Details of the Target
General Information of Target
Target ID | LDTP12492 | |||||
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Target Name | Sialin (SLC17A5) | |||||
Gene Name | SLC17A5 | |||||
Gene ID | 26503 | |||||
Synonyms |
Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT |
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3D Structure | ||||||
Sequence |
MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDPQHERIITVSTNGSIHS
PRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGTIL GRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEAVSPSVLPPSA LPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRPTWQLLGKAFVFGRKSRVVDLNL LTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSK VTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG |
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Target Type |
Literature-reported
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Target Bioclass |
Transporter and channel
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Family |
Major facilitator superfamily, Sodium/anion cotransporter family
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Subcellular location |
Basolateral cell membrane
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Function |
Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva. Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release.; Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.
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TTD ID | ||||||
Uniprot ID | ||||||
DrugMap ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Target Site Mutations in Different Cell Lines
Cell line | Mutation details | Probe for labeling this protein in this cell | |||
---|---|---|---|---|---|
CAL51 | SNV: p.W282C | DBIA Probe Info | |||
HCT15 | SNV: p.L167F | DBIA Probe Info | |||
IGROV1 | SNV: p.Y461S | DBIA Probe Info | |||
IM95 | Deletion: p.Y117MfsTer17 | DBIA Probe Info | |||
Ishikawa (Heraklio) 02 ER | SNV: p.Q483R | DBIA Probe Info | |||
KELLY | SNV: p.A382D | . | |||
MDAMB231 | SNV: p.L242V; p.S268L | . | |||
MDAMB453 | SNV: p.G49V | DBIA Probe Info | |||
NCIH23 | SNV: p.W244C | DBIA Probe Info | |||
RKO | SNV: p.T79A | DBIA Probe Info | |||
SNGM | Insertion: p.Y117LfsTer78 | DBIA Probe Info |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
STPyne Probe Info |
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K263(2.51) | LDD0277 | [1] | |
BTD Probe Info |
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C83(0.29) | LDD2091 | [2] | |
