Details of the Target

General Information of Target

Target ID LDTP09805
Target Name Hamartin (TSC1)
Gene Name TSC1
Gene ID 7248
Synonyms
KIAA0243; TSC; Hamartin; Tuberous sclerosis 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
DISIKVPNLPSFK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation. Acts as a tumor suppressor. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1.
Uniprot ID
Q92574
Ensemble ID
ENST00000298552.9
HGNC ID
HGNC:12362

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.G1034C .
EFO21 SNV: p.H894Y .
HT115 SNV: p.E981K .
IM95 SNV: p.Y373C .
JURKAT SNV: p.R1093Ter .
LNCaP clone FGC SNV: p.G147W; p.T294A; p.A523T .
MOLT4 SNV: p.D541Y;p.E788K;p.E1162K
Substitution: p.P1142_P1143delinsQT		 .
SNU308 SNV: p.S278F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K971(0.82)  LDD0274  [2]
STPyne
 Probe Info  		K919(4.33)  LDD0277  [2]
DBIA
 Probe Info  		C306(1.55); C572(0.97); C586(0.97)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C165(0.78)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C572(1.18)  LDD0813  [3]
 LDCM0216  AC100 PaTu 8988t C572(1.20); C586(1.20)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C572(0.93); C586(0.93)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C572(0.80); C586(0.80)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C572(1.02); C586(1.02)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C572(1.15); C586(1.15)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C572(0.93); C586(0.93)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C572(1.14); C586(1.14)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C572(0.85); C586(0.85)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C572(0.99); C586(0.99)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C572(1.26); C586(1.26)  LDD1104  [3]
 LDCM0226  AC11 HEK-293T C572(1.17)  LDD0824  [3]
 LDCM0227  AC110 PaTu 8988t C572(1.01); C586(1.01)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C572(1.41); C586(1.41)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C572(1.07); C586(1.07)  LDD1108  [3]
 LDCM0230  AC113 HEK-293T C572(1.24); C586(1.20)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C572(0.91); C586(1.03)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C572(1.53); C586(1.23)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C572(0.81); C586(0.87)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C572(1.03); C586(0.96)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C572(1.15); C586(1.12)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C572(0.97); C586(1.01)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C572(1.11)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C572(1.09); C586(1.12)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C572(1.06); C586(0.96)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C572(0.97); C586(0.94)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C572(0.89); C586(0.90)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C572(1.23); C586(1.02)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C572(1.20); C586(1.07)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C572(1.44); C586(1.26)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C572(1.01); C586(1.04)  LDD0843  [3]
 LDCM0246  AC128 PaTu 8988t C306(0.56); C165(1.24); C572(1.66); C586(1.66)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C306(0.74); C165(1.07); C572(1.40); C586(1.40)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C306(1.08); C165(1.04); C572(1.59); C586(1.59)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C306(1.18); C165(1.11); C572(0.88); C586(0.88)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C306(1.06); C165(0.99); C572(1.05); C586(1.05)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C306(0.77); C165(1.44); C572(1.51); C586(1.51)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C306(0.84); C165(1.24); C572(1.65); C586(1.65)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C306(1.31); C165(1.25); C572(1.32); C586(1.32)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C306(0.52); C165(1.44); C572(2.92); C586(2.92)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C306(0.52); C165(1.47); C572(1.52); C586(1.52)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C306(0.56); C165(0.93); C572(1.42); C586(1.42)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C306(0.82); C165(0.95); C572(1.52); C586(1.52)  LDD1137  [3]
 LDCM0259  AC14 HEK-293T C572(1.19)  LDD0857  [3]
 LDCM0260  AC140 PaTu 8988t C306(0.61); C165(1.06); C572(1.77); C586(1.77)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C306(1.00); C165(1.06); C572(1.14); C586(1.14)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C306(0.71); C165(1.23); C572(1.70); C586(1.70)  LDD1141  [3]
 LDCM0263  AC143 HEK-293T C572(0.71); C586(0.71)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C572(0.95); C586(0.95)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C572(0.59); C586(0.59)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C572(0.55); C586(0.55)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C572(0.36); C586(0.36)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C572(0.53); C586(0.53)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C572(0.75); C586(0.75)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C572(1.16)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C572(0.59); C586(0.59)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C572(0.76); C586(0.76)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C572(0.89); C586(0.89)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C572(0.67); C586(0.67)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C572(0.66); C586(0.66)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C572(1.24); C586(1.24)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C572(0.81); C586(0.81)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C572(0.78); C586(0.78)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C165(0.93)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C165(0.86)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C165(0.93)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C165(0.65)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C165(0.92)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C165(0.81)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C165(0.84)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C165(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C165(0.98)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C306(0.61); C197(1.08); C165(1.16); C572(0.86)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C306(1.32); C197(1.15); C165(1.24); C572(0.89)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C306(0.81); C197(1.04); C165(1.31); C572(0.94)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C306(1.20); C197(1.39); C165(1.12); C572(1.09)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C306(0.69); C197(1.15); C165(1.39); C572(0.92)  LDD1168  [3]
 LDCM0290  AC3 HCT 116 C165(0.87)  LDD0607  [3]
