Details of the Target

General Information of Target

Target ID LDTP13771
Target Name Zinc finger protein 148 (ZNF148)
Gene Name ZNF148
Gene ID 7707
Synonyms
ZBP89; Zinc finger protein 148; Transcription factor ZBP-89; Zinc finger DNA-binding protein 89
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPV
NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGT
CEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEA
IDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP
GTSVPIVKNIAKTESSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSS
VKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVY
VNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGG
EVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEH
DKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENL
SEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKF
QMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEI
DGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Uniprot ID
Q9UQR1
Ensemble ID
ENST00000360647.9
HGNC ID
HGNC:12933

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.T513A DBIA    Probe Info 
HT115 SNV: p.I112L; p.R660Ter .
MEWO SNV: p.F766Y; p.P770L DBIA    Probe Info 
MFE319 SNV: p.I237T .
WM115 SNV: p.G292S .
WM2664 SNV: p.G292S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.23  LDD0403  [1]
AHL-Pu-1
 Probe Info  		C277(8.34)  LDD0171  [2]
DBIA
 Probe Info  		C14(0.94)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		C288(0.00); C14(0.00)  LDD0147  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C277(8.34)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C14(0.74)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C14(1.25)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C14(0.65)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C14(0.63)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C14(0.67)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C14(0.80)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C14(0.66)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C14(0.86)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C14(0.78)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C14(1.02)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C14(0.70)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C14(0.34)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C14(2.04)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C14(0.44)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C14(0.74)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C14(0.98)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C14(1.00)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C14(1.12)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C14(1.32)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C14(1.59)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C14(1.28)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C14(1.49)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C14(1.34)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C14(0.92)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C14(0.69)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C14(0.98)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C14(1.19)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C14(0.94)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C14(1.25)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C14(1.62)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C14(1.55)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C14(2.48)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C14(0.25)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C14(0.35)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C14(0.37)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C14(0.21)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C14(0.37)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C14(0.36)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C14(0.60)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C14(0.40)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C14(0.32)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C14(0.29)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C14(0.52)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C14(0.52)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C14(1.44)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C14(0.63)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C14(0.56)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C14(0.50)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C14(1.22)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C14(2.66)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C14(2.13)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C14(1.53)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C14(1.85)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C14(3.91)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C14(2.79)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C14(1.49)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C14(1.52)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C14(2.09)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C14(1.70)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C14(4.29)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C14(2.72)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C14(1.67)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C14(1.53)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C14(1.61)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C14(1.22)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C14(1.12)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C14(0.97)  LDD1517  [7]
 LDCM0279  AC2 HCT 116 C14(1.08)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C14(1.04)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C14(1.06)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C14(1.04)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C14(1.00); C277(0.96)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C14(0.99); C277(0.92)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C14(1.14)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C14(1.13)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C14(0.96)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C14(1.10)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C14(0.99)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C14(0.83)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C14(1.10)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C14(0.98); C277(1.00)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C14(0.97); C277(1.02)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C14(1.17)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C14(1.14)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C14(1.16)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C14(1.00)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C14(0.92)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C14(1.07)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C14(1.17); C277(1.14)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C14(0.97)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C14(1.05); C277(1.03)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C14(1.31)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C14(1.18)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C14(1.06)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C14(1.25)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C14(1.05)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C14(1.12)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C14(1.16); C277(1.04)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C14(1.13); C277(1.06)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C14(1.31)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C14(0.99)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C14(1.13)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C14(1.03)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C14(1.08)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C14(1.05)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C14(1.14)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C14(1.31); C277(1.01)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C14(1.15); C277(1.12)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C14(1.18)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C14(1.09)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C14(1.04)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C14(0.83)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C14(1.03)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C14(0.95)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C14(1.03)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C14(1.06); C277(0.92)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C14(1.10); C277(1.11)  LDD1567  [7]
