Details of the Target

General Information of Target

Target ID LDTP12463
Target Name Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)
Gene Name ACSS2
Gene ID 55902
Synonyms
ACAS2; Acetyl-coenzyme A synthetase, cytoplasmic; EC 6.2.1.1; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMLPQNSWHIDFGRCCCHQNLFSAVVTCILLLNSCFLISSFNGTDLELRLVNGDGPCSGT
VEVKFQGQWGTVCDDGWNTTASTVVCKQLGCPFSFAMFRFGQAVTRHGKIWLDDVSCYGN
ESALWECQHREWGSHNCYHGEDVGVNCYGEANLGLRLVDGNNSCSGRVEVKFQERWGTIC
DDGWNLNTAAVVCRQLGCPSSFISSGVVNSPAVLRPIWLDDILCQGNELALWNCRHRGWG
NHDCSHNEDVTLTCYDSSDLELRLVGGTNRCMGRVELKIQGRWGTVCHHKWNNAAADVVC
KQLGCGTALHFAGLPHLQSGSDVVWLDGVSCSGNESFLWDCRHSGTVNFDCLHQNDVSVI
CSDGADLELRLADGSNNCSGRVEVRIHEQWWTICDQNWKNEQALVVCKQLGCPFSVFGSR
RAKPSNEARDIWINSISCTGNESALWDCTYDGKAKRTCFRRSDAGVICSDKADLDLRLVG
AHSPCYGRLEVKYQGEWGTVCHDRWSTRNAAVVCKQLGCGKPLHVFGMTYFKEASGPIWL
DDVSCIGNESNIWDCEHSGWGKHNCVHREDVIVTCSGDATWGLRLVGGSNRCSGRLEVYF
QGRWGTVCDDGWNSKAAAVVCSQLDCPSSIIGMGLGNASTGYGKIWLDDVSCDGDESDLW
SCRNSGWGNNDCSHSEDVGVICSDASDMELRLVGGSSRCAGKVEVNVQGAVGILCANGWG
MNIAEVVCRQLECGSAIRVSREPHFTERTLHILMSNSGCTGGEASLWDCIRWEWKQTACH
LNMEASLICSAHRQPRLVGADMPCSGRVEVKHADTWRSVCDSDFSLHAANVLCRELNCGD
AISLSVGDHFGKGNGLTWAEKFQCEGSETHLALCPIVQHPEDTCIHSREVGVVCSRYTDV
RLVNGKSQCDGQVEINVLGHWGSLCDTHWDPEDARVLCRQLSCGTALSTTGGKYIGERSV
RVWGHRFHCLGNESLLDNCQMTVLGAPPCIHGNTVSVICTGSLTQPLFPCLANVSDPYLS
AVPEGSALICLEDKRLRLVDGDSRCAGRVEIYHDGFWGTICDDGWDLSDAHVVCQKLGCG
VAFNATVSAHFGEGSGPIWLDDLNCTGMESHLWQCPSRGWGQHDCRHKEDAGVICSEFTA
LRLYSETETESCAGRLEVFYNGTWGSVGRRNITTAIAGIVCRQLGCGENGVVSLAPLSKT
GSGFMWVDDIQCPKTHISIWQCLSAPWERRISSPAEETWITCEDRIRVRGGDTECSGRVE
IWHAGSWGTVCDDSWDLAEAEVVCQQLGCGSALAALRDASFGQGTGTIWLDDMRCKGNES
FLWDCHAKPWGQSDCGHKEDAGVRCSGQSLKSLNASSGHLALILSSIFGLLLLVLFILFL
TWCRVQKQKHLPLRVSTRRRGSLEENLFHEMETCLKREDPHGTRTSDDTPNHGCEDASDT
SLLGVLPASEATK
Target Bioclass
Enzyme
Family
ATP-dependent AMP-binding enzyme family
Subcellular location
Cytoplasm, cytosol
Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis. Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription. The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival. Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes. Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory.
Uniprot ID
Q9NR19
Ensemble ID
ENST00000253382.5
HGNC ID
HGNC:15814
ChEMBL ID
CHEMBL4523467

