Details of the Target

General Information of Target

Target ID LDTP11828
Target Name Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)
Gene Name TNKS2
Gene ID 80351
Synonyms
PARP5B; TANK2; TNKL; Poly [ADP-ribose] polymerase tankyrase-2; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; Protein poly-ADP-ribosyltransferase tankyrase-2; EC 2.4.2.-; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-2; TANK2; Tankyrase-like protein; Tankyrase-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALFLKRLTLQTVKSENSCIRCFGKHILQKTAPAQLSPIASAPRLSFLIHAKAFSTAED
TQNEGKKTKKNKTAFSNVGRKISQRVIHLFDEKGNDLGNMHRANVIRLMDERDLRLVQRN
TSTEPAEYQLMTGLQILQERQRLREMEKANPKTGPTLRKELILSSNIGQHDLDTKTKQIQ
QWIKKKHLVQITIKKGKNVDVSENEMEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVL
RAFSKNEEKAYKETQETQERDTLNKDHGNDKESNVLHQ
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
ARTD/PARP family
Subcellular location
Cytoplasm
Function
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
TTD ID
T38087
Uniprot ID
Q9H2K2
DrugMap ID
TTFQI4H
Ensemble ID
ENST00000371627.5
HGNC ID
HGNC:15677
ChEMBL ID
CHEMBL6154

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C269(0.85)  LDD2227  [1]
DBIA
 Probe Info  		C13(0.94); C6(0.94)  LDD0078  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C13(0.86); C6(0.86)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C13(1.15); C6(1.15)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C13(1.27); C6(1.27)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C13(1.26); C6(1.26)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C13(1.31); C6(1.31)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C13(1.41); C6(1.41)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C13(1.02); C6(1.02)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C13(1.93); C6(1.93)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C13(1.98); C6(1.98)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C13(1.36); C6(1.36)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C13(1.45); C6(1.45)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C13(1.15); C6(1.15)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C13(1.40); C6(1.40)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C13(1.66); C6(1.66)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C13(1.58); C6(1.58)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C13(2.06); C6(2.06)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C13(0.73); C6(0.73)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C13(1.20); C6(1.20)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C13(1.30); C6(1.30)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C13(1.15); C6(1.15)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C13(1.22); C6(1.22)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C13(1.25); C6(1.25)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C13(1.17); C6(1.17)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C13(1.07); C6(1.07)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C13(1.12); C6(1.12)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C13(1.10); C6(1.10)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C13(1.15); C6(1.15)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C13(1.12); C6(1.12)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C13(0.93); C6(0.93)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C13(1.47); C6(1.47)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C13(1.22); C6(1.22)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C13(1.14); C6(1.14)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C13(0.46); C6(0.46)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C13(0.60); C6(0.60)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C13(0.55); C6(0.55)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C13(1.26); C6(1.26)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C13(0.74); C6(0.74)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C13(0.65); C6(0.65)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C13(0.78); C6(0.78)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C13(0.57); C6(0.57)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C13(1.05); C6(1.05)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C13(1.28); C6(1.28)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C13(1.22); C6(1.22)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C13(0.60); C6(0.60)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C13(1.37); C6(1.37)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C13(1.02); C6(1.02)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C13(1.10); C6(1.10)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C13(1.06); C6(1.06)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C13(0.91); C6(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C13(0.92); C6(0.92)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C13(0.74); C6(0.74)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C13(0.73); C6(0.73)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C13(0.77); C6(0.77)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C13(0.86); C6(0.86)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C13(1.13); C6(1.13)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C13(1.15); C6(1.15)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C13(0.78); C6(0.78)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C13(1.06); C6(1.06)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C13(0.67); C6(0.67)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C13(0.73); C6(0.73)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C13(0.78); C6(0.78)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C13(0.80); C6(0.80)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C13(0.91); C6(0.91)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C13(0.76); C6(0.76)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C13(0.88); C6(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C13(0.74); C6(0.74)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C13(0.85); C6(0.85)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C13(1.04); C6(1.04)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C13(0.50); C6(0.50)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C13(0.71); C6(0.71)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C13(0.77); C6(0.77)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C13(0.72); C6(0.72)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C13(0.82); C6(0.82)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C13(0.78); C6(0.78)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C13(0.81); C6(0.81)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C13(0.73); C6(0.73)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C13(0.88); C6(0.88)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C13(0.64); C6(0.64)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C13(0.83); C6(0.83)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C13(0.94); C6(0.94)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C13(0.70); C6(0.70)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C13(0.94); C6(0.94)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C13(0.71); C6(0.71)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C13(0.92); C6(0.92)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C13(1.30); C6(1.30)