Details of the Target

General Information of Target

Target ID LDTP10767
Target Name BRCA1-A complex subunit RAP80 (UIMC1)
Gene Name UIMC1
Gene ID 51720
Synonyms
RAP80; RXRIP110; BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQ
ETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAA
IEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLL
EGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAIL
AAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLA
PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA
YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEFDSEMVEM
AQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQQPLGSNQALGQAMSSAAAYRT
LPSGAGGTSQFTKPPSLPLEPEPAVESSPTETSEQIREK
Target Bioclass
Other
Family
RAP80 family
Subcellular location
Nucleus
Function
Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {|Ref.38}.
Uniprot ID
Q96RL1
Ensemble ID
ENST00000377227.8
HGNC ID
HGNC:30298

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A96D DBIA    Probe Info 
IGROV1 SNV: p.A418T DBIA    Probe Info 
JURKAT SNV: p.W369R Compound 10    Probe Info 
NB4 SNV: p.G231E .
SKMEL24 SNV: p.S44F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C121(1.06)  LDD2093  [2]
AHL-Pu-1
 Probe Info  		C691(2.07); C257(2.05); C121(3.25)  LDD0168  [3]
DBIA
 Probe Info  		C298(2.43); C601(1.89); C661(1.86); C691(1.44)  LDD0080  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C601(0.00); C691(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C257(0.00); C283(0.00); C298(0.00); C336(0.00)  LDD2226  [7]
TFBX
 Probe Info  		C601(0.00); C121(0.00)  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		C121(0.00); C661(0.00)  LDD0005  [9]
Phosphinate-6
 Probe Info  		C70(0.00); C257(0.00); C601(0.00); C121(0.00)  LDD0018  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C121(0.00); C257(0.00); C298(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C691(2.07); C257(2.05); C121(3.25)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C691(2.75); C121(4.96)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C298(0.86)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C298(0.89)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C298(1.24); C601(0.92)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C298(1.26); C601(1.00)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C298(1.27); C601(0.94)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C298(1.51); C601(1.22)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C298(1.19); C601(1.16)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C298(1.37); C601(1.15)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C298(1.46); C601(1.13)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C298(1.30); C601(1.47)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C298(1.20); C601(0.90)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C298(1.00); C601(0.93)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C298(0.99)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C298(1.41); C601(0.97)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C298(1.28); C601(1.07)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C298(1.40); C601(1.25)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C298(1.26); C601(1.25)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C298(1.10); C601(0.90)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C298(1.06); C601(0.99)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C298(0.99); C601(1.14)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C298(1.03); C601(1.12)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C298(1.11); C601(1.05)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C298(1.07); C601(1.13)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C298(0.87)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C298(1.12); C601(1.07)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C298(1.20); C601(0.93)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C298(1.05); C601(0.57)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C298(0.92); C601(0.72)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C298(1.16); C601(1.01)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C298(1.23); C601(1.03)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C298(1.27); C601(0.50)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C298(1.13); C601(0.41)  LDD0843  [4]
 LDCM0246  AC128 HCT 116 C298(0.64)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C298(0.68)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C298(0.72)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C298(0.73)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C298(0.73)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C298(0.72)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C298(0.90)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C298(0.81)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C298(0.79)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C298(0.87)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C298(0.94)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C298(0.86)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C298(1.00)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C298(1.03)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C298(1.03)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C298(0.72)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C298(1.08)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C298(0.76)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C298(0.81)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C298(0.96)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C298(0.91)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C298(0.89)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C298(0.83)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C298(0.89)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C298(0.75)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C298(0.86)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C298(1.05)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C298(0.80)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C298(1.11)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C298(0.87)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C298(0.98)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C298(0.82)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C601(0.91); C298(1.02)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C601(0.93); C298(0.96)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C298(1.03); C601(1.18)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C298(0.96)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C601(0.95); C298(1.12)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C298(0.97); C601(1.01)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C298(1.01); C601(1.18)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C298(0.93); C601(1.03)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C298(0.98); C601(1.15)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C298(1.01)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C298(1.16)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C298(1.34)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C298(1.31)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C298(1.04)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C298(0.87)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C298(1.06)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C298(1.25)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C298(1.31)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C298(1.45)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C298(1.35)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C577(0.97); C582(0.97)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C577(0.81); C582(0.81)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C577(0.77); C582(0.77)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C577(0.88); C582(0.88)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C577(1.07); C582(1.07)  LDD0898  [4]
