Details of the Target

General Information of Target

Target ID LDTP11290
Target Name Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8)
Gene Name ALG8
Gene ID 79053
Synonyms
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; EC 2.4.1.265; Asparagine-linked glycosylation protein 8 homolog; Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHR
LRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGD
AIAEIRRLRPGSIETYEQEKAVFQFYQRTK
Target Bioclass
Enzyme
Family
ALG6/ALG8 glucosyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide. Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia.
Uniprot ID
Q9BVK2
Ensemble ID
ENST00000299626.10
HGNC ID
HGNC:23161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.G401V .
HEC1 SNV: p.K313N .
HT115 SNV: p.R237C .
NCIH358 SNV: p.V115L .
NUGC3 SNV: p.A45V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K273(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C277(7.30); C218(5.97)  LDD3365  [2]
BTD
 Probe Info  		C218(0.44)  LDD2091  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C225
 Probe Info  		5.31  LDD1898  [8]
OEA-DA
 Probe Info  		13.37  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C218(0.82)  LDD2112  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C218(1.21)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C218(0.94)  LDD2103  [3]
 LDCM0214  AC1 HEK-293T C26(1.04); C277(0.90); C218(0.94)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C218(0.46)  LDD1094  [11]
 LDCM0226  AC11 PaTu 8988t C218(0.60)  LDD1105  [11]
 LDCM0237  AC12 PaTu 8988t C218(0.64)  LDD1116  [11]
 LDCM0246  AC128 PaTu 8988t C218(0.58)  LDD1125  [11]
 LDCM0247  AC129 PaTu 8988t C218(0.76)  LDD1126  [11]
 LDCM0249  AC130 PaTu 8988t C218(0.82)  LDD1128  [11]
 LDCM0250  AC131 PaTu 8988t C218(0.59)  LDD1129  [11]
 LDCM0251  AC132 PaTu 8988t C218(0.66)  LDD1130  [11]
 LDCM0252  AC133 PaTu 8988t C218(0.47)  LDD1131  [11]
 LDCM0253  AC134 PaTu 8988t C218(0.56)  LDD1132  [11]
 LDCM0254  AC135 PaTu 8988t C218(0.49)  LDD1133  [11]
 LDCM0255  AC136 PaTu 8988t C218(0.62)  LDD1134  [11]
 LDCM0256  AC137 PaTu 8988t C218(0.51)  LDD1135  [11]
 LDCM0257  AC138 PaTu 8988t C218(0.70)  LDD1136  [11]
 LDCM0258  AC139 PaTu 8988t C218(0.56)  LDD1137  [11]
 LDCM0259  AC14 PaTu 8988t C218(0.63)  LDD1138  [11]
 LDCM0260  AC140 PaTu 8988t C218(0.69)  LDD1139  [11]
 LDCM0261  AC141 PaTu 8988t C218(0.65)  LDD1140  [11]
 LDCM0262  AC142 PaTu 8988t C218(0.83)  LDD1141  [11]
 LDCM0270  AC15 PaTu 8988t C218(0.56)  LDD1149  [11]
 LDCM0276  AC17 PaTu 8988t C218(0.56)  LDD1155  [11]
 LDCM0277  AC18 PaTu 8988t C218(0.58)  LDD1156  [11]
 LDCM0278  AC19 PaTu 8988t C218(0.74)  LDD1157  [11]
 LDCM0279  AC2 HEK-293T C26(1.06); C277(0.93)  LDD1518  [10]
 LDCM0280  AC20 PaTu 8988t C218(0.58)  LDD1159  [11]
 LDCM0281  AC21 PaTu 8988t C218(0.71)  LDD1160  [11]
 LDCM0282  AC22 PaTu 8988t C218(0.76)  LDD1161  [11]
 LDCM0283  AC23 PaTu 8988t C218(0.47)  LDD1162  [11]
 LDCM0284  AC24 PaTu 8988t C218(0.55)  LDD1163  [11]
 LDCM0285  AC25 PaTu 8988t C218(1.37)  LDD1164  [11]
 LDCM0286  AC26 PaTu 8988t C218(1.11)  LDD1165  [11]
 LDCM0287  AC27 PaTu 8988t C218(1.30)  LDD1166  [11]
 LDCM0288  AC28 PaTu 8988t C218(1.14)  LDD1167  [11]
 LDCM0289  AC29 PaTu 8988t C218(1.19)  LDD1168  [11]
 LDCM0290  AC3 HEK-293T C277(0.83); C218(0.94)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C218(0.98)  LDD1170  [11]
 LDCM0292  AC31 PaTu 8988t C218(1.63)  LDD1171  [11]
 LDCM0293  AC32 PaTu 8988t C218(1.02)  LDD1172  [11]
 LDCM0294  AC33 PaTu 8988t C218(0.90)  LDD1173  [11]
 LDCM0295  AC34 PaTu 8988t C218(0.92)  LDD1174  [11]
 LDCM0296  AC35 HEK-293T C277(0.71); C218(1.08)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C26(1.12); C277(0.97)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C277(0.95); C218(0.87)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C26(1.03); C277(1.00)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C26(1.15); C277(0.98); C218(0.84)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C26(1.08); C277(0.96)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C26(1.13); C277(0.90); C218(0.97)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C26(1.00); C277(0.88); C218(0.89)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C26(0.98); C277(0.98)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C277(0.75); C218(0.96)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C26(1.03); C277(0.95)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C277(0.90); C218(0.78)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C26(0.90); C277(0.94)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C26(1.05); C277(0.87); C218(0.84)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C26(1.16); C277(0.97); C218(0.94)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C26(0.90); C