Details of the Target

General Information of Target

Target ID LDTP08672
Target Name E3 ubiquitin-protein ligase HACE1 (HACE1)
Gene Name HACE1
Gene ID 57531
Synonyms
KIAA1320; E3 ubiquitin-protein ligase HACE1; EC 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYA
FGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEY
SADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTV
QCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGG
YGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVAT
TNGHKLLSLSSNYDAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPL
ELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLS
TGTRESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFV
CKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQP
DSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREW
FDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNI
YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEE
VPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYE
LELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSR
VPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH
CGSYGYTMA
Target Bioclass
Enzyme
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Uniprot ID
Q8IYU2
Ensemble ID
ENST00000262903.9
HGNC ID
HGNC:21033

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.T421S .
COLO679 SNV: p.P685S DBIA    Probe Info 
HCT15 SNV: p.V154D .
HT115 SNV: p.R332Q; p.R642W .
MCC26 SNV: p.P407L DBIA    Probe Info 
NCIH358 SNV: p.G902V DBIA    Probe Info 
SNU1 Insertion: p.L761FfsTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C481(1.03)  LDD0531  [1]
IA-alkyne
 Probe Info  		C508(0.00); C567(0.00)  LDD2241  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C481(1.03)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C481(0.98)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C481(0.72)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C481(0.69)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C481(0.81)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C481(0.93)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C481(0.83)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C481(0.80)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C481(0.89)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C481(0.83)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C481(0.71)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C481(0.94)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C481(1.00)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C481(0.90)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C481(0.74)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C481(0.83)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C481(0.99); C99(0.84)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C481(1.03); C99(0.90)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C481(0.97); C99(0.81)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C481(0.94); C99(0.71)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C481(1.08); C99(0.81)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C481(1.13); C99(0.82)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C481(1.00); C99(0.77)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C481(0.93)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C481(0.79); C99(0.76)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C481(0.87); C99(0.72)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C481(0.87); C99(0.86)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C481(0.84); C99(0.70)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C481(1.06); C99(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C481(0.90); C99(0.86)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C481(0.95); C99(0.76)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C481(0.94); C99(0.79)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C481(1.18)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C481(0.97)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C481(1.06)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C481(0.93)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C481(1.06)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C481(1.08)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C481(0.98)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C481(1.06)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C481(1.12)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C481(1.04)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C481(1.08)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C481(1.00)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C481(1.00)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C481(1.06)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C481(1.07)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C481(1.06)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C481(1.05)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C481(0.92)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C481(0.94)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C481(1.01)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C481(0.98)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C481(1.08)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C481(1.04)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C481(0.94)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C481(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C481(1.04)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C481(1.07)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C481(1.14)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C481(1.00)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C481(0.96)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C481(1.06)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C481(0.83)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C99(0.98)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C99(1.01)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C99(1.01)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C481(1.11)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C99(1.17)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C99(0.88)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C99(1.02)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C99(1.09)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C99(1.06)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C481(0.83); C99(1.29)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C481(0.92); C99(1.23)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C481(0.96); C99(1.00)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C481(1.04); C99(1.39)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C481(1.04); C99(1.43)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C481(1.18)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C481(1.09); C99(1.30)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C481(1.12); C99(1.33)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C481(1.11); C99(1.16)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C481(0.91); C99(1.28)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C481(1.19); C99(1.38)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C182(1.14); C205(1.24)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C182(1.30); C205(1.31)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C182(2.65); C205(2.00)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C182(1.09); C205(1.18)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C182(1.44); C205(1.35)  LDD0898  [1]
 LDCM0301  AC4 HCT 116 C481(1.06)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C182(0.89); C205(1.03)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C182(0.94); C205(1.03)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C182(0.94); C205(1.10)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C182(1.05); C205(1.07)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C182(1.00); C205(1.22)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C182(1.34); C205(1.41)  LDD0905  [1]
 LDCM0308  AC46 HCT 116 C481(0.76)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C481(0.93)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C481(0.71)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C481(0.30)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C481(1.11)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C481(0.48)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C481(0.39)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C481(0.47)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C481(0.54)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C481(0.66)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C481(0.99)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C481(0.56)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C99(1.05); C481(1.29)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C99(0.96); C481(1.23)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C99(0.82); C481(1.29)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C481(1.14)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C99(1.20); C481(1.26)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C99(1.04); C481(1.32)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C99(1.03); C481(1.22)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C99(1.09); C481(1.31)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C99(1.18); C481(1.37)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C99(1.01); C481(1.72)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C99(0.89); C481(1.45)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C99(1.23); C481(1.72)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C481(0.86)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C481(0.85)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C481(0.96)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C481(1.12)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C481(1.05)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C481(0.97)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C481(0.99)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C481(0.98)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C481(0.96)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C481(0.97)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C481(0.90)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C481(1.00)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C481(1.04)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C