Details of the Target

General Information of Target

Target ID LDTP12736
Target Name Large ribosomal subunit protein uL22m (MRPL22)
Gene Name MRPL22
Gene ID 29093
Synonyms
MRPL25; RPML25; Large ribosomal subunit protein uL22m; 39S ribosomal protein L22, mitochondrial; L22mt; MRP-L22; 39S ribosomal protein L25, mitochondrial; L25mt; MRP-L25
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVD
LETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEA
ALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAV
LDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK
Target Bioclass
Other
Family
Universal ribosomal protein uL22 family
Subcellular location
Mitochondrion
Uniprot ID
Q9NWU5
Ensemble ID
ENST00000265229.12
HGNC ID
HGNC:14480

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.A108PfsTer3 DBIA    Probe Info 
DU145 SNV: p.E174V DBIA    Probe Info 
KMCH1 SNV: p.G175R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.95  LDD0402  [1]
STPyne
 Probe Info  		K191(16.45)  LDD2217  [2]
BTD
 Probe Info  		C70(0.83)  LDD2096  [3]
DBIA
 Probe Info  		C70(1.31)  LDD0080  [4]
ATP probe
 Probe Info  		K191(0.00); K50(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C70(0.00); C166(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		C70(0.00); C146(0.00)  LDD0025  [8]
JW-RF-010
 Probe Info  		C70(0.00); C146(0.00)  LDD0026  [8]
TFBX
 Probe Info  		C70(0.00); C146(0.00)  LDD0027  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Crotonaldehyde
 Probe Info  		C70(0.00); C166(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		C166(0.00); C70(0.00)  LDD0218  [10]
AOyne
 Probe Info  		12.20  LDD0443  [11]
NAIA_5
 Probe Info  		C70(0.00); C146(0.00); C166(0.00)  LDD2223  [12]
TER-AC
 Probe Info  		N.A.  LDD0426  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		8.88  LDD1766  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C70(0.85)  LDD2142  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C70(1.66)  LDD2152  [3]
 LDCM0214  AC1 HEK-293T C70(1.13)  LDD0812  [4]
 LDCM0215  AC10 HCT 116 C70(0.39)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C70(0.36)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C70(0.45)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C70(0.31)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C70(0.15)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C70(0.14)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C70(0.15)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C70(0.15)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C70(0.16)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C70(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C70(0.97)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C70(0.34)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C70(0.53)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C70(0.61)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C70(0.25)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C70(1.08)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C70(1.03)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C70(0.94)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C70(0.89)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C70(0.89)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C70(0.91)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C70(0.90)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C70(0.77)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C70(1.02)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C70(0.98)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C70(1.08)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C70(1.01)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C70(0.89)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C70(0.97)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C70(1.15)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C70(1.19)  LDD0843  [4]
 LDCM0246  AC128 HCT 116 C70(0.85)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C70(1.90)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C70(0.84)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C70(1.85)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C70(2.11)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C70(0.88)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C70(0.73)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C70(0.79)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C70(0.90)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C70(1.14)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C70(0.78)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C70(0.90)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C70(0.61)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C70(0.77)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C70(0.85)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C70(5.43)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C70(0.77)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C70(0.11)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C70(0.39)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C70(0.22)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C70(0.11)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C70(0.14)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C70(0.12)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C70(0.34)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C70(0.43)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C70(0.65)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C70(0.11)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C70(0.15)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C70(0.12)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C70(0.13)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C70(0.85)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C70(0.85)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C70(0.89)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C70(0.84)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C70(0.91)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C70(0.95)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C70(0.98)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C70(1.04)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C70(0.83)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C70(0.77)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C70(0.84)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C70(0.78)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C70(0.84)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C70(0.81)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C70(1.91)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C70(0.73)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C70(1.02)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C70(0.63)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C70(0.96)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C70(0.82)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C70(0.81)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C70(0.73)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C70(0.91)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C70(0.69)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C70(0.59)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C70(0.62)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C70(0.84)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C70(1.22)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C70(0.79)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C70(0.74)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C70(0.69)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C70(0.96)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C70(1.01)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C70(0.68)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C70(1.26)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C70(0.89)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C70(4.71)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C70(1.05)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C70(1.10)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C70(0.96)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C70(2.71)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C70(0.90)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C70(0.90)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C70(0.80)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C70(1.04)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C70(1.27)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C70(0.23)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C70(0.24)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C70(0.20)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C70(0.34)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C70(0.35)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C70(0.97)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C70(0.22)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C70(0.25)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C70(0.22)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C70(0.23)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C70(0.27)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C70(0.25)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C70(0.53)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C70(0.54)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C70(0.73)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C70(0.48)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C70(0.90)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C70(0.48)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C70(0.65)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C70(0.71)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C70(0.74)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C70(0.47)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C70(0.49)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C70(1.56)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C70(0.53)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C70(0.43)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C70(0.45)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C70(1.86)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C70(0.80)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C70(0.19)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C70(0.18)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C70(0.50)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C70(0.26)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C70(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C70(0.32)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C70(0.16)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C70(1.59)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C70(0.17)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C70(0.15)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C70(0.22)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C70(0.63)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C70(1.13)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C70(0.22)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C70(0.15)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C70(0.17)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C70(0.56)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C70(0.97)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C70(0.64)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C70(0.17)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 8.82  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C70(1.11)  LDD2171  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C70(20.00)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C70(0.98)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C70(1.00)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C70(0.93)  LDD0967  [4]
