Details of the Target

General Information of Target

Target ID LDTP10725
Target Name Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)
Gene Name ALKBH3
Gene ID 221120
Synonyms
ABH3; DEPC1; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; EC 1.14.11.33; EC 1.14.11.54; Alkylated DNA repair protein alkB homolog 3; hABH3; DEPC-1; Prostate cancer antigen 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
IYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
Target Bioclass
Enzyme
Family
AlkB family
Subcellular location
Nucleus
Function
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.
Uniprot ID
Q96Q83
Ensemble ID
ENST00000302708.9
HGNC ID
HGNC:30141
ChEMBL ID
CHEMBL3112376

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R64C; p.W286R DBIA    Probe Info 
HCT15 SNV: p.L92F .
KATOIII SNV: p.W190Ter .
SUPT1 SNV: p.R64C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		Y127(10.00)  LDD2237  [1]
DBIA
 Probe Info  		C91(1.78)  LDD0531  [2]
ATP probe
 Probe Info  		K37(0.00); K43(0.00)  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		C201(0.00); C110(0.00); C91(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
MPP-AC
 Probe Info  		N.A.  LDD0428  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C91(1.78)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C91(1.00)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C91(0.95)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C91(1.07)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C91(0.93)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C91(0.84)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C91(0.83)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C91(1.04)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C91(1.00)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C91(0.98)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C91(0.93)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C91(0.97)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C91(0.90)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C91(0.84)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C91(1.04)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C91(1.02)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C91(1.41)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C91(1.17)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C91(0.89)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C91(1.07)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C91(1.05)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C91(1.11)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C91(1.64)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C91(1.00)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C91(1.47)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C91(1.06)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C91(1.60)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C91(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C91(1.38)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C91(1.42)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C91(1.30)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C91(1.23)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C91(0.92)  LDD0857  [2]
 LDCM0263  AC143 HCT 116 C91(1.08)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C91(0.71)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C91(1.10)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C91(0.72)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C91(0.81)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C91(0.58)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C91(0.87)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C91(1.01)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C91(0.95)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C91(0.90)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C91(0.57)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C91(0.51)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C91(0.90)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C91(0.68)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C91(0.93)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C91(1.37)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C91(0.83)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C91(0.97)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C91(0.97)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C91(1.24)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C91(0.75)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C91(0.75)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C91(0.84)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C91(0.73)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C91(1.04)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C91(1.29)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C91(1.40)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C91(1.08)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C91(1.08)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C91(1.24)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C91(1.33)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C91(1.24)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C91(1.08)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C91(1.26)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C91(1.21)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C91(1.18)  LDD0893  [2]
 LDCM0301  AC4 HCT 116 C91(1.65)  LDD0618  [2]
 LDCM0304  AC42 HEK-293T C110(1.18)  LDD1543  [8]
 LDCM0312  AC5 HCT 116 C91(1.44)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C110(0.91)  LDD1552  [8]
 LDCM0320  AC57 HCT 116 C91(0.46)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C91(0.41)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C91(0.49)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C91(1.11)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C91(0.40)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C91(0.35)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C91(0.35)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C91(0.41)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C91(0.40)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C91(0.53)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C91(0.58)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C91(0.33)  LDD0648  [2]
 LDCM0334  AC7 HEK-293T C91(1.17)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C91(1.24)  LDD0943  [2]
 LDCM0349  AC83 HCT 116 C91(2.27)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C91(1.70)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C91(1.98)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C91(1.84)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C91(1.76)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C91(1.61)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C91(1.81)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C91(1.64)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C91(2.49)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C91(2.23)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C91(1.72)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C91(2.54)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C91(1.58)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C91(1.90)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C91(1.49)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C91(1.10)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C91(0.96)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C91(1.05)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C91(1.15)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C91(1.16)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C91(1.05)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C91(0.79)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C91(1.52)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C91(1.25)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C91(1.13)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C91(1.23)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C91(1.22)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C91(0.72)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C91(0.73)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C91(0.77)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C91(0.80)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C91(0.80)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C91(0.72)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C91(0.92)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C91(0.83)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C91(1.24)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C91(1.42)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C91(1.54)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C91(1.38)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C91(1.34)  LDD0984  [2]
 LDCM0389  CL119 HEK-293T C201(1.21)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C91(0.90)  LDD0707  [2]
 LDCM0394  CL123 HEK-293T C201(1.10)  LDD1598  [8]
 LDCM0396  CL125 HCT 116 C91(0.79)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C91(0.70)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C91(0.70)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C91(0.53)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C91(0.89)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C91(1.10)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C91(0.89)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C91(0.73)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C91(0.79)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C91(0.65)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C91(0.77)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C91(0.91)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C91(0.71)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C91(0.77)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C91(0.79)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C91(0.75)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C91(0.75)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C91(0.71)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C91(0.75)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C91(0.82)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C91(0.65)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C91(0.71)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C91(1.07)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C91(0.81)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C91(0.99)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C91(0.58)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C91(0.63)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C91(0.57)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C91(0.61)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C91(0.69)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C91(0.59)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C91(0.70)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C91(1.05)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C91(0.67)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C91(0.77)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C91(0.64)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C91(0.60)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C91(0.57)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C91(0.57)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C91(0.85)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C91(1.16)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C91(0.85)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C91(0.89)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C91(1.18)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C91(1.03)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C91(1.28)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C91(0.75)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C91(0.91)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C91(0.75)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C91(1.27)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C91(1.17)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C91(0.92)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C91(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C91(1.06)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C91(0.90)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C91(0.93)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C91(0.83)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C91(0.69)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C91(0.68)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C91(0.61)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C91(0.82)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C91(0.46)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C91(0.58)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C91(0.52)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C91(0.50)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C91(0.96)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C91(0.47)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C91(0.61)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C91(0.84)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C91(0.65)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C91(0.68)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C91(1.72)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C91(1.78)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C91(1.06)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C91(1.56)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C91(0.74)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C91(1.44)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C91(2.07)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C91(2.67)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C91(1.76)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C91(1.55)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C91(1.46)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C91(1.71)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C91(1.89)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C91(2.20)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C91(1.56)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C91(0.88)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C91(1.97)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C91(0.74)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C91(0.95)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C91(1.35)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C91(2.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C91(0.91)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C91(0.95)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C91(0.97)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C91(1.06)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C91(1.40)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C201(0.96)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C91(0.73)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C91(0.62)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C201(1.00)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C201(1.02)  LDD1497  [8]
 LDCM0024  KB05 NALM-6 C201(1.38)  LDD3339  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
Caspase-6 (CASP6) Peptidase C14A family P55212
GTP-binding nuclear protein Ran (RAN) Ran family P62826
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Glutaredoxin-3 (GLRX3) . O76003
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126

References

1 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840