Details of the Target

General Information of Target

Target ID LDTP12088
Target Name RecQ-mediated genome instability protein 1 (RMI1)
Gene Name RMI1
Gene ID 80010
Synonyms
C9orf76; RecQ-mediated genome instability protein 1; BLM-associated protein of 75 kDa; BLAP75; FAAP75
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADKPADQGAEKHEGTGQSSGITDQEKELSTNAFQAFTSGNYDACLQHLACLQDINKDD
YKIILNTAVAEFFKSNQTTTDNLRQTLNQLKNQVHSAVEEMDGLDDVENSMLYYNQAVIL
YHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVDLYILTYQAEKALHLLAVLEKMIS
QGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKIHQYKVRAYIQMKSLKACKREIK
SVMNTAGNSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLG
CIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGSTDPGKKFSGRPMCTLLTNKRYELLYN
CGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANKGTSEQETKGLPSKKGI
VQSIVGQGYHRKIVLASQSIQNTVYNDGQSSAIPVASMEFAAICLRNALLLLPEEQQDPK
QENGAKNSNQLGGNTESSESSETCSSKSHDGDKFIPAPPSSPLRKQELENLKCSILACSA
YVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPENVT
DVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYD
KARKCLHQAASMIHPKEVPPEAILLAVYLELQNGNTQLALQIIKRNQLLPAVKTHSEVRK
KPVFQPVHPIQPIQMPAFTTVQRK
Target Bioclass
Other
Family
RMI1 family
Subcellular location
Nucleus
Function
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Uniprot ID
Q9H9A7
Ensemble ID
ENST00000325875.7
HGNC ID
HGNC:25764

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C391(2.15)  LDD0170  [1]
DBIA
 Probe Info  		C366(0.98)  LDD0078  [2]
IA-alkyne
 Probe Info  		C406(0.00); C268(0.00)  LDD0165  [3]
NAIA_4
 Probe Info  		C268(0.00); C366(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C391(2.15)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C391(2.18); C268(2.30); C406(2.14)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C268(0.97); C366(0.90)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C391(0.88)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C366(0.80); C391(1.00)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C366(1.06); C391(1.21)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C366(0.86); C391(0.99)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C366(1.14); C391(1.06)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C366(0.95); C391(0.94)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C366(0.85); C391(1.17)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C366(1.00); C391(1.12)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C366(0.82); C391(1.10)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C366(0.69); C391(1.18)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C366(0.73); C391(0.98)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C391(0.97)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C366(0.74); C391(1.14)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C366(0.85); C391(1.07)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C366(0.79); C391(1.14)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C268(0.84); C391(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C268(0.87); C391(0.99)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C268(2.06); C391(1.12)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C268(1.76); C391(0.97)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C268(1.02); C391(0.89)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C268(0.97); C391(1.02)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C268(1.05); C391(0.96)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C391(0.90)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C268(0.75); C391(1.13)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C268(1.14); C391(0.73)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C268(0.93); C391(1.00)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C268(1.04); C391(0.79)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C268(1.16); C391(0.90)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C268(1.12); C391(1.06)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C268(1.37); C391(1.08)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C268(1.19); C391(0.92)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C366(1.15)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C366(0.95)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C366(0.95)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C366(1.07)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C366(0.76)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C366(0.74)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C366(0.87)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C366(0.78)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C366(0.85)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C366(0.67)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C366(0.70)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C366(0.73)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C391(1.06)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C366(0.79)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C366(0.74)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C366(0.67)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C268(1.09); C366(1.19)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C366(1.38); C268(1.50)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C366(0.92); C268(1.80)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C366(1.16); C268(1.44)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C366(1.09); C268(1.20)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C366(1.31); C268(1.52)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C366(1.26); C268(1.55)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C391(0.88)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C366(1.02); C268(1.24)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C268(1.14); C366(1.18)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C366(1.30); C268(1.54)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C366(1.58); C268(2.02)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C268(1.33); C366(1.36)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C268(1.26); C366(1.29)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C268(1.19); C366(1.07)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C268(1.16); C366(1.32)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C268(0.76)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C268(0.92)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C268(1.09)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C366(0.93); C268(1.04)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C268(0.82)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C268(0.76)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C268(0.78)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C268(0.74)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C268(0.74)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C268(1.49)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C268(1.45)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C268(1.77)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C268(1.21)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C268(1.46)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C366(0.80); C268(1.11)