Details of the Target

General Information of Target

Target ID LDTP10747
Target Name PHD finger protein 12 (PHF12)
Gene Name PHF12
Gene ID 57649
Synonyms
KIAA1523; PHD finger protein 12; PHD factor 1; Pf1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAM
KYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVI
LQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGV
AKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNN
LHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTV
LEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNE
ALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRV
DIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNT
KQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSL
GGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKK
KRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYR
SMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNST
CLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKA
EMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLP
ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK
VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA
GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA
ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY
LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS
LFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVT
FERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKV
HNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMK
DDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNK
NQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAF
VGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKIS
RRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVER
NNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMG
GGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRA
AQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIP
TNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGE
DAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNS
VRLML
Target Bioclass
Other
Subcellular location
Nucleus
Function
Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail. SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules. SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. May also play a role in ribosomal biogenesis.
Uniprot ID
Q96QT6
Ensemble ID
ENST00000268756.7
HGNC ID
HGNC:20816

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.S706F DBIA    Probe Info 
HEPG2 SNV: p.E428V .
ICC9 SNV: p.P303L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.N181S DBIA    Probe Info 
JURKAT SNV: p.A382V .
MCC13 SNV: p.P768L DBIA    Probe Info 
MOLT4 SNV: p.P468S .
RPMI7951 SNV: p.L417R DBIA    Probe Info 
SNU1196 SNV: p.R795G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C534(2.58)  LDD0171  [1]
DBIA
 Probe Info  		C613(0.96)  LDD0078  [2]
IA-alkyne
 Probe Info  		C534(0.00); C613(0.00)  LDD0165  [3]
NAIA_4
 Probe Info  		C233(0.00); C534(0.00); C613(0.00); C811(0.00)  LDD2226  [4]
TFBX
 Probe Info  		C613(0.00); C534(0.00)  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		C613(0.00); C233(0.00)  LDD0007  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C534(2.58)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C274(0.84); C277(0.84); C842(1.31)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C274(0.70); C277(0.70); C613(1.00); C842(0.69)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C274(0.98); C277(0.91); C842(1.00)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C274(1.08); C277(0.95); C842(0.85)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C274(1.06); C277(0.84); C842(0.87)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C274(0.97); C277(0.89); C842(1.23)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C274(1.12); C277(0.95); C842(1.17)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C274(0.83); C277(0.75); C842(1.12)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C274(0.94); C277(0.93); C842(1.07)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C274(0.77); C277(0.78); C842(0.81)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C274(0.80); C277(0.93); C842(0.69)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C274(0.78); C277(0.76); C842(0.92)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C274(1.00); C277(1.00); C613(0.90); C842(0.94)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C274(0.98); C277(1.03); C842(0.80)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C274(0.86); C277(0.78); C842(0.96)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C274(0.79); C277(0.78); C842(0.69)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C274(1.02); C277(1.02); C613(0.93)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C274(0.81); C277(0.81); C613(1.03)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C274(0.94); C277(0.94); C613(1.11)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C274(1.02); C277(1.02); C613(1.08)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C274(0.84); C277(0.84); C613(1.09)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C274(0.87); C277(0.87); C613(0.89)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C274(0.95); C277(0.95); C613(1.00)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C274(0.72); C277(0.72); C613(0.85); C842(1.09)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C274(0.85); C277(0.85); C613(1.20)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C274(0.82); C277(0.82); C613(0.89)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C274(0.88); C277(0.88); C613(0.96)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C274(0.82); C277(0.82); C613(0.58)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C274(0.86); C277(0.86); C613(1.01)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C274(0.98); C277(0.98); C613(1.11)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C274(1.03); C277(1.03); C613(0.85)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C274(0.93); C277(0.93); C613(0.87)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C274(0.86); C277(0.86)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C274(1.09); C277(1.09)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C274(0.82); C277(0.82)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C274(1.01); C277(1.01)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C274(0.83); C277(0.83)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C274(1.09); C277(1.09)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C274(1.07); C277(1.07)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C274(0.80); C277(0.80)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C274(0.92); C277(0.92)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C274(0.99); C277(0.99)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C274(0.84); C277(0.84)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C274(0.98); C277(0.98)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C274(0.76); C277(0.76); C613(0.74); C842(1.00)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C274(0.86); C277(0.86)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C274(1.01); C277(1.01)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C274(0.89); C277(0.89)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C274(0.83); C277(0.83); C613(1.39)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C274(1.06); C277(1.06); C613(2.00)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C274(0.94); C277(0.94); C613(1.61)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C274(1.02); C277(1.02); C613(1.73)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C274(1.03); C277(1.03); C613(1.78)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C274(1.20); C277(1.20); C613(2.90)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C274(0.97); C277(0.97); C613(2.19)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C274(0.84); C277(0.84); C613(1.03); C842(1.15)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C274(1.13); C277(1.13); C613(1.38)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C274(1.05); C277(1.05); C613(1.40)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C274(1.16); C277(1.16); C613(1.72)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C274(1.23); C277(1.23); C613(3.03)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C274(1.00); C277(1.00); C613(1.62)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C274(1.24); C277(1.24); C613(1.85)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C274(0.96); C277(0.96); C613(1.32)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C274(1.09); C277(1.09); C613(1.28)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C274(0.88); C277(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C274(0.89); C277(0.89)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C274(1.54); C277(1.54)