DBIA Probe Info |
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C362(1.09) | LDD0532 | [3] | |
IPM Probe Info |
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N.A. | LDD0005 | [4] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C83(0.98) | LDD2142 | [2] |
LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C83(0.85) | LDD2112 | [2] |
LDCM0539 | 3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C83(0.31) | LDD2132 | [2] |
LDCM0214 | AC1 | HEK-293T | C83(1.01) | LDD1507 | [5] |
LDCM0215 | AC10 | HCT 116 | C362(1.09) | LDD0532 | [3] |
LDCM0216 | AC100 | HCT 116 | C362(0.99) | LDD0533 | [3] |
LDCM0217 | AC101 | HCT 116 | C362(0.99) | LDD0534 | [3] |
LDCM0218 | AC102 | HCT 116 | C362(0.79) | LDD0535 | [3] |
LDCM0219 | AC103 | HCT 116 | C362(1.12) | LDD0536 | [3] |
LDCM0220 | AC104 | HCT 116 | C362(0.98) | LDD0537 | [3] |
LDCM0221 | AC105 | HCT 116 | C362(1.04) | LDD0538 | [3] |
LDCM0222 | AC106 | HCT 116 | C362(1.06) | LDD0539 | [3] |
LDCM0223 | AC107 | HCT 116 | C362(1.03) | LDD0540 | [3] |
LDCM0224 | AC108 | HCT 116 | C362(0.76) | LDD0541 | [3] |
LDCM0225 | AC109 | HCT 116 | C362(0.73) | LDD0542 | [3] |
LDCM0226 | AC11 | HCT 116 | C362(1.16) | LDD0543 | [3] |
LDCM0227 | AC110 | HCT 116 | C362(0.93) | LDD0544 | [3] |
LDCM0228 | AC111 | HCT 116 | C362(0.87) | LDD0545 | [3] |
LDCM0229 | AC112 | HCT 116 | C362(1.04) | LDD0546 | [3] |
LDCM0230 | AC113 | HCT 116 | C362(0.99) | LDD0547 | [3] |
LDCM0231 | AC114 | HCT 116 | C362(1.36) | LDD0548 | [3] |
LDCM0232 | AC115 | HCT 116 | C362(1.48) | LDD0549 | [3] |
LDCM0233 | AC116 | HCT 116 | C362(1.37) | LDD0550 | [3] |
LDCM0234 | AC117 | HCT 116 | C362(1.08) | LDD0551 | [3] |
LDCM0235 | AC118 | HCT 116 | C362(1.15) | LDD0552 | [3] |
LDCM0236 | AC119 | HCT 116 | C362(1.29) | LDD0553 | [3] |
LDCM0237 | AC12 | HCT 116 | C362(1.11) | LDD0554 | [3] |
LDCM0238 | AC120 | HCT 116 | C362(1.23) | LDD0555 | [3] |
LDCM0239 | AC121 | HCT 116 | C362(1.23) | LDD0556 | [3] |
LDCM0240 | AC122 | HCT 116 | C362(1.14) | LDD0557 | [3] |
LDCM0241 | AC123 | HCT 116 | C362(1.53) | LDD0558 | [3] |
LDCM0242 | AC124 | HCT 116 | C362(1.18) | LDD0559 | [3] |
LDCM0243 | AC125 | HCT 116 | C362(1.17) | LDD0560 | [3] |
LDCM0244 | AC126 | HCT 116 | C362(1.31) | LDD0561 | [3] |
LDCM0245 | AC127 | HCT 116 | C362(1.29) | LDD0562 | [3] |
LDCM0259 | AC14 | HCT 116 | C362(1.06) | LDD0576 | [3] |
LDCM0263 | AC143 | HCT 116 | C362(1.20) | LDD0580 | [3] |
LDCM0264 | AC144 | HCT 116 | C362(0.86) | LDD0581 | [3] |
