Details of the Target

General Information of Target

Target ID LDTP13565
Target Name CCR4-NOT transcription complex subunit 6 (CNOT6)
Gene Name CNOT6
Synonyms
CCR4; CCR4a; KIAA1194; CCR4-NOT transcription complex subunit 6; EC 3.1.13.4; CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHE
IEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPS
RSSSPANQRAETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRD
TSRITGSHKTEQRNADLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRG
SRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKR
IDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIP
APVKASSPIKQSHEPVPDTSVEKGFPASTEAERHTPFYALPSSLERTPTKMTTSQKVTFC
SHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPT
STPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQGTGSPVPK
IHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPH
VPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALP
STVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKA
QVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQG
AILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGP
GGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLK
VISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPA
VALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVP
TPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSF
STSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNY
VIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMT
MRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSE
PECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKF
YLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGY
QTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ
Target Bioclass
Enzyme
Family
CCR4/nocturin family
Subcellular location
Cytoplasm
Function
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
Uniprot ID
Q9ULM6
Ensemble ID
ENST00000261951.9
HGNC ID
HGNC:14099
ChEMBL ID
CHEMBL3616363

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(0.95)  LDD0532  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C338
 Probe Info  		24.25  LDD2001  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C210(1.14)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C210(0.95)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C210(0.95)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C210(0.87)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C210(0.91)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C210(0.88)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C210(0.98)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C210(0.98)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C210(0.96)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C210(0.91)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C210(0.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C210(1.14)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C210(1.01)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C210(1.00)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C210(1.18)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C210(0.83)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C210(0.86)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C210(0.90)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C210(1.16)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C210(1.08)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C210(1.59)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C210(1.31)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C210(1.10)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C210(1.26)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C210(0.77)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C210(1.67)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C210(0.94)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C210(1.44)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C210(1.22)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C210(0.75)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C210(0.90)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C210(1.06)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C210(0.98)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C210(1.03)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C210(1.03)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C210(0.96)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C210(1.06)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C210(1.08)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C210(1.09)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C210(1.10)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C210(1.17)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C210(0.99)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C210(0.84)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C210(0.88)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C210(1.53)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C210(1.03)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C210(0.94)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C210(1.03)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C210(1.06)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C210(1.05)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C210(1.41)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C210(1.04)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C210(0.91)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C210(0.92)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C210(0.88)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C210(1.25)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C210(1.21)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C210(1.09)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C210(0.92)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C210(0.76)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C210(1.07)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C210(1.11)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C210(1.20)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C210(1.83)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C210(1.08)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C210(0.97)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C210(1.02)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C210(1.09)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C210(1.02)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C210(1.19)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C210(0.90)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C210(1.02)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C210(1.04)  LDD0882  [1]
 LDCM0290  AC3 HEK-293T C210(0.95)  LDD0888  [1]
 LDCM0292  AC31 HEK-293T C451(1.01)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C451(1.17)  LDD1532  [7]
 LDCM0300  AC39 HEK-293T C451(1.03)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C210(1.27)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C451(0.91)  LDD1541  [7]
 LDCM0308  AC46 HCT 116 C210(1.03)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C210(0.96)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C210(0.88)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C210(0.91)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C210(1.05)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C210(0.99)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C210(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C210(0.99)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C210(0.92)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C210(0.89)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C210(0.66)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C210(0.77)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C210(1.14)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C210(0.84)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C210(0.80)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C210(1.44)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C210(0.86)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C210(0.88)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C210(0.83)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C210(0.89)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C210(0.93)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C210(0.94)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C210(0.83)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C210(0.82)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C210(0.78)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C210(0.60)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C210(1.15)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C210(0.38)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C210(0.86)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C210(0.65)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C210(0.55)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C210(0.53)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C210(0.56)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C210(0.46)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C210(0.52)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C210(0.91)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C210(0.70)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C210(0.86)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C210(0.59)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C210(0.93)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C210(0.49)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C210(1.06)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C210(1.07)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C210(1.14)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C210(1.18)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C210(1.13)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C210(1.11)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C210(1.13)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C210(1.11)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C210(1.13)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C210(1.02)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C210(1.15)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C210(1.19)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C210(1.10)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C210(1.22)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C210(0.83)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C210(1.01)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C210(0.97)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C210(0.91)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C210(1.20)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C210(1.66)  LDD0592  [1]
