Details of the Target

General Information of Target

Target ID LDTP09360
Target Name tRNA methyltransferase 10 homolog A (TRMT10A)
Gene Name TRMT10A
Gene ID 93587
Synonyms
RG9MTD2; tRNA methyltransferase 10 homolog A; EC 2.1.1.221; RNA; guanine-9-)-methyltransferase domain-containing protein 2; tRNA; guanine(9)-N(1))-methyltransferase TRMT10A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSEMLPAFIETSNVDKKQGINEDQEESQKPRLGEGCEPISKRQMKKLIKQKQWEEQREL
RKQKRKEKRKRKKLERQCQMEPNSDGHDRKRVRRDVVHSTLRLIIDCSFDHLMVLKDIKK
LHKQIQRCYAENRRALHPVQFYLTSHGGQLKKNMDENDKGWVNWKDIHIKPEHYSELIKK
EDLIYLTSDSPNILKELDESKAYVIGGLVDHNHHKGLTYKQASDYGINHAQLPLGNFVKM
NSRKVLAVNHVFEIILEYLETRDWQEAFFTILPQRKGAVPTDKACESASHDNQSVRMEEG
GSDSDSSEEEYSRNELDSPHEEKQDKENHTESTVNSLPH
Target Bioclass
Enzyme
Family
Class IV-like SAM-binding methyltransferase superfamily, TRM10 family
Subcellular location
Nucleus
Function
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.
Uniprot ID
Q8TBZ6
Ensemble ID
ENST00000273962.7
HGNC ID
HGNC:28403