LDCM0265 | AC145 | HCT 116 | C362(1.00) | LDD0582 | [3] |
LDCM0266 | AC146 | HCT 116 | C362(1.20) | LDD0583 | [3] |
LDCM0267 | AC147 | HCT 116 | C362(0.95) | LDD0584 | [3] |
LDCM0268 | AC148 | HCT 116 | C362(1.36) | LDD0585 | [3] |
LDCM0269 | AC149 | HCT 116 | C362(1.25) | LDD0586 | [3] |
LDCM0270 | AC15 | HCT 116 | C362(1.17) | LDD0587 | [3] |
LDCM0271 | AC150 | HCT 116 | C362(1.06) | LDD0588 | [3] |
LDCM0272 | AC151 | HCT 116 | C362(1.01) | LDD0589 | [3] |
LDCM0273 | AC152 | HCT 116 | C362(1.17) | LDD0590 | [3] |
LDCM0274 | AC153 | HCT 116 | C362(1.36) | LDD0591 | [3] |
LDCM0621 | AC154 | HCT 116 | C362(0.93) | LDD2158 | [3] |
LDCM0622 | AC155 | HCT 116 | C362(1.35) | LDD2159 | [3] |
LDCM0623 | AC156 | HCT 116 | C362(1.05) | LDD2160 | [3] |
LDCM0624 | AC157 | HCT 116 | C362(1.06) | LDD2161 | [3] |
LDCM0276 | AC17 | HCT 116 | C362(1.00) | LDD0593 | [3] |
LDCM0277 | AC18 | HCT 116 | C362(1.21) | LDD0594 | [3] |
LDCM0278 | AC19 | HCT 116 | C362(0.90) | LDD0595 | [3] |
LDCM0279 | AC2 | HEK-293T | C83(0.99) | LDD1518 | [5] |
LDCM0280 | AC20 | HCT 116 | C362(0.98) | LDD0597 | [3] |
LDCM0281 | AC21 | HCT 116 | C362(1.02) | LDD0598 | [3] |
LDCM0282 | AC22 | HCT 116 | C362(0.98) | LDD0599 | [3] |
LDCM0283 | AC23 | HCT 116 | C362(1.09) | LDD0600 | [3] |
LDCM0284 | AC24 | HCT 116 | C362(0.93) | LDD0601 | [3] |
LDCM0285 | AC25 | HCT 116 | C362(1.02) | LDD0602 | [3] |
LDCM0286 | AC26 | HCT 116 | C362(1.12) | LDD0603 | [3] |
LDCM0287 | AC27 | HCT 116 | C362(1.24) | LDD0604 | [3] |
LDCM0288 | AC28 | HCT 116 | C362(1.18) | LDD0605 | [3] |
LDCM0289 | AC29 | HCT 116 | C362(1.29) | LDD0606 | [3] |
LDCM0290 | AC3 | HEK-293T | C83(0.94) | LDD1529 | [5] |
LDCM0291 | AC30 | HCT 116 | C362(1.30) | LDD0608 | [3] |
LDCM0292 | AC31 | HCT 116 | C362(1.32) | LDD0609 | [3] |
LDCM0293 | AC32 | HCT 116 | C362(1.38) | LDD0610 | [3] |
LDCM0294 | AC33 | HCT 116 | C362(1.33) | LDD0611 | [3] |
LDCM0295 | AC34 | HCT 116 | C362(1.42) | LDD0612 | [3] |
LDCM0296 | AC35 | HEK-293T | C83(0.94) | LDD1535 | [5] |
LDCM0297 | AC36 | HEK-293T | C83(1.00) | LDD1536 | [5] |
LDCM0298 | AC37 | HEK-293T | C83(0.92) | LDD1537 | [5] |
LDCM0299 | AC38 | HEK-293T | C83(0.90) | LDD1538 | [5] |
LDCM0300 | AC39 | HEK-293T | C83(0.97) | LDD1539 | [5] |
LDCM0301 | AC4 | HEK-293T | C83(0.99) | LDD1540 | [5] |
LDCM0302 | AC40 | HEK-293T | C83(0.91) | LDD1541 | [5] |
LDCM0303 | AC41 | HEK-293T | C83(0.92) | LDD1542 | [5] |
LDCM0304 | AC42 | HEK-293T | C83(1.10) | LDD1543 | [5] |
LDCM0305 | AC43 | HEK-293T | C83(0.94) | LDD1544 | [5] |
