Details of the Target

General Information of Target

Target ID LDTP10157
Target Name Galactose mutarotase (GALM)
Gene Name GALM
Gene ID 130589
Synonyms
Galactose mutarotase; EC 5.1.3.3; Aldose 1-epimerase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAKPTLTDSLSFCLAQLAAAAGEALGGEKDPATNETPLSRALLALRTRHIKAAGGIER
FRARGGLRPLLALLRRAAAAGSAPSQAGPGSAPSSAASGASSPAPASGPAPSAVSSSSPT
PPVRLRKTLDLALSILADCCTEGACRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGN
LAMEPESCGDIHCAGAVPLLVESLTACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVR
PLAELLATAPDAALTLALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREG
TILILANLCAQGLIRPALGNAGGVEVLVDELRQRRDPNGASPTSQQPLVRAVCLLCREAI
NRARLRDAGGLDLLMGLLRDPRASAWHPRIVAALVGFLYDTGALGRLQALGLVPLLAGQL
CGEAGEEEEEGREAASWDFPEERTPERAQGGSFRSLRSWLISEGYATGPDDISPDWSPEQ
CPPEPMEPASPAPTPTSLRAPRTQRTPGRSPAAAIEEPWGREGPALLLLSRFSQAPDPSG
ALVTGPALYGLLTYVTGAPGPPSPRALRILSRLTCNPACLEAFVRSYGAALLRAWLVLGV
APDDWPAPRARPTLHSRHRELGERLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALT
LPFICRKPSLWRRLLLEQGGLRLLLAALTRPAPHPLFLFFAADSLSCLQDLVSPTVSPAV
PQAVPMDLDSPSPCLYEPLLGPAPVPAPDLHFLLDSGLQLPAQRAASATASPFFRALLSG
SFAEAQMDLVPLRGLSPGAAWPVLHHLHGCRGCGAALGPVPPPGQPLLGSEAEEALEAAG
RFLLPGLEEELEEAVGRIHLGPQGGPESVGEVFRLGRPRLAAHCARWTLGSEQCPRKRGL
ALVGLVEAAGEEAGPLTEALLAVVMGIELGARVPA
Target Bioclass
Enzyme
Family
Aldose epimerase family
Subcellular location
Cytoplasm
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Uniprot ID
Q96C23
Ensemble ID
ENST00000272252.10
HGNC ID
HGNC:24063