 LDCM0291  AC30 PaTu 8988t C306(0.77); C197(0.84); C165(1.21); C572(0.93)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C306(1.29); C197(0.79); C165(1.21); C572(0.81)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C306(1.20); C197(1.20); C165(1.24); C572(1.00)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C306(1.37); C197(1.19); C165(1.21); C572(1.37)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C306(0.82); C197(1.40); C165(1.42); C572(1.18)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C197(1.22); C572(0.85); C586(0.85)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C197(1.19); C572(0.92); C586(0.92)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C197(1.39); C572(1.09); C586(1.09)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C197(1.20); C572(1.19); C586(1.19)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C197(1.49); C572(1.40); C586(1.40)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C165(1.06)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C197(1.45); C572(1.02); C586(1.02)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C197(1.30); C572(1.64); C586(1.64)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C197(1.32); C572(1.24); C586(1.24)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C197(1.20); C572(1.17); C586(1.17)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C197(1.28); C572(1.38); C586(1.38)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C197(1.36); C572(1.06); C586(1.06)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C306(1.67); C197(1.08); C572(0.89); C586(0.89)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C306(1.10); C197(1.06); C572(0.77); C586(0.77)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C306(1.04); C197(0.97); C572(1.07); C586(1.07)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C306(2.38); C197(1.46); C572(1.08); C586(1.08)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C165(0.85)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C306(1.27); C197(1.53); C572(0.94); C586(0.94)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C306(1.12); C197(2.55); C572(0.95); C586(0.95)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C306(1.01); C197(1.23); C572(1.10); C586(1.10)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C306(1.30); C197(1.46); C572(1.06); C586(1.06)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C306(2.08); C197(1.74); C572(1.26); C586(1.26)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C306(0.94); C197(1.16); C572(1.07); C586(1.07)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C306(2.94); C197(1.33); C572(1.01); C586(1.01)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C572(0.56); C586(0.56)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C572(0.71); C586(0.71)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C572(0.59); C586(0.59)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C572(1.07)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C572(0.64); C586(0.64)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C572(0.50); C586(0.50)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C572(0.55); C586(0.55)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C572(0.68); C586(0.68)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C572(0.53); C586(0.53)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C572(0.73); C586(0.73)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C572(0.64); C586(0.64)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C572(0.61); C586(0.61)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C572(1.10)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C572(1.21)  LDD0943  [3]
 LDCM0349  AC83 HCT 116 C572(1.69); C586(1.69)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C572(1.68); C586(1.68)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C572(0.97); C586(0.97)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C572(1.42); C586(1.42)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C572(1.24); C586(1.24)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C572(1.66); C586(1.66)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C572(1.64); C586(1.64)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C572(1.29); C586(1.29)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C572(1.81); C586(1.81)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C572(1.91); C586(1.91)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C572(1.43); C586(1.43)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C572(1.43); C586(1.43)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C572(1.56); C586(1.56)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C572(1.77); C586(1.77)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C572(1.73); C586(1.73)  LDD0681  [3]
 LDCM0365  AC98 PaTu 8988t C572(0.87); C586(0.87)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C572(0.97); C586(0.97)  LDD1245  [3]
 LDCM0248  AKOS034007472 HEK-293T C572(1.25)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C572(1.24)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C572(1.22)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C306(1.55); C572(0.97); C586(0.97)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C259(20.00)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C572(0.86); C586(0.86); C165(1.02)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C572(1.06); C586(1.06); C165(1.07)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C165(0.85)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C572(1.21)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C572(1.10)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C572(1.19)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C572(1.23)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C165(0.86)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C165(0.90)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C165(0.84)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C165(0.97)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C165(0.91)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C572(1.17); C586(1.17); C165(1.27)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C165(0.79)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C165(0.86)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C306(0.91); C197(0.88); C165(1.08); C572(1.14)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C306(0.89); C197(1.66); C165(1.07); C572(0.86)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C306(1.22); C197(1.15); C165(1.07); C572(1.28)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C306(0.87); C197(0.97); C165(1.16); C572(1.11)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C306(0.90); C197(1.02); C165(1.23); C572(1.00)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C197(1.06); C572(1.29); C586(1.29)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C197(0.97); C572(0.99); C586(0.99)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C197(1.17); C572(1.18); C586(1.18)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C572(1.23); C586(1.23); C165(1.26)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C197(1.22); C572(0.91); C586(0.91)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C306(1.04); C197(0.97); C572(1.09); C586(1.09)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C306(8.60); C197(1.26); C572(1.05); C586(1.05)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C306(1.10); C197(1.17); C572(1.23); C586(1.23)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C306(1.52); C197(1.28); C572(1.09); C586(1.09)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C572(0.71); C586(0.71)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C572(0.90); C586(0.90)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C572(0.73); C586(0.73)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C572(0.88); C586(0.88)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C572(0.95); C586(0.95); C165(1.16)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C165(1.05); C572(1.10); C