LDCM0306 | AC44 | HEK-293T | C83(1.01) | LDD1545 | [5] |
LDCM0307 | AC45 | HEK-293T | C83(0.94) | LDD1546 | [5] |
LDCM0308 | AC46 | HEK-293T | C83(0.95) | LDD1547 | [5] |
LDCM0309 | AC47 | HEK-293T | C83(0.98) | LDD1548 | [5] |
LDCM0310 | AC48 | HEK-293T | C83(0.92) | LDD1549 | [5] |
LDCM0311 | AC49 | HEK-293T | C83(0.95) | LDD1550 | [5] |
LDCM0312 | AC5 | HEK-293T | C83(0.92) | LDD1551 | [5] |
LDCM0313 | AC50 | HEK-293T | C83(1.01) | LDD1552 | [5] |
LDCM0314 | AC51 | HEK-293T | C83(0.98) | LDD1553 | [5] |
LDCM0315 | AC52 | HEK-293T | C83(0.98) | LDD1554 | [5] |
LDCM0316 | AC53 | HEK-293T | C83(0.91) | LDD1555 | [5] |
LDCM0317 | AC54 | HEK-293T | C83(0.95) | LDD1556 | [5] |
LDCM0318 | AC55 | HEK-293T | C83(0.94) | LDD1557 | [5] |
LDCM0319 | AC56 | HEK-293T | C83(0.85) | LDD1558 | [5] |
LDCM0320 | AC57 | HCT 116 | C362(0.92) | LDD0637 | [3] |
LDCM0321 | AC58 | HCT 116 | C362(0.97) | LDD0638 | [3] |
LDCM0322 | AC59 | HCT 116 | C362(0.91) | LDD0639 | [3] |
LDCM0323 | AC6 | HCT 116 | C362(1.03) | LDD0640 | [3] |
LDCM0324 | AC60 | HCT 116 | C362(0.89) | LDD0641 | [3] |
LDCM0325 | AC61 | HCT 116 | C362(0.71) | LDD0642 | [3] |
LDCM0326 | AC62 | HCT 116 | C362(0.92) | LDD0643 | [3] |
LDCM0327 | AC63 | HCT 116 | C362(0.69) | LDD0644 | [3] |
LDCM0328 | AC64 | HCT 116 | C362(0.83) | LDD0645 | [3] |
LDCM0329 | AC65 | HCT 116 | C362(0.75) | LDD0646 | [3] |
LDCM0330 | AC66 | HCT 116 | C362(0.80) | LDD0647 | [3] |
LDCM0331 | AC67 | HCT 116 | C362(0.82) | LDD0648 | [3] |
LDCM0332 | AC68 | HCT 116 | C362(1.42) | LDD0649 | [3] |
LDCM0333 | AC69 | HCT 116 | C362(1.55) | LDD0650 | [3] |
LDCM0334 | AC7 | HCT 116 | C362(1.02) | LDD0651 | [3] |
LDCM0335 | AC70 | HCT 116 | C362(1.18) | LDD0652 | [3] |
LDCM0336 | AC71 | HCT 116 | C362(1.39) | LDD0653 | [3] |
LDCM0337 | AC72 | HCT 116 | C362(1.41) | LDD0654 | [3] |
LDCM0338 | AC73 | HCT 116 | C362(1.95) | LDD0655 | [3] |
LDCM0339 | AC74 | HCT 116 | C362(1.96) | LDD0656 | [3] |
LDCM0340 | AC75 | HCT 116 | C362(2.22) | LDD0657 | [3] |
LDCM0341 | AC76 | HCT 116 | C362(1.40) | LDD0658 | [3] |
LDCM0342 | AC77 | HCT 116 | C362(1.48) | LDD0659 | [3] |
LDCM0343 | AC78 | HCT 116 | C362(1.23) | LDD0660 | [3] |
LDCM0344 | AC79 | HCT 116 | C362(1.30) | LDD0661 | [3] |
LDCM0345 | AC8 | HCT 116 | C362(1.06) | LDD0662 | [3] |
LDCM0346 | AC80 | HCT 116 | C362(1.49) | LDD0663 | [3] |
LDCM0347 | AC81 | HCT 116 | C362(1.03) | LDD0664 | [3] |
LDCM0348 | AC82 | HCT 116 | C362(1.60) | LDD0665 | [3] |
LDCM0349 | AC83 | HCT 116 | C362(1.34) | LDD0666 | [3] |
