Details of the Target

General Information of Target

Target ID LDTP11141
Target Name WD repeat domain-containing protein 83 (WDR83)
Gene Name WDR83
Gene ID 84292
Synonyms
MORG1; WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKE
PRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTE
VKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFI
LGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK
Target Bioclass
Other
Family
WD repeat MORG1 family
Subcellular location
Cytoplasm
Function
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.
Uniprot ID
Q9BRX9
Ensemble ID
ENST00000418543.8
HGNC ID
HGNC:32672

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C253(11.71)  LDD0204  [1]
IA-alkyne
 Probe Info  		C23(0.00); C205(0.00)  LDD0162  [2]
Lodoacetamide azide
 Probe Info  		C205(0.00); C23(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C196(0.61); C40(0.99); C43(0.89)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C40(1.05)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C196(1.12)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C196(0.95)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C196(1.02)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C196(1.36)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C196(1.12)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C196(0.88)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C196(0.71)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C196(1.03)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C196(1.04)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C196(1.04)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C40(1.04)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C196(1.56)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C196(2.20)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C196(1.96)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C196(0.96)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C196(0.97)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C196(1.33)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C196(1.42)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C196(1.12)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C196(1.16)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C196(2.09)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C40(1.06)  LDD0835  [7]
 LDCM0238  AC120 HEK-293T C196(1.74)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C196(1.46)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C196(2.36)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C196(1.81)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C196(1.90)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C196(1.76)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C196(2.07)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C196(2.10)  LDD0843  [7]
 LDCM0246  AC128 HCT 116 C241(1.16); C242(1.16)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C241(0.95); C242(0.95)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C241(0.92); C242(0.92)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C241(1.26); C242(1.26)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C241(1.03); C242(1.03)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C241(1.11); C242(1.11)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C241(1.28); C242(1.28)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C241(1.06); C242(1.06)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C241(1.16); C242(1.16)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C241(1.21); C242(1.21)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C241(1.20); C242(1.20)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C241(1.33); C242(1.33)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C40(1.27)  LDD0857  [7]
 LDCM0260  AC140 HCT 116 C241(1.30); C242(1.30)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C241(1.36); C242(1.36)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C241(1.07); C242(1.07)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C40(1.08); C43(1.08)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C40(0.87); C43(0.87)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C40(0.88); C43(0.88)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C40(1.08); C43(1.08)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C40(0.98); C43(0.98)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C40(0.99); C43(0.99)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C40(0.92); C43(0.92)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C40(1.48)  LDD0868  [7]
 LDCM0271  AC150 HCT 116 C40(0.74); C43(0.74)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C40(0.93); C43(0.93)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C40(1.05); C43(1.05)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C40(1.03); C43(1.03)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C40(1.00); C43(1.00)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C40(1.02); C43(1.02)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C40(0.91); C43(0.91)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C40(0.89); C43(0.89)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C196(1.53); C198(1.05); C40(0.59); C43(0.58)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C196(1.77); C198(1.04); C40(0.74); C43(0.73)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C196(1.44); C198(1.26); C40(0.81); C43(0.81)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C196(1.03); C40(1.13); C43(1.02)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C196(1.07); C198(2.35); C40(0.71); C43(0.79)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C196(1.02); C198(1.14); C40(0.84); C43(0.83)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C196(1.26); C198(1.27); C40(0.74); C43(0.88)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C196(1.70); C198(1.18); C40(0.64); C43(0.71)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C196(1.33); C198(1.02); C40(0.73); C43(0.68)  LDD0882  [7]
 LDCM0285  AC25 HCT 116 C241(0.81); C242(0.81)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C241(0.69); C242(0.69)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C241(0.71); C242(0.71)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C241(0.78); C242(0.78)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C241(0.84); C242(0.84)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C196(0.57); C40(1.01); C43(1.16)  LDD0888  [7]
 LDCM0291  AC30 HCT 116 C241(0.92); C242(0.92)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C241(0.73); C242(0.73)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C241(1.24); C242(1.24)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C241(0.74); C242(0.74)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C241(0.73); C242(0.73)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C241(1.05); C242(1.05)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C241(1.05); C242(1.05)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C241(1.24); C242(1.24)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C241(1.01); C242(1.01)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C241(1.03); C242(1.03)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C196(0.48); C40(0.99); C43(1.07)  LDD0899  [7]
 LDCM0302  AC40 HCT 116 C241(1.07); C242(1.07)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C241(1.09); C242(1.09)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C241(1.10); C242(1.10)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C241(1.17); C242(1.17)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C241(1.10); C242(1.10)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C241(1.08); C242(1.08)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C241(0.91); C242(0.91)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C241(0.55); C242(0.55)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C241(0.64); C242(0.64)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C241(0.88); C242(0.88)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C196(0.85); C40(0.97); C43(1.23)  LDD0910  [7]
