Details of the Target

General Information of Target

Target ID LDTP11286
Target Name PHD finger protein 20 (PHF20)
Gene Name PHF20
Gene ID 51230
Synonyms
C20orf104; GLEA2; HCA58; NZF; TZP; PHD finger protein 20; Glioma-expressed antigen 2; Hepatocellular carcinoma-associated antigen 58; Novel zinc finger protein; Transcription factor TZP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAA
ESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECV
IRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRD
GKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTI
ALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITE
KRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF
Target Bioclass
Other
Subcellular location
Nucleus
Function
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.
Uniprot ID
Q9BVI0
Ensemble ID
ENST00000374012.8
HGNC ID
HGNC:16098

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S581F .
AU565 SNV: p.E858Q .
CAL51 Deletion: p.K912RfsTer21 .
CCK81 SNV: p.H839R .
DU145 SNV: p.H757Y .
JHH6 SNV: p.M473V .
JHH7 SNV: p.H472P .
MDAMB436 Deletion: p.A913GfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C555(0.86); C557(0.86)  LDD0078  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0147  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C59(1.28); C778(0.99)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C59(1.47); C778(1.07)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C778(0.95)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C778(0.99)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C778(0.99)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C778(1.03)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C778(1.03)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C778(0.84)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C778(0.98)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C778(0.83)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C778(1.09)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C778(1.19)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C59(1.35); C778(1.16)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C778(1.10)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C778(1.04)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C778(0.86)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C778(1.11)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C778(0.97)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C778(1.03)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C778(1.07)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C778(0.98)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C778(0.95)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C778(1.10)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C59(1.17); C778(0.99)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C778(1.00)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C778(1.01)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C778(1.09)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C778(1.14)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C778(1.11)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C778(1.12)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C778(1.17)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C778(1.05)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C59(1.34); C778(1.24)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C778(0.93)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C778(1.20)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C778(0.97)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C778(0.86)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C778(0.92)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C778(0.84)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C778(0.83)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C778(0.99); C59(1.55)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C778(1.07)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C778(1.27)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C778(1.39)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C778(1.01)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C778(1.16)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C778(1.23)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C778(1.08)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C778(1.18)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C778(0.89); C59(1.25)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C778(1.03); C59(3.75)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C778(1.03); C59(1.19)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C778(1.02); C59(1.26)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C778(1.02); C59(1.35)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C778(0.93); C59(1.17)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C778(0.93); C59(0.98)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C778(0.97); C59(1.17)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C778(0.99); C59(1.28)  LDD0601  [1]
 LDCM0285  AC25 PaTu 8988t C59(0.86)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C59(1.13)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C59(1.21)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C59(1.42)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C59(1.21)  LDD1168  [1]
 LDCM0290  AC3 HCT 116 C778(1.08); C59(1.16)  LDD0607  [1]
 LDCM0291  AC30 PaTu 8988t C59(1.04)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C59(0.95)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C59(1.06)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C59(1.37)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C59(1.33)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C59(1.12)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C59(1.23)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C59(1.40)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C59(1.06)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C59(1.32)  LDD1179  [1]
 LDCM0301  AC4 HCT 116 C778(1.09); C59(1.42)  LDD0618  [1]
 LDCM0302  AC40 PaTu 8988t C59(1.43)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C59(1.21)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C59(1.21)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C59(1.33)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C59(1.78)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C59(1.41)  LDD1186  [1]
 LDCM0308  AC46 HCT 116 C778(1.04)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C778(0.92)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C778(1.11)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C778(1.27)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C778(1.13); C59(1.52)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C778(1.18)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C778(0.94)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C778(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C778(1.20)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C778(1.07)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C778(1.16)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C778(1.58)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C778(1.00)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C778(0.88)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C778(1.13)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C778(1.10); C59(1.47)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C778(1.01)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C778(0.79)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C778(0.96)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C778(0.99)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C778(0.89)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C778(0.88)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C778(0.85)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C778(0.94)  LDD0648  [1]
 LDCM0332  AC68 PaTu 8988t C59(1.14)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C59(1.24)  LDD1212  [1]
 LDCM0334  AC7 HCT 116 C778(1.00); C59(1.32)  LDD0651  [1]
 LDCM0335  AC70 PaTu 8988t C59(1.08)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C59(1.08)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C59(0.99)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C59(1.16)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C59(1.52)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C59(1.14)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C59(1.20)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C59(1.09)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C59(1.25)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C59(1.34)  LDD1223  [1]
 LDCM0345  AC8 HCT 116 C778(0.95); C59(1.50)  LDD0662  [1]
 LDCM0346  AC80 PaTu 8988t C59(1.39)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C59(1.29)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C59(1.31)  LDD1227  [1]