LDCM0350 | AC84 | HCT 116 | C362(1.49) | LDD0667 | [3] |
LDCM0351 | AC85 | HCT 116 | C362(1.32) | LDD0668 | [3] |
LDCM0352 | AC86 | HCT 116 | C362(1.22) | LDD0669 | [3] |
LDCM0353 | AC87 | HCT 116 | C362(1.11) | LDD0670 | [3] |
LDCM0354 | AC88 | HCT 116 | C362(1.25) | LDD0671 | [3] |
LDCM0355 | AC89 | HCT 116 | C362(1.31) | LDD0672 | [3] |
LDCM0357 | AC90 | HCT 116 | C362(1.04) | LDD0674 | [3] |
LDCM0358 | AC91 | HCT 116 | C362(1.41) | LDD0675 | [3] |
LDCM0359 | AC92 | HCT 116 | C362(1.33) | LDD0676 | [3] |
LDCM0360 | AC93 | HCT 116 | C362(1.23) | LDD0677 | [3] |
LDCM0361 | AC94 | HCT 116 | C362(1.18) | LDD0678 | [3] |
LDCM0362 | AC95 | HCT 116 | C362(1.23) | LDD0679 | [3] |
LDCM0363 | AC96 | HCT 116 | C362(1.37) | LDD0680 | [3] |
LDCM0364 | AC97 | HCT 116 | C362(1.47) | LDD0681 | [3] |
LDCM0365 | AC98 | HCT 116 | C362(1.20) | LDD0682 | [3] |
LDCM0366 | AC99 | HCT 116 | C362(0.86) | LDD0683 | [3] |
LDCM0545 | Acetamide | MDA-MB-231 | C83(0.26) | LDD2138 | [2] |
LDCM0248 | AKOS034007472 | HCT 116 | C362(1.11) | LDD0565 | [3] |
LDCM0356 | AKOS034007680 | HCT 116 | C362(1.08) | LDD0673 | [3] |
LDCM0275 | AKOS034007705 | HCT 116 | C362(1.46) | LDD0592 | [3] |
LDCM0498 | BS-3668 | MDA-MB-231 | C83(0.29) | LDD2091 | [2] |
LDCM0367 | CL1 | HCT 116 | C362(1.21) | LDD0684 | [3] |
LDCM0368 | CL10 | HCT 116 | C362(1.32) | LDD0685 | [3] |
LDCM0369 | CL100 | HEK-293T | C83(0.92) | LDD1573 | [5] |
LDCM0370 | CL101 | HCT 116 | C362(0.96) | LDD0687 | [3] |
LDCM0371 | CL102 | HCT 116 | C362(0.97) | LDD0688 | [3] |
LDCM0372 | CL103 | HCT 116 | C362(1.16) | LDD0689 | [3] |
LDCM0373 | CL104 | HCT 116 | C362(1.01) | LDD0690 | [3] |
LDCM0374 | CL105 | HCT 116 | C362(1.45) | LDD0691 | [3] |
LDCM0375 | CL106 | HCT 116 | C362(1.62) | LDD0692 | [3] |
LDCM0376 | CL107 | HCT 116 | C362(1.52) | LDD0693 | [3] |
LDCM0377 | CL108 | HCT 116 | C362(1.78) | LDD0694 | [3] |
LDCM0378 | CL109 | HCT 116 | C362(1.32) | LDD0695 | [3] |
LDCM0379 | CL11 | HCT 116 | C362(1.24) | LDD0696 | [3] |
LDCM0380 | CL110 | HCT 116 | C362(1.51) | LDD0697 | [3] |
LDCM0381 | CL111 | HCT 116 | C362(1.28) | LDD0698 | [3] |
LDCM0382 | CL112 | HCT 116 | C362(1.08) | LDD0699 | [3] |
LDCM0383 | CL113 | HCT 116 | C362(1.35) | LDD0700 | [3] |
LDCM0384 | CL114 | HCT 116 | C362(2.20) | LDD0701 | [3] |
LDCM0385 | CL115 | HCT 116 | C362(1.15) | LDD0702 | [3] |
LDCM0386 | CL116 | HCT 116 | C362(1.30) | LDD0703 | [3] |
LDCM0387 | CL117 | HEK-293T | C83(0.93) | LDD1591 | [5] |
LDCM0388 | CL118 | HEK-293T | C83(0.96) | LDD1592 | [5] |
