Details of the Target

General Information of Target

Target ID LDTP14208
Target Name Spindlin-1 (SPIN1)
Gene Name SPIN1
Gene ID 10927
Synonyms
OCR; SPIN; Spindlin-1; Ovarian cancer-related protein; Spindlin1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTPDLRISIEN
SEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASSLL
CFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFSFHSPPHTAAHNASVDMCELK
RDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTSVRFMGDMVSFEEDRINATVWKL
QPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQRTKGRSGEAEKRLLLVDFSSQALFQ
DKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGH
WSSAGCETVRRETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLV
TIAAYLCSRVPLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAI
FLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVD
NYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLR
PHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWS
MRLQARGGPSPLKSNSDSARLPISSGSTSSSRI
Target Bioclass
Other
Family
SPIN/STSY family
Subcellular location
Nucleus
Function
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Uniprot ID
Q9Y657
Ensemble ID
ENST00000375859.4
HGNC ID
HGNC:11243
ChEMBL ID
CHEMBL4523509

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C56(1.20)  LDD2093  [1]
Acrolein
 Probe Info  		C96(0.00); C56(0.00)  LDD0221  [2]
DBIA
 Probe Info  		C96(1.06)  LDD0531  [3]
5E-2FA
 Probe Info  		H19(0.00); H127(0.00); H234(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H19(0.00); H234(0.00)  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C56(0.00); C96(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C96(1.06)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C96(0.97)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C96(0.83)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C96(0.79)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C96(0.85)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C96(0.65)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C96(0.72)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C96(0.72)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C96(0.70)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C96(0.69)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C96(0.93)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C96(0.74)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C96(1.11)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C96(0.80)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C96(0.74)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C96(0.60)  LDD0546  [3]
 LDCM0237  AC12 HCT 116 C96(1.27)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C96(2.20)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C96(2.13)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C96(1.77)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C96(1.61)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C96(1.38)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C96(1.70)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C96(1.21)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C96(1.38)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C96(1.23)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C96(1.38)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C96(1.26)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C96(1.02)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C96(1.18)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C96(1.05)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C96(1.11)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C96(1.32)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C96(1.29)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C96(1.19)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C96(1.27)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C96(1.43)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C96(1.23)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C96(1.23)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C96(1.03)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C96(1.06)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C96(0.90)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C96(0.90)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C96(1.24)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C96(1.11)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C96(1.35)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C96(1.28)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C96(1.18)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C96(1.19)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C96(1.04)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C96(1.09)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C96(0.95)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C96(0.99)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C96(0.96)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C96(0.75)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C96(0.85)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C96(0.86)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C96(1.02)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C96(0.89)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C96(0.94)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C96(0.89)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C96(0.80)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C96(0.77)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C96(1.27)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C96(0.83)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C96(1.09)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C96(0.88)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C96(0.81)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C96(0.73)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C96(1.16)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C96(1.04)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C96(1.01)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C96(1.05)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C96(1.00)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C96(1.43)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C96(0.93)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C96(1.01)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C96(0.98)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C96(0.97)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C96(1.10)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C96(0.97)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C96(0.75)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C96(0.74)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C96(0.74)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C96(0.63)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C96(1.33)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C96(0.59)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C96(0.54)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C96(0.65)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C96(0.64)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C96(0.57)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C96(0.63)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C96(0.53)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C96(1.15)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C96(1.00)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C96(1.07)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C96(0.89)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C96(1.00)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C96(0.93)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C96(1.10)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C96(1.09)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C96(1.01)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C96(1.09)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C96(1.13)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C96(0.87)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C96(0.72)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C96(0.74)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C96(0.88)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C96(0.67)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C96(0.83)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C96(0.65)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C96(0.64)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C96(0.84)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C96(0.68)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C96(0.86)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C96(0.66)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C96(0.80)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C96(0.63)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C96(0.89)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C96(0.85)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C96(0.71)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C96(0.81)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C96(0.47)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C96(0.49)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C96(0.56)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C96(0.53)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C96(0.58)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C96(0.58)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C96(0.49)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C96(0.71)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C96(0.56)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C96(0.57)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C96(0.61)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C96(0.78)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C96(0.51)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C96(0.66)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C96(0.47)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C96(0.43)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C96(0.91)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C96(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C96(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C96(0.83)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa C56(0.00); C96(0.00)  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C96(0.86)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C96(0.76)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C96(0.84)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C96(0.91)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C96(0.88)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C96(1.08)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C96(1.01)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C96(0.91)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C96(0.59)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C96(1.03)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C96(1.06)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C96(0.93)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C96(0.78)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C96(0.78)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C96(0.93)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C96(0.98)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C96(0.88)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C96(0.80)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C96(0.84)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C96(0.91)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C96(0.91)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C96(1.14)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C96(1.01)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C96(0.94)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C96(1.02)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C96(0.64)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C96(0.70)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C96(0.62)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C96(0.66)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C96(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C96(1.05)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C96(1.11)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C96(1.13)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C96(0.81)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C96(0.88)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C96(0.85)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C96(1.12)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C96(0.88)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C96(0.53)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C96(0.78)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C96(0.92)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C96(1.28)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C96(1.44)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C96(1.06)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C96(1.32)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C96(1.12)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C96(0.98)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C96(1.00)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C96(1.37)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C96(0.93)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C96(1.01)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C96(0.85)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C96(1.21)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C96(0.90)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C96(0.67)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C96(0.80)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C96(0.85)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C96(0.93)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C96(1.10)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C96(0.99)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C96(0.89)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C96(0.86)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C96(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C96(0.96)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C96(1.01)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C96(0.84)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C96(0.93)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C96(0.88)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C96(1.17)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C96(0.95)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C96(1.27)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C96(1.10)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C96(1.04)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C96(1.07)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C96(0.99)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C96(1.00)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C96(1.02)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C96(1.03)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C96(1.09)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C96(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C96(1.13)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C96(1.15)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C96(1.07)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C96(0.75)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C96(0.99)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C96(1.17)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C96(1.12)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C96(1.06)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C96(1.14)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C96(1.09)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C96(1.01)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C96(0.78)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C96(0.86)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C96(1.20)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C96(0.88)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C96(1.15)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C96(1.41)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C96(1.84)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C96(1.25)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C96(1.32)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C96(0.62)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C96(0.82)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C96(0.78)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C96(1.25)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C96(0.90)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C96(0.74)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C96(0.85)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C96(0.72)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C96(0.55)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C96(0.76)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C96(1.03)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C96(0.63)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C96(0.65)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C96(0.84)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C96(1.03)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C96(0.83)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C96(0.85)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C96(1.06)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C96(1.09)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C96(1.45)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C96(0.89)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C96(1.16)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C96(1.11)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C96(0.94)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C96(1.01)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C96(1.13)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C56(0.94)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C96(1.11)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C96(1.03)  LDD0744  [3]
 LDCM0107  IAA HeLa C96(0.00); C56(0.00)  LDD0221  [2]
 LDCM0023  KB03 MDA-MB-231 C56(1.94)  LDD1701  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C56(1.20)  LDD2093  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C56(1.03)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C56(0.76)  LDD2107  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C56(1.72)  LDD2119  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C56(1.40)  LDD2135  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C56(0.79)  LDD2140  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.