Details of the Target

General Information of Target

Target ID LDTP09826
Target Name Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN)
Gene Name RUBCN
Gene ID 9711
Synonyms
KIAA0226; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Rubicon; Beclin-1 associated RUN domain containing protein; Baron
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKN
VQQHEKVQKASTEGVAIQGQQGTRLLPEQLIKEAFILSDLFDIGELAAVELLLAGEHQQP
HFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSP
LGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIHQLPL
LTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKVKQLRNRADEDARM
IHMSMQMGNEPPISLRRDLEHLMLLIGELYKKNPFHLELALEYWCPTEPLQTPTIMGSYL
GVAHQRPPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCAHYCFSLLKVNGSS
HVENIQGAGGSPVSWEHFFHSLMLYHEHLRKDLPSADSVQYRHLPSRGITQKEQDGLIAF
LQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFGKSPEIA
ASLWQSLEYTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVESSFP
SNLGAGLRPPGFDPYLQFLRDSVFLRFRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQL
EDFVDQFVELQGEEIIAYKPPGFSLMYHLLNESPMLELALSLLEEGVKQLDTYAPFPGKK
HLEKAVQHCLALLNLTLQKENLFMDLLRESQLALIVCPLEQLLQGINPRTKKADNVVNIA
RYLYHGNTNPELAFESAKILCCISCNSNIQIKLVGDFTHDQSISQKLMAGFVECLDCEDA
EEFVRLEEGSELEKKLVAIRHETRIHILNLLITSLECNPPNLALYLLGFELKKPVSTTNL
QDPGVLGCPRTCLHAILNILEKGTEGRTGPVAVRESPQLAELCYQVIYQLCACSDTSGPT
MRYLRTSQDFLFSQLQYLPFSNKEYEISMLNQMSWLMKTASIELRVTSLNRQRSHTQRLL
HLLLDDMPVKPYSDGEGGIEDENRSVSGFLHFDTATKVRRKILNILDSIDFSQEIPEPLQ
LDFFDRAQIEQVIANCEHKNLRGQTVCNVKLLHRVLVAEVNALQGMAAIGQRPLLMEEIS
TVLQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACPQDLIQAEDRQLIIRDILQDVHD
KILDDEAAQELMPVVAGAVFTLTAHLSQAVLTEQKETSVLGPAEAHYAFMLDSCFTSPPP
EENPLVGFASIGDSSLYIILKKLLDFILKTGGGFQRVRTHLYGSLLYYLQIAQRPDEPDT
LEAAKKTMWERLTAPEDVFSKLQRENIAIIESYGAALMEVVCRDACDGHEIGRMLALALL
DRIVSVDKQQQWLLYLSNSGYLKVLVDSLVEDDRTLQSLLTPQPPLLKALYTYESKMAFL
TRVAKIQQGALELLRSGVIVRLAQCQVYDMRPETDPQSMFGMRDPPMFIPTPVDRYRQIL
LPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILRCQDVSAGSLQELALLTGII
SKAALPGILSELDVDVNEGSLMELQGHIGRFQRQCLGLLSRFGGSDRLRQFKFQDDNVEG
DKVSKKDEIELAMQQICANVMEYCQSLMLQSSPTFQHAVCLFTPSLSETVNRDGPRQDTQ
APVVPYWRLPGLGIIIYLLKQSANDFFSYYDSHRQSVSKLQNVEQLPPDEIKELCQSVMP
AGVDKISTAQKYVLARRRLVKVINNRAKLLSLCSFIIETCLFILWRHLEYYLLHCMPTDS
QDSLFASRTLFKSRRLQDSFASETNLDFRSGLAIVSQHDLDQLQADAINAFGESLQKKLL
DIEGLYSKVRSRYSFIQALVRRIRGLLRISRN
Target Bioclass
Other
Subcellular location
Late endosome
Function
Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
Uniprot ID
Q92622
Ensemble ID
ENST00000273582.9
HGNC ID
HGNC:28991

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.N807K DBIA    Probe Info 
EFO27 Insertion: p.S381VfsTer45
SNV: p.L380P		 .
HT SNV: p.H98R .
IM95 SNV: p.V773A .
IPC298 SNV: p.S355F .
Ishikawa (Heraklio) 02 ER SNV: p.F616V .