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C13(1.14); C6(1.14)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C13(0.65); C6(0.65)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C13(1.25); C6(1.25)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C13(1.10); C6(1.10)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C13(0.83); C6(0.83)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C13(0.72); C6(0.72)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C13(1.25); C6(1.25)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C13(1.74); C6(1.74)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C13(2.39); C6(2.39)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C13(0.68); C6(0.68)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C13(0.83); C6(0.83)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C13(0.76); C6(0.76)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C13(0.67); C6(0.67)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C13(0.89); C6(0.89)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C13(0.93); C6(0.93)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C13(0.75); C6(0.75)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C13(0.93); C6(0.93)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C13(0.77); C6(0.77)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C13(0.87); C6(0.87)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C13(1.01); C6(1.01)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C13(0.80); C6(0.80)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C13(0.74); C6(0.74)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C13(0.79); C6(0.79)  LDD0917  [2]
 LDCM0323  AC6 HCT 116 C13(1.12); C6(1.12)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C13(1.05); C6(1.05)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C13(0.64); C6(0.64)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C13(1.16); C6(1.16)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C13(1.09); C6(1.09)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C13(0.75); C6(0.75)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C13(0.83); C6(0.83)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C13(0.88); C6(0.88)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C13(0.73); C6(0.73)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C13(1.08); C6(1.08)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C13(0.79); C6(0.79)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C13(0.91); C6(0.91)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C13(0.86); C6(0.86)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C13(0.90); C6(0.90)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C13(1.11); C6(1.11)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C13(0.74); C6(0.74)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C13(0.82); C6(0.82)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C13(0.92); C6(0.92)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C13(1.13); C6(1.13)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C13(1.16); C6(1.16)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C13(1.07); C6(1.07)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C13(1.17); C6(1.17)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C13(1.12); C6(1.12)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C13(1.16); C6(1.16)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C13(1.20); C6(1.20)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C13(1.39); C6(1.39)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C13(1.00); C6(1.00)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C13(1.02); C6(1.02)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C13(1.06); C6(1.06)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C13(0.89); C6(0.89)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C13(1.28); C6(1.28)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C13(0.91); C6(0.91)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C13(1.35); C6(1.35)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C13(1.49); C6(1.49)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C13(1.37); C6(1.37)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C13(1.28); C6(1.28)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C13(1.32); C6(1.32)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C13(1.23); C6(1.23)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C13(0.94); C6(0.94)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C269(0.85)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C13(1.46); C6(1.46)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C13(1.45); C6(1.45)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C13(0.69); C6(0.69)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C13(1.68); C6(1.68)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C13(2.46); C6(2.46)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C13(1.53); C6(1.53)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C13(1.38); C6(1.38)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C13(0.70); C6(0.70)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C13(0.81); C6(0.81)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C13(0.74); C6(0.74)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C13(0.95); C6(0.95)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C13(1.01); C6(1.01)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C13(1.41); C6(1.41)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C13(1.00); C6(1.00)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C13(1.13); C6(1.13)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C13(0.75); C6(0.75)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C13(0.71); C6(0.71)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C13(0.79); C6(0.79)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C13(0.72); C6(0.72)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C13(0.68); C6(0.68)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C13(1.10); C6(1.10)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C13(1.20); C6(1.20)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C13(1.28); C6(1.28)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C13(1.66); C6(1.66)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C13(1.57); C6(1.57)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C13(0.60); C6(0.60)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C13(0.79); C6(0.79)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C13(1.10); C6(1.10)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C13(0.78); C6(0.78)  LDD0993  [2]