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC3 SNV: p.Q135H; p.R245T .
IM95 SNV: p.R393C DBIA    Probe Info 
MEWO SNV: p.L80F DBIA    Probe Info 
OVCAR5 SNV: p.M96I DBIA    Probe Info 
RL952 SNV: p.W125R DBIA    Probe Info 
SKMEL5 SNV: p.H328Y DBIA    Probe Info 
SNGM SNV: p.V250I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K222(7.78); K418(9.43); K426(8.28); K656(10.00)  LDD0277  [2]
DBIA
 Probe Info  		C104(3.49)  LDD3314  [3]
BTD
 Probe Info  		C237(1.05)  LDD2140  [4]
HHS-482
 Probe Info  		Y647(0.93)  LDD0285  [5]
HHS-475
 Probe Info  		Y105(0.52); Y647(4.39)  LDD0264  [6]
IPM
 Probe Info  		C75(0.99)  LDD1701  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
AOyne
 Probe Info  		9.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C459(0.95)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C459(1.13)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C459(1.08); C75(1.11)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C459(0.91)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C459(0.91)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C459(1.16)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C459(1.22)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C459(0.95)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C459(0.93); C75(1.01)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C459(1.10)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C459(0.96)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C459(1.10)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C459(0.90)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C459(0.99)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C459(1.06)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C459(1.17)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C459(1.15)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C459(1.04); C75(1.04)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C459(0.95)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C459(1.01)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C459(1.17); C75(1.03)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C459(0.89)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C459(1.11)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C459(1.13)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C459(1.12)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C459(0.94)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C459(1.22); C75(1.06)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C459(0.97)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C459(0.93)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C459(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C459(1.12)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C459(0.96)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C459(0.92)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C459(1.09)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C459(0.99)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C459(1.08); C75(1.08)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C459(1.01)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C459(0.99)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C459(0.89)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C459(1.12)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C459(0.95)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C459(1.02)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C459(1.14)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C459(1.18)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C459(1.08); C75(1.10)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C459(0.99)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C459(1.00)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C459(0.93)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C459(1.27)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C459(0.96)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C459(1.13)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C459(1.08)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C459(1.05); C75(0.99)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C459(0.89)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C459(0.98)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C459(1.12)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C459(0.97)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C459(1.00)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C459(1.23)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C459(1.06)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C459(1.04)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C459(0.92)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C459(1.06)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C459(1.04)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 13.04  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C459(1.15)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C459(1.13)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C459(1.05); C75(0.96)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C459(1.05)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C459(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C459(1.01)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C459(1.04); C75(1.06)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C459(1.06)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C459(0.89)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C459(0.94)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C459(1.00); C75(1.13)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C459(1.18)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C459(1.32)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C459(0.82)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C459(1.06)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C459(0.67); C75(0.99)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C459(1.23)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C459(0.82)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C459(1.15)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C459(0.86); C75(1.04)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C459(1.11)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C459(0.98)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C459(1.17)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C459(1.48)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C459(0.96); C75(0.99)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C459(1.00)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C459(0.90)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C459(0.80)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C459(1.02); C75(0.97)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C459(1.08)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C459(0.86)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C459(1.03)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C459(1.00); C75(1.02)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C459(0.99)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C459(0.91)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C459(1.13)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C459(1.10); C75(1.12)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C459(1.05)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C459(1.33)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C459(1.15); C75(1.16)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C459(0.98)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C459(1.09)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C459(1.13)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C459(1.19)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C459(1.44)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C459(1.09)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C459(0.99)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C459(0.94)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C459(0.95)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C459(0.84); C75(0.95)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C459(1.03)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C459(1.36)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C459(1.03)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C459(1.12); C75(1.01)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C459(1.00)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C459(1.14)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C459(1.31)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C459(1.63)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C459(1.58)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C459(0.97)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C459(1.05)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C459(0.95); C75(1.03)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C459(0.96); C75(1.18)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C459(0.96)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C459(1.14)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C459(1.19); C75(1.03)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C459(1.07)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C459(1.12)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C459(1.31)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C459(1.64)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C459(1.53)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C459(1.19)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C459(1.04)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C459(0.96)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C459(0.92); C75(1.10)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C459(0.82)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C459(1.11)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C459(1.24); C75(1.20)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C459(1.06)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C459(1.17)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C459(1.26)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C459(1.51)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C459(1.09)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C459(1.41)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C459(1.35)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C459(0.90)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C459(1.02)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C459(0.89); C75(1.09)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C459(0.93)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C459(1.24)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C459(1.18); C75(1.08)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C459(1.03)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C459(1.12)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C459(1.05); C75(1.15)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C459(1.21)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C459(1.30)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C459(1.38)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C459(1.07)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C459(0.97)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C459(0.93); C75(1.15)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C459(0.90)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C459(1.00)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C459(1.01); C75(1.22)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C459(1.02)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C459(0.97)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C459(1.20)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C459(1.03)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C459(1.28)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C459(1.26)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C459(1.21)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C459(0.87)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C459(1.11)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C459(0.86); C75(1.02)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C459(1.00)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C459(1.21)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C459(1.19)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C459(1.09); C75(1.24)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C459(0.97)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C459(1.05)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C459(1.09)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C459(1.12)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C459(1.05)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C459(1.04)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C459(0.57)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C459(1.00)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C459(1.23)  LDD1698  [13]
 LDCM0625  F8 Ramos C75(1.99)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C75(0.09)  LDD2190  [14]
 LDCM0468  Fragment33 HEK-293T C459(1.03)  LDD1671  [13]
 LDCM0566  Fragment4 Ramos C75(0.77)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C459(1.06)  LDD1631  [13]
 LDCM0569  Fragment7 Ramos C75(0.56)  LDD2186  [14]
 LDCM0116  HHS-0101 DM93 Y105(0.52); Y647(4.39)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y105(0.97); Y647(1.90)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y647(1.26); Y105(1.80)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y105(1.23); Y647(4.31)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y105(0.70); Y647(2.04)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y647(0.93)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y647(0.33)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y647(0.80)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y647(0.79)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y647(1.32)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y647(1.28)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y647(0.20)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y647(0.47)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C459(0.98)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C459(1.02)  LDD1497  [13]
 LDCM0024  KB05 IGR37 C104(3.49)  LDD3314  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C237(1.05)  LDD2140  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine Phosphate Small molecular drug DB00131
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578