277(0.83); C218(1.01)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C277(0.88); C218(0.87)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C26(1.04); C277(0.97)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C277(0.78); C218(1.03)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C26(1.03); C277(0.95)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C277(0.90); C218(0.83)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C26(1.03); C277(1.00)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C26(0.99); C277(0.97); C218(0.92)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C26(1.18); C277(0.91); C218(0.98)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C26(1.00); C277(0.92); C218(1.00)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C26(0.95); C277(1.04)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C277(0.97); C218(1.05)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C218(0.76)  LDD1202  [11]
 LDCM0324  AC60 HEK-293T C26(1.05); C277(1.01)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C277(1.02); C218(0.90)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C26(0.97); C277(1.00)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C26(1.09); C277(0.91); C218(1.02)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C26(1.12); C277(1.09); C218(0.92)  LDD1567  [10]
 LDCM0334  AC7 PaTu 8988t C218(1.36)  LDD1213  [11]
 LDCM0345  AC8 PaTu 8988t C218(1.06)  LDD1224  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C218(0.86)  LDD2113  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C218(0.48)  LDD1127  [11]
 LDCM0356  AKOS034007680 PaTu 8988t C218(0.55)  LDD1235  [11]
 LDCM0275  AKOS034007705 PaTu 8988t C218(0.53)  LDD1154  [11]
 LDCM0498  BS-3668 MDA-MB-231 C218(0.44)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C26(1.09); C277(1.42)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C26(1.00); C277(1.41)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C26(0.92); C277(1.00); C218(0.99)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C218(0.92)  LDD1249  [11]
 LDCM0371  CL102 PaTu 8988t C218(0.87)  LDD1250  [11]
 LDCM0372  CL103 PaTu 8988t C218(0.57)  LDD1251  [11]
 LDCM0373  CL104 PaTu 8988t C218(0.76)  LDD1252  [11]
 LDCM0374  CL105 PaTu 8988t C218(0.97)  LDD1253  [11]
 LDCM0375  CL106 PaTu 8988t C218(1.06)  LDD1254  [11]
 LDCM0376  CL107 PaTu 8988t C218(0.85)  LDD1255  [11]
 LDCM0377  CL108 PaTu 8988t C218(0.78)  LDD1256  [11]
 LDCM0378  CL109 PaTu 8988t C218(0.76)  LDD1257  [11]
 LDCM0379  CL11 HEK-293T C26(1.17); C277(1.01); C218(1.34)  LDD1583  [10]
 LDCM0380  CL110 PaTu 8988t C218(0.71)  LDD1259  [11]
 LDCM0381  CL111 PaTu 8988t C218(0.57)  LDD1260  [11]
 LDCM0382  CL112 PaTu 8988t C218(1.60)  LDD1261  [11]
 LDCM0383  CL113 PaTu 8988t C218(1.27)  LDD1262  [11]
 LDCM0384  CL114 PaTu 8988t C218(1.22)  LDD1263  [11]
 LDCM0385  CL115 PaTu 8988t C218(1.26)  LDD1264  [11]
 LDCM0386  CL116 PaTu 8988t C218(1.44)  LDD1265  [11]
 LDCM0387  CL117 HEK-293T C26(1.06); C277(0.94)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C277(1.05)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C26(1.03); C277(0.92); C218(1.00)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C26(1.43); C277(1.13); C218(1.47)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C26(0.96); C277(1.03); C218(1.00)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C26(0.95); C277(1.02)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C277(1.21)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C26(0.90); C277(1.28); C218(1.00)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C26(0.93); C277(1.07); C218(0.96)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C26(0.96); C277(1.03)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C277(1.22)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C26(0.92); C277(1.16); C218(1.03)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C26(0.90); C277(1.04); C218(1.00)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C26(0.98); C277(1.38)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C277(1.17)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C26(1.11); C277(1.46); C218(1.16)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C26(1.08); C277(1.01); C218(1.01)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C26(1.02); C277(1.01); C218(1.01)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C26(1.14); C277(0.96)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C277(0.68); C218(1.09)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C277(1.16)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C26(1.06); C277(0.91)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C277(1.02); C218(1.17)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C26(1.12); C277(0.99)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C26(1.13); C277(0.90); C218(1.26)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C26(1.59); C277(1.12); C218(1.26)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C26(0.98); C277(1.57)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C277(1.02)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C26(1.00); C277(1.01); C218(1.01)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C26(0.97); C277(1.03); C218(1.00)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C26(0.98); C277(0.89); C218(0.97)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C26(1.04); C277(1.26); C218(1.17)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C26(1.03); C277(0.95)  LDD1623  [10]