 LDCM0400  CL13 HCT 116 C13(1.39); C6(1.39)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C13(1.42); C6(1.42)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C13(1.29); C6(1.29)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C13(1.15); C6(1.15)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C13(1.20); C6(1.20)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C13(1.07); C6(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C13(1.04); C6(1.04)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C13(1.40); C6(1.40)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C13(1.61); C6(1.61)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C13(1.14); C6(1.14)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C13(1.00); C6(1.00)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C13(0.62); C6(0.62)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C13(1.06); C6(1.06)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C13(0.77); C6(0.77)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C13(0.81); C6(0.81)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C13(0.95); C6(0.95)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C13(1.11); C6(1.11)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C13(1.22); C6(1.22)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C13(1.67); C6(1.67)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C13(0.87); C6(0.87)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C13(1.04); C6(1.04)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C13(1.08); C6(1.08)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C13(1.19); C6(1.19)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C13(1.08); C6(1.08)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C13(1.17); C6(1.17)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C13(1.27); C6(1.27)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C13(1.12); C6(1.12)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C13(1.18); C6(1.18)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C13(1.24); C6(1.24)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C13(1.30); C6(1.30)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C13(1.30); C6(1.30)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C13(1.01); C6(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C13(1.26); C6(1.26)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C13(1.04); C6(1.04)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C13(1.03); C6(1.03)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C13(0.95); C6(0.95)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C13(0.90); C6(0.90)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C13(1.07); C6(1.07)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C13(1.06); C6(1.06)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C13(1.25); C6(1.25)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C13(0.97); C6(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C13(0.99); C6(0.99)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C13(1.37); C6(1.37)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C13(1.03); C6(1.03)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C13(1.26); C6(1.26)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C13(1.09); C6(1.09)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C13(0.97); C6(0.97)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C13(1.00); C6(1.00)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C13(1.27); C6(1.27)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C13(1.25); C6(1.25)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C13(1.88); C6(1.88)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C13(1.07); C6(1.07)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C13(0.85); C6(0.85)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C13(1.06); C6(1.06)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C13(0.94); C6(0.94)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C13(0.86); C6(0.86)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C13(1.04); C6(1.04)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C13(0.90); C6(0.90)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C13(0.89); C6(0.89)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C13(0.94); C6(0.94)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C13(1.43); C6(1.43)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C13(1.39); C6(1.39)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C13(0.90); C6(0.90)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C13(1.05); C6(1.05)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C13(1.35); C6(1.35)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C13(1.15); C6(1.15)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C13(1.39); C6(1.39)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C13(0.75); C6(0.75)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C13(0.61); C6(0.61)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C13(0.88); C6(0.88)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C13(0.86); C6(0.86)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C13(1.41); C6(1.41)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C13(0.69); C6(0.69)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C13(0.64); C6(0.64)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C13(0.64); C6(0.64)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C13(0.75); C6(0.75)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C13(0.82); C6(0.82)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C13(0.86); C6(0.86)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C13(0.79); C6(0.79)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C13(0.88); C6(0.88)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C13(0.74); C6(0.74)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C13(0.79); C6(0.79)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C13(1.25); C6(1.25)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C13(0.78); C6(0.78)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C13(0.95); C6(0.95)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C13(1.01); C6(1.01)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C13(0.83); C6(0.83)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C13(0.91); C6(0.91)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C13(1.14); C6(1.14)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C13(0.75); C6(0.75)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C13(1.08); C6(1.08)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C13(0.76); C6(0.76)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C13(1.01); C6(1.01)  LDD1092  [2]
 LDCM0468  Fragment33 HCT 116 C13(0.89); C6(0.89)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C13(1.65); C6(1.65)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucyl-cystinyl aminopeptidase (LNPEP) Peptidase M1 family Q9UIQ6
DNA repair and recombination protein RAD54-like (RAD54L) SNF2/RAD54 helicase family Q92698
Breakpoint cluster region protein (BCR) . P11274
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) . Q9NWT6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) Calcium channel alpha-1 subunit (TC 1.A.1.11) family Q13698
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B2 (HOXB2) Antp homeobox family P14652
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BRISC and BRCA1-A complex member 1 (BABAM1) BABAM1 family Q9NWV8
Striatin (STRN) WD repeat striatin family O43815
182 kDa tankyrase-1-binding protein (TNKS1BP1) . Q9C0C2
Axin-1 (AXIN1) . O15169
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Nuclear mitotic apparatus protein 1 (NUMA1) . Q14980
Protein phosphatase 1 regulatory subunit 12C (PPP1R12C) . Q9BZL4
Protocadherin Fat 4 (FAT4) . Q6V0I7
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) . O15084
SH3 domain-binding protein 2 (SH3BP2) . P78314
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27841036-compound-37 Small molecular drug D0F5TD
Stenoparib Small molecular drug DP48WE

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004