Details of the Target

General Information of Target

Target ID LDTP13898
Target Name RNA 3'-terminal phosphate cyclase-like protein (RCL1)
Gene Name RCL1
Gene ID 10171
Synonyms
RNAC; RPC2; RPCL1; RTC2; RNA 3'-terminal phosphate cyclase-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAELTAPAQGIVTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLGGSGAGD
EEAPYQQSTSPQRVSQVRIPKALPSPQKTNPCEICGPVLRQILHLVEHQGTHHGQKLYTD
GACRKQLQFTAYLHQHQKQHVGQKHFRSNGGRDMFLSSCTFEVSGKPFTCKEVGKDFLVR
SRFLQQQAAHTRKKSNRTKSAVAFHSVKNHYNWGECVKAFSYKHVRVQHQGDLIRERSYM
CSECGKSFSTSCSLSDHLRVHTSEKPYTCGECGKSYRQSSSLITHRRIHTGVRPHQCDEC
GKLFNRKYDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIHTGMRPYECSECGKSF
IHSSSLITHQRVHTGTRPYMCSECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRS
RFFQHQRVHTGVRSHECHECGKLFSRKFDLIVHERVHTGERPYECSECGKSFTCKSYLIS
HWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFFSQSSSLIRHRRS
HTGERPYECSECWKSFSNHSSLVKHRRVHTGERPYECSECGKSFSQSSNLTNHQRIHSGE
RPYECSDCGKFFTFNSNLLKHQNVHKG
Target Bioclass
Enzyme
Family
RNA 3'-terminal cyclase family, Type 2 subfamily
Subcellular location
Nucleus, nucleolus
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Does not have cyclase activity.
Uniprot ID
Q9Y2P8
Ensemble ID
ENST00000381728.5
HGNC ID
HGNC:17687