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.94  LDD0066  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
Probe 1
 Probe Info  		Y140(14.39); Y298(14.57)  LDD3495  [3]
HHS-475
 Probe Info  		Y95(0.26)  LDD0264  [4]
DBIA
 Probe Info  		C247(1.03)  LDD0625  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		C305(0.00); C247(0.00)  LDD0165  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NHS
 Probe Info  		N.A.  LDD0010  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
HHS-465
 Probe Info  		K101(0.00); Y95(0.00)  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C305(4.49)  LDD0372  [12]
 LDCM0214  AC1 HEK-293T C305(1.18)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C305(1.17)  LDD1508  [13]
 LDCM0237  AC12 HEK-293T C305(0.99)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C305(0.78)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C305(1.15)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C305(0.81)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C305(0.87)  LDD1516  [13]
 LDCM0279  AC2 HEK-293T C305(0.89)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C305(1.47)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C305(0.85); C247(0.82)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C305(0.93)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C305(0.94)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C305(0.96)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C305(0.88)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C305(1.09)  LDD1525  [13]
 LDCM0288  AC28 HEK-293T C305(1.31)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C305(0.95); C247(1.04)  LDD1528  [13]
 LDCM0291  AC30 HEK-293T C305(0.91)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C305(0.91)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C305(1.00)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C305(0.72)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C305(1.09)  LDD1534  [13]
 LDCM0297  AC36 HEK-293T C305(1.36)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C305(0.91); C247(1.01)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C305(1.01)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C305(1.07)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C305(1.12)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C305(0.98)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C305(0.68)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C305(0.83)  LDD1543  [13]
 LDCM0306  AC44 HEK-293T C305(1.30)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C305(0.98); C247(1.16)  LDD1546  [13]
 LDCM0308  AC46 HCT 116 C247(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C247(1.01)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C247(0.96)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C247(0.57)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C305(0.98); C247(0.94)  LDD1551  [13]
 LDCM0313  AC50 HCT 116 C247(0.72)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C247(0.93)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C247(1.18)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C247(0.84)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C247(0.88)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C247(0.58)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C247(0.26)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C305(0.94)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C305(0.74)  LDD1560  [13]
 LDCM0323  AC6 HEK-293T C305(1.00)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C305(1.01)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C305(0.97); C247(0.88)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C305(0.87)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C305(1.03)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C305(1.16)  LDD1567  [13]
 LDCM0332  AC68 HCT 116 C247(1.26)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C247(1.50)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C305(1.06)  LDD1568  [13]
 LDCM0335  AC70 HCT 116 C247(1.07)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C247(1.26)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C247(1.22)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C247(0.84)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C247(1.05)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C247(0.59)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C247(1.25)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C247(1.24)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C247(1.31)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C247(1.38)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C305(1.11)  LDD1569  [13]
 LDCM0346  AC80 HCT 116 C247(1.02)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C247(1.01)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C247(0.60)  LDD0665  [5]
 LDCM0248  AKOS034007472 HEK-293T C305(0.98); C247(0.95)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C305(0.75)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C305(1.05)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C305(0.88)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C305(0.79)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C305(0.78)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C305(0.79)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C305(1.04)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C305(1.01); C247(0.94)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C305(1.20)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C305(0.92)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C305(1.03)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C305(1.30); C247(1.00)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C305(0.93)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C305(1.24)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C305(1.19)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C305(0.96)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C305(1.18); C247(0.93)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C305(1.42)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C305(1.14)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C305(1.17)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C305(1.33); C247(1.00)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C305(0.86)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C305(0.67)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C305(1.11)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C305(1.28); C247(1.07)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C305(0.91)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C305(1.23)  LDD1595  [13]
 LDCM0392  CL121 HCT 116 C247(1.07)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C247(1.00)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C247(0.89)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C247(0.77)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C305(1.12)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C305(1.19)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C305(1.09); C247(1.07)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C305(0.98)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C305(1.03)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C305(1.12)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C305(1.00); C247(0.91)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C305(0.91)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C305(1.02)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C305(0.91)  LDD1609  [13]
 LDCM0407  CL2 HEK-293T C305(1.42)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C305(1.27)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C305(0.86); C247(0.73)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C305(0.95)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C305(1.20)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C305(1.07)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C305(0.87)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C305(1.08)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C305(1.22); C247(0.98)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C305(0.86)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C305(0.97)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C305(1.17); C247(1.03)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C305(0.80)  LDD1623  [13]
 LDCM0420  CL31 HCT 116 C247(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C247(1.02)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C247(0.92)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C247(0.79)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C247(0.67)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C247(0.90)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C247(0.60)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C247(0.70)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C305(0.94)  LDD1633  [13]
 LDCM0430  CL40 HCT 116 C247(0.81)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C247(0.95)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C247(0.18)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C247(0.45)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C247(0.87)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C247(0.96)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C305(0.85)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C305(0.81)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C305(0.87)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C305(0.85)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C305(0.95)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C305(1.04)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C305(0.92)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C305(0.82)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C305(0.85)  LDD1648  [13]
 LDCM0447  CL56 HEK-293T C305(1.14)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C305(0.86); C247(0.90)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C305(0.78)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C305(1.12)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C305(1.17)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C305(0.87)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C305(1.03)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C305(1.12)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C305(0.97); C247(0.92)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C305(1.00)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C305(0.82)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C305(0.84)  LDD1661  [13]
 LDCM0460  CL68 HEK-293T C305(1.49)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C305(0.94); C247(0.89)  LDD1664  [13]
 LDCM0463  CL70 HEK-293T C305(1.12)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C305(0.71)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C305(0.91)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C305(1.20)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C305(1.15)  LDD1670  [13]
 LDCM0469  CL76 HCT 116 C247(1.00)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C247(0.78)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C247(0.95)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C247(0.98)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C305(0.81)  LDD1676  [13]
 LDCM0474  CL80 HCT 116 C247(0.88)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C247(1.07)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C247(0.75)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C247(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C247(0.44)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C247(1.08)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C247(1.14)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C247(1.37)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C247(0.97)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C247(0.34)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C305(0.82); C247(0.85)  LDD1687  [13]
 LDCM0485  CL90 HCT 116 C247(0.93)  LDD0802  [5]
 LDCM0487  CL92 HEK-293T C305(1.17)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C305(0.81); C247(0.92)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C305(1.05)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C305(0.97)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C305(0.99)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C305(0.88)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C305(1.06)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C305(1.10); C247(0.97)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C305(1.08); C247(0.89)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C305(1.19); C247(1.07)  LDD1671  [13]
 LDCM0427  Fragment51 HCT 116 C247(0.29)  LDD0744  [5]
 LDCM0116  HHS-0101 DM93 Y95(0.26)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y95(0.52)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y95(0.58)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y95(0.74)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y95(0.45)  LDD0268  [4]
 LDCM0022  KB02 BRX211 C305(1.29)  LDD2268  [14]
 LDCM0023  KB03 BRX211 C305(1.31)  LDD2685  [14]
 LDCM0024  KB05 IGR37 C305(1.74)  LDD3314  [14]
 LDCM0131  RA190 MM1.R C38(1.37); C305(1.32)  LDD0304  [15]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.