Details of the Target

General Information of Target

Target ID LDTP12262
Target Name Casein kinase I isoform gamma-1 (CSNK1G1)
Gene Name CSNK1G1
Gene ID 53944
Synonyms
Casein kinase I isoform gamma-1; CKI-gamma 1; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLE
KLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQP
GPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRC
YSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFT
TETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRH
RGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN.
TTD ID
T41702
Uniprot ID
Q9HCP0
DrugMap ID
TTQR5YD
Ensemble ID
ENST00000303052.13
HGNC ID
HGNC:2454
ChEMBL ID
CHEMBL2426

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.R134Q .
HUH1 SNV: p.N177Y .
Ishikawa (Heraklio) 02 ER SNV: p.P336Q DBIA    Probe Info 
JURLMK1 SNV: p.Y324H .
MDAMB468 Deletion: p.K260RfsTer77 .
MEWO SNV: p.S79L DBIA    Probe Info 
NCIH196 SNV: p.I77V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K49(2.96); K62(2.29)  LDD0277  [1]
DBIA
 Probe Info  		C110(1.15)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		C52(0.00); C25(0.00); C54(0.00); C51(0.00)  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		11.70  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C110(1.15)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C110(0.84)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C110(0.96)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C110(1.07)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C110(0.75)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C110(0.83)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C110(0.86)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C110(0.94)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C110(1.00)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C110(0.75)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C110(1.10)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C110(0.74)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C110(0.69)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C279(0.96)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C279(1.12)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C279(0.83)  LDD1513  [7]
 LDCM0280  AC20 HEK-293T C279(1.04)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C110(1.01)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C279(1.03)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C279(0.82)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C279(0.88)  LDD1523  [7]
 LDCM0285  AC25 HCT 116 C110(0.97)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C110(0.99)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C110(1.15)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C110(1.10)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C110(1.09)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C110(1.01)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C110(1.09)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C110(1.05)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C110(1.02)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C110(1.37)  LDD0612  [2]
 LDCM0297  AC36 HEK-293T C279(0.86)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C110(0.99)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C279(1.25)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C279(1.12)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C279(1.04)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C279(0.97)  LDD1541  [7]
 LDCM0306  AC44 HEK-293T C279(1.03)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C110(1.21)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C110(1.37)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C110(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C110(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C110(1.05)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C110(1.12)  LDD1551  [7]
 LDCM0313  AC50 HCT 116 C110(1.82)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C110(1.30)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C110(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C110(1.56)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C110(1.32)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C110(0.84)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C110(1.11)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C110(1.03)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C110(1.27)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C110(1.07)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C279(1.17)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C110(1.06)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C110(0.98)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C110(1.03)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C110(1.06)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C110(1.05)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C110(1.07)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C110(1.13)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C110(1.02)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C110(1.16)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C110(1.17)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C279(1.01)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C110(0.74)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C110(1.12)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C110(1.03)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C110(0.87)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C110(1.04)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C110(0.96)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C110(0.98)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C110(1.01)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C110(1.02)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C110(0.98)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C279(1.08)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C110(1.01)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C110(0.98)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C110(0.92)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C110(0.76)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C110(0.81)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C110(0.80)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C110(0.84)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C110(0.87)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C110(0.88)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C110(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C110(0.94)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C110(0.70)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C110(0.86)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C110(0.92)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C110(0.85)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C110(0.80)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C110(0.75)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C110(0.81)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C110(0.40)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C110(0.97)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C110(1.02)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C279(1.11)  LDD1514  [7]
 LDCM0367  CL1 HCT 116 C110(0.88)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C110(0.88)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C279(0.99)  LDD1573  [7]
 LDCM0371  CL102 HEK-293T C279(1.09)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C279(1.34)  LDD1577  [7]
 LDCM0375  CL106 HEK-293T C279(0.99)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C279(1.16)  LDD1581  [7]
 LDCM0379  CL11 HCT 116 C110(0.66)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C279(1.06)  LDD1584  [7]