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C268(1.24)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C268(1.19)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C268(1.20)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C268(1.26)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C268(1.45)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C268(0.85); C366(1.02)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C268(1.00); C366(1.13)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C268(0.88); C366(1.02)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C268(0.95); C366(0.99); C589(1.08)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C268(1.15); C366(1.07)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C366(0.75); C268(1.01)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C268(0.99); C366(1.06)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C268(1.25); C366(1.10)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C268(0.94); C366(0.99)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C268(0.91); C366(0.98)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C268(0.96); C366(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C268(0.87); C366(1.08)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C268(1.13); C366(1.08); C589(0.89)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C268(1.12); C366(1.07)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C268(1.10); C366(1.10)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C268(1.16); C366(1.03)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C366(0.70); C268(0.97)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C268(0.91); C366(0.91)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C268(1.04); C366(1.02)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C268(1.31); C366(1.03)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C268(1.10); C366(1.04)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C268(0.95); C366(1.01); C589(0.87)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C268(1.14); C366(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C268(0.94); C366(1.06)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C268(1.05); C366(1.12)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C268(0.97); C366(0.94)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C268(1.03); C366(0.98)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C391(1.06)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C268(1.16); C366(1.05)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C268(1.09); C366(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C268(1.03); C366(1.06); C589(1.09)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C268(1.02); C366(0.97)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C268(1.00); C366(1.03)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C268(0.99); C391(1.06); C366(1.39)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C268(0.85); C391(1.37); C366(1.48)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C391(1.07)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C391(1.53); C268(1.77); C366(1.86)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C391(0.96); C366(1.07); C268(1.25)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C391(1.63); C268(1.68); C366(2.47)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C268(1.50); C391(2.07); C366(2.52)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C366(1.60); C268(1.63); C391(1.83)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C268(1.56); C391(2.00); C366(2.34)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C268(0.71); C366(1.67); C391(2.08)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C268(1.41); C391(1.72); C366(1.83)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C268(0.90); C366(1.33); C391(1.40)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C268(0.94); C391(1.21); C366(1.35)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C391(0.98)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C268(0.87); C391(1.47); C366(2.03)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C391(0.82); C268(1.44); C366(1.45)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C268(1.12); C391(1.94); C366(2.46)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C391(1.10); C366(2.03)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C366(0.67); C391(1.12)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C391(0.97)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C391(1.14)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C391(0.73)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C366(0.98)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C366(1.06); C268(1.07)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C366(0.67); C268(1.30)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C366(0.84); C268(0.90)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C391(0.89)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C391(0.77)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C391(0.82)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C391(0.87)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C268(0.84)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C268(0.72)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C268(0.85)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C268(1.00)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C268(1.02)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C366(0.61); C268(1.04)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C268(0.71)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C268(0.72)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C268(1.16)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C268(1.11)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C268(1.34)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C268(1.90)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C268(1.38)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C268(1.13); C366(1.08); C406(1.09)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C268(0.96); C366(1.06)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C268(0.96); C366(1.06); C406(1.04)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C366(0.63); C268(1.33)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C268(1.22); C366(1.15)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C268(1.08); C366(0.99); C406(0.96)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C268(0.89); C366(1.04)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C268(0.90); C366(0.92); C406(0.95)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C268(1.01); C366(1.09)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C268(1.06); C366(0.96); C406(0.76)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C268(1.04); C366(1.03)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C268(1.02); C366(1.03); C406(0.87)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C268(1.05); C366(1.07)  LDD1603  [7]