586(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C165(0.94); C572(1.33); C586(1.33)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C165(1.04); C572(1.11); C586(1.11)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C572(0.81); C586(0.81); C165(0.94)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C572(0.87); C586(0.87); C165(1.08)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C572(0.92); C586(0.92); C165(1.15)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C165(0.93); C572(0.96); C586(0.96)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C572(1.08); C586(1.08); C165(1.13)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C165(1.04); C572(1.15); C586(1.15)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C572(1.24); C586(1.24); C165(1.33)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C165(1.12); C572(1.17); C586(1.17)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C165(1.34); C572(1.24); C586(1.24)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C165(0.90); C572(1.15); C586(1.15)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C165(0.97); C572(0.99); C586(0.99)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C165(0.95); C572(1.02); C586(1.02)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C165(1.05); C572(1.27); C586(1.27)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C165(1.07); C572(1.28); C586(1.28)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C165(1.16); C572(0.91); C586(0.91)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C165(0.85); C572(1.06); C586(1.06)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C572(0.97)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C572(0.79); C586(0.79)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C572(1.23); C586(1.23)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C572(0.72); C586(0.72)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C572(1.19); C586(1.19)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C572(0.64); C586(0.64)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C572(0.89); C586(0.89)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C572(0.91); C586(0.91)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C165(1.00); C572(1.01); C586(1.01)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C572(0.80); C586(0.80)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C572(1.19); C586(1.19)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C572(0.76); C586(0.76)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C572(1.02); C586(1.02)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C572(0.86); C586(0.86)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C572(0.96); C586(0.96)  LDD0752  [3]
 LDCM0436  CL46 PaTu 8988t C165(0.78)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C165(0.96)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C165(0.70)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C165(0.97)  LDD1318  [3]
 LDCM0440  CL5 HCT 116 C165(0.92); C572(0.87); C586(0.87)  LDD0757  [3]
 LDCM0441  CL50 PaTu 8988t C165(0.84)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C165(0.95)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C165(0.85)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C165(0.97)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C165(1.12)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C165(0.82)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C165(0.77)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C165(0.82)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C165(0.86)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C165(1.04)  LDD1329  [3]
 LDCM0451  CL6 HCT 116 C165(1.06); C572(1.07); C586(1.07)  LDD0768  [3]
 LDCM0452  CL60 PaTu 8988t C165(0.74)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C165(1.11)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C165(1.06)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C165(0.99)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C165(1.27)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C165(1.02)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C165(1.36)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C165(1.21)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C165(1.16)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C165(0.93)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C165(1.12); C572(1.04); C586(1.04)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C165(1.14)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C165(1.09)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C165(1.17)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C165(1.27)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C165(1.13)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C572(1.04); C586(1.04)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C572(0.82); C586(0.82)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C572(0.88); C586(0.88)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C572(0.83); C586(0.83)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C165(0.89); C572(1.20); C586(1.20)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C572(0.90); C586(0.90)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C572(0.95); C586(0.95)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C572(1.07); C586(1.07)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C572(0.89); C586(0.89)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C572(0.99); C586(0.99)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C572(0.81); C586(0.81)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C572(1.14); C586(1.14)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C572(1.04); C586(1.04)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C572(1.12); C586(1.12)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C572(0.85); C586(0.85)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C165(1.31); C572(0.93); C586(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C572(1.23); C586(1.23)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C165(0.95)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C165(0.58)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C165(0.48)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C165(0.59)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C165(0.82)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C165(0.72)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C165(1.04)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C165(0.89)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C165(0.89)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C822(0.97); C165(0.94); C1104(0.86); C197(1.11)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C165(1.11)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C572(1.03); C586(1.03)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C306(3.33); C572(4.93); C586(4.93)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C306(2.17); C572(2.22); C586(2.22)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C306(3.67); C572(3.51); C586(3.51)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C306(0.83)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ferritin heavy chain (FTH1) Ferritin family P02794
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX3 (BEX3) BEX family Q00994
Kazrin (KAZN) Kazrin family Q674X7
PRKCA-binding protein (PICK1) . Q9NRD5
TRAF family member-associated NF-kappa-B activator (TANK) . Q92844
Tuberin (TSC2) . P49815

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402