0.93)  LDD1593  [4]
 LDCM0390  CL12 HCT 116 C345(0.67)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C302(1.08); C345(1.01)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C302(1.07); C345(1.19)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C302(0.90); C345(1.17)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C302(0.86); C345(1.00)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C302(0.83); C345(0.95)  LDD1599  [4]
 LDCM0396  CL125 HCT 116 C345(1.04)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C345(0.60)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C345(0.69)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C345(0.43)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C345(0.62)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C345(1.01)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C345(0.95)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C345(0.77)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C345(0.63)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C345(0.44)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C345(0.64)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C345(1.25)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C345(0.40)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C345(0.56)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C345(0.54)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C345(0.41)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C345(0.43)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C345(0.50)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C345(0.39)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C345(0.42)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C345(0.41)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C345(0.39)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C345(0.77)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C345(0.68)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C345(0.68)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C345(0.61)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C345(0.92)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C345(0.45)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C345(0.41)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C345(0.41)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C345(0.46)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C345(0.55)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C345(0.82)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C345(0.41)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C345(0.43)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C345(0.62)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C345(0.50)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C345(0.52)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C345(0.54)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C302(0.86); C345(1.06)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C302(1.21)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C302(0.99); C345(0.99)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C302(1.13); C345(1.41)  LDD1643  [4]
 LDCM0440  CL5 HCT 116 C345(0.73)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C302(1.01); C345(1.13)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C302(1.07); C345(1.19)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C345(0.60)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C302(0.79); C345(1.05)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C302(1.18); C345(1.07)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C302(0.80); C345(1.01)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C302(0.91); C345(1.25)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C302(0.92)  LDD1653  [4]
 LDCM0451  CL6 HCT 116 C345(1.03)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C302(0.97); C345(0.88)  LDD1655  [4]
 LDCM0453  CL61 HCT 116 C345(1.05)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C345(1.00)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C345(0.68)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C345(0.56)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C345(0.96)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C345(0.48)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C345(0.51)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C345(0.58)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C345(0.79)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C345(0.66)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C345(0.73)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C345(0.56)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C345(1.07)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C345(0.60)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C345(0.55)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C345(0.95)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C345(0.69)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C345(0.61)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C345(0.56)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C345(1.07)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C345(0.90)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C345(0.52)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C345(0.51)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C345(0.60)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C345(0.76)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C345(0.73)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C345(1.08)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C345(0.73)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C345(0.51)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C345(0.69)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C345(0.59)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C345(2.29)  LDD0802  [2]
 LDCM0487  CL92 HEK-293T C302(0.76); C345(1.00)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C302(0.73); C345(0.91)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C302(0.98); C345(1.00)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C302(0.83)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C302(0.89); C345(0.91)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C302(0.92); C345(1.46)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C302(0.41); C345(1.11)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C302(0.63); C345(1.02)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C302(0.94); C345(1.07)  LDD1698  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C345(1.68)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C345(0.64)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C345(0.52)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C345(0.97); C302(1.32)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C345(0.92); C302(0.81)  LDD1497  [4]
 LDCM0024  KB05 NCI-H1650 C345(2.08)  LDD3345  [5]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840