Details of the Target

General Information of Target

Target ID LDTP13918
Target Name Conserved oligomeric Golgi complex subunit 6 (COG6)
Gene Name COG6
Gene ID 57511
Synonyms
KIAA1134; Conserved oligomeric Golgi complex subunit 6; COG complex subunit 6; Component of oligomeric Golgi complex 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGA
KERDRRLGARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPA
TGEAKLSEEEQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRV
QVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALP
LESWLGPPLPGGGATALQSLPGFGPPAQSLPASYTPPPPPPPFLNSPPLGPGLQPLAPPP
PSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGKPWQAL
Target Bioclass
Other
Family
COG6 family
Subcellular location
Golgi apparatus membrane
Function Required for normal Golgi function.
Uniprot ID
Q9Y2V7
Ensemble ID
ENST00000356576.8
HGNC ID
HGNC:18621
ChEMBL ID
CHEMBL4105962

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.E539K DBIA    Probe Info 
HT SNV: p.T486A DBIA    Probe Info 
HT115 SNV: p.E89Ter .
IGROV1 Deletion: p.D50del DBIA    Probe Info 
KYM1 SNV: p.M447I DBIA    Probe Info 
MDST8 SNV: p.F414I DBIA    Probe Info 
NCIH23 SNV: p.R306K DBIA    Probe Info 
SKNSH SNV: p.G15V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.88  LDD0402  [1]
DBIA
 Probe Info  		C621(1.36)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C242(0.00); C234(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C242(0.00); C234(0.00); C354(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C242(0.00); C234(0.00)  LDD0037  [3]
IPM
 Probe Info  		C354(0.00); C242(0.00)  LDD2156  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C354(0.00); C242(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C234(1.35); C621(1.36)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C114(0.64); C115(0.64); C234(1.07); C621(0.95)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C234(0.94)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C234(0.78)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C234(1.21)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C234(0.87)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C234(0.88)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C234(0.94)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C234(1.17)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C234(0.89)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C234(0.78)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C234(1.11)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C114(0.55); C115(0.55); C234(0.89); C621(1.15)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C234(0.79)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C234(0.79)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C234(0.92)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C234(1.27); C621(2.02)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C234(1.32); C621(0.98)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C234(0.93); C621(0.90)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C234(0.92); C621(1.09)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C234(0.91); C621(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C234(1.14); C621(1.08)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C234(0.86); C621(1.18)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C114(0.61); C115(0.61); C234(0.91); C621(0.83)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C234(1.18); C621(1.23)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C234(0.98); C621(0.90)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C234(0.97); C621(1.20)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C234(1.07); C621(0.72)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C234(1.02); C621(1.32)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C234(0.92); C621(1.14)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C234(0.97); C621(0.96)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C234(1.06); C621(1.17)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C114(0.98); C115(0.98); C234(0.97)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C114(0.97); C115(0.97); C234(0.82)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C114(1.02); C115(1.02); C234(0.84)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C114(1.12); C115(1.12); C234(0.88)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C114(0.90); C115(0.90); C234(0.78)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C114(1.09); C115(1.09); C234(0.65)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C114(1.10); C115(1.10); C234(0.65)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C114(1.11); C115(1.11); C234(0.81)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C114(0.90); C115(0.90); C234(0.62)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C114(1.30); C115(1.30); C234(0.46)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C114(1.22); C115(1.22); C234(0.39)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C114(1.01); C115(1.01); C234(0.52)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C114(0.79); C115(0.79); C234(1.10); C621(0.84)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C114(1.13); C115(1.13); C234(0.57)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C114(1.23); C115(1.23); C234(0.49)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C114(1.11); C115(1.11); C234(0.57)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C234(0.91); C621(1.06)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C621(1.02); C234(1.02)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C234(0.64); C621(0.98)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C234(0.74); C621(0.90)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C621(0.80); C234(0.81)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C234(0.88); C621(1.09)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C234(0.79); C621(0.96)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C114(0.82); C115(0.82); C621(0.92); C234(1.27)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C621(0.92); C234(0.93)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C621(0.72); C234(1.11)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C621(0.85); C234(0.90)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C621(0.89); C234(0.95)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C234(1.24); C621(0.94)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C234(0.85); C621(0.99)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C234(0.88); C621(0.86)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C234(0.74); C621(0.99)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C114(0.71); C115(0.71)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C114(0.82); C115(0.82)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C114(0.76); C115(0.76)  LDD0876  [2]
 LDCM0279  AC2 HCT 116 C621(1.15); C234(1.17)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C114(0.84); C115(0.84)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C114(0.77); C115(0.77)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C114(0.83); C115(0.83)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C114(0.70); C115(0.70)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C114(0.85); C115(0.85)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C114(0.57); C115(0.57); C234(0.89); C621(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C621(0.72); C234(0.85); C114(0.98); C115(0.98)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C234(0.79); C621(1.04); C114(1.07); C115(1.07)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C114(0.84); C115(0.84); C234(0.88); C621(1.00)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C114(0.78); C115(0.78); C234(0.88); C621(0.90)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C234(1.30); C621(1.55)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C621(0.69); C114(0.72); C115(0.72); C234(0.94)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C114(0.92); C115(0.92); C234(0.93); C621(1.05)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C114(0.81); C115(0.81); C234(0.84); C621(0.89)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C621(0.70); C114(0.70); C115(0.70); C234(0.86)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C621(0.73); C114(0.91); C115(0.91); C234(0.98)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C621(1.14); C234(1.15); C114(1.72); C115(1.72)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C621(0.79