Details of the Target

General Information of Target

Target ID LDTP13446
Target Name TRAF2 and NCK-interacting protein kinase (TNIK)
Gene Name TNIK
Gene ID 23043
Synonyms
KIAA0551; TRAF2 and NCK-interacting protein kinase; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAA
AAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQY
DEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKI
DLSGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPGDWTAAIGDDTFTFWRGL
KDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLAS
HKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPPPVKRPR
LARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPLGKVVSTLPSTVLGKGSLQAPPA
SSPASPLLGGYTVLASSGSTYPSTVEIHPDASSLTVLSTAAVQDGSTVFKVVSPLQLLTL
PGLGPTLQNVAQASPGSSTIVTVPAGAAPGPEEHTATIEVAAMAEDHERK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Nucleus
Function
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
TTD ID
T72534
Uniprot ID
Q9UKE5
DrugMap ID
TTPB1W3
Ensemble ID
ENST00000284483.12
HGNC ID
HGNC:30765
ChEMBL ID
CHEMBL4527

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.S77F .
G361 SNV: p.G749R .
HCC1395 SNV: p.R477S .
HCT15 SNV: p.E414D; p.R789W .
HSC4 SNV: p.P689T .
HT3 SNV: p.E332D .
JURKAT Deletion: p.L683Ter
SNV: p.A682E		 .
KPL1 SNV: p.G884V .
MCF7 SNV: p.G884V .
MDST8 SNV: p.Y323Ter .
MEWO SNV: p.P246S; p.S830F; p.G1280R .
NCIH2170 SNV: p.S1021L .
NCIH2172 SNV: p.R632L .
NCIH358 SNV: p.R313P .
SKMEL2 SNV: p.P776H .
SSP25 SNV: p.E886Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		50.00  LDD0214  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C269(0.95)  LDD0547  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-4
 Probe Info  		3.20  LDD0075  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C269(1.49)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C234(0.93)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C234(0.94); C269(0.97)  LDD1509  [7]
 LDCM0230  AC113 HCT 116 C269(0.95)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C269(0.80)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C269(0.78)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C269(0.82)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C269(0.80)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C269(0.88)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C269(0.81)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C202(0.92); C234(0.93)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C269(0.92)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C269(0.90)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C269(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C269(0.93)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C269(0.90)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C269(0.86)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C269(0.73)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C269(0.78)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C202(1.21); C234(0.83)  LDD1512  [7]
 LDCM0263  AC143 HEK-293T C269(0.91)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C269(0.86)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C269(1.00)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C269(0.84)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C269(1.19)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C269(1.02)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C269(0.74)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C202(0.97); C234(1.07)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C269(0.99)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C269(1.00)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C269(0.86)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C269(0.82)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C269(0.91)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C269(1.02)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C269(0.97)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C269(1.13)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C269(1.13)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C269(1.16)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C269(1.02)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C269(0.92)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C269(0.81)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C269(0.92)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C269(0.72)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C269(0.80)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C269(0.80)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C234(1.05)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C234(0.82)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C234(1.28); C269(1.01)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C202(1.06); C234(1.01)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C202(1.11); C269(0.98)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C269(0.76)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C202(0.82); C234(1.49)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C202(0.94); C234(1.00)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C202(0.92)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C234(1.01)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C234(1.02)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C269(0.99)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C269(1.12)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C269(1.16)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C269(0.88)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C269(0.91)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C269(1.11)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C269(1.20)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C269(1.08)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C269(0.93)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C269(1.26)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C269(0.96)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C269(0.84)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C269(1.10)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C269(0.97)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C269(1.00)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C269(0.89)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C269(1.10)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C269(1.02)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C269(0.96)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C269(1.08)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C269(0.96)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C269(1.05)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C269(0.89)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C269(0.94)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C269(0.70)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C269(0.71)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C269(0.67)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C202(0.86); C234(0.73)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C269(1.49)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C269(0.86)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C269(0.81)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C269(0.86)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C269(0.69)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C269(0.82)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C269(0.81)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C269(0.65)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C202(1.20); C234(0.79)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C202(1.16)  LDD1569  [7]