 LDCM0382  CL112 HCT 116 C110(0.80)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C110(1.00)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C110(0.88)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C110(0.97)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C110(1.06)  LDD0703  [2]
 LDCM0388  CL118 HEK-293T C279(0.95)  LDD1592  [7]
 LDCM0390  CL12 HCT 116 C110(0.78)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C279(1.07)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C110(1.00)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C110(0.85)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C110(1.09)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C110(1.29)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C110(1.05)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C110(1.04)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C110(0.84)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C110(1.03)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C110(1.16)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C110(1.35)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C110(0.81)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C279(1.06)  LDD1607  [7]
 LDCM0407  CL2 HCT 116 C110(1.01)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C279(1.03)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C110(1.08)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C279(1.18)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C279(1.25)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C279(1.04)  LDD1616  [7]
 LDCM0414  CL26 HEK-293T C279(0.97)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C279(1.38)  LDD1620  [7]
 LDCM0418  CL3 HCT 116 C110(0.94)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C110(1.13)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C110(1.23)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C110(1.00)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C110(1.09)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C110(1.20)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C110(1.21)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C110(1.25)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C110(1.30)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C110(0.80)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C110(1.09)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C110(1.68)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C110(1.30)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C110(1.56)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C110(1.24)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C110(1.03)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C110(0.62)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C110(0.65)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C110(0.64)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C110(0.76)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C110(0.95)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C110(0.62)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C110(0.59)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C110(0.80)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C110(0.54)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C110(0.49)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C110(0.91)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C110(0.77)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C110(0.75)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C110(0.81)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C110(0.48)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C110(0.88)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C110(0.80)  LDD0769  [2]
 LDCM0454  CL62 HEK-293T C279(1.04)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C279(0.90)  LDD1659  [7]
 LDCM0460  CL68 HEK-293T C279(1.08)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C110(1.09)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C110(0.94)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C279(1.02)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C279(1.48)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C279(1.02)  LDD1668  [7]
 LDCM0467  CL74 HEK-293T C279(1.19)  LDD1670  [7]
 LDCM0469  CL76 HCT 116 C110(0.96)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C110(0.84)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C110(0.78)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C110(0.88)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C110(0.86)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C110(0.71)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C110(0.92)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C110(0.86)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C110(0.66)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C110(0.78)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C110(0.74)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C110(0.86)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C110(0.87)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C110(0.81)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C110(0.81)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C110(1.10)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C110(0.85)  LDD0802  [2]
 LDCM0487  CL92 HEK-293T C279(1.04)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C110(1.12)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C279(1.16)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C279(1.97)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C279(1.10)  LDD1694  [7]
 LDCM0493  CL98 HEK-293T C279(1.10)  LDD1696  [7]
 LDCM0625  F8 Ramos C52(1.16); C25(2.63)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C52(0.92)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C52(0.33); C25(20.00)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C52(0.56)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C52(1.81); C25(1.06)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C52(1.15); C25(1.49)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C52(0.62); C25(1.20)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C52(0.78); C25(1.32)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C52(0.46); C25(1.68)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C52(0.85); C25(1.21)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C52(1.29); C25(1.11)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C52(0.70); C25(0.91)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C52(0.77); C25(1.74)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C52(0.98); C25(2.46)  LDD2201  [8]
 LDCM0468  Fragment33 Ramos C52(1.02); C25(1.41)  LDD2202  [8]
 LDCM0596  Fragment38 Ramos C52(3.44); C25(2.13)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C52(0.93); C25(1.87)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C110(1.65)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C52(0.75); C25(1.64)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C52(0.85); C25(1.06)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C52(1.04); C25(1.46)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C52(0.65)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C110(0.97)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C110(0.88)  LDD1497  [7]
 LDCM0024  KB05 MKN-1 C110(1.35)  LDD3331  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C52(0.92)  LDD2206  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C52(0.30)  LDD2207  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid19364658c33 Small molecular drug D01YWE
2-({6-[(3-chlorophenyl)Amino]-9-isopropyl-9h-purin-2-yl}Amino)Ethanol . DB08325

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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