 LDCM0349  AC83 HCT 116 C778(1.21)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C778(1.23)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C778(1.06)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C778(1.01)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C778(0.98)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C778(0.99)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C778(1.26)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C778(0.91)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C778(1.32)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C778(1.18)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C778(1.01)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C778(1.11)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C778(1.00)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C778(1.10)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C778(1.12)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C778(0.78)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C778(1.01)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C59(1.14); C778(0.97)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C778(1.04); C59(1.45)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C778(1.33); C59(1.83)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C555(0.86); C557(0.86)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C778(0.79)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C778(1.08)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C778(1.01); C59(1.36)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C778(1.04); C59(1.66)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C59(0.93); C778(1.06)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C778(1.06); C59(1.06)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C778(1.10); C59(1.13)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C778(1.02); C59(1.53)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C778(1.25); C59(2.25)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C778(1.18); C59(2.06)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C778(1.18); C59(1.96)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C778(0.98); C59(1.48)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C778(1.18)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C778(1.11); C59(1.73)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C778(1.02); C59(1.78)  LDD0698  [1]
 LDCM0382  CL112 PaTu 8988t C59(1.07)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C59(0.97)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C59(0.95)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C59(1.01)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C59(0.98)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C59(1.41)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C59(1.18)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C59(1.20)  LDD1268  [1]
 LDCM0390  CL12 HCT 116 C778(1.12)  LDD0707  [1]
 LDCM0391  CL120 PaTu 8988t C59(1.27)  LDD1270  [1]
 LDCM0392  CL121 HCT 116 C778(0.86)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C778(1.22)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C778(0.98)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C778(1.12)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C778(0.84)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C778(0.79)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C778(0.89)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C778(0.87)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C778(1.05)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C778(0.92)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C778(1.04)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C778(1.00)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C778(0.85)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C778(1.18)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C778(1.38)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C778(0.86)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C778(1.14)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C778(1.27)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C778(1.67)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C778(1.25)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C778(1.09)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C778(1.43)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C778(1.10)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C778(0.93)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C778(1.13)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C778(1.21)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C778(0.83)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C778(1.34)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C778(0.93)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C778(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C778(0.83)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C778(1.08)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C778(1.13)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C778(0.89)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C778(1.17)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C778(1.00)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C778(0.95)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C778(0.85)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C778(1.14)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C778(1.33)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C778(1.13)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C778(1.05)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C778(1.19)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C778(0.91)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C778(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C778(0.97)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C778(0.99)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C778(1.09)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C778(0.92)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C778(0.93)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C778(1.02)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C778(0.74)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C778(0.89)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C778(0.95)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C778(0.94)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C778(0.83)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C778(1.03)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C778(0.88)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C778(1.07)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C778(1.10)  LDD0769  [1]
 LDCM0453  CL61 PaTu 8988t C59(1.21)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C59(1.71)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C59(1.33)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C59(1.57)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C59(1.58)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C59(2.08)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C59(1.51)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C59(1.43)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C59(2.16)  LDD1340  [1]
 LDCM0462  CL7 HCT 116 C778(1.20)  LDD0779  [1]
 LDCM0463  CL70 PaTu 8988t C59(1.45)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C59(1.53)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C59(1.54)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C59(1.93)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C59(1.77)  LDD1346  [1]
 LDCM0469  CL76 HCT 116 C59(1.14)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C59(1.34)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C59(1.29)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C59(1.37)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C778(1.15)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C59(1.12)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C59(1.21)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C59(1.85)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C59(1.87)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C59(2.46)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C59(1.31)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C59(1.15)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C59(1.39)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C59(1.52)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C59(1.90)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C778(0.98)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C59(1.10)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C59(1.22); C778(0.96)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C59(1.10); C778(0.91)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C59(1.09); C778(0.99)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C59(1.41); C778(1.06)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C59(1.39); C778(0.95)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C59(1.08); C778(0.97)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C59(1.14); C778(1.02)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C59(1.37); C778(1.17)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C59(1.32); C778(1.08)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C840(1.15); C59(1.26)  LDD1698  [6]
 LDCM0468  Fragment33 PaTu 8988t C59(2.24)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C778(1.43)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C840(0.84); C294(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C840(1.11); C294(1.07)  LDD1497  [6]
 LDCM0024  KB05 PF-382 C59(1.31)  LDD3397  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840