Details of the Target

General Information of Target

Target ID LDTP09430
Target Name Mucolipin-3 (MCOLN3)
Gene Name MCOLN3
Gene ID 55283
Synonyms
Mucolipin-3; Transient receptor potential channel mucolipin 3; TRPML3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKP
WKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQS
DVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPE
IETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYD
FTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSL
ILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKM
EIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAA
MIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRI
YLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLE
DDPPVSLFCCCKK
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN3 sub-subfamily
Subcellular location
Cell membrane
Function
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3.
TTD ID
T14241
Uniprot ID
Q8TDD5
DrugMap ID
TT0NLAQ
Ensemble ID
ENST00000341115.8
HGNC ID
HGNC:13358
ChEMBL ID
CHEMBL1293243

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.R522C .
KMCH1 SNV: p.T198K .
LNCaP clone FGC SNV: p.P170T .
MFE319 Insertion: p.M47HfsTer5 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C528(2.66)  LDD3332  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C528(1.06)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C528(0.95)  LDD1508  [3]
 LDCM0216  AC100 HEK-293T C528(0.93)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C528(1.13)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C528(0.89)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C528(1.24)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C528(1.18)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C528(1.20)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C528(0.70)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C528(1.05)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C528(0.93)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C528(1.04)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C528(0.91)  LDD1509  [3]
 LDCM0227  AC110 HEK-293T C528(1.19)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C528(1.91)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C528(1.60)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C528(1.05)  LDD1510  [3]
 LDCM0246  AC128 HEK-293T C528(0.94)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C528(1.17)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C528(1.16)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C528(1.03)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C528(1.10)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C528(1.25)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C528(1.18)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C528(1.36)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C528(1.35)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C528(1.37)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C528(1.56)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C528(1.44)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C528(1.02)  LDD1512  [3]
 LDCM0260  AC140 HEK-293T C528(1.39)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C528(1.44)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C528(1.26)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C528(1.31)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C528(1.42)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C528(1.38)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C528(1.40)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C528(1.39)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C528(1.39)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C528(1.07)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C528(1.01)  LDD1513  [3]
 LDCM0271  AC150 HEK-293T C528(1.29)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C528(1.32)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C528(1.33)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C528(1.42)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C528(1.13)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C528(1.18)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C528(1.35)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C528(1.56)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C528(1.34)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C528(1.17)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C528(1.16)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C528(1.22)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C528(1.29)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C528(1.42)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C528(1.31)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C528(1.47)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C528(1.08)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C528(1.11)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C528(1.25)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C528(1.17)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C528(1.44)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C528(1.28)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C528(0.99)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C528(1.20)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C528(0.97)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C528(1.09)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C528(1.21)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C528(1.00)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C528(1.01)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C528(1.00)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C528(0.95)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C528(0.99)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C528(1.00)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C528(1.01)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C528(1.01)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C528(1.03)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C528(0.96)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C528(0.95)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C528(1.02)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C528(1.02)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C528(1.03)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C528(1.06)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C528(0.96)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C528(0.91)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C528(1.01)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C528(0.95)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C528(0.98)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C528(1.04)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C528(0.99)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C528(0.93)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C528(1.03)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C528(1.01)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C528(0.88)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C528(0.88)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C528(0.84)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C528(1.10)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C528(0.85)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C528(1.28)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C528(0.98)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C528(1.17)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C528(0.98)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C528(1.18)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C528(0.91)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C528(1.16)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C528(1.08)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C528(1.10)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C528(0.99)  LDD1568  [3]
 LDCM0335  AC70 HEK-293T C528(1.38)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C528(1.18)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C528(1.18)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C528(1.41)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C528(1.29)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C528(1.18)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C528(1.18)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C528(1.28)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C528(1.35)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C528(1.10)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C528(0.97)  LDD1569  [3]
 LDCM0346  AC80 HEK-293T C528(1.31)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C528(1.20)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C528(1.70)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C528(0.74)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C528(0.67)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C528(1.00)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C528(1.06)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C528(1.04)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C528(0.97)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C528(3.13)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C528(1.35)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C528(0.96)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C528(1.01)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C528(1.00)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C528(0.93)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C528(1.10)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C528(1.13)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C528(1.02)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C528(1.12)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C528(1.13)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C528(2.26)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C528(1.12)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C528(0.97)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C528(1.19)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C528(1.03)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C528(1.60)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C528(1.23)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C528(1.34)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C528(1.07)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C528(0.94)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C528(1.02)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C528(1.38)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C528(0.95)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C528(0.98)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C528(0.89)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C528(0.97)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C528(0.88)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C528(0.98)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C528(1.14)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C528(0.95)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C528(0.81)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C528(1.38)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C528(1.40)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C528(1.74)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C528(0.64)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C528(0.72)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C528(0.54)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C528(0.55)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C528(1.13)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C528(0.40)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C528(0.38)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C528(0.34)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C528(0.49)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C528(0.53)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C528(0.46)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C528(0.64)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C528(0.71)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C528(0.42)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C528(0.59)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C528(0.98)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C528(0.53)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C528(0.99)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C528(0.72)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C528(0.68)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C528(0.81)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C528(0.67)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C528(0.90)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C528(0.76)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C528(0.62)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C528(1.38)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C528(0.79)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C528(0.83)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C528(0.73)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C528(0.59)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C528(0.60)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C528(0.64)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C528(0.64)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C528(0.79)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C528(0.86)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C528(0.51)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C528(1.48)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C528(0.70)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C528(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C528(0.68)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C528(0.61)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C528(0.54)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C528(0.77)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C528(0.73)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C528(1.04)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C528(0.65)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C528(0.90)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C528(1.23)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C528(0.87)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C528(0.95)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C528(1.07)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C528(1.19)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C528(0.88)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C528(1.04)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C528(1.15)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C528(1.11)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C528(1.17)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C528(0.87)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C528(1.82)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C528(1.00)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C528(0.97)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C528(1.03)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C528(0.59)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C528(0.97)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C528(0.59)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C528(0.26)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C528(0.98)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C528(0.65)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C528(0.97)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C528(0.47)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C528(0.58)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C528(0.74)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C528(0.69)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C528(0.45)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C528(0.76)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C528(0.57)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C528(0.58)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C528(0.70)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C528(0.52)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C528(0.99)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C528(1.18)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C528(0.88)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C528(0.92)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C528(0.94)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C528(1.31)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C528(1.51)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C528(0.99)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C528(1.02)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C528(1.09)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C528(1.10)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C528(0.97)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C528(0.89)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C528(0.74)  LDD0744  [2]
 LDCM0022  KB02 A101D C528(1.67)  LDD2250  [1]
 LDCM0023  KB03 A101D C528(2.40)  LDD2667  [1]
 LDCM0024  KB05 MKN45 C528(2.66)  LDD3332  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sf-11 Small molecular drug D04OPE
Sf-21 Small molecular drug D0BK2Y
Sn-1 Small molecular drug D0E9FD
Sn-2 Small molecular drug D0G1LN

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402