LDCM0389 | CL119 | HEK-293T | C83(0.89) | LDD1593 | [5] |
LDCM0390 | CL12 | HCT 116 | C362(1.18) | LDD0707 | [3] |
LDCM0391 | CL120 | HEK-293T | C83(0.97) | LDD1595 | [5] |
LDCM0392 | CL121 | HEK-293T | C83(0.91) | LDD1596 | [5] |
LDCM0393 | CL122 | HEK-293T | C83(0.92) | LDD1597 | [5] |
LDCM0394 | CL123 | HEK-293T | C83(0.92) | LDD1598 | [5] |
LDCM0395 | CL124 | HEK-293T | C83(0.97) | LDD1599 | [5] |
LDCM0396 | CL125 | HCT 116 | C362(0.90) | LDD0713 | [3] |
LDCM0397 | CL126 | HCT 116 | C362(1.17) | LDD0714 | [3] |
LDCM0398 | CL127 | HCT 116 | C362(0.77) | LDD0715 | [3] |
LDCM0399 | CL128 | HCT 116 | C362(0.80) | LDD0716 | [3] |
LDCM0400 | CL13 | HCT 116 | C362(1.05) | LDD0717 | [3] |
LDCM0401 | CL14 | HCT 116 | C362(1.25) | LDD0718 | [3] |
LDCM0402 | CL15 | HCT 116 | C362(1.22) | LDD0719 | [3] |
LDCM0403 | CL16 | HCT 116 | C362(1.07) | LDD0720 | [3] |
LDCM0404 | CL17 | HCT 116 | C362(2.41) | LDD0721 | [3] |
LDCM0405 | CL18 | HCT 116 | C362(0.98) | LDD0722 | [3] |
LDCM0406 | CL19 | HCT 116 | C362(0.98) | LDD0723 | [3] |
LDCM0407 | CL2 | HCT 116 | C362(0.99) | LDD0724 | [3] |
LDCM0408 | CL20 | HCT 116 | C362(1.08) | LDD0725 | [3] |
LDCM0409 | CL21 | HCT 116 | C362(2.77) | LDD0726 | [3] |
LDCM0410 | CL22 | HCT 116 | C362(1.77) | LDD0727 | [3] |
LDCM0411 | CL23 | HCT 116 | C362(0.96) | LDD0728 | [3] |
LDCM0412 | CL24 | HCT 116 | C362(1.22) | LDD0729 | [3] |
LDCM0413 | CL25 | HCT 116 | C362(1.62) | LDD0730 | [3] |
LDCM0414 | CL26 | HCT 116 | C362(0.98) | LDD0731 | [3] |
LDCM0415 | CL27 | HCT 116 | C362(0.95) | LDD0732 | [3] |
LDCM0416 | CL28 | HCT 116 | C362(1.32) | LDD0733 | [3] |
LDCM0417 | CL29 | HCT 116 | C362(1.18) | LDD0734 | [3] |
LDCM0418 | CL3 | HCT 116 | C362(1.12) | LDD0735 | [3] |
LDCM0419 | CL30 | HCT 116 | C362(0.92) | LDD0736 | [3] |
LDCM0420 | CL31 | HCT 116 | C362(1.32) | LDD0737 | [3] |
LDCM0421 | CL32 | HCT 116 | C362(1.56) | LDD0738 | [3] |
LDCM0422 | CL33 | HCT 116 | C362(2.48) | LDD0739 | [3] |
LDCM0423 | CL34 | HCT 116 | C362(2.30) | LDD0740 | [3] |
LDCM0424 | CL35 | HCT 116 | C362(1.45) | LDD0741 | [3] |
LDCM0425 | CL36 | HCT 116 | C362(1.60) | LDD0742 | [3] |
LDCM0426 | CL37 | HCT 116 | C362(1.53) | LDD0743 | [3] |
LDCM0428 | CL39 | HCT 116 | C362(1.85) | LDD0745 | [3] |
LDCM0429 | CL4 | HCT 116 | C362(1.22) | LDD0746 | [3] |
LDCM0430 | CL40 | HCT 116 | C362(1.45) | LDD0747 | [3] |
LDCM0431 | CL41 | HCT 116 | C362(1.46) | LDD0748 | [3] |
LDCM0432 | CL42 | HCT 116 | C362(1.58) | LDD0749 | [3] |