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C274(0.96); C277(0.96); C842(1.58)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C274(1.34); C277(1.34)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C274(1.00); C277(1.00)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C274(0.99); C277(0.99)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C274(0.77); C277(0.77)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C274(1.29); C277(1.29)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C274(0.73); C277(0.73); C613(1.08)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C274(0.70); C277(0.70); C613(1.18)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C274(0.75); C277(0.75); C613(0.91)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C613(0.53); C274(0.54); C277(0.54)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C274(0.77); C277(0.77); C613(1.00)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C274(0.90); C277(0.90); C842(1.17)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C613(0.52); C274(0.74); C277(0.74)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C274(1.29); C277(1.29); C613(2.05)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C274(0.86); C277(0.86); C613(1.09)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C274(0.81); C277(0.81); C613(0.84)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C274(0.68); C277(0.68); C613(1.04)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C274(0.90); C277(0.90)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C274(1.04); C277(1.04)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C274(1.06); C277(1.06)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C274(1.05); C277(1.05)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C274(0.72); C277(0.72)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C274(1.07); C277(1.07); C842(1.37)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C274(1.22); C277(1.22)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C274(0.77); C277(0.77)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C274(0.91); C277(0.91)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C274(0.88); C277(0.88)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C274(0.88); C277(0.88)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C274(0.90); C277(0.90)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C842(1.02)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C842(1.00)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C842(1.69)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C842(1.30)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C274(0.92); C277(0.92); C842(1.23)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C842(1.18)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C842(1.30)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C842(1.22)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C842(1.30)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C842(1.30)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C842(0.97)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C842(1.52)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C274(0.82); C277(0.82)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C274(0.91); C277(0.91)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C274(0.73); C277(0.73)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C274(0.90); C277(0.90); C613(0.91); C842(1.07)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C274(0.86); C277(0.86)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C274(0.75); C277(0.75)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C274(0.74); C277(0.74)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C274(0.73); C277(0.73)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C274(0.84); C277(0.84)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C274(0.62); C277(0.62)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C274(0.61); C277(0.61)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C274(0.52); C277(0.52)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C274(0.83); C277(0.83)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C274(0.73); C277(0.73)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C613(0.82); C274(0.82); C277(0.82); C842(0.96)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C274(0.71); C277(0.71)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C274(0.65); C277(0.65)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C274(0.64); C277(0.64)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C274(0.88); C277(0.88)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C274(1.03); C277(1.03)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C274(1.51); C277(1.51)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C274(0.87); C277(0.87)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C274(0.84); C277(0.84)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C274(0.88); C277(0.88)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C274(0.84); C277(0.84)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C274(0.72); C277(0.72); C842(0.83); C613(0.85)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C274(0.67); C277(0.67)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C274(0.69); C277(0.69)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C274(1.02); C277(1.02)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C274(0.92); C277(0.92); C613(2.00)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C274(1.10); C277(1.10); C613(1.63)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C274(1.13); C277(1.13); C613(1.47)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C274(1.03); C277(1.03); C613(1.51)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C274(0.86); C277(0.86); C613(1.54)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C274(0.96); C277(0.96); C613(1.56)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C274(1.08); C277(1.08); C613(1.80)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C274(1.18); C277(1.18); C613(1.50)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C274(1.05); C277(1.05); C613(1.51)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C274(0.99); C277(0.99); C613(1.39)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C274(1.10); C277(1.10); C613(1.59)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C274(1.18); C277(1.18); C613(1.18)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C274(1.30); C277(1.30); C613(1.65)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C613(1.10); C274(1.22); C277(1.22)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C274(1.15); C277(1.15); C613(1.74)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C277(0.93); C842(1.01); C274(1.09)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C277(0.86); C274(1.07); C842(1.09)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C274(0.57); C277(0.57); C613(0.81); C842(1.13)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C613(0.96); C274(0.97); C277(0.97); C842(1.01)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C842(0.83); C613(0.83); C274(0.84); C277(0.84)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C613(0.96)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C613(0.83); C274(1.02); C277(1.02)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C613(0.90); C274(1.39); C277(1.39)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C274(0.97); C277(0.97); C842(1.18)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C613(0.73); C274(0.92); C277(0.92); C842(0.97)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C613(0.67); C274(0.86); C277(0.86); C842(0.98)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C613(0.72); C842(0.95); C274(1.13); C277(1.13)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C613(0.71); C842(0.79); C274(0.82); C277(0.82)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C274(0.90); C277(0.90)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C274(1.01); C277(1.01)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C274(0.95); C277(0.95)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C274(1.04); C277(1.04)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C274(1.12); C277(1.12)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C613(0.88); C274(0.95); C277(0.95)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C274(0.99); C277(0.99)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C274(1.27); C277(1.27)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C274(0.75); C277(0.75); C613(0.91)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C274(0.70); C277(0.70); C613(1.01)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C274(0.61); C277(0.61); C613(1.72)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C274(0.76); C277(0.76); C613(0.95)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C274(0