 LDCM0301  AC4 HCT 116 C298(0.93)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C577(1.20); C582(1.20)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C577(0.66); C582(0.66)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C577(0.62); C582(0.62)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C577(1.07); C582(1.07)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C577(0.78); C582(0.78)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C577(0.84); C582(0.84)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C298(1.16); C577(1.05); C582(1.05); C601(1.58)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C298(0.94); C577(1.17); C582(1.17); C601(1.15)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C298(0.69); C577(1.16); C582(1.16); C601(1.18)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C298(1.21); C577(1.15); C582(1.15); C601(1.03)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C298(0.90)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C298(0.82); C577(1.17); C582(1.17); C601(1.29)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C298(0.73); C577(1.22); C582(1.22); C601(1.22)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C298(0.80); C577(1.47); C582(1.47); C601(1.17)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C298(0.79); C577(1.45); C582(1.45); C601(1.13)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C298(1.19); C577(1.91); C582(1.91); C601(1.42)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C298(0.91); C577(1.36); C582(1.36); C601(1.05)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C298(0.78); C577(1.02); C582(1.02); C601(1.13)  LDD0917  [4]
 LDCM0320  AC57 HCT 116 C298(1.42)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C298(1.67)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C298(1.69)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C298(0.93)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C298(1.44)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C298(1.24)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C298(1.74)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C298(1.21)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C298(1.85)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C298(0.96)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C298(0.93)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C298(1.16)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C298(1.29)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C298(1.33)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C298(0.85)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C298(1.64)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C298(1.29)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C298(1.40)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C298(1.86)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C298(1.78)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C298(1.83)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C298(1.53)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C298(1.32)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C298(1.40)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C298(1.46)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C298(0.90)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C298(1.38)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C298(1.51)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C298(2.02)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C298(1.46); C601(1.75)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C298(1.45); C601(1.52)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C601(1.16); C298(1.25)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C601(1.27); C298(1.30)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C601(0.96); C298(1.14)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C601(1.20); C298(1.29)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C601(1.32); C298(1.35)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C601(0.91); C298(1.11)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C298(1.53); C601(1.88)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C298(1.37); C601(1.75)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C601(1.14); C298(1.22)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C298(1.21); C601(1.37)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C601(1.11); C298(1.26)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C298(1.18); C601(1.40)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C298(1.47); C601(1.54)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C298(1.59); C601(1.94)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C601(0.86); C298(1.12)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C298(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C298(0.85)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C298(0.98)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.85  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C577(1.23); C582(1.23); C220(1.02); C230(1.02)  LDD2171  [4]
 LDCM0632  CL-Sc Hep-G2 C601(20.00); C121(0.83); C257(0.73); C298(0.49)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C298(1.12)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C298(0.94)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C298(0.97)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C298(0.95)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C298(0.91)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C298(0.92)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C298(0.95)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C601(1.00); C298(1.06)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C298(0.80); C601(1.30)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C298(0.83); C601(1.14)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C298(0.91); C601(1.57)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C298(0.98); C601(1.07)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C298(1.00)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C298(0.97); C601(1.50)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C298(0.94); C601(1.24)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C298(1.11)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C298(1.22)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C298(0.92)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C298(1.30)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C298(1.11)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C577(0.72); C582(0.72)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C577(0.63); C582(0.63)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C577(0.66); C582(0.66)  LDD0987  [4]
 LDCM0390  CL12 HCT 116 C298(0.96)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C577(0.84); C582(0.84)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C298(0.72); C577(1.17); C582(1.17); C601(1.43)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C298(1.01); C577(1.34); C582(1.34); C601(1.29)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C298(1.56); C577(2.24); C582(2.24); C601(0.82)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C298(0.93); C577(1.26); C582(1.26); C601(1.50)  LDD0993  [4]
 LDCM0396  CL125 HCT 116 C298(1.01)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C298(1.03)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C298(1.03)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C298(1.74)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C298(0.96)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C298(1.03)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C298(1.01)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C298(0.90); C601(1.42)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C298(0.95); C601(0.97)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C298(0.93); C601(1.06)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C298(0.89); C601(1.71)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C298(1.05)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C298(1.02); C601(1.79)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C298(0.93); C601(1.28)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C601(0.95); C298(0.98)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C298(0.85); C601(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C298(0.95); C601(1.27)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C298(0.86); C601(1.15)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C298(1.03); C601(1.22)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C298(0.95); C601(1.23)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C298(0.97); C601(1.16)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C298(1.01); C601(1.27)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C298(1.00)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C298(0.89); C601(1.24)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C298(0.97)  LDD0737  [4]