LDCM0433 | CL43 | HCT 116 | C362(1.71) | LDD0750 | [3] |
LDCM0434 | CL44 | HCT 116 | C362(1.86) | LDD0751 | [3] |
LDCM0435 | CL45 | HCT 116 | C362(1.67) | LDD0752 | [3] |
LDCM0436 | CL46 | HEK-293T | C83(0.98) | LDD1640 | [5] |
LDCM0437 | CL47 | HEK-293T | C83(1.08) | LDD1641 | [5] |
LDCM0438 | CL48 | HEK-293T | C83(1.06) | LDD1642 | [5] |
LDCM0439 | CL49 | HEK-293T | C83(0.85) | LDD1643 | [5] |
LDCM0440 | CL5 | HCT 116 | C362(1.00) | LDD0757 | [3] |
LDCM0441 | CL50 | HEK-293T | C83(0.94) | LDD1645 | [5] |
LDCM0443 | CL52 | HEK-293T | C83(0.88) | LDD1646 | [5] |
LDCM0444 | CL53 | HEK-293T | C83(0.97) | LDD1647 | [5] |
LDCM0445 | CL54 | HEK-293T | C83(0.99) | LDD1648 | [5] |
LDCM0446 | CL55 | HEK-293T | C83(0.99) | LDD1649 | [5] |
LDCM0447 | CL56 | HEK-293T | C83(1.10) | LDD1650 | [5] |
LDCM0448 | CL57 | HEK-293T | C83(0.98) | LDD1651 | [5] |
LDCM0449 | CL58 | HEK-293T | C83(0.97) | LDD1652 | [5] |
LDCM0450 | CL59 | HEK-293T | C83(0.99) | LDD1653 | [5] |
LDCM0451 | CL6 | HCT 116 | C362(1.33) | LDD0768 | [3] |
LDCM0452 | CL60 | HEK-293T | C83(0.94) | LDD1655 | [5] |
LDCM0453 | CL61 | HCT 116 | C362(1.12) | LDD0770 | [3] |
LDCM0454 | CL62 | HCT 116 | C362(1.11) | LDD0771 | [3] |
LDCM0455 | CL63 | HCT 116 | C362(1.13) | LDD0772 | [3] |
LDCM0456 | CL64 | HCT 116 | C362(1.72) | LDD0773 | [3] |
LDCM0457 | CL65 | HCT 116 | C362(1.11) | LDD0774 | [3] |
LDCM0458 | CL66 | HCT 116 | C362(1.50) | LDD0775 | [3] |
LDCM0459 | CL67 | HCT 116 | C362(1.63) | LDD0776 | [3] |
LDCM0460 | CL68 | HCT 116 | C362(1.55) | LDD0777 | [3] |
LDCM0461 | CL69 | HCT 116 | C362(1.58) | LDD0778 | [3] |
LDCM0462 | CL7 | HCT 116 | C362(1.08) | LDD0779 | [3] |
LDCM0463 | CL70 | HCT 116 | C362(1.22) | LDD0780 | [3] |
LDCM0464 | CL71 | HCT 116 | C362(1.23) | LDD0781 | [3] |
LDCM0465 | CL72 | HCT 116 | C362(0.96) | LDD0782 | [3] |
LDCM0466 | CL73 | HCT 116 | C362(1.26) | LDD0783 | [3] |
LDCM0467 | CL74 | HCT 116 | C362(1.20) | LDD0784 | [3] |
LDCM0469 | CL76 | HEK-293T | C83(0.92) | LDD1672 | [5] |
LDCM0470 | CL77 | HEK-293T | C83(1.00) | LDD1673 | [5] |
LDCM0471 | CL78 | HEK-293T | C83(0.98) | LDD1674 | [5] |
LDCM0472 | CL79 | HEK-293T | C83(0.98) | LDD1675 | [5] |
LDCM0473 | CL8 | HCT 116 | C362(1.59) | LDD0790 | [3] |
LDCM0474 | CL80 | HEK-293T | C83(1.00) | LDD1677 | [5] |
LDCM0475 | CL81 | HEK-293T | C83(0.94) | LDD1678 | [5] |
LDCM0476 | CL82 | HEK-293T | C83(0.99) | LDD1679 | [5] |
LDCM0477 | CL83 | HEK-293T | C83(1.06) | LDD1680 | [5] |
LDCM0478 | CL84 | HEK-293T | C83(0.92) | LDD1681 | [5] |