); C234(1.09); C114(1.15); C115(1.15)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C621(0.75); C114(0.88); C115(0.88); C234(1.07)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C234(0.98); C621(1.01); C114(1.09); C115(1.09)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C621(0.82); C234(1.19); C114(1.47); C115(1.47)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C234(1.40); C621(1.42)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C621(0.85); C234(1.29); C114(2.15); C115(2.15)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C621(0.62); C234(1.14); C114(1.36); C115(1.36)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C621(0.78); C234(1.12); C114(1.18); C115(1.18)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C621(0.94); C234(1.02); C114(1.15); C115(1.15)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C234(1.19); C114(1.19); C115(1.19); C621(1.23)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C621(1.09); C114(1.15); C115(1.15); C234(1.64)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C234(1.16)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C234(1.12)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C234(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C234(0.97)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C234(1.26); C621(1.57)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C234(1.16)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C234(1.03)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C234(1.05)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C234(1.24)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C234(1.14)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C234(1.30)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C234(1.13)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C114(0.75); C115(0.75); C234(0.94)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C114(0.70); C115(0.70); C234(0.88)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C114(0.53); C115(0.53); C234(0.83)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C114(0.68); C115(0.68); C621(0.92); C234(1.12)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C114(0.81); C115(0.81); C234(0.94)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C234(0.88); C114(1.26); C115(1.26)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C234(0.99); C114(1.07); C115(1.07)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C114(0.83); C115(0.83); C234(0.93)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C114(0.79); C115(0.79); C234(1.03)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C114(0.84); C115(0.84); C234(1.08)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C114(0.67); C115(0.67); C234(1.10)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C114(0.66); C115(0.66); C234(0.97)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C234(0.90)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C234(0.94)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C114(0.49); C115(0.49); C621(0.89); C234(1.05)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C234(0.92)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C234(1.01)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C234(1.01)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C234(0.98)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C234(0.95)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C234(0.96)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C234(0.90)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C234(1.08)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C234(1.00)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C234(0.89)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C114(0.51); C115(0.51); C621(0.76); C234(1.17)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C234(1.06)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C234(0.95)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C234(0.95)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C114(1.35); C115(1.35); C234(0.85); C621(1.08)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C114(1.28); C115(1.28); C234(0.74); C621(1.35)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C114(1.14); C115(1.14); C234(0.74); C621(1.03)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C114(0.97); C115(0.97); C234(0.72); C621(0.98)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C114(1.19); C115(1.19); C234(0.54); C621(1.09)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C114(1.08); C115(1.08); C234(0.90); C621(1.00)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C114(1.31); C115(1.31); C234(0.81); C621(1.02)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C114(1.10); C115(1.10); C234(0.74); C621(1.32)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C114(1.24); C115(1.24); C234(0.73); C621(1.13)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C114(1.39); C115(1.39); C234(0.76); C621(1.25)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C114(1.23); C115(1.23); C234(1.01); C621(1.39)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C114(1.17); C115(1.17); C234(0.98); C621(1.20)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C114(1.10); C115(1.10); C234(1.02); C621(1.06)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C114(1.29); C115(1.29); C234(0.64); C621(1.38)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C114(1.36); C115(1.36); C234(0.85); C621(1.77)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C234(0.80)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C234(0.85)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C114(1.02); C115(1.02); C234(0.85); C621(0.95)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C114(0.66); C115(0.66); C621(0.95); C234(0.97)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C114(0.96); C115(0.96); C621(1.00); C234(1.20)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C621(1.09)  LDD2171  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C242(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C114(0.84); C115(0.84); C234(0.97)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C114(1.20); C115(1.20); C234(0.25)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C234(1.17); C621(1.36)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C234(0.97); C621(0.98); C114(1.23); C115(1.23)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C114(0.66); C115(0.66); C234(0.83); C621(1.10)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C114(0.86); C115(0.86); C234(0.97); C621(1.07)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C114(0.68); C115(0.68); C621(0.93); C234(1.16)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C114(0.87); C115(0.87)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C114(0.84); C115(0.84)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C114(0.83); C115(0.83)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C114(0.74); C115(0.74)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C114(0.95); C115(0.95)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C114(1.10); C115(1.10); C234(0.25)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C114(0.75); C115(0.75)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C114(0.63); C115(0.63)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C114(0.78); C115(0.78); C234(0.88); C621(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C621(0.71); C234(0.88); C114(1.04); C115(1.04)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C621(0.78); C234(0.85); C114(0.90); C115(0.90)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C621(0.89); C234(0.89); C114(1.04); C115(1.04)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C621(0.81); C234(0.86); C114(1.82); C115(1.82)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C621(1.08); C234(1.31); C114(1.32); C115(1.32)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C621(0.80); C234(1.19); C114(1.37); C115(1.37)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C621(0.99); C234(1.03); C114(1.07); C115(1.07)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C114(0.76); C115(0.76); C234(1.32)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C621(0.82); C234(1.08); C114(1.19); C115(1.19)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C234(1.06)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C234(1.06)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C234(0.92)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C234(1.03)