KYSE30 SNV: p.A961V DBIA    Probe Info 
LNCaP clone FGC SNV: p.R764L .
MCC13 SNV: p.P759S DBIA    Probe Info 
MFE319 Insertion: p.V278SfsTer16 .
NCIH1155 SNV: p.S399N .
RVH421 SNV: p.P695S .
TGBC52TKB SNV: p.S623A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C486(42.43); C739(5.62)  LDD0209  [1]
IPM
 Probe Info  		C929(2.06)  LDD1701  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C739(0.00); C459(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C739(1.02)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C134(1.01)  LDD1508  [4]
 LDCM0216  AC100 HCT 116 C747(0.64); C749(0.64); C750(0.64)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C747(0.46); C749(0.46); C750(0.46)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C747(0.85); C749(0.85); C750(0.85)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C747(0.69); C749(0.69); C750(0.69)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C747(0.65); C749(0.65); C750(0.65)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C747(0.64); C749(0.64); C750(0.64)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C747(0.51); C749(0.51); C750(0.51)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C747(0.78); C749(0.51); C750(0.51)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C747(0.41); C749(0.77); C750(0.77)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C747(0.81); C749(0.61); C750(0.61)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C739(1.11); C134(0.86); C171(1.04)  LDD1509  [4]
 LDCM0227  AC110 HCT 116 C747(0.53); C749(0.81); C750(0.81)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C747(0.63); C749(1.00); C750(1.00)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C747(0.74); C749(0.69); C750(0.69)  LDD0546  [5]
 LDCM0237  AC12 HEK-293T C739(1.00)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C134(1.18)  LDD1512  [4]
 LDCM0263  AC143 HEK-293T C747(0.99); C749(0.97)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C747(1.39); C749(1.21)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C747(1.16); C749(1.29)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C747(1.06); C749(1.07)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C747(0.92); C749(0.96)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C747(1.37); C749(1.28)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C747(1.43); C749(1.05)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C739(0.98); C134(0.71)  LDD1513  [4]
 LDCM0271  AC150 HEK-293T C747(1.03); C749(1.01)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C747(0.81); C749(0.87)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C747(1.15); C749(1.01)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C747(0.92); C749(0.93)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C747(0.76); C749(1.04)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C747(0.99); C749(1.07)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C747(1.58); C749(1.33)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C747(1.95); C749(1.33)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C749(0.82)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C749(0.73)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C749(0.78)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C134(0.83)  LDD1518  [4]
 LDCM0280  AC20 HCT 116 C749(0.80)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C749(0.84)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C749(0.81)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C749(0.81)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C749(0.75)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C747(0.76); C749(0.76); C750(0.76)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C747(0.58); C749(0.58); C750(0.58)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C747(0.97); C749(0.97); C750(0.97)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C747(0.66); C749(0.66); C750(0.66)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C747(0.89); C749(0.89); C750(0.89)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C739(1.07); C134(1.08); C171(0.94)  LDD1529  [4]
 LDCM0291  AC30 HCT 116 C747(0.66); C749(0.66); C750(0.66)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C747(0.70); C749(0.70); C750(0.70)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C747(0.65); C749(0.65); C750(0.65)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C747(1.07); C749(1.07); C750(1.07)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C747(0.70); C749(0.70); C750(0.70)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C747(0.88); C749(0.88); C750(0.88)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C747(0.66); C749(0.66); C750(0.66)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C747(0.79); C749(0.79); C750(0.79)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C747(0.45); C749(0.45); C750(0.45)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C747(0.67); C749(0.67); C750(0.67)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C739(1.13)  LDD1540  [4]
 LDCM0302  AC40 HCT 116 C747(0.60); C749(0.60); C750(0.60)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C747(0.60); C749(0.60); C750(0.60)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C747(0.59); C749(0.59); C750(0.59)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C747(0.61); C749(0.61); C750(0.61)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C747(0.68); C749(0.68); C750(0.68)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C747(0.54); C749(0.54); C750(0.54)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C747(0.89); C749(0.89)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C747(1.10); C749(1.10)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C747(1.15); C749(1.15)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C747(1.00); C749(1.00)  LDD0909  [5]
 LDCM0313  AC50 HEK-293T C747(1.15); C749(1.15)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C747(1.18); C749(1.18)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C747(1.10); C749(1.10)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C747(1.43); C749(1.43)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C747(1.23); C749(1.23)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C747(1.15); C749(1.15)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C747(1.43); C749(1.43)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C747(0.83); C749(0.83); C750(0.83)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C747(0.79); C749(0.79); C750(0.79)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C747(0.95); C749(0.95); C750(0.95)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C134(1.38)  LDD1562  [4]
