Details of the Target

General Information of Target

Target ID LDTP12785
Target Name DNA helicase MCM9 (MCM9)
Gene Name MCM9
Gene ID 254394
Synonyms
C6orf61; MCMDC1; DNA helicase MCM9; hMCM9; EC 3.6.4.12; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEQPRKAVVVTGFGPFGEHTVNASWIAVQELEKLGLGDSVDLHVYEIPVEYQTVQRLIPA
LWEKHSPQLVVHVGVSGMATTVTLEKCGHNKGYKGLDNCRFCPGSQCCVEDGPESIDSII
DMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYQSHGRSAFVHVPPLGKPYNADQ
LGRALRAIIEEMLDLLEQSEGKINYCHKH
Target Bioclass
Enzyme
Family
MCM family
Subcellular location
Nucleus
Function
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
Uniprot ID
Q9NXL9
Ensemble ID
ENST00000316068.7
HGNC ID
HGNC:21484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.N847Y .
CAL33 SNV: p.D24N .
COLO800 SNV: p.G1082S .
HGC27 SNV: p.S956F .
ICC4 SNV: p.G102C .
IPC298 SNV: p.S181F .
LNCaP clone FGC SNV: p.V270I .
MCC13 SNV: p.R32K; p.S1119F .
NUGC3 SNV: p.L634I .
OVK18 SNV: p.Y164H .
PF382 SNV: p.A900T .
SKMEL2 Insertion: p.S1143VfsTer59 .
SNU1 SNV: p.D885N .
TE10 SNV: p.T975I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C106(2.44)  LDD0169  [1]
DBIA
 Probe Info  		C185(0.90)  LDD0547  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		C1053(0.00); C1009(0.00); C852(0.00)  LDD0018  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C106(2.44)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C106(0.68); C167(1.12)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C106(0.77); C167(1.33); C172(1.08)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C106(0.94); C167(1.08); C172(0.88)  LDD0824  [2]
 LDCM0230  AC113 HCT 116 C185(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C185(1.26)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C185(1.09)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C185(1.21)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C185(1.13)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C185(1.11)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C185(0.88)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C106(0.70); C167(1.36); C172(0.92)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C185(0.87)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C185(0.94)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C185(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C185(0.94)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C185(0.99)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C185(1.19)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C185(1.10)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C185(1.14)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C106(1.14); C167(1.09); C185(0.68)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C106(0.76); C167(0.97); C185(0.76)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C106(0.92); C167(1.30); C185(0.66)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C106(1.00); C167(1.10); C185(0.86)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C106(0.94); C167(1.04); C185(0.61)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C106(0.81); C167(1.10); C185(0.79)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C106(0.84); C167(1.12); C185(0.69)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C106(0.87); C167(0.89); C185(0.68)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C106(0.92); C167(1.10); C185(1.17)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C106(0.93); C167(0.97); C185(0.74)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C106(1.06); C167(1.11); C185(0.79)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C106(0.92); C167(1.39); C185(1.33)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C106(0.74); C167(1.52); C172(1.26)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C106(0.85); C167(1.14); C185(1.06)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C106(0.86); C167(1.04); C185(0.87)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C106(0.86); C167(1.00); C185(0.67)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C106(1.05); C185(0.51)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C106(1.17); C185(0.68)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C106(1.11); C185(0.85)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C106(1.11); C185(0.59)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C106(1.30); C185(0.92)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C106(1.20); C185(0.59)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C106(1.07); C185(0.77)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C106(0.66); C167(1.04); C172(1.14)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C106(1.13); C185(0.56)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C106(0.93); C185(0.73)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C106(1.00); C185(0.57)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C106(1.05); C185(0.63)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C106(1.00); C185(0.67)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C106(1.05); C185(0.75)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C106(1.32); C185(0.80)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C106(1.35); C185(0.61)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C185(1.07)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C185(0.76)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C185(0.77)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C106(0.71); C167(0.81)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C185(0.88)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C185(1.51)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C185(1.08)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C185(0.81)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C185(0.91)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C185(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C185(0.96)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C185(0.95)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C185(1.03)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C185(1.02)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C106(0.95); C167(0.86)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C185(1.07)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C185(1.14)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C185(1.00)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C185(0.95)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C185(0.93)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C185(0.66)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C185(0.68)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C185(0.53)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C185(0.74)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C185(0.70)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C106(0.94); C167(0.76)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C185(0.76)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C185(0.65)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C185(0.47)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C185(0.73)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C185(0.75)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C185(0.59)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C185(0.96)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C185(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C185(1.28)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C185(0.98)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C106(0.67); C167(0.72)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C185(1.03)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C185(0.93)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C185(1.02)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C185(1.40)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C185(0.96)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C185(1.10)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C185(1.29)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C185(1.13)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C185(1.61)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C185(1.20)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C106(0.93); C167(0.87); C172(0.52)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C185(1.23)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C185(1.15)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C185(1.56)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C185(1.39)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C185(1.46)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C185(1.55)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C185(1.49)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C185(1.47)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C106(0.98); C185(1.03)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C106(0.96); C185(1.11)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C106(0.66); C167(0.84); C172(0.85)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C106(0.88); C185(1.04)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C106(0.95); C185(1.17)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C106(1.05); C185(1.12)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C106(0.89); C185(0.98)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C106(0.85); C185(0.87)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C106(0.92); C185(1.01)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C106(0.90); C185(0.93)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C106(0.92); C185(0.98)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C106(0.76); C185(1.12)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C106(0.93); C185(1.16)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C106(0.58); C167(0.97); C172(0.75)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C106(0.89); C185(0.98)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C106(0.94); C185(0.91)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C106(0.90); C185(1.18)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C185(0.94)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C185(0.94)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C185(1.08)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C185(1.14)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C185(1.08)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C185(0.98)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