 LDCM0420  CL31 PaTu 8988t C218(0.79)  LDD1299  [11]
 LDCM0421  CL32 PaTu 8988t C218(0.88)  LDD1300  [11]
 LDCM0422  CL33 PaTu 8988t C218(0.67)  LDD1301  [11]
 LDCM0423  CL34 PaTu 8988t C218(0.60)  LDD1302  [11]
 LDCM0424  CL35 PaTu 8988t C218(0.59)  LDD1303  [11]
 LDCM0425  CL36 PaTu 8988t C218(0.74)  LDD1304  [11]
 LDCM0426  CL37 PaTu 8988t C218(0.63)  LDD1305  [11]
 LDCM0428  CL39 PaTu 8988t C218(0.61)  LDD1307  [11]
 LDCM0429  CL4 HEK-293T C26(1.01); C277(1.22); C218(1.28)  LDD1633  [10]
 LDCM0430  CL40 PaTu 8988t C218(1.12)  LDD1309  [11]
 LDCM0431  CL41 PaTu 8988t C218(0.66)  LDD1310  [11]
 LDCM0432  CL42 PaTu 8988t C218(0.58)  LDD1311  [11]
 LDCM0433  CL43 PaTu 8988t C218(0.75)  LDD1312  [11]
 LDCM0434  CL44 PaTu 8988t C218(0.69)  LDD1313  [11]
 LDCM0435  CL45 PaTu 8988t C218(0.87)  LDD1314  [11]
 LDCM0436  CL46 PaTu 8988t C218(0.80)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C218(0.81)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C218(0.66)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C218(0.67)  LDD1318  [11]
 LDCM0440  CL5 HEK-293T C26(1.10); C277(1.18); C218(1.10)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C218(0.63)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C218(0.64)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C218(0.62)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C218(0.59)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C218(0.64)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C218(0.66)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C218(0.42)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C218(0.47)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C218(0.57)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C218(0.59)  LDD1329  [11]
 LDCM0451  CL6 HEK-293T C26(1.02); C277(1.40)  LDD1654  [10]
 LDCM0452  CL60 PaTu 8988t C218(0.60)  LDD1331  [11]
 LDCM0453  CL61 HEK-293T C26(1.10); C277(1.11)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C277(1.24)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C26(1.19); C277(1.02); C218(0.94)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C26(1.06); C277(1.14); C218(1.02)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C26(1.03); C277(0.93); C218(0.90)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C26(1.01); C277(1.02)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C277(1.10); C218(1.07)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C26(1.09); C277(0.98)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C277(0.98); C218(1.01)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C277(0.94); C218(1.24)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C26(1.07); C277(0.91)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C26(1.09); C277(0.88); C218(1.06)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C26(1.27); C277(0.99); C218(1.13)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C26(0.96); C277(1.35)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C277(1.10)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C26(1.02); C277(1.01); C218(1.12)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C26(1.03); C277(1.06); C218(0.99)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C26(0.95); C277(0.97)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C277(0.79); C218(0.97)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C26(0.89); C277(1.41)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C26(1.02); C277(0.94)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C277(0.93); C218(0.88)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C26(0.91); C277(0.90)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C26(1.02); C277(0.95); C218(1.04)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C26(1.17); C277(1.25); C218(1.26)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C26(1.07); C277(1.13)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C277(1.30)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C26(0.91); C277(1.21); C218(0.99)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C26(0.96); C277(