Details of the Target

General Information of Target

Target ID LDTP14721
Target Name Poly(rC)-binding protein 4 (PCBP4)
Gene Name PCBP4
Gene ID 57060
Synonyms
Poly(rC)-binding protein 4; Alpha-CP4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFK
QHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLA
QSQCVEQLEKLRIQYQKRQGSS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Uniprot ID
P57723
Ensemble ID
ENST00000322099.11
HGNC ID
HGNC:8652

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A71V .
IGR1 SNV: p.S185I DBIA    Probe Info 
JURKAT SNV: p.A312D; p.A384T .
KYSE510 SNV: p.E28K .
SNU869 SNV: p.A92V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C58(61.85)  LDD0209  [1]
IA-alkyne
 Probe Info  		C113(0.84)  LDD2207  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
NAIA_4
 Probe Info  		C58(0.00); C255(0.00)  LDD2226  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
W1
 Probe Info  		C113(0.00); C58(0.00)  LDD0236  [5]
HHS-465
 Probe Info  		N.A.  LDD2240  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C88(0.97)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C88(1.23)  LDD0532  [7]
 LDCM0226  AC11 HCT 116 C88(1.49)  LDD0543  [7]
 LDCM0237  AC12 HCT 116 C88(1.56)  LDD0554  [7]
 LDCM0246  AC128 HCT 116 C58(0.93)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C58(0.97)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C58(0.98)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C58(0.89)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C58(1.16)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C58(1.09)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C58(1.11)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C58(1.03)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C58(1.13)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C58(1.15)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C58(1.12)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C58(1.35)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C88(1.09)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C58(1.18)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C58(1.30)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C58(1.09)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C58(0.95); C88(1.11)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C88(0.92); C58(0.99)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C88(0.94); C58(1.31)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C58(1.11); C88(1.37)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C58(1.27); C88(1.75)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C58(1.14); C88(1.55)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C58(1.06); C88(1.07)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C88(1.04)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C58(1.00); C88(1.31)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C88(1.17); C58(1.24)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C58(1.04); C88(1.08)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C58(1.29); C88(1.32)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C58(1.22); C88(0.98)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C58(1.56); C88(1.42)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C58(1.33); C88(1.08)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C58(0.94); C88(1.27)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C58(0.72)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C58(0.58)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C58(0.68)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C88(1.01)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C58(0.71)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C58(0.75)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C58(0.67)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C58(0.72)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C58(0.79)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C113(0.92); C58(1.24)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C113(0.94); C58(1.12)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C113(1.03); C58(1.41)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C58(1.06); C113(1.23)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C58(1.21); C113(1.30)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C88(1.01)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C113(1.11); C58(1.19)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C113(0.93); C58(1.12)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C113(0.95); C58(1.43)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C113(1.02); C58(1.55)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C113(0.92); C58(1.38)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C58(0.86); C113(0.87)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C58(0.83); C113(0.84)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C113(0.86); C58(0.93)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C113(0.82); C58(0.92)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C58(0.86); C113(1.01)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C88(0.88)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C113(1.03); C58(1.06)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C113(0.79); C58(1.30)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C113(0.64); C58(1.11)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C58(1.05); C113(1.16)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C58(0.88); C113(1.27)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C58(0.94); C113(1.06)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C58(1.43); C88(1.48)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C88(1.42); C58(1.43)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C88(1.39); C58(1.41)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C88(1.42); C58(1.51)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C88(1.39)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C58(1.00); C88(1.28)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C58(0.76); C88(1.41)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C88(1.10); C58(1.37)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C58(1.45); C88(2.78)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C58(1.15); C88(2.10)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C88(1.13); C58(1.77)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C58(1.76); C88(1.81)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C58(1.36)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C58(1.15)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C58(1.69)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C88(1.18)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C58(1.66)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C58(1.18)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C58(1.83)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C58(1.65)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C58(1.59)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C58(1.39)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C58(1.38)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C58(1.67)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C113(0.97)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C113(0.97)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C88(0.90)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C113(0.96)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C113(0.95)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C113(0.92)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C113(0.95)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C113(0.95)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C113(0.91)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C113(0.95)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C113(0.93)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C113(0.84)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C113(0.98)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C88(1.21)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C113(0.87)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C113(0.86)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C113(0.85)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C58(1.24)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C58(1.21)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C58(1.43)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C58(1.25)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C58(1.16)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C58(1.20)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C58(1.17)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C58(1.36)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C58(1.17)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C58(1.24)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C58(1.18)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C58(1.44)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C58(1.44)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C58(1.23)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C58(1.32)  LDD0681  [7]