 LDCM0367  CL1 PaTu 8988t C210(0.88)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C210(0.38)  LDD1247  [1]
 LDCM0369  CL100 HEK-293T C210(1.07)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C210(1.25)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C210(1.85)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C210(1.44)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C210(1.57)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C210(0.95)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C210(0.88)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C210(1.00)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C210(0.97)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C210(0.94)  LDD0976  [1]
 LDCM0379  CL11 PaTu 8988t C210(0.85)  LDD1258  [1]
 LDCM0380  CL110 HEK-293T C210(0.96)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C210(0.92)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C283(0.95)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C451(1.02)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C451(0.97)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C283(1.01)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C451(1.03)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C451(0.94)  LDD1592  [7]
 LDCM0390  CL12 PaTu 8988t C210(0.64)  LDD1269  [1]
 LDCM0391  CL120 HEK-293T C283(1.01)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C210(0.71)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C210(0.79)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C210(0.81)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C210(0.78)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C210(0.81)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C210(0.86)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C210(0.95)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C210(0.81)  LDD0997  [1]
 LDCM0400  CL13 PaTu 8988t C210(0.51)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C210(0.48)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C210(0.71)  LDD1281  [1]
 LDCM0403  CL16 HCT 116 C210(0.65)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C210(0.95)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C210(0.91)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C210(1.06)  LDD0723  [1]
 LDCM0407  CL2 PaTu 8988t C210(0.71)  LDD1286  [1]
 LDCM0408  CL20 HCT 116 C210(0.92)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C210(0.95)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C210(1.03)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C210(1.13)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C210(0.71)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C210(0.71)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C210(0.78)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C210(0.99)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C210(0.76)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C210(0.89)  LDD0734  [1]
 LDCM0418  CL3 PaTu 8988t C210(0.53)  LDD1297  [1]
 LDCM0419  CL30 HCT 116 C210(0.93)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C210(0.78)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C210(0.59)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C210(0.79)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C210(0.46)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C210(0.42)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C210(0.45)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C210(0.45)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C210(0.42)  LDD0745  [1]
 LDCM0429  CL4 PaTu 8988t C210(0.61)  LDD1308  [1]
 LDCM0430  CL40 HCT 116 C210(0.50)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C210(0.55)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C210(0.45)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C210(0.50)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C210(0.61)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C210(0.48)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C210(1.45)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C210(1.09)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C210(1.68)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C210(1.04)  LDD0756  [1]
 LDCM0440  CL5 PaTu 8988t C210(0.47)  LDD1319  [1]
 LDCM0441  CL50 HCT 116 C210(0.67)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C210(1.37)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C210(1.09)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C210(1.14)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C210(1.20)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C210(1.02)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C210(0.77)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C210(1.71)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C210(1.72)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C210(0.91)  LDD0767  [1]
 LDCM0451  CL6 PaTu 8988t C210(0.49)  LDD1330  [1]
 LDCM0452  CL60 HCT 116 C210(1.05)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C210(0.98)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C210(0.95)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C210(0.72)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C210(0.84)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C210(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C210(0.40)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C210(0.68)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C210(0.53)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C210(0.57)  LDD0778  [1]
 LDCM0462  CL7 PaTu 8988t C210(0.48)  LDD1341  [1]
 LDCM0463  CL70 HCT 116 C210(0.72)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C210(0.75)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C210(0.87)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C210(0.83)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C210(0.96)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C210(0.72)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C210(0.94)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C210(0.76)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C210(1.20)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C210(0.46)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C210(0.68)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C210(0.71)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C210(0.71)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C210(0.66)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C210(0.64)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C210(0.84)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C210(0.71)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C210(0.61)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C210(0.68)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C210(0.66)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C210(0.46)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C210(0.59)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C210(1.02)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C210(1.33)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C210(0.84)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C210(1.18)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C210(1.28)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C210(1.24)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C210(1.06)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C210(1.26)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C210(1.05)  LDD1092  [1]
 LDCM0575  Fragment13 Ramos C451(0.83)  LDD2192  [8]
 LDCM0580  Fragment21 Ramos C451(0.68)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C451(1.24)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C451(0.72)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C451(0.89)  LDD2198  [8]
 LDCM0589  Fragment31 Ramos C451(0.70)  LDD2200  [8]
 LDCM0468  Fragment33 HCT 116 C210(0.67)  LDD0785  [1]
 LDCM0596  Fragment38 Ramos C451(0.82)  LDD2203  [8]
 LDCM0427  Fragment51 HCT 116 C210(0.43)  LDD0744  [1]
 LDCM0610  Fragment52 Ramos C451(1.50)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C451(0.77)  LDD2205  [8]
 LDCM0022  KB02 COLO 320 C210(1.32)  LDD2303  [9]
 LDCM0023  KB03 HuP-T3 C210(1.95)  LDD2794  [9]
 LDCM0024  KB05 PaTu 8988t C210(1.60)  LDD3393  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 7 (CNOT7) CAF1 family Q9UIV1
CCR4-NOT transcription complex subunit 8 (CNOT8) CAF1 family Q9UFF9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
Trinucleotide repeat-containing gene 6C protein (TNRC6C) GW182 family Q9HCJ0
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840