C185(1.10)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C185(1.14)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C185(1.08)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C185(1.06)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C185(1.01)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C185(0.98)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C185(1.10)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C185(1.08)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C185(1.16)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C106(0.82); C167(1.15); C172(1.00)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C106(0.61); C167(1.16); C172(1.01)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C106(0.62); C167(0.55); C172(0.95)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C1009(1.00); C106(0.97); C870(0.76); C632(1.10)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C1009(0.84); C106(1.26); C632(1.12); C185(0.83)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C106(0.58); C167(0.77)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C106(0.53); C167(1.16); C172(0.81)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C106(0.54); C167(0.96); C172(1.15)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C106(0.53); C167(1.16); C172(1.06)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C106(0.67); C167(1.07); C172(0.84)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C185(0.96)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C185(0.75)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C185(1.39)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C185(1.26)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C185(0.77)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C1009(1.01); C106(1.15); C185(0.97); C1053(1.11)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C185(0.70)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C185(0.74)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C185(0.83)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C185(0.95)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C185(1.00)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C185(0.93)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C185(1.13)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C185(0.69)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C185(0.65)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C185(0.65)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C1009(1.03); C106(0.92); C870(1.29); C185(0.93)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C185(0.76)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C185(0.81)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C185(1.16)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C185(0.92)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C185(1.19)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C185(0.95)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C185(1.20)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C185(0.99)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C185(1.76)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C1009(1.06); C106(0.98); C870(1.08); C632(1.05)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C1009(1.13); C106(0.98); C870(1.10); C185(0.94)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C1009(0.91); C106(1.03); C185(0.90); C1133(0.99)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C106(0.79)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C106(0.77)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C106(0.73)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C106(0.80)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C1009(1.06); C106(0.93); C870(1.05); C185(1.09)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C106(0.79)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C106(0.70)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C106(0.71)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C106(1.11)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C106(0.98)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C106(0.70)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C106(0.75)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C106(0.86)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C106(0.91)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C106(0.79)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C1009(0.93); C106(0.93); C185(0.98); C1133(1.03)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C106(0.87)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C185(0.69)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C185(0.96)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C185(1.24)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C185(1.06)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C185(0.81)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C185(0.81)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C185(1.72)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C185(1.44)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C1009(1.00); C106(1.03); C870(1.18); C185(1.01)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C185(0.72)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C185(1.19)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C185(1.37)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C185(1.10)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C185(1.59)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C185(1.22)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C106(0.73); C172(0.66)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C106(0.82); C172(0.82)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C106(0.86); C172(0.63)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C106(0.72); C172(0.96)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C1009(1.10); C106(1.05); C870(1.08); C185(1.06)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C106(0.73); C172(1.21)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C106(0.79); C172(1.16)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C106(1.48); C172(0.79)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C106(1.12); C172(0.86)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C106(0.85); C172(1.06)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C106(0.71); C172(0.83)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C106(1.11); C172(0.82)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C106(0.78); C172(0.87)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C106(0.94); C172(1.10)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C106(0.75); C172(1.06)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C1009(0.86); C106(1.08); C185(1.21); C1053(1.14)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C106(0.64); C172(1.17)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C185(1.06)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C185(0.88)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C185(0.71)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C185(1.03)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C185(0.83)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C185(0.75)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C185(0.89)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C185(1.11)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C185(1.14)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C1009(0.96); C106(1.03); C185(1.01); C1053(0.92)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C185(0.87)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C185(0.98)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C185(1.11)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C185(1.48)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C185(1.76)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C185(1.04)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C185(1.38)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C185(1.32)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C185(1.11)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C1009(0.87); C106(1.62); C632(1.08); C185(0.81)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C185(1.20)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C185(1.07)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C185(1.20)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C185(1.77)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C185(1.31)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C185(0.89)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C185(1.42)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C185(1.28)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C185(1.27)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C185(1.39)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C1009(1.12); C106(1.04); C870(0.96); C632(1.07)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C185(1.32)  LDD1364  [2]
 LDCM0486  CL91 HEK-293T C106(0.99); C167(0.75)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C106(0.78); C167(0.56)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C106(0.82); C167(0.75)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C106(0.60); C167(0.77)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C106(0.52); C167(0.85)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C106(0.66); C167(1.46)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C106(0.69); C167(0.91)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C106(0.77); C167(0.75)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C106(0.86); C167(1.10)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C1009(0.89); C106(1.05); C185(0.87); C1133(1.20)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C185(0.92)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C185(1.32)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C870(0.91); C185(1.03); C106(0.87)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C870(0.96); C185(1.05); C106(0.96)  LDD1497  [7]
 LDCM0024  KB05 OCUG-1 C529(3.37)  LDD3373  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C632(0.98)  LDD2207  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA helicase MCM8 (MCM8) MCM family Q9UJA3
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
DNA mismatch repair protein Msh6 (MSH6) DNA mismatch repair MutS family P52701
LRP chaperone MESD (MESD) MESD family Q14696

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.