Details of the Target

General Information of Target

Target ID LDTP15424
Target Name Zinc finger protein 808 (ZNF808)
Gene Name ZNF808
Gene ID 388558
Synonyms
Zinc finger protein 808
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP
PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ
LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL
TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH
GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL
SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional repressor that targets mainly transposable elements. Primarily targets the long terminal repeat of endogenous retroviruses classified as MER11 elements which comprise subfamilies A, B and C. May silence transposable elements through the establishment of heterochromatin-associated trimethylation of 'Lys-9' of histone H3 (H3K9me3). Can also bind to certain gene promoters and other genomic regions. Represses transcription of specific MER11 elements during differentiation toward pancreatic lineages in early pancreas development. By repressing transcription, prevents a liver gene expression program from being aberrantly activated during pancreas differentiation.
Uniprot ID
Q8N4W9
Ensemble ID
ENST00000359798.9
HGNC ID
HGNC:33230

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.Q91E .
HCC1187 SNV: p.Y595Ter .
HT115 SNV: p.E536D .
L428 SNV: p.G255R .
MCAS SNV: p.E676K .
NCIH1793 SNV: p.A639S .
NCIH2286 SNV: p.Q411E .
SW480 SNV: p.E676K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C102(20.00)  LDD2227  [1]
DBIA
 Probe Info  		C466(1.37); C752(0.96)  LDD0531  [2]
HHS-465
 Probe Info  		K341(0.00); K344(0.00); K425(0.00); K428(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C466(1.37); C752(0.96)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C752(0.70)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C752(0.68)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C752(1.12)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C752(1.00)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C752(1.22)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C752(1.15)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C752(1.07)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C752(1.05)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C752(1.14)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C752(0.76)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C752(1.17)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C752(1.05)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C752(1.07)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C752(1.04)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C752(0.93)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C752(1.01)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C752(1.05)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C752(1.13)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C752(1.46)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C752(0.88)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C752(1.18)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C752(1.00)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C752(0.99)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C752(1.11)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C752(1.25)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C752(1.32)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C752(1.37)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C752(1.09)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C752(1.13)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C752(1.14)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C752(0.64)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C752(1.02)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C752(1.21)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C752(1.04)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C752(1.06); C466(1.12)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C752(0.92); C466(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C752(1.05); C466(1.15)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C466(1.21); C752(1.30)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C466(0.94); C752(1.21)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C752(1.09); C466(1.21)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C752(0.91); C466(1.29)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C752(0.75)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C466(1.10); C752(1.19)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C752(0.92); C466(0.99)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C466(1.12); C752(1.22)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C752(1.08); C466(1.58)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C466(1.35); C752(1.12)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C466(1.23); C752(1.29)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C466(1.24); C752(1.17)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C466(1.22); C752(1.09)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C752(1.02)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C752(1.11)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C752(1.05)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C752(1.10); C466(1.34)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C752(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C752(1.06)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C752(0.88)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C752(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C752(1.07)  LDD0601  [2]
 LDCM0290  AC3 HCT 116 C752(0.95); C466(1.67)  LDD0607  [2]
 LDCM0296  AC35 HCT 116 C752(0.72)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C752(0.78)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C752(0.78)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C752(0.87)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C752(0.89)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C752(1.14); C466(1.55)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C752(0.77)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C752(0.83)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C752(0.94)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C752(1.02)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C752(0.78)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C752(0.78)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C752(1.32)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C752(1.09)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C752(1.26)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C752(1.36)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C752(1.19); C466(1.54)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C752(1.47)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C752(1.24)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C752(1.15)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C752(1.05)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C752(1.20)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C752(1.06)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C752(1.11)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C752(1.16)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C752(1.21)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C752(1.22)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C752(1.05)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C752(1.21)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C752(1.08)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C752(1.14)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C752(1.30)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C752(1.17)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C752(1.17)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C752(1.24)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C752(1.34)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C752(0.79)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C752(0.80)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C752(0.85)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C752(0.93)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C752(0.77)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C752(0.98)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C752(1.00)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C752(0.86)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C752(1.01)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C752(0.78)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C752(0.82)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C752(0.80)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C752(0.93)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C752