 LDCM0370  CL101 HCT 116 C70(0.26)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C70(0.74)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C70(0.70)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C70(0.69)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C70(0.89)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C70(0.89)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C70(1.00)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C70(0.91)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C70(0.90)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C70(0.97)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C70(0.92)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C70(0.89)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C70(0.82)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C70(0.93)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C70(0.79)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C70(0.69)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C70(0.64)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C70(0.65)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C70(0.73)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C70(0.78)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C70(0.93)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C70(0.77)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C70(0.72)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C70(1.17)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C70(0.93)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C70(0.96)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C70(0.78)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C70(0.55)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C70(0.58)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C70(0.19)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C70(0.77)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C70(1.07)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C70(1.17)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C70(0.92)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C70(0.83)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C70(0.95)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C70(0.93)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C70(1.01)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C70(0.90)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C70(1.03)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C70(0.94)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C70(0.87)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C70(0.97)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C70(0.82)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C70(1.06)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C70(0.89)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C70(0.83)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C70(0.96)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C70(0.82)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C70(0.96)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C70(0.91)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C70(1.02)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C70(0.89)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C70(0.97)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C70(0.91)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C70(0.94)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C70(0.87)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C70(0.95)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C70(0.80)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C70(0.96)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C70(0.84)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C70(0.83)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C70(0.92)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C70(0.93)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C70(0.83)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C70(3.25)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C70(2.52)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C70(2.78)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C70(0.87)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C70(0.70)  LDD1038  [4]
 LDCM0441  CL50 HCT 116 C70(1.82)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C70(1.71)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C70(1.87)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C70(1.70)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C70(2.11)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C70(2.31)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C70(0.96)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C70(2.05)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C70(2.43)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C70(1.02)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C70(0.73)  LDD1049  [4]
 LDCM0452  CL60 HCT 116 C70(1.24)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C70(0.80)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C70(0.49)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C70(0.30)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C70(0.17)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C70(0.49)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C70(0.16)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C70(0.16)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C70(0.42)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C70(1.68)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C70(1.01)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C70(0.76)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C70(0.26)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C70(0.67)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C70(0.31)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C70(0.23)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C70(0.87)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C70(0.82)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C70(0.34)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C70(0.21)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C70(1.25)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C70(1.61)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C70(0.27)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C70(0.25)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C70(0.27)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C70(0.30)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C70(0.26)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C70(0.57)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C70(0.26)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C70(0.23)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C70(0.34)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C70(1.34)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C70(1.03)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C70(1.18)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C70(1.36)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C70(0.95)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C70(0.82)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C70(0.91)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C70(0.97)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C70(0.93)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C70(1.01)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C70(1.12)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C166(1.06); C70(0.99)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C70(0.85)  LDD1702  [3]
 LDCM0572  Fragment10 Ramos C166(0.39)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C166(0.63); C70(1.44)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C166(0.51)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C166(1.16)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C166(0.84); C70(1.18)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C166(0.43)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C166(0.85)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C166(0.78)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C166(0.85)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C166(0.53); C70(0.68)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C166(1.00)  LDD2199  [16]
 LDCM0590  Fragment32 Ramos C166(0.62)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C70(0.24)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C166(0.61)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C70(1.31)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C70(0.99)  LDD1025  [4]
 LDCM0610  Fragment52 Ramos C166(0.65)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C166(0.98)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C70(0.98)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C166(0.61)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C70(1.31)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C70(1.34)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C70(1.81)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C70(0.83)  LDD2096  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C70(0.92)  LDD2106  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C70(1.14)  LDD2123  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C70(0.66)  LDD2133  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C70(1.14)  LDD2135  [3]
 LDCM0021  THZ1 HCT 116 C70(1.11)  LDD2173  [4]

References

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2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578