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 Deletion: p.G347del DBIA    Probe Info 
MCC13 SNV: p.S261F DBIA    Probe Info 
PF382 SNV: p.I64T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C346(0.98)  LDD2100  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C171(1.15)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C292(0.00); C89(0.00); C346(0.00); C104(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C104(0.00); C292(0.00); C346(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C292(0.00); C104(0.00); C346(0.00); C89(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
SF
 Probe Info  		N.A.  LDD0028  [7]
1c-yne
 Probe Info  		K133(0.00); K141(0.00)  LDD0228  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
NAIA_5
 Probe Info  		C292(0.00); C104(0.00); C89(0.00); C13(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C171(1.15)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C171(0.84)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C171(0.45)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C171(0.50)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C171(0.78)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C171(0.47)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C171(0.83)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C171(0.69)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C171(0.46)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C171(0.57)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C171(0.53)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C171(0.83)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C171(0.76)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C171(0.49)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C171(0.49)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C171(0.53)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C171(1.42)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C171(1.15)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C171(1.09)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C171(1.15)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C171(1.05)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C171(0.95)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C171(0.89)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C171(0.94)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C171(1.00)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C171(1.02)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C171(1.03)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C171(1.06)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C171(1.02)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C171(1.12)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C171(1.06)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C171(1.05)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C171(1.02)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C171(1.06)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C171(1.28)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C171(1.18)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C171(0.99)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C171(1.12)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C171(1.08)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C171(1.11)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C171(1.00)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C171(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C171(0.76)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C171(0.84)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C171(0.77)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C171(0.86)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C171(0.84)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C171(1.07)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C171(1.03)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C171(1.48)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C171(1.18)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C171(1.46)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C171(1.00)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C171(0.98)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C171(1.02)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C171(1.09)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C171(1.13)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C171(1.11)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C171(1.04)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C171(1.06)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C171(1.09)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C171(0.94)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C171(0.96)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C171(1.27)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C171(0.89)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C171(1.31)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C171(0.74)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C171(0.72)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C171(0.63)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C171(1.36)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C171(1.08)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C171(1.32)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C171(1.01)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C171(0.97)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C171(1.27)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C171(0.91)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C171(1.03)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C171(0.96)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C171(0.81)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C171(1.18)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C171(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C171(1.11)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C171(0.86)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C171(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C171(0.34)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C171(1.47)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C171(0.42)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C171(1.68)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C171(0.98)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C171(0.60)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C171(0.59)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C171(0.36)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C171(0.27)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C171(0.39)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C171(0.37)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C171(0.39)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C171(0.84)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C171(0.43)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C171(0.41)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C171(0.29)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C171(0.49)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C171(0.32)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C171(0.45)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C171(0.50)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C171(0.20)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C171(0.71)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C171(0.94)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C171(0.30)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C171(0.35)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C171(0.62)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C171(0.66)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C171(0.84)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C171(0.77)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C171(0.44)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C171(1.19)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C171(0.29)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C171(0.33)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C171(0.66)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C171(0.58)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C171(0.89)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C171(0.48)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C171(0.41)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C171(0.51)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C171(0.56)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C171(0.85)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C171(0.92)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C171(0.99)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C346(0.90); C292(1.06)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C346(0.91); C89(0.41); C104(0.59)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C171(1.08)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C171(0.81)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C171(0.80)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C171(0.81)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C171(0.91)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C171(1.04)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C171(0.96)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C171(0.88)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C171(1.21)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C171(0.82)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C346(1.04); C171(0.85)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C171(1.05)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C171(1.10)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C171(1.78)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C171(1.49)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C171(0.99)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C171(1.46)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C171(1.35)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C171(0.68)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C171(1.05)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C171(0.87)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C346(0.96); C360(1.19)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C171(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C171(0.90)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C171(0.69)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C171(0.60)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C171(0.48)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C171(0.82)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C171(0.68)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C171(0.72)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C171(0.43)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C346(0.91); C292(0.98)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C346(0.95); C171(0.98); C360(1.15)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C346(1.03); C292(0.94); C171(0.91)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C171(1.05)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C171(0.93)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C171(0.93)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C171(1.23)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C346(0.96); C171(1.03); C360(1.00)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C171(0.99)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C171(0.90)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C171(1.01)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C171(1.23)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C171(1.08)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C171(1.13)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C171(1.19)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C171(1.11)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C171(1.04)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C171(0.94)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C346(1.16); C292(1.03); C171(1.18)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C171(0.98)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C171(1.18)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C171(1.24)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C171(1.07)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C171(0.98)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C171(0.87)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C171(0.85)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C171(0.67)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C171(0.70)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C346(1.15); C171(0.88)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C171(0.73)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C171(1.01)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C171(0.67)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C171(0.69)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C171(0.83)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C171(0.76)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C346(1.10); C89(0.29); C104(0.64)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C346(1.14); C171(0.88)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C346(1.13); C360(1.09)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C346(0.94); C292(0.99)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C346(0.90); C292(1.17); C171(1.18)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C346(0.86); C171(1.49); C360(1.07)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C346(0.97); C171(1.02)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C346(0.80); C292(0.91); C171(0.80)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C346(0.89); C292(0.93)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C346(1.20); C171(1.17); C104(1.08)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C346(0.93); C292(1.06); C171(0.85)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C346(0.84)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C346(0.99); C89(0.26); C104(0.68)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C346(1.09); C171(0.86)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C346(1.01); C292(0.84)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C346(0.93); C360(1.22)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C346(0.93); C292(1.17)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C346(0.90); C171(1.09); C360(1.00)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C346(1.18); C292(0.99); C171(1.22)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C346(0.98); C171(1.47)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C346(0.84); C292(1.33); C171(1.10)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C346(1.01); C292(1.02)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C346(1.22); C171(0.81); C104(0.87)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C346(0.98); C292(1.08); C171(0.95)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C346(0.99)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C346(1.21); C171(0.89); C104(0.91)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C346(1.02); C89(0.30); C104(0.73)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C346(1.10); C171(1.23)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C346(0.92); C360(1.11)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C346(0.93); C292(1.02)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C346(0.91); C171(1.02); C360(0.91)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C171(0.69)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C171(0.81)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C171(0.76)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C171(0.62)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C346(0.73); C292(0.88); C171(1.14)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C171(0.80)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C171(0.70)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C171(0.39)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C171(0.53)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C171(0.37)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C171(0.77)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C171(1.13)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C171(0.71)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C171(0.46)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C171(0.39)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C346(1.09)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C171(0.98)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C171(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C171(0.68)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C171(0.72)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C171(0.73)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C171(0.74)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C171(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C171(0.94)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C171(1.25)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C171(1.41)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C346(1.16); C292(0.96); C171(0.97)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C346(1.10); C292(1.13); C171(1.20)  LDD1671  [11]
 LDCM0427  Fragment51 HCT 116 C171(0.54)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C292(1.05); C346(0.96)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C292(1.01); C346(1.10)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C292(1.58)  LDD3310  [12]
 LDCM0109  NEM HeLa N.A.  LDD0225  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C346(0.98)  LDD2100  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C346(0.74)  LDD2109  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C346(0.70)  LDD2127  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C346(0.90)  LDD2141  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840