 LDCM0313  AC50 HCT 116 C241(1.00); C242(1.00)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C241(0.86); C242(0.86)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C241(0.94); C242(0.94)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C241(0.67); C242(0.67)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C241(0.65); C242(0.65)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C241(0.66); C242(0.66)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C241(0.85); C242(0.85)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C196(0.93); C40(1.11); C43(0.88)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C196(0.95); C40(1.10); C43(0.92)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C196(0.80); C40(0.97); C43(0.90)  LDD0920  [7]
 LDCM0323  AC6 HEK-293T C40(1.05)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C196(0.77); C40(1.27); C43(1.04)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C196(1.11); C40(1.02); C43(1.15)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C196(1.17); C40(1.06); C43(1.12)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C196(0.95); C40(1.00); C43(0.93)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C196(1.40); C40(1.07); C43(1.00)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C196(0.92); C40(1.21); C43(1.07)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C196(0.93); C40(1.00); C43(0.99)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C196(1.05); C40(1.07); C43(1.09)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C241(0.67); C242(0.67); C40(1.11); C43(1.11)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C241(0.61); C242(0.61); C40(1.01); C43(1.01)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C40(1.13)  LDD0932  [7]
 LDCM0335  AC70 HCT 116 C40(0.81); C43(0.81); C241(1.06); C242(1.06)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C241(0.78); C242(0.78); C40(1.15); C43(1.15)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C40(0.95); C43(0.95); C241(1.23); C242(1.23)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C40(0.72); C43(0.72); C241(1.18); C242(1.18)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C40(0.75); C43(0.75); C241(0.88); C242(0.88)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C40(0.69); C43(0.69); C241(0.83); C242(0.83)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C40(0.86); C43(0.86); C241(1.03); C242(1.03)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C241(0.61); C242(0.61); C40(0.78); C43(0.78)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C241(0.80); C242(0.80); C40(0.99); C43(0.99)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C241(0.95); C242(0.95); C40(0.98); C43(0.98)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C40(1.05)  LDD0943  [7]
 LDCM0346  AC80 HCT 116 C40(0.92); C43(0.92); C241(1.01); C242(1.01)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C241(0.93); C242(0.93); C40(1.16); C43(1.16)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C40(0.59); C43(0.59); C241(0.98); C242(0.98)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C40(0.80); C43(0.80)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C40(0.83); C43(0.83)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C40(0.98); C43(0.98)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C40(0.74); C43(0.74)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C40(0.82); C43(0.82)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C40(0.86); C43(0.86)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C40(0.94); C43(0.94)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C40(0.99); C43(0.99)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C40(0.66); C43(0.66)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C40(0.66); C43(0.66)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C40(0.83); C43(0.83)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C40(0.93); C43(0.93)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C40(0.98); C43(0.98)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C40(0.86); C43(0.86)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C40(0.79); C43(0.79)  LDD0681  [7]
 LDCM0365  AC98 HEK-293T C196(0.82)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C196(0.78)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C40(1.26)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C40(1.30)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C40(1.11)  LDD0873  [7]
 LDCM0020  ARS-1620 HCC44 C23(1.10)  LDD2171  [7]
 LDCM0102  BDHI 8 Jurkat C253(11.71)  LDD0204  [1]
 LDCM0367  CL1 HCT 116 C241(0.65); C242(0.65)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C241(0.88); C242(0.88)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C196(0.69); C40(0.88); C43(1.11)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C40(1.05)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C40(1.18)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C40(1.07)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C40(1.03)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C196(1.33); C198(1.40); C40(0.79); C43(0.74)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C196(0.73); C198(1.66); C40(0.77); C43(0.80)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C196(1.22); C198(1.23); C40(0.96); C43(1.10)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C196(1.31); C198(1.61); C40(0.73); C43(0.65)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C196(1.13); C198(1.45); C40(0.79); C43(0.68)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C241(0.86); C242(0.86)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C196(1.61); C198(1.89); C40(0.72); C43(0.73)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C196(1.91); C198(1.39); C40(0.66); C43(0.58)  LDD0979  [7]
 LDCM0382  CL112 HCT 116 C241(0.77); C242(0.77)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C241(1.09); C242(1.09)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C241(0.72); C242(0.72)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C241(1.28); C242(1.28)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C241(0.99); C242(0.99)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C241(0.95); C242(0.95)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C241(1.00); C242(1.00)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C241(1.09); C242(1.09)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C241(1.03); C242(1.03)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C241(1.07); C242(1.07)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C241(0.86); C242(0.86)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C241(0.89); C242(0.89)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C241(0.59); C242(0.59)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C241(0.73); C242(0.73)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C196(0.95); C40(1.02); C43(0.95)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C196(1.15); C40(0.91); C43(0.94)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C196(0.73); C40(0.95); C43(1.01)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C196(0.77); C40(1.01); C43(0.88)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C241(0.96); C242(0.96)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C241(0.80); C242(0.80)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C241(0.93); C242(0.93)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C40(0.99); C43(0.99); C241(1.12); C242(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C40(0.84); C43(0.84); C241(0.89); C242(0.89)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C241(0.98); C242(0.98); C40(1.56); C43(1.56)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