1.02); C218(1.17)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C26(1.00); C277(0.81); C218(1.06)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C277(0.92); C218(1.14)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C26(0.91); C277(1.41)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C277(0.89); C218(1.14)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C26(0.94); C277(0.99)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C277(1.05); C218(0.97)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C26(0.96); C277(1.00)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C26(0.92); C277(0.99); C218(1.19)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C26(1.19); C277(1.28); C218(1.29)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C26(0.92); C277(1.19)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C277(1.10)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C26(0.94); C277(1.31); C218(0.94)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C26(1.21); C277(1.05); C218(0.90)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C218(42.90)  LDD1702  [3]
 LDCM0625  F8 Ramos C218(1.67); C26(0.94)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C26(0.70)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C218(1.76); C26(0.12)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C26(0.92)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C218(0.70); C26(0.58)  LDD2192  [12]
 LDCM0580  Fragment21 Ramos C218(0.99); C26(0.56)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C218(0.99); C26(2.37)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C218(1.01); C26(0.88)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C218(0.68); C26(0.56)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C218(1.16); C26(0.81)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C218(1.30); C26(0.70)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C218(1.90); C26(0.55)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C26(0.99); C277(1.18); C218(1.01)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C218(1.16); C26(1.40)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C218(2.13); C26(0.76)  LDD2184  [12]
 LDCM0427  Fragment51 PaTu 8988t C218(0.48)  LDD1306  [11]
 LDCM0610  Fragment52 Ramos C218(1.15)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C218(0.84); C26(0.67)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C218(1.90); C26(0.75)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C26(2.09)  LDD2188  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C218(0.97); C26(1.07); C277(1.08)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C218(1.01); C26(0.89); C277(1.06)  LDD1497  [10]
 LDCM0024  KB05 OVCAR-3 C277(7.30); C218(5.97)  LDD3365  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C218(1.73)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C218(1.85)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C218(0.65)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C218(1.08)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C218(1.13)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C218(1.07)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C218(0.89)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C218(0.79)  LDD2104  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C218(0.79)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C218(1.10)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C218(0.85)  LDD2114  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C218(0.50)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C218(2.00)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C218(0.89)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C218(0.96)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C218(0.42)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C218(1.03)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C218(1.09)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C218(1.09)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C218(0.55)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C218(0.49)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C218(1.46)  LDD2135  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C218(0.87)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C218(0.41)  LDD2141  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C218(4.83)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C218(0.83)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C218(0.53)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C218(0.38)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clarin-1 (CLRN1) Clarin family P58418
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Bcl-2-interacting killer (BIK) . Q13323

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578