 LDCM0421  CL32 HEK-293T C298(0.96)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C298(1.20)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C298(0.87)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C298(0.98)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C298(0.98)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C298(0.91)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C298(0.89)  LDD1026  [4]
 LDCM0429  CL4 HCT 116 C298(1.00)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C298(0.98)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C298(1.28)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C298(1.08)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C298(1.02)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C298(1.15)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C298(0.92)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C298(0.76)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C298(0.88)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C298(0.77)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C298(0.79)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C298(1.02)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C298(0.94)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C298(0.94)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C298(0.95)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C298(0.90)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C298(0.90)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C298(0.76)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C298(0.86)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C298(0.84)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C298(0.82)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C298(0.75)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C298(1.10)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C298(0.78)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C601(0.79)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C601(1.07)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C601(0.92)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C601(0.89)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C601(0.75)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C601(0.83)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C601(0.86)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C601(0.78)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C601(1.02)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C298(1.04)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C601(0.88)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C601(0.84)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C601(0.83)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C601(0.81)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C601(0.96)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C298(1.03); C601(1.51)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C298(1.01); C601(1.10)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C298(1.06); C601(1.00)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C298(1.31); C601(0.73)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C298(1.18)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C298(1.02); C601(1.00)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C298(1.23); C601(0.91)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C298(1.87); C601(1.03)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C298(1.63); C601(0.65)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C298(1.69); C601(0.62)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C298(1.14); C601(0.55)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C298(0.84); C601(0.94)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C298(1.31); C601(0.65)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C298(1.55); C601(0.76)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C298(2.07); C601(1.20)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C298(1.08)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C298(0.85); C601(0.78)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C298(1.02)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C298(0.95)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C298(0.84)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C298(1.01)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C298(1.01)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C298(1.02)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C298(0.92)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C298(0.94)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C298(0.89)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C601(0.91); C121(1.13); C661(0.99); C257(0.99)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C257(0.93)  LDD1702  [2]
 LDCM0625  F8 Ramos C601(1.68); C121(0.88)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C601(1.36); C121(1.32)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C601(0.81); C121(0.30)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C601(0.77); C121(0.85)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C601(0.94); C121(0.91)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C601(1.09); C121(0.70)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C601(0.93); C121(0.82)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C601(1.00); C121(1.04)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C601(1.29); C121(1.49)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C601(1.02); C121(0.95)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C601(1.04); C121(0.84)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C601(1.24); C121(1.30)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C601(1.06); C121(1.00)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C601(1.18); C121(1.08)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C601(0.81)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C601(0.96); C121(0.99)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C601(1.27); C121(0.91)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C298(0.99)  LDD1025  [4]
 LDCM0610  Fragment52 Ramos C601(1.33); C121(1.07)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C601(1.57); C121(1.49)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C601(1.38); C121(1.10)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C601(1.03); C121(1.23)  LDD2188  [15]
 LDCM0022  KB02 HCT 116 C298(2.43); C601(1.89); C661(1.86); C691(1.44)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C298(2.16); C601(1.17); C661(1.35); C691(1.32)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C298(2.55); C601(1.64); C661(1.62); C691(1.31)  LDD0082  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C121(1.06)  LDD2093  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C121(0.64)  LDD2109  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C257(0.31)  LDD2134  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C121(0.90)  LDD2136  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C121(0.82); C257(0.97)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C121(1.65)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C121(0.83); C257(1.47)  LDD2146  [2]
 LDCM0021  THZ1 HCT 116 C577(1.23); C582(1.23); C220(1.02); C230(1.02)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RecQ-like DNA helicase BLM (BLM) Helicase family P54132
Lys-63-specific deubiquitinase BRCC36 (BRCC3) Peptidase M67A family P46736
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-synuclein (SNCA) Synuclein family P37840
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
BRCA1-A complex subunit Abraxas 1 (ABRAXAS1) FAM175 family Q6UWZ7
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578