.79); C277(0.79); C613(1.25)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C274(1.17); C277(1.17)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C274(1.05); C277(1.05)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C274(0.98); C277(0.98)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C613(0.71); C274(1.42); C277(1.42)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C274(1.18); C277(1.18)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C842(1.18)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C842(1.47)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C842(1.21)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C842(1.08)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C274(0.81); C277(0.81)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C274(1.14); C277(1.14)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C274(0.75); C277(0.75)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C274(0.90); C277(0.90)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C613(0.89); C274(1.16); C277(1.16)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C613(0.79); C274(1.24); C277(1.24)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C613(1.01); C274(1.16); C277(1.16)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C274(0.83); C277(0.83); C842(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C274(0.76); C277(0.76); C842(1.09)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C274(1.12); C277(1.12); C842(1.39)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C842(0.93); C274(1.04); C277(1.04)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C613(0.83); C274(1.16); C277(1.16)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C274(0.71); C277(0.71); C842(0.95)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C274(0.81); C277(0.81); C842(0.97)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C842(0.96); C274(1.01); C277(1.01)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C274(0.78); C277(0.78); C842(1.06)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C274(0.95); C277(0.95); C842(1.06)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C274(1.04); C277(1.04); C842(1.02)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C274(0.65); C277(0.65); C842(0.98)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C274(1.03); C277(1.03); C842(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C274(0.82); C277(0.82); C842(0.89)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C274(0.89); C277(0.89); C842(1.00)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C274(1.13); C277(1.13); C613(0.76)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C274(0.74); C277(0.74); C842(1.02)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C842(1.21)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C842(2.13)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C842(2.27)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C842(1.41)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C842(1.86)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C842(2.13)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C842(1.76)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C842(1.96)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C274(0.92); C277(0.92); C613(0.89)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C842(1.70)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C842(1.77)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C842(1.43)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C842(1.82)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C842(1.15)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C842(1.21)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C613(1.47); C274(0.92); C277(0.92)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C613(0.97); C274(0.97); C277(0.97)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C613(1.73); C274(0.93); C277(0.93)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C613(1.17); C274(1.02); C277(1.02)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C274(1.14); C277(1.14); C613(0.89)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C613(1.46); C274(0.99); C277(0.99)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C613(1.99); C274(0.95); C277(0.95)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C613(1.07); C274(1.05); C277(1.05)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C613(1.30); C274(1.12); C277(1.12)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C613(2.69); C274(0.98); C277(0.98)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C613(2.22); C274(1.11); C277(1.11)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C613(0.28); C274(0.81); C277(0.81)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C613(3.09); C274(1.02); C277(1.02)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C613(2.33); C274(1.12); C277(1.12)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C613(2.94); C274(1.14); C277(1.14)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C274(1.12); C277(1.12); C613(0.92)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C613(2.63); C274(1.02); C277(1.02)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C613(0.91); C842(1.19)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C613(0.78); C842(1.22)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C613(1.21); C842(1.19)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C613(0.92); C842(1.21)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C613(0.97); C842(1.22)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C613(1.08); C842(1.37)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C613(1.16); C842(1.31)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C613(0.77); C842(1.27)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C613(1.03); C842(1.45)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C274(1.42); C277(1.42); C613(0.93)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C613(1.11); C842(1.42)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C613(0.94); C842(1.24)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C613(1.05); C842(1.33)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C613(1.06); C842(1.19)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C613(1.31); C842(1.09)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C613(1.16)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C613(1.11)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C613(1.39)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C613(1.26)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C274(0.95); C277(0.95); C613(0.97)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C613(1.09)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C613(1.26)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C613(1.14)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C613(1.07)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C613(1.26)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C613(1.12)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C613(1.17)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C613(1.15)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C613(1.18)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C613(1.14)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C274(1.21); C277(1.21); C613(0.77)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C613(1.72)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C274(0.96); C277(0.96); C842(1.26)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C274(1.04); C277(1.04); C842(1.38)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C274(1.00); C277(1.00); C842(1.41)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C274(0.98); C277(0.98); C842(1.56)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C274(0.80); C277(0.80); C842(1.93)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C274(0.93); C277(0.93); C842(1.31)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C274(0.90); C277(0.90); C842(1.17)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C274(1.01); C277(1.01); C842(1.35)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C274(1.05); C277(1.05); C842(1.13)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C613(0.98); C233(1.04); C632(0.83)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C335(0.88)  LDD1702  [9]
 LDCM0468  Fragment33 HCT 116 C613(0.87); C842(1.14)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C842(1.01)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C613(3.00)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C613(1.54)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C613(1.82)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-type proton ATPase subunit d 2 (ATP6V0D2) V-ATPase V0D/AC39 subunit family Q8N8Y2

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761