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C37(1.92)  LDD1699  [2]
AHL-Pu-1
 Probe Info  		C285(2.05)  LDD0168  [3]
DBIA
 Probe Info  		C37(1.09)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C78(0.00); C285(0.00); C37(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C37(0.00); C107(0.00); C78(0.00); C285(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C37(0.00); C285(0.00); C78(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		13.20  LDD0443  [10]
NAIA_5
 Probe Info  		C285(0.00); C128(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C285(2.05)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C285(2.51)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C285(0.98); C78(0.97)  LDD1507  [12]
 LDCM0215  AC10 HCT 116 C37(0.89)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C37(0.75)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C37(0.64)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C37(0.72)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C37(0.65)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C37(0.53)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C37(0.94)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C37(0.68)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C37(0.52)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C37(0.97)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C37(0.53)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C37(0.98)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C37(0.80)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C37(0.42)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C37(0.58)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C78(1.14)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C78(1.04)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C78(1.25)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C78(0.93)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C78(0.89)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C78(1.21)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C78(0.89)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C37(0.95)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C78(1.14)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C78(0.88)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C78(1.22)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C78(0.80)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C78(0.83)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C78(0.80)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C78(1.55)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C78(1.49)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C37(0.90)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C37(0.90)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C78(1.24)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C78(0.87)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C78(1.15)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C285(0.86); C78(0.84); C37(0.98)  LDD1518  [12]
 LDCM0280  AC20 HCT 116 C78(1.12)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C78(1.08)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C78(1.13)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C78(1.27)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C78(1.43)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C78(1.54)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C78(1.58)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C78(1.87)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C78(1.72)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C78(1.58)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C285(0.93); C78(0.95); C37(0.99)  LDD1529  [12]
 LDCM0291  AC30 HCT 116 C78(1.83)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C78(1.62)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C78(1.69)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C78(1.32)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C78(1.80)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C78(1.00)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C78(1.11)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C78(0.78)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C78(0.77)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C78(1.11)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C285(1.03); C78(0.88)  LDD1540  [12]
 LDCM0302  AC40 HCT 116 C78(1.25)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C78(1.13)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C78(1.31)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C78(1.02)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C78(1.26)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C78(1.28)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C78(0.89); C37(0.93)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C37(0.97); C78(1.02)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C78(0.84); C37(1.03)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C78(1.27); C37(1.44)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C285(1.06); C78(0.99); C37(0.88)  LDD1551  [12]
 LDCM0313  AC50 HCT 116 C78(1.05); C37(1.11)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C78(0.78); C37(0.97)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C78(0.88); C37(1.05)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C37(1.10); C78(1.27)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C37(1.01); C78(1.33)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C78(1.18); C37(1.55)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C78(1.32); C37(1.35)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C285(0.97); C78(0.88)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C285(0.72); C78(0.92); C37(0.89)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C285(0.93); C78(0.95); C37(1.06)  LDD1561  [12]
 LDCM0323  AC6 HCT 116 C37(0.94)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C285(1.00); C78(0.96)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C285(0.89); C78(0.98); C37(0.92)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C285(0.62); C78(1.00); C37(0.90)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C285(0.76); C78(1.14); C37(0.90)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C78(1.12); C37(0.90)  LDD1567  [12]
 LDCM0334  AC7 HCT 116 C37(0.94)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C37(0.95)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C37(1.07); C78(1.41)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C37(1.29); C78(1.71)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C37(1.26); C78(1.29)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C37(1.08); C78(1.22)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C37(1.02); C78(1.06)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C37(0.96); C78(1.12)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C37(0.97); C78(1.04)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C78(0.83); C37(1.00)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C37(1.35); C78(1.64)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C37(1.43); C78(1.47)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C37(0.91); C78(1.21)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C37(1.05); C78(1.37)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C78(0.98); C37(1.15)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C78(1.08); C37(1.08)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C37(1.32); C78(1.62)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C37(1.21)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C37(1.36)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C37(0.89)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C37(1.09)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C37(0.91)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.81  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C285(0.70); C37(0.39)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C78(1.22)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C78(1.09)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C285(0.96); C78(0.78); C37(0.94)  LDD1573  [12]
 LDCM0370  CL101 HCT 116 C37(0.82)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C37(0.80)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C37(0.83)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C37(0.92)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C78(0.88)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C78(0.82)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C78(0.92)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C78(0.99)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C78(1.30)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C78(1.19)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C78(1.21)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C78(1.36)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C78(1.53)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C78(1.52)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C78(1.46)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C78(2.24)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C78(1.30)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C78(1.59)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C78(1.15)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C78(1.15)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C78(1.03)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C78(0.82)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C37(1.26); C78(1.41)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C37(1.04); C78(1.09)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C78(1.08); C37(1.20)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C78(1.20); C37(1.30)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C285(0.78); C78(1.01); C37(0.89)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C285(0.76); C78(0.91); C37(0.89)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C285(0.75); C78(0.99)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C285(0.77); C78(0.81); C37(0.93)  LDD1603  [12]
 LDCM0400  CL13 HCT 116 C78(1.02)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C78(0.99)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C78(1.87)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C285(0.90); C78(0.75); C37(1.01)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C285(0.91); C78(0.77)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C285(0.74); C78(0.73); C37(0.99)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C285(0.85); C78(0.87); C37(1.15)  LDD1610  [12]
 LDCM0407  CL2 HCT 116 C78(1.10)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C285(0.96); C78(0.99)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C285(0.92); C78(0.80); C37(0.88)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C285(0.72); C78(0.88); C37(0.94)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C285(0.99); C78(0.94); C37(0.93)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C78(1.02); C37(0.89)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C285(0.76); C78(0.92); C37(0.90)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C285(0.88); C78(1.00); C37(0.90)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C285(0.88); C78(0.93)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C285(0.89); C78(0.72); C37(0.94)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C285(0.91); C78(0.96)  LDD1621  [12]
 LDCM0418  CL3 HCT 116 C78(1.32)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C285(0.92); C78(0.83); C37(1.07)  LDD1623  [12]
 LDCM0420  CL31 HCT 116 C78(0.94)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C78(0.97)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C78(0.89)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C78(1.02)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C78(0.89)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C78(0.98)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C78(0.89)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C78(0.88)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C78(1.65)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C78(0.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C78(0.88)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C78(0.82)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C78(0.77)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C78(0.98)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C78(0.90)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C78(1.09)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C78(1.09)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C78(0.98)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C78(0.92)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C78(0.99)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C78(0.96)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C78(0.92)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C78(1.24)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C78(1.38)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C78(0.96)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C78(0.94)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C78(1.09)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C78(1.30)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C78(1.02)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C78(1.02)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C78(1.05)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C78(0.88)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C285(0.92); C78(1.01); C37(0.89)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C285(0.95); C78(1.04); C37(0.95)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C285(0.96); C78(0.99)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C285(0.92); C78(0.71); C37(0.88)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C285(1.14); C78(0.95)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C285(0.71); C78(0.95); C37(0.95)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C285(0.94); C78(0.97); C37(1.08)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C285(0.98); C78(0.91)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C285(0.88); C78(0.91); C37(0.88)  LDD1664  [12]
 LDCM0462  CL7 HCT 116 C78(1.34)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C285(0.73); C78(0.96); C37(1.00)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C285(0.84); C78(1.07); C37(0.89)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C78(1.07); C37(0.89)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C285(0.82); C78(0.99); C37(0.92)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C285(0.87); C78(1.02); C37(0.89)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C285(0.87); C78(0.70); C37(0.92)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C285(1.00); C78(0.81)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C285(0.66); C78(0.90); C37(0.99)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C285(0.94); C78(0.86); C37(1.09)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C78(1.18)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C285(0.91); C78(0.93)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C285(0.91); C78(0.86); C37(0.94)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C285(0.78); C78(0.98); C37(0.96)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C285(0.86); C78(0.93); C37(0.86)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C78(0.98); C37(0.85)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C285(0.75); C78(1.09); C37(0.85)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C285(0.67); C78(0.99); C37(0.88)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C285(0.71); C78(0.93)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C285(0.83); C78(0.81); C37(0.89)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C285(0.84); C78(0.92)  LDD1686  [12]
 LDCM0484  CL9 HCT 116 C78(1.13)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C285(0.57); C78(0.67); C37(0.71)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C285(0.73); C78(0.88); C37(1.01)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C285(0.88); C78(0.91)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C285(0.79); C78(0.85); C37(0.85)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C285(0.87); C78(1.04); C37(0.88)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C285(0.75); C78(0.86); C37(0.74)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C78(1.00); C37(0.77)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C285(0.88); C78(0.91); C37(0.84)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C285(0.97); C78(1.11); C37(0.86)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C285(0.94); C78(1.01)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C285(1.01); C78(0.91)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C285(1.66)  LDD1702  [2]
 LDCM0625  F8 Ramos C37(1.62); C285(1.82)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C37(1.05); C285(1.05)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C37(0.09); C285(2.60)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C37(0.63); C285(0.83)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C37(0.76); C285(1.00)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C37(0.68); C285(0.70)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C37(0.49); C285(0.75)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C37(0.93); C285(0.90)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C37(0.86); C285(1.02)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C37(0.85); C285(1.19)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C37(0.74); C285(0.71)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C37(1.08); C285(1.28)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C37(0.75); C285(0.83)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C37(0.72); C285(1.25)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C285(0.87); C78(0.87)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C37(0.87); C285(1.03)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C37(0.76); C285(0.83)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C78(0.89)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C37(0.90); C285(1.13)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C37(1.30); C285(1.57)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C37(0.71); C285(0.89)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C37(0.78); C285(0.82)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C37(1.09)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C37(0.99)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C37(1.12)  LDD0082  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C37(1.81)  LDD2135  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM7 (TRIM7) TRIM/RBCC family Q9C029

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578