 LDCM0248  AKOS034007472 HCT 116 C88(1.46)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C88(1.20)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C88(1.17)  LDD0592  [7]
 LDCM0367  CL1 HCT 116 C113(1.10)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C113(0.96)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C88(1.03)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C88(1.39)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C88(1.30)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C88(1.69)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C88(1.22)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C58(1.12)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C58(0.75)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C58(0.57)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C58(0.63)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C58(0.81)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C113(1.08)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C58(0.63)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C58(0.90)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C113(1.09); C58(1.25)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C113(0.95); C58(1.18)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C113(0.98); C58(1.23)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C113(1.01); C58(1.02)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C58(0.99); C113(1.11)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C113(0.98); C58(1.46)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C113(0.94); C58(1.36)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C113(0.81); C58(1.11)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C113(1.07)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C113(0.83); C58(0.91)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C58(0.61); C88(1.13)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C88(1.25); C58(1.30)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C58(1.15); C88(1.36)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C88(1.57); C58(1.58)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C58(1.57)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C58(1.24)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C58(1.33)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C58(1.16)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C113(1.02)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C113(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C113(1.18)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C58(0.92); C113(0.92)  LDD1607  [8]
 LDCM0404  CL17 HCT 116 C58(2.53)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C58(1.65)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C58(2.17)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C113(0.98)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C58(1.57)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C58(3.21)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C58(2.19)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C58(2.92)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C58(1.71)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C58(3.56)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C58(2.41)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C58(1.49)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C58(1.85)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C58(1.78)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C113(1.07)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C58(1.60)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C58(1.80); C88(0.97)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C58(1.33); C88(0.76)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C58(1.14); C88(1.06)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C58(1.24); C88(1.67)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C58(1.37); C88(1.00)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C58(1.06); C88(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C58(1.06); C88(0.87)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C58(2.21); C88(0.92)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C113(1.02)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C58(1.63); C88(0.85)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C58(1.05); C88(0.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C58(1.96); C88(0.89)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C58(1.38); C88(1.12)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C58(1.48); C88(0.92)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C58(1.77); C88(1.01)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C88(1.59)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C88(1.62)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C88(1.08)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C88(1.49)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C113(1.17)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C88(1.13)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C88(1.31)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C88(1.57)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C88(0.86)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C88(0.94)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C88(1.00)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C88(1.24)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C88(1.15)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C88(3.77)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C88(1.32)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C113(1.00)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C88(1.58)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C58(0.82)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C58(1.06)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C58(1.16)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C58(1.06)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C58(0.93)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C58(1.24)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C58(1.21)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C58(1.03)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C58(1.33)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C113(0.91)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C58(1.07)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C58(0.80)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C58(0.80)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C58(1.58)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C58(1.09)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C113(0.87)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C113(0.81)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C113(0.98)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C113(0.85)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C113(1.04)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C113(0.93)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C113(1.15)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C113(0.91)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C113(0.97)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C113(0.89)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C113(0.80)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C113(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C113(1.10)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C113(0.83)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C113(1.17)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C113(1.01)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C113(0.67)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C88(1.18)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C88(1.00)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C88(0.81)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C88(0.66)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C88(1.12)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C88(1.44)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C88(1.04)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C88(1.13)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C88(1.12)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C58(1.15); C113(0.95); C308(0.77)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C58(1.22)  LDD1347  [7]
 LDCM0427  Fragment51 HCT 116 C58(1.67); C88(0.99)  LDD0744  [7]
 LDCM0022  KB02 HEK-293T C58(0.95); C113(1.01)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C58(61.85)  LDD0209  [1]
 LDCM0024  KB05 MKN45 C58(2.53); C88(2.03); C113(3.42)  LDD3332  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C113(0.84)  LDD2207  [2]

References

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2 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840