 LDCM0400  CL13 HCT 116 C366(0.75); C268(1.09)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C366(0.92); C268(1.16)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C366(0.83); C268(1.09)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C391(1.16)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C391(1.02); C268(1.14)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C391(1.06); C268(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C391(1.06); C268(1.16)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C268(1.04); C366(1.05)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C268(1.11); C391(1.22)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C268(0.97); C391(1.03)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C268(0.92); C391(0.94)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C268(0.98); C391(1.20)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C268(0.95); C391(1.07)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C268(0.97); C391(1.08)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C268(1.16); C391(1.19)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C268(1.06); C391(1.00)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C268(0.84); C391(1.10)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C268(1.11); C391(1.16)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C268(1.27); C366(1.00)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C268(0.90); C391(1.20)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C268(0.93)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C268(0.89); C366(0.97)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C268(0.80); C366(0.87)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C268(0.89); C366(1.01); C589(0.86)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C268(0.91); C366(1.04)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C268(1.09); C366(1.05)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C268(0.95); C366(0.99); C406(0.93)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C268(0.89); C366(1.02); C406(0.94)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C268(1.11); C366(0.97)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C268(0.99); C366(1.04)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C268(1.23); C366(1.09)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C268(0.90); C366(0.97)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C268(0.96); C366(0.81)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C268(1.05); C366(1.06)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C268(1.01); C366(1.02)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C391(0.68)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C391(0.71)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C391(0.67)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C391(0.59)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C268(1.23); C366(0.89)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C391(0.78)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C391(0.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C391(0.63)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C391(0.57)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C391(0.80)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C391(0.69)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C391(0.65)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C391(0.62)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C391(0.64)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C391(0.64)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C268(1.34); C366(1.06)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C391(0.78)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C268(1.11); C366(1.14); C406(0.95)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C268(1.17); C366(1.03)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C268(0.92); C366(0.96); C406(0.95)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C268(1.05); C366(1.14)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C268(1.16); C366(1.05)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C268(0.87); C366(0.98)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C268(0.87); C366(0.87)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C268(0.88); C366(1.05)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C268(1.13); C366(0.99)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C268(1.14); C366(0.60)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C268(1.13); C366(0.97); C589(0.78)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C268(1.04); C366(1.02)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C268(1.05); C366(1.01)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C268(1.03); C366(1.08); C406(0.88)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C268(0.99); C366(1.00)  LDD1670  [7]
 LDCM0469  CL76 HCT 116 C366(0.82)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C366(0.86)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C366(0.90)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C366(0.75)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C268(0.85); C366(1.58)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C366(0.70)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C366(0.77)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C366(0.56)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C366(0.67)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C366(1.05)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C366(0.95)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C366(1.14)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C366(0.77)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C366(0.94)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C366(0.74)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C268(1.17); C366(0.87)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C366(0.97)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C268(0.82); C366(1.06)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C268(0.81); C366(0.89)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C268(0.72); C366(0.70)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C268(0.87); C366(1.00)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C268(0.80); C366(0.94)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C268(0.89); C366(0.75)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C268(0.92); C366(0.84)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C268(0.98); C366(0.97)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C268(0.91); C366(0.92)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C268(0.99); C366(1.02); C406(1.07)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C391(0.94)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C268(0.98); C366(1.05); C406(1.00)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C268(1.04); C366(1.11)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C268(0.95); C366(0.96); C406(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C268(1.21); C366(1.01); C406(0.91)  LDD1497  [7]
 LDCM0024  KB05 MEWO C366(1.32)  LDD3319  [9]
 LDCM0021  THZ1 HCT 116 C366(1.00)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RecQ-like DNA helicase BLM (BLM) Helicase family P54132
DNA topoisomerase 3-alpha (TOP3A) Type IA topoisomerase family Q13472
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RecQ-mediated genome instability protein 2 (RMI2) RMI2 family Q96E14

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840