 LDCM0324  AC60 HCT 116 C747(0.74); C749(0.74); C750(0.74)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C747(0.81); C749(0.81); C750(0.81)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C747(0.96); C749(0.96); C750(0.96)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C747(0.77); C749(0.77); C750(0.77)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C747(0.84); C749(0.84); C750(0.84)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C747(0.85); C749(0.85); C750(0.85)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C747(1.16); C749(1.16); C750(1.16)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C747(0.94); C749(0.94); C750(0.94)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C747(0.76); C749(0.76); C750(0.76)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C747(0.58); C749(0.58); C750(0.58)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C739(1.05); C134(0.81)  LDD1568  [4]
 LDCM0335  AC70 HCT 116 C747(0.81); C749(0.81); C750(0.81)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C747(0.64); C749(0.64); C750(0.64)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C747(0.63); C749(0.63); C750(0.63)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C747(0.62); C749(0.62); C750(0.62)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C747(0.66); C749(0.66); C750(0.66)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C747(0.82); C749(0.82); C750(0.82)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C747(0.64); C749(0.64); C750(0.64)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C747(0.51); C749(0.51); C750(0.51)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C747(0.77); C749(0.77); C750(0.77)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C747(0.88); C749(0.88); C750(0.88)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C134(0.98)  LDD1569  [4]
 LDCM0346  AC80 HCT 116 C747(0.59); C749(0.59); C750(0.59)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C747(0.69); C749(0.69); C750(0.69)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C747(0.76); C749(0.76); C750(0.76)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C747(1.33); C749(1.33); C750(1.33)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C747(1.18); C749(1.18); C750(1.18)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C747(0.62); C749(0.62); C750(0.62)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C747(0.80); C749(0.80); C750(0.80)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C747(1.11); C749(1.11); C750(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C747(1.22); C749(1.22); C750(1.22)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C747(0.88); C749(0.88); C750(0.88)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C747(1.05); C749(1.05); C750(1.05)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C747(1.35); C749(1.35); C750(1.35)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C747(1.52); C749(1.52); C750(1.52)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C747(0.83); C749(0.83); C750(0.83)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C747(1.24); C749(1.24); C750(1.24)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C747(1.18); C749(1.18); C750(1.18)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C747(1.26); C749(1.26); C750(1.26)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C747(0.78); C749(0.78); C750(0.78)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C747(0.73); C749(0.73); C750(0.73)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C747(0.57); C749(0.57); C750(0.57)  LDD0683  [5]
 LDCM0356  AKOS034007680 HEK-293T C739(1.11)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C134(1.16)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C739(0.99)  LDD2171  [5]
 LDCM0367  CL1 PaTu 8988t C750(1.25)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C750(1.91)  LDD1247  [5]
 LDCM0370  CL101 HEK-293T C739(1.10)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C134(0.88)  LDD1575  [4]
 LDCM0374  CL105 HCT 116 C749(0.65)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C749(0.64)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C749(0.54)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C749(0.53)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C749(0.82)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C750(1.23)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C749(0.94)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C749(0.85)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C747(0.94); C749(0.94); C750(0.94)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C747(0.75); C749(0.75); C750(0.75)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C747(0.67); C749(0.67); C750(0.67)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C747(0.69); C749(0.69); C750(0.69)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C747(0.79); C749(0.79); C750(0.79)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C747(0.64); C749(0.64); C750(0.64)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C747(0.84); C749(0.84); C750(0.84)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C747(0.71); C749(0.71); C750(0.71)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C750(1.41)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C747(0.52); C749(0.52); C750(0.52)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C747(1.08); C749(1.08)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C747(1.42); C749(1.42)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C747(1.88); C749(1.88)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C747(1.26); C749(1.26)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C747(1.08); C749(1.08); C750(1.08)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C747(1.01); C749(1.01); C750(1.01)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C747(0.88); C749(0.88); C750(0.88)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C747(0.90); C749(0.90); C750(0.90)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C750(2.75)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C750(3.05)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C750(1.29)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C749(1.01); C750(1.01)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C749(0.57); C750(0.57)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C749(1.24); C750(1.24)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C749(0.72); C750(0.72)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C750(1.30)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C749(0.80); C750(0.80)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C749(1.04); C750(1.04)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