LDCM0479 | CL85 | HEK-293T | C83(0.87) | LDD1682 | [5] |
LDCM0480 | CL86 | HEK-293T | C83(0.95) | LDD1683 | [5] |
LDCM0481 | CL87 | HEK-293T | C83(0.94) | LDD1684 | [5] |
LDCM0482 | CL88 | HEK-293T | C83(0.93) | LDD1685 | [5] |
LDCM0483 | CL89 | HEK-293T | C83(0.94) | LDD1686 | [5] |
LDCM0484 | CL9 | HCT 116 | C362(1.14) | LDD0801 | [3] |
LDCM0485 | CL90 | HEK-293T | C83(1.03) | LDD1688 | [5] |
LDCM0486 | CL91 | HEK-293T | C83(0.95) | LDD1689 | [5] |
LDCM0487 | CL92 | HEK-293T | C83(1.02) | LDD1690 | [5] |
LDCM0488 | CL93 | HEK-293T | C83(0.94) | LDD1691 | [5] |
LDCM0489 | CL94 | HEK-293T | C83(0.98) | LDD1692 | [5] |
LDCM0490 | CL95 | HEK-293T | C83(1.04) | LDD1693 | [5] |
LDCM0491 | CL96 | HEK-293T | C83(0.90) | LDD1694 | [5] |
LDCM0492 | CL97 | HEK-293T | C83(0.94) | LDD1695 | [5] |
LDCM0493 | CL98 | HEK-293T | C83(0.97) | LDD1696 | [5] |
LDCM0494 | CL99 | HEK-293T | C83(1.07) | LDD1697 | [5] |
LDCM0495 | E2913 | HEK-293T | C83(0.88) | LDD1698 | [5] |
LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C83(1.50) | LDD1702 | [2] |
LDCM0468 | Fragment33 | HCT 116 | C362(1.28) | LDD0785 | [3] |
LDCM0427 | Fragment51 | HCT 116 | C362(1.53) | LDD0744 | [3] |
LDCM0022 | KB02 | HEK-293T | C83(1.07) | LDD1492 | [5] |
LDCM0023 | KB03 | HEK-293T | C83(1.06) | LDD1497 | [5] |
LDCM0024 | KB05 | HMCB | C83(1.80) | LDD3312 | [6] |
LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C83(0.34) | LDD2121 | [2] |
LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C83(0.91) | LDD2092 | [2] |
LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C83(1.03) | LDD2098 | [2] |
LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C83(0.97) | LDD2100 | [2] |
LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C83(0.95) | LDD2104 | [2] |
LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C83(1.04) | LDD2105 | [2] |
LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C83(1.00) | LDD2108 | [2] |
LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C83(1.11) | LDD2114 | [2] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C83(1.13) | LDD2120 | [2] |
LDCM0535 | Nucleophilic fragment 30b | MDA-MB-231 | C83(0.91) | LDD2128 | [2] |
LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C83(0.64) | LDD2140 | [2] |
LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C83(0.93) | LDD2141 | [2] |
LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C83(1.10) | LDD2143 | [2] |
LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C83(2.74) | LDD2144 | [2] |
References