 LDCM0349  AC83 HCT 116 C269(0.78)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C269(0.90)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C269(0.82)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C269(0.99)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C269(1.01)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C269(0.91)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C269(0.81)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C269(0.89)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C269(0.90)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C269(0.83)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C269(0.79)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C269(0.92)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C269(0.83)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C269(0.68)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C269(0.86)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C202(0.95); C269(1.03)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C234(1.13)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C202(1.05)  LDD1514  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C269(0.82)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C269(0.88)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C269(0.82)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C202(1.10); C234(0.99)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C202(1.19); C269(0.76)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C202(1.12); C234(0.96)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C202(0.93); C234(1.04); C269(0.97)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C269(0.78)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C269(0.96)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C269(1.00)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C269(0.88)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C269(0.86)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C269(0.84)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C269(1.11)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C269(1.14)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C202(0.95); C234(1.17); C269(0.90)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C202(1.07); C234(0.99)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C202(1.10); C269(1.00)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C202(1.37); C234(0.86)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C202(1.04); C234(1.12); C269(0.99)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C269(1.26)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C269(0.96)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C269(1.13)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C269(0.67)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C269(0.90)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C269(0.89)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C269(0.95)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C269(0.96)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C269(0.94)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C269(0.76)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C269(0.63)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C269(0.91)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C269(0.74)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C269(0.75)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C269(0.74)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C269(0.62)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C269(0.86)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C269(0.84)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C269(0.65)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C269(0.80)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C269(0.67)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C269(0.81)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C269(0.69)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C269(0.66)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C269(0.71)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C269(0.70)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C269(0.66)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C269(0.82)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C269(0.70)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C269(0.74)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C269(0.74)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C269(0.73)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C269(0.80)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C269(0.80)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C269(0.84)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C269(0.78)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C269(0.84)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C269(0.75)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C269(0.74)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C269(0.75)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C269(0.83)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C269(0.64)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C269(0.68)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C269(0.88)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C269(0.78)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C269(0.83)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C269(0.82)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C269(0.75)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C202(0.80); C234(1.00)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C202(0.71); C234(1.07)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C202(0.65)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C202(1.02); C234(1.02)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C269(0.80)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C202(1.02); C269(0.94)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C202(0.95); C234(1.00); C269(1.10)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C234(1.10)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C234(0.56)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C234(1.16); C269(1.11)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C202(0.73); C234(0.83)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C202(0.77); C269(0.98)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C202(1.08); C234(1.10)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C202(0.75); C234(1.02)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C269(0.61)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C202(0.81)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C269(1.07)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C269(0.91)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C269(0.84)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C269(0.76)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C269(0.94)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C269(0.78)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C269(0.84)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C269(0.77)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C269(0.81)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C269(0.99)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C269(0.83)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C269(0.86)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C269(1.01)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C269(0.78)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C269(0.84)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C202(1.02); C234(1.07); C269(0.93)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C234(1.04)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C234(0.99)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C234(0.89); C269(1.05)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C269(1.20)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C202(0.89); C234(0.83)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C202(0.94); C269(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C202(0.76); C234(0.92)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C202(0.69); C234(1.08)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C202(0.79)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C202(1.02); C234(1.04)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C202(1.07); C269(1.01)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C202(1.17); C234(1.00)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C202(0.83); C234(1.10); C269(0.82)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C234(1.17)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C269(1.24)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C234(0.72)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C269(1.05)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C269(1.00)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C269(0.53)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C269(0.79)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C269(0.87)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C269(0.90)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C269(1.05)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C269(0.80)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C269(0.88)  LDD1092  [3]
 LDCM0017  DFG-out-2 A431 3.20  LDD0075  [6]
 LDCM0495  E2913 HEK-293T C202(1.03); C234(1.02)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C269(0.87)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C269(0.60)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C234(1.21)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C234(0.96)  LDD1497  [7]
 LDCM0024  KB05 SNG-M C202(1.49)  LDD3436  [8]
 LDCM0109  NEM HeLa N.A.  LDD0225  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) STE Ser/Thr protein kinase family O43318
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor 7-like 2 (TCF7L2) TCF/LEF family Q9NQB0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) . Q9NYJ8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid23232060c5 Small molecular drug D0K0UM

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840