Details of the Target

General Information of Target

Target ID LDTP11226
Target Name Spindlin interactor and repressor of chromatin-binding protein (SPINDOC)
Gene Name SPINDOC
Gene ID 144097
Synonyms
C11orf84; Spindlin interactor and repressor of chromatin-binding protein; SPIN1-docking protein; SPIN-DOC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAY
CLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAE
TCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMF
ALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRH
ECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGA
PS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4. Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity.
Uniprot ID
Q9BUA3
Ensemble ID
ENST00000294244.9
HGNC ID
HGNC:25115

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C64(0.93)  LDD2090  [1]
AHL-Pu-1
 Probe Info  		C64(3.61); C12(3.29)  LDD0170  [2]
DBIA
 Probe Info  		C12(1.40)  LDD0532  [3]
IA-alkyne
 Probe Info  		C12(0.00); C64(0.00)  LDD0165  [4]
IPM
 Probe Info  		C64(0.00); C12(0.00)  LDD2156  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C64(0.80)  LDD2142  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C64(0.95)  LDD2117  [1]
 LDCM0025  4SU-RNA DM93 C64(3.61); C12(3.29)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C64(3.79); C12(4.88)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C64(0.95); C12(0.91)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C12(1.40)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C12(0.91)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C12(0.97)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C12(0.94)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C12(1.32)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C12(1.18)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C12(1.20)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C12(1.12)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C12(0.90)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C12(0.72)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C12(0.73)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C12(1.33)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C12(0.77)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C12(0.73)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C12(0.78)  LDD0546  [3]
 LDCM0237  AC12 HCT 116 C12(1.32)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C12(1.28)  LDD0576  [3]
 LDCM0263  AC143 HEK-293T C12(1.09)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C12(1.09)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C12(1.09)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C12(1.20)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C12(1.01)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C12(0.96)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C12(1.16)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C12(1.45)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C12(0.94)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C12(1.18)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C12(1.00)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C12(0.92)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C12(0.90)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C12(1.03)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C12(1.24)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C12(0.98)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C64(0.98); C12(0.98)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C64(1.00); C12(1.06); C19(1.06)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C64(1.04); C12(1.29)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C64(1.06); C12(1.04); C19(1.02)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C64(0.96); C12(1.00); C19(0.97)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C64(1.13); C12(1.01)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C64(1.02); C12(1.03); C19(1.17)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C64(1.05); C12(1.04); C19(1.01)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C64(1.17); C19(1.06)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C64(0.96); C12(1.00)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C64(1.02); C12(0.94); C19(1.07)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C64(0.93); C12(0.99)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C64(1.05); C12(1.00); C19(1.06)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C64(1.04); C12(0.98)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C64(0.98); C12(0.93)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C64(0.97); C12(0.89); C19(1.11)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C64(0.95); C12(1.07); C19(1.10)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C64(1.12); C19(1.10)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C64(0.96); C12(1.04)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C64(0.99); C12(0.98); C19(1.02)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C64(1.03); C12(1.09)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C64(1.13); C12(0.99); C19(1.13)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C64(1.16); C12(1.02)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C64(0.92); C12(0.92); C19(1.05)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C64(0.93); C12(1.21); C19(1.06)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C64(1.07); C12(0.99); C19(1.20)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C64(1.09); C19(1.08)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C64(1.11); C12(1.02)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C64(0.96); C12(0.96); C19(1.18)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C64(1.07); C12(0.96)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C64(1.14); C12(1.02); C19(1.14)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C64(1.05); C12(1.14)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C64(0.86); C12(0.97); C19(1.09)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C64(0.99); C12(1.19); C19(1.21)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C64(1.10); C19(1.16)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C64(1.10); C12(1.01)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C64(1.16); C12(0.96)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C64(1.08); C12(1.05); C19(1.21)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C64(1.19); C12(0.96)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C64(1.07); C12(1.05); C19(1.40)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C64(1.06); C12(1.00)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C64(0.95); C12(1.06); C19(1.11)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C64(1.03); C12(1.15); C19(0.99)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C64(1.06); C19(1.03)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C64(0.93); C12(0.97)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C64(0.96); C12(0.98); C19(1.08)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C64(1.10); C12(0.92)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C12(1.36)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C64(0.97); C12(0.99); C19(1.00)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C64(1.16); C12(1.13)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C64(0.98); C12(1.01); C19(1.06)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C64(0.96); C12(1.11); C19(0.99)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C64(1.05); C19(1.12)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C12(1.27)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C12(1.33)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C12(1.17)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C12(1.25)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C12(1.09)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C12(1.40)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C12(1.69)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C12(1.73)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C12(1.89)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C12(1.36)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C12(1.48)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C12(1.21)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C12(1.16)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C12(1.30)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C12(1.27)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C12(1.14)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C12(2.36)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C12(1.74)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C12(0.90)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C12(1.20)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C12(1.29)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C12(1.94)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C64(0.90); C12(0.97)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C64(0.94); C12(0.86); C19(0.80)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C64(0.97); C12(0.95); C19(1.04)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C12(1.28)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C12(1.25)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C12(1.08)