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C114(0.50); C115(0.50); C234(0.94)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C114(0.57); C115(0.57); C234(0.77)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C114(0.87); C115(0.87); C234(0.94)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C114(0.87); C115(0.87); C234(0.98)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C114(0.84); C115(0.84); C234(1.03)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C114(0.85); C115(0.85); C234(0.92)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C114(0.89); C115(0.89); C234(0.61)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C234(0.72)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C234(0.75)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C234(0.74)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C234(0.93)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C114(0.82); C115(0.82); C234(1.29)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C234(0.82)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C234(0.81)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C234(1.31)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C234(0.88)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C234(0.94)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C234(0.93)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C234(0.71)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C234(0.88)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C234(0.84)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C234(0.96)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C114(0.84); C115(0.84); C234(0.79)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C234(0.82)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C234(1.03)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C234(1.34)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C234(1.31)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C234(1.04)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C234(0.91)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C234(0.89)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C234(1.04)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C234(1.23)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C114(0.88); C115(0.88); C234(0.91)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C234(0.88)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C234(0.78)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C234(0.85)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C234(1.21)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C234(1.10)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C234(0.99)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C621(1.10)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C621(1.09)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C621(0.95)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C621(1.27)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C114(0.97); C115(0.97); C234(0.84)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C621(1.02)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C621(1.10)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C621(1.12)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C621(0.93)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C621(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C621(1.05)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C621(0.89)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C621(1.00)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C621(1.24)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C621(1.04)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C114(0.87); C115(0.87); C234(0.75)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C621(1.09)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C621(1.12)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C621(1.00)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C621(0.89)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C621(1.54)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C621(1.06)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C621(1.13)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C621(1.06)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C621(0.88)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C621(0.99)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C114(0.99); C115(0.99); C234(0.76)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C621(1.15)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C621(1.18)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C621(0.99)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C621(1.03)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C621(0.94)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C234(0.89); C242(0.97); C354(0.91)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C234(0.92); C242(1.07); C354(0.86)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C234(1.03); C242(1.02); C354(1.04); C621(1.00)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C234(1.02); C242(0.95); C354(0.87)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C114(1.15); C115(1.23)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C234(0.98); C242(1.03); C354(0.95)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C234(1.03); C242(1.04); C354(0.99)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C234(1.05); C242(1.00); C354(1.00)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C234(1.22); C242(0.97); C354(1.03)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C234(1.14); C242(1.06); C354(0.97)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C234(0.98); C242(1.03)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C234(1.00); C242(1.04); C354(0.82)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C234(1.01); C242(0.97); C354(1.00)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C234(0.97); C242(0.99); C354(0.84)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C234(1.00); C242(0.98); C354(0.74)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C114(1.07); C115(1.54)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C234(1.18); C242(1.26); C354(1.18); C621(0.80)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C234(1.03); C621(1.23)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C234(1.07); C621(0.67)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C234(1.07); C621(0.94)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C234(1.26); C621(0.95)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C234(1.09); C621(0.96)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C234(1.14); C621(1.19)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C234(1.26); C621(1.04)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C234(1.06); C621(1.32)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C234(1.24); C621(1.14)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C234(0.87); C242(0.86); C354(0.85)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C621(1.36)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C234(0.76)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C621(1.36)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C621(1.30)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C621(1.45)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C621(1.09)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Cullin-5 (CUL5) Cullin family Q93034
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Ras-related protein Rab-6B (RAB6B) Rab family Q9NRW1
GTP-binding protein GEM (GEM) RGK family P55040
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
Other
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) SEC2 family Q8TBN0
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Thymosin beta-4 (TMSB4X) Thymosin beta family P62328
Translin-associated protein X (TSNAX) Translin family Q99598
B-cell lymphoma/leukemia 10 (BCL10) . O95999
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Cysteine and glycine-rich protein 2 (CSRP2) . Q16527
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
LIM domain transcription factor LMO4 (LMO4) . P61968
Phostensin (PPP1R18) . Q6NYC8
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) . Q9HB19
Receptor-transporting protein 5 (RTP5) . Q14D33
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Tetratricopeptide repeat protein 7B (TTC7B) . Q86TV6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402