(0.93)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C752(0.91)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C752(0.84)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C752(0.78)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C752(2.14)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C752(1.84)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C752(1.56)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C752(1.27)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C752(1.16)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C752(1.18)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C752(1.35)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C752(1.05)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C752(2.22)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C752(1.98)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C752(1.21)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C752(1.70)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C752(1.28)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C752(1.62)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C752(1.77)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C752(0.72)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C752(0.71)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C752(0.83)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C102(20.00)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C752(0.97)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C752(1.12)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C752(0.97); C466(1.33)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C752(1.02)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C752(1.01)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C752(0.69)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C752(0.80)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C752(1.20)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C752(1.36)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C752(1.23)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C752(1.26)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C752(1.06)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C752(1.01)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C752(1.10)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C752(1.03)  LDD0698  [2]
 LDCM0387  CL117 HCT 116 C752(0.88)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C752(0.93)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C752(0.89)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C752(1.06)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C752(0.89)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C752(1.14)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C752(1.13)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C752(1.06)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C752(1.34)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C752(1.28)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C752(1.37)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C752(1.22)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C752(1.23)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C752(1.06)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C752(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C752(1.07)  LDD0719  [2]
 LDCM0407  CL2 HCT 116 C752(1.00)  LDD0724  [2]
 LDCM0418  CL3 HCT 116 C752(0.88)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C752(0.89)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C752(1.03)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C752(1.07)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C752(1.14)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C752(1.04)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C752(1.03)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C752(1.08)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C752(0.96)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C752(1.03)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C752(1.05)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C752(1.01)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C752(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C752(0.93)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C752(1.03)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C752(1.04)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C752(1.12)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C752(1.14)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C752(1.09)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C752(1.05)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C752(0.86)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C752(1.03)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C752(1.06)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C752(1.17)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C752(1.22)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C752(1.16)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C752(1.15)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C752(1.14)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C752(1.05)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C752(1.13)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C752(1.05)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C752(0.92)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C752(1.04)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C466(1.07); C752(1.13)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C466(1.12); C752(1.10)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C466(1.08); C752(1.16)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C466(1.20); C752(1.36)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C466(0.89); C752(1.12)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C466(1.15); C752(1.37)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C466(1.02); C752(1.29)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C466(0.79); C752(1.20)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C466(1.13); C752(1.07)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C752(0.94)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C466(0.97); C752(1.24)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C466(1.09); C752(1.14)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C466(1.24); C752(1.16)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C466(1.03); C752(1.30)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C466(0.99); C752(1.23)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C466(0.95); C752(0.88)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C466(1.03); C752(0.89)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C466(1.02); C752(0.84)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C466(1.01); C752(0.91)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C752(1.16)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C466(0.96); C752(0.95)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C466(1.07); C752(0.93)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C466(0.82); C752(0.91)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C466(1.04); C752(1.02)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C466(0.95); C752(0.99)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C466(0.89); C752(0.99)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C466(0.91); C752(0.83)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C466(0.96); C752(0.97)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C466(0.90); C752(0.92)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C466(0.66); C752(1.00)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C752(0.96)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C466(0.95); C752(0.95)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C466(1.45); C752(1.13)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C466(1.08); C752(1.13)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C466(1.23); C752(1.02)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C466(1.41); C752(1.21)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C466(1.61); C752(1.38)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C466(1.84); C752(1.05)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C466(1.91); C752(1.10)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C466(1.16); C752(1.15)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C466(1.16); C752(0.94)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C466(1.31); C752(1.18)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C752(1.44)  LDD0744  [2]
 LDCM0022  KB02 22RV1 C752(2.56)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C752(1.66)  LDD2660  [4]
 LDCM0024  KB05 MKN45 C752(2.67)  LDD3332  [4]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840