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C12(1.21)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C64(0.93); C12(1.11)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C64(1.02); C12(0.99); C19(1.03)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C64(1.01); C12(1.02); C19(1.06)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C64(0.95); C12(1.00); C19(1.19)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C64(0.84); C12(0.97)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C64(0.90); C12(0.94); C19(0.82)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C64(0.90); C12(1.11); C19(0.81)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C64(0.85); C12(1.00); C19(1.14)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C64(0.99); C12(1.01); C19(1.02)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C64(0.89); C12(1.14)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C64(0.93); C12(1.09); C19(0.94)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C64(0.97); C12(1.07); C19(1.35)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C64(1.00); C12(1.14); C19(1.11)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C64(1.08); C12(1.06)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C64(0.97); C12(1.07); C19(1.18)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C64(0.96); C12(1.06); C19(1.15)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C64(0.96); C19(0.82)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C64(1.07); C12(1.13); C19(1.07)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C64(0.87); C12(1.12)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C64(1.00); C12(1.13); C19(1.23)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C64(0.87); C12(1.00); C19(1.09)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C64(1.12); C12(1.09); C19(1.35)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C64(0.80); C12(1.08)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C64(0.97); C12(1.08); C19(1.19)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C64(0.88); C12(1.23); C19(1.12)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C64(0.89); C12(1.02); C19(1.17)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C64(0.96); C12(1.24)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C64(1.05); C12(1.00); C19(0.98)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C64(0.83); C12(1.17); C19(0.99)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C12(1.12)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C12(2.94)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C12(1.74)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C12(2.18)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C64(1.05); C12(0.93); C19(1.01)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C12(1.31)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C12(1.69)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C12(2.32)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C12(1.82)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C12(1.47)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C12(1.58)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C12(1.54)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C12(1.88)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C12(2.26)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C12(1.82)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C64(0.92); C12(1.05); C19(1.03)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C12(2.09)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C64(1.15); C12(1.03)  LDD1624  [7]
 LDCM0421  CL32 HCT 116 C12(1.08)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C12(0.83)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C12(0.99)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C12(1.11)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C12(0.85)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C12(1.13)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C12(1.08)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C64(0.85); C12(0.96); C19(1.07)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C12(0.96)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C12(0.90)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C12(0.94)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C12(0.87)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C12(0.95)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C12(0.95)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C12(0.73)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C12(0.69)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C12(0.68)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C12(0.80)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C64(1.07); C12(0.98)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C12(0.74)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C12(0.78)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C12(0.79)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C12(0.63)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C12(0.64)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C12(0.66)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C12(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C12(0.77)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C12(0.74)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C12(0.82)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C64(0.93); C12(1.04); C19(0.87)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C12(0.84)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C64(0.89); C12(1.05)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C64(1.05); C12(0.95); C19(0.93)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C64(0.97); C12(1.15); C19(1.12)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C64(0.97); C12(1.09); C19(0.99)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C64(1.09); C12(1.08)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C64(0.99); C12(0.99); C19(0.96)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C64(1.07); C12(0.97)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C64(1.11); C12(1.01); C19(0.95)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C64(1.05); C12(1.06)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C64(1.13); C12(0.96)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C64(0.85); C12(1.03); C19(0.92)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C64(0.99); C12(1.08); C19(0.85)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C64(1.04); C19(0.85)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C64(0.83); C12(0.98)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C64(0.99); C12(0.91); C19(0.97)  LDD1670  [7]
 LDCM0469  CL76 HCT 116 C12(0.93)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C12(1.07)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C12(1.01)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C12(0.85)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C64(0.72); C12(0.98); C19(0.76)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C12(1.09)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C12(0.90)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C12(1.13)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C12(0.93)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C12(1.15)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C12(1.10)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C12(1.07)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C12(0.90)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C12(1.02)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C12(1.21)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C64(1.08); C12(0.94)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C12(0.87)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C64(1.19); C12(1.05)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C64(1.06); C12(0.96); C19(1.07)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C64(1.05); C12(1.08)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C64(0.97); C12(0.98); C19(0.96)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C64(0.85); C12(0.88); C19(0.90)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C64(0.97); C19(0.88)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C64(0.97); C12(1.01)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C64(0.89); C12(1.18); C19(0.92)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C64(0.90); C12(1.17); C19(1.20)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C64(0.89); C12(1.11); C19(1.08)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C64(0.89); C12(1.09); C19(1.28)  LDD1671  [7]
 LDCM0427  Fragment51 HCT 116 C12(0.94)  LDD0744  [3]
 LDCM0022  KB02 42-MG-BA C64(2.29)  LDD2244  [8]
 LDCM0023  KB03 697 C12(1.72); C64(0.98)  LDD2662  [8]
 LDCM0024  KB05 HMCB C12(1.58)  LDD3312  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C64(0.84)  LDD2102  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C64(0.93)  LDD2090  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C64(1.42)  LDD2098  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C64(1.03)  LDD2105  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C64(0.97)  LDD2124  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C64(1.13)  LDD2125  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840