481(1.00)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C481(1.05)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C481(1.10)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C481(1.17)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C481(0.93); C182(1.13); C205(1.13)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C481(1.00); C182(1.41); C205(1.41)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C481(0.95); C182(0.82); C205(0.82)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C481(0.96); C182(0.97); C205(0.97)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C481(0.98); C182(1.90); C205(1.90)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C481(0.93); C182(1.12); C205(1.12)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C481(0.93); C182(1.03); C205(1.03)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C481(0.93); C182(0.92); C205(0.92)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C481(0.97); C182(1.08); C205(1.08)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C481(0.99); C182(1.22); C205(1.22)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C481(1.02); C182(1.01); C205(1.01)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C481(0.93); C182(1.29); C205(1.29)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C481(0.92); C182(1.35); C205(1.35)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C481(0.95); C182(1.66); C205(1.66)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C481(0.93); C182(0.65); C205(0.65)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C481(0.87)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C481(0.89)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C481(1.03)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C481(0.98)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C481(0.99)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C481(0.92)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C481(1.02)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C481(0.91)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C481(1.13)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C481(0.98)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C481(0.95)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C481(1.10)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C99(1.29)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C99(1.13)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C99(1.22)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C99(1.02)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C99(1.17)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C481(1.12)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C99(1.24)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C99(0.97)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C481(0.86); C99(0.93)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C481(0.95); C99(1.45)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C481(1.07); C99(1.15)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C481(1.03); C99(1.53)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C481(1.05); C99(1.27)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C182(1.19); C205(1.31)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C182(0.62); C205(1.11)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C182(0.95); C205(1.18)  LDD0987  [1]
 LDCM0390  CL12 HCT 116 C481(1.22)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C182(0.87); C205(1.12)  LDD0989  [1]
 LDCM0392  CL121 HCT 116 C481(1.02)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C481(0.66)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C481(0.79)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C481(0.59)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C481(0.96); C99(1.18)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C99(0.90); C481(1.09)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C99(0.91); C481(1.05)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C99(0.85); C481(1.16)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C481(1.08)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C481(0.96)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C481(1.09)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C481(1.06)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C99(0.93); C481(1.01)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C481(0.97); C99(0.98)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C99(1.08); C481(1.10)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C481(0.99)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C481(1.04); C99(1.18)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C481(1.08); C99(1.09)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C99(1.20); C481(1.33)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C99(0.80); C481(1.09)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C99(0.93); C481(1.13)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C481(1.19); C99(1.11)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C481(0.94); C99(0.95)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C481(1.00); C99(0.99)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C481(1.03); C99(0.81)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C481(1.13); C99(1.26)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C481(1.01)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C481(1.06); C99(1.06)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C481(1.00); C99(1.01)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C481(0.96)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C481(0.80)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C481(1.07)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C481(1.04)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C481(0.96)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C481(1.03)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C481(0.97)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C481(1.05)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C481(0.95)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C481(1.07)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C481(1.39)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C481(1.07)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C481(0.98)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C481(1.09)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C481(0.91)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C481(0.94)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C481(0.87)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C481(1.03)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C481(1.01)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C481(0.90)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C481(0.95)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C481(0.90)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C481(0.86)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C481(0.94)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C481(0.83)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C481(0.86)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C481(0.92)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C481(0.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C481(0.89)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C481(1.04)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C481(0.94)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C481(1.14)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C481(1.05)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C481(1.27)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C481(1.35)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C481(1.14)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C481(1.13)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C481(1.02)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C481(0.95)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C481(1.01)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C481(1.19)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C481(1.07)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C481(1.14)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C481(1.15)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C481(0.93)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C481(1.03)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C205(0.83)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C205(1.13)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C205(0.58)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C205(0.65)  LDD1070  [1]
 LDCM0473  CL8 HCT 116 C481(1.18)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C205(0.74)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C205(0.76)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C205(0.95)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C205(0.88)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C205(0.77)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C205(0.73)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C205(0.64)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C205(0.87)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C205(0.82)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C205(0.73)  LDD1081  [1]
 LDCM0484  CL9 HCT 116 C481(1.01)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C205(2.32)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C481(1.11)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C481(0.92)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C481(0.95)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C481(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C481(0.90)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C481(1.11)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C481(1.12)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C481(1.05)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C481(1.19)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C481(0.92); C508(1.07); C99(0.92); C567(0.95)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C481(0.98)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C481(1.30)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C99(1.02); C508(1.28)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C99(1.09); C508(1.53)  LDD1497  [3]
 LDCM0024  KB05 IGR37 C481(1.71)  LDD3314  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-4A (RAB4A) Rab family P20338
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840