C241(0.94); C242(0.94); C40(1.05); C43(1.05)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C241(0.88); C242(0.88)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C241(1.05); C242(1.05); C40(1.35); C43(1.35)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C241(0.93); C242(0.93); C40(1.06); C43(1.06)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C241(0.81); C242(0.81); C40(1.06); C43(1.06)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C241(1.01); C242(1.01); C40(1.05); C43(1.05)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C241(1.01); C242(1.01); C40(1.00); C43(1.00)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C241(1.05); C242(1.05); C40(0.99); C43(0.99)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C241(0.86); C242(0.86); C40(1.04); C43(1.04)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C241(1.12); C242(1.12); C40(0.89); C43(0.89)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C241(1.06); C242(1.06); C40(1.03); C43(1.03)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C241(1.25); C242(1.25); C40(1.41); C43(1.41)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C241(0.98); C242(0.98)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C241(1.07); C242(1.07); C40(1.40); C43(1.40)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C241(0.84); C242(0.84); C40(0.88); C43(0.88)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C241(0.94); C242(0.94); C40(1.09); C43(1.09)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C241(0.52); C242(0.52); C40(0.75); C43(0.75)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C241(1.06); C242(1.06); C40(0.89); C43(0.89)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C241(1.06); C242(1.06); C40(0.69); C43(0.69)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C241(0.90); C242(0.90); C40(0.74); C43(0.74)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C241(1.57); C242(1.57); C40(0.65); C43(0.65)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C241(0.81); C242(0.81); C40(0.79); C43(0.79)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C241(0.94); C242(0.94)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C241(0.80); C242(0.80); C40(0.84); C43(0.84)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C241(0.93); C242(0.93); C40(0.89); C43(0.89)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C241(0.68); C242(0.68); C40(0.69); C43(0.69)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C241(0.93); C242(0.93); C40(0.74); C43(0.74)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C241(1.07); C242(1.07); C40(1.03); C43(1.03)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C241(1.21); C242(1.21); C40(0.75); C43(0.75)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C241(0.85); C242(0.85); C40(0.80); C43(0.80)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C241(1.00); C242(1.00); C40(0.86); C43(0.86)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C241(1.11); C242(1.11); C40(0.84); C43(0.84)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C241(1.14); C242(1.14); C40(0.88); C43(0.88)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C241(0.86); C242(0.86)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C241(0.82); C242(0.82); C40(0.93); C43(0.93)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C241(1.02); C242(1.02); C40(0.88); C43(0.88)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C241(0.98); C242(0.98); C40(0.88); C43(0.88)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C241(1.16); C242(1.16); C40(0.87); C43(0.87)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C241(1.07); C242(1.07); C40(0.83); C43(0.83)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C241(1.02); C242(1.02); C40(0.70); C43(0.70)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C241(1.23); C242(1.23); C40(0.93); C43(0.93)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C241(0.98); C242(0.98); C40(0.81); C43(0.81)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C241(1.50); C242(1.50); C40(0.90); C43(0.90)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C241(1.12); C242(1.12); C40(1.10); C43(1.10)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C241(0.83); C242(0.83)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C241(1.08); C242(1.08); C40(1.10); C43(1.10)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C40(0.85)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C40(0.95)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C40(0.71)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C40(0.81)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C40(1.01)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C40(0.89)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C40(1.13)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C40(1.09)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C40(1.06)  LDD1059  [7]
 LDCM0462  CL7 HCT 116 C241(1.02); C242(1.02)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C40(1.18)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C40(1.13)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C40(2.34)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C40(1.07)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C40(1.23)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C40(0.92)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C40(1.03)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C40(1.19)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C40(0.90)  LDD1070  [7]
 LDCM0473  CL8 HCT 116 C241(0.85); C242(0.85)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C40(0.99)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C40(1.02)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C40(1.62)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C40(1.46)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C40(0.94)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C40(0.95)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C40(1.02)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C40(1.22)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C40(1.43)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C40(0.92)  LDD1081  [7]
 LDCM0484  CL9 HCT 116 C241(1.03); C242(1.03)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C40(0.78)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C196(0.81); C40(0.78); C43(1.13)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C196(0.79); C40(0.66); C43(0.95)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C196(0.61); C40(0.70); C43(0.80)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C196(0.63); C40(0.84); C43(0.90)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C196(1.20); C40(1.02); C43(0.99)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C196(0.52); C40(0.88); C43(0.94)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C196(0.77); C40(0.84); C43(0.98)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C196(0.72); C40(0.93); C43(1.14)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C196(0.75); C40(0.78); C43(0.99)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C253(0.98)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C40(1.14)  LDD1066  [7]
 LDCM0427  Fragment51 HCT 116 C241(1.06); C242(1.06); C40(0.73); C43(0.73)  LDD0744  [7]
 LDCM0022  KB02 786-O C23(1.66)  LDD2247  [9]
 LDCM0023  KB03 Jurkat C23(8.36)  LDD0209  [1]
 LDCM0024  KB05 COLO792 C23(1.68)  LDD3310  [9]
 LDCM0021  THZ1 HCT 116 C23(1.10)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) Cyclophilin-type PPIase family Q9Y3C6
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transthyretin (TTR) Transthyretin family P02766
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
B-cell lymphoma 6 protein (BCL6) . P41182
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Adapter molecule crk (CRK) CRK family P46108
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840