 LDCM0334  AC7 HCT 116 C14(1.11)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C14(1.11)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C14(1.95)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C14(1.59)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C14(0.93)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C14(1.52)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C14(1.22)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C14(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C14(2.12)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C14(0.93)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C14(2.37)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C14(2.29)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C14(1.22)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C14(1.04)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C14(2.11)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C14(1.98)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C14(1.34)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C14(1.39)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C14(0.53)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C14(1.10)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C14(1.63)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C14(1.13)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.23  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C14(0.94)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C14(1.00)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C14(1.39)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C14(0.80)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C14(1.15)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C14(1.21)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C14(1.01)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C14(1.12)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C14(1.03)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C14(1.15)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C14(1.19); C277(0.92)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C14(1.29)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C14(0.95)  LDD1582  [7]
 LDCM0379  CL11 HCT 116 C14(1.47)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C14(1.09)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C14(1.02); C277(1.10)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C14(1.20)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C14(1.08)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C14(1.08)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C14(1.26); C277(0.92)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C14(1.22)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C14(1.21)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C14(1.15)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C14(1.09); C277(1.04)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C14(1.61)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C14(1.11)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C14(1.15)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C14(1.14)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C14(1.04); C277(0.71)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C14(1.34)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C14(1.10)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C14(1.08)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C14(1.21); C277(1.00)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C14(1.07)  LDD1603  [7]
 LDCM0400  CL13 HCT 116 C14(1.28)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C14(1.52)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C14(1.04)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C14(1.13)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C14(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C14(1.15)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C14(1.01)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C14(0.97)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C14(1.02)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C14(0.97)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C14(1.33)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C14(1.23)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C14(1.23)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C14(1.03)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C14(1.13)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C14(1.23)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C14(1.24)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C14(1.18)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C14(1.20)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C14(1.12)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C14(1.21)  LDD1624  [7]
 LDCM0421  CL32 HCT 116 C14(1.02)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C14(0.84)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C14(0.90)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C14(1.20)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C14(0.80)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C14(1.27)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C14(0.96)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C14(0.80)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C14(0.78)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C14(0.95)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C14(0.78)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C14(0.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C14(1.15)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C14(1.13)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C14(1.25)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C14(1.17); C277(1.00)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C14(1.13); C277(1.07)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C14(1.00)  LDD1643  [7]
 LDCM0440  CL5 HCT 116 C14(1.04)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C14(1.07)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C14(1.22)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C14(1.22)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C14(1.09)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C14(1.13)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C14(1.11)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C14(0.95)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C14(1.23)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C14(1.11); C277(1.00)  LDD1653  [7]
 LDCM0451  CL6 HCT 116 C14(1.06)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C14(1.16); C277(1.15)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C14(0.94)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C14(0.74)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C14(1.06)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C14(0.86)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C14(0.84)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C14(0.86)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C14(0.94)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C14(0.64)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C14(1.05)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C14(1.50)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C14(0.68)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C14(0.81)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C14(0.88)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C14(0.78)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C14(0.94)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C14(1.11)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C14(1.13)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C14(1.17)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C14(1.10)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C14(0.95)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C14(1.04)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C14(1.09)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C14(1.06)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C14(1.22); C277(1.20)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C14(1.07); C277(1.16)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C14(0.86)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C14(0.96)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C14(0.98); C277(0.98)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C14(1.03)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C14(1.12)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C14(1.11)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C14(0.85)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C14(0.82)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C14(0.76)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C14(1.01)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C14(1.05)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C14(0.86)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C14(0.83)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C14(0.89)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C14(0.86)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C14(0.95)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C14(1.03); C277(0.92)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C14(0.78)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C14(0.90)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C14(0.86); C277(0.75)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C14(1.00); C277(1.05)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1155 C14(2.41)  LDD3342  [8]
 LDCM0021  THZ1 HCT 116 C14(1.11)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Tripartite motif-containing protein 10 (TRIM10) TRIM/RBCC family Q9UDY6
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Glutaredoxin-3 (GLRX3) . O76003
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Puratrophin-1 (PLEKHG4) . Q58EX7
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840