C749(0.96); C750(0.96)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C749(0.97); C750(0.97)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C749(1.13); C750(1.13)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C749(0.76); C750(0.76)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C749(0.96); C750(0.96)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C749(1.19); C750(1.19)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C749(1.15); C750(1.15)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C749(0.99); C750(0.99)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C750(1.46)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C749(0.78); C750(0.78)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C747(0.94)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C747(0.75)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C747(0.90)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C747(1.08)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C747(1.11)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C747(1.13)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C747(1.21)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C747(0.90)  LDD0745  [5]
 LDCM0429  CL4 PaTu 8988t C750(1.69)  LDD1308  [5]
 LDCM0430  CL40 HCT 116 C747(0.93)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C747(0.86)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C747(0.87)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C747(0.81)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C747(0.76)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C747(0.78)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C747(0.99); C749(0.79); C750(0.79)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C747(0.97); C749(0.78); C750(0.78)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C747(0.97); C749(0.80); C750(0.80)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C747(0.91); C749(0.86); C750(0.86)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C750(2.67)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C747(0.98); C749(0.88); C750(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C747(0.99); C749(0.83); C750(0.83)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C747(1.05); C749(1.15); C750(1.15)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C747(1.47); C749(1.13); C750(1.13)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C747(0.89); C749(0.79); C750(0.79)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C747(0.90); C749(0.89); C750(0.89)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C747(0.88); C749(0.81); C750(0.81)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C747(0.83); C749(0.74); C750(0.74)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C747(0.80); C749(0.90); C750(0.90)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C747(1.17); C749(1.24); C750(1.24)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C750(1.35)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C747(0.83); C749(0.81); C750(0.81)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C747(0.94); C749(0.94); C750(0.94)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C747(0.81); C749(0.81); C750(0.81)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C747(0.97); C749(0.97); C750(0.97)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C747(1.19); C749(1.19); C750(1.19)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C747(0.73); C749(0.73); C750(0.73)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C747(0.97); C749(0.97); C750(0.97)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C747(1.09); C749(1.09); C750(1.09)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C747(1.09); C749(1.09); C750(1.09)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C747(0.96); C749(0.96); C750(0.96)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C750(2.03)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C747(1.17); C749(1.17); C750(1.17)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C747(0.80); C749(0.80); C750(0.80)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C747(1.04); C749(1.04); C750(1.04)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C747(0.98); C749(0.98); C750(0.98)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C747(0.93); C749(0.93); C750(0.93)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C749(1.18)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C749(0.95)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C749(0.82)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C749(1.13)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C750(1.85)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C749(0.94)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C749(0.99)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C749(0.91)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C749(0.75)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C749(0.85)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C749(1.02)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C749(0.76)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C749(0.68)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C749(0.79)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C749(0.64)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C750(2.20)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C749(0.72)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C739(1.22); C134(0.69); C171(0.86)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C739(1.15)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C134(0.66)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C739(1.26); C134(0.56)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C134(0.87)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C739(1.26)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C134(0.67)  LDD1696  [4]
 LDCM0468  Fragment33 HCT 116 C747(0.93); C749(0.93); C750(0.93)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C747(1.67)  LDD0744  [5]
 LDCM0022  KB02 697 C423(2.13)  LDD2245  [6]
 LDCM0023  KB03 Jurkat C486(42.43); C739(5.62)  LDD0209  [1]
 LDCM0024  KB05 MIA PaCa-2 C423(3.19)  LDD3330  [6]
 LDCM0021  THZ1 HCT 116 C739(0.99)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) PI3/PI4-kinase family Q8NEB9
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Bromodomain-containing protein 1 (BRD1) . O95696
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Zinc finger protein ubi-d4 (DPF2) Requiem/DPF family Q92785
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
UV radiation resistance-associated gene protein (UVRAG) . Q9P2Y5

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840