Details of the Target

General Information of Target

Target ID LDTP07562
Target Name F-box/LRR-repeat protein 19 (FBXL19)
Gene Name FBXL19
Gene ID 54620
Synonyms
FBL19; F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK
KFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI
VHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW
KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK
VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP
SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS
SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS
DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV
VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR
WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS
ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR
SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
Target Bioclass
Enzyme
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization. Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Mediates also ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis. Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination.
Uniprot ID
Q6PCT2
Ensemble ID
ENST00000562319.7
HGNC ID
HGNC:25300
ChEMBL ID
CHEMBL5169165

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C50(2.28); C56(2.28); C53(2.28); C142(1.14)  LDD0080  [1]
IA-alkyne
 Probe Info  		C644(0.00); C72(0.00); C148(0.00)  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C314(8.95)  LDD0372  [5]
 LDCM0214  AC1 HCT 116 C644(1.17)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C637(1.19)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C637(0.57)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C637(0.65)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C637(0.56)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C637(0.56)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C637(0.58)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C637(0.56)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C637(0.55)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C637(0.28)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C637(0.68)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C637(0.54)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C637(1.70)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C637(0.57)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C637(0.55)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C637(0.40)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C670(1.28)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C670(0.70)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C670(0.80)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C670(1.06)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C670(1.14)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C670(0.99)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C670(1.09)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C637(1.40)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C670(0.96)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C670(0.85)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C670(0.87)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C670(0.84)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C670(1.01)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C670(1.21)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C670(1.01)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C670(0.98)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C637(1.07)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C670(0.63)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C670(0.68)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C670(0.76)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C670(0.53)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C670(0.63)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C670(0.61)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C670(0.62)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C637(1.00)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C670(0.82)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C670(0.84)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C670(0.54)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C670(0.57)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C670(0.86)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C670(0.85)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C670(0.73)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C670(0.83)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C644(0.96); C637(0.99); C670(1.21)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C670(0.64); C637(0.65); C644(1.11)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C670(0.84); C637(0.91); C644(1.21)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C644(1.13)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C637(0.94); C644(0.99); C670(1.09)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C637(0.84); C644(0.96); C670(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C637(0.90); C644(0.92); C670(1.22)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C637(0.83); C644(1.05); C670(1.06)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C637(0.96); C644(1.07); C670(1.41)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C670(0.88)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C670(0.70)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C670(0.81)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C670(0.86)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C670(0.80)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C644(1.16)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C670(0.73)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C670(0.63)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C670(0.64)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C670(0.63)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C670(0.69)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C644(0.99); C670(1.17)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C644(1.04); C670(1.20)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C670(0.96); C644(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C644(1.01); C670(1.19)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C644(0.99); C670(1.35)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C644(1.15)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C670(1.13); C644(1.20)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C670(0.96); C644(1.00)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C670(0.98); C644(0.99)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C670(0.98); C644(1.05)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C644(1.07); C670(1.08)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C644(1.00); C670(1.30)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C637(1.09); C670(1.20)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C637(1.14); C670(1.20)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C670(1.04); C637(1.11)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C670(0.92); C637(1.06)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C644(1.30)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C670(1.01); C637(1.08)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C637(1.12); C670(1.43)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C637(1.11); C670(1.28)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C670(0.89); C637(1.11)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C637(0.96); C670(1.14)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C670(0.92); C637(1.16)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C670(1.10); C637(1.34)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C670(0.80); C637(0.97); C644(1.14)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C670(0.69); C637(0.92); C644(1.15)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C670(0.71); C637(0.87); C644(1.12)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C637(1.36)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C670(0.81); C637(0.96); C644(1.01)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C670(0.58); C637(0.87); C644(1.18)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C670(0.83); C637(0.94); C644(1.16)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C670(0.66); C637(0.82); C644(1.16)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C670(0.73); C637(0.88); C644(1.09)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C670(0.54); C637(1.12); C644(1.18)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C670(0.54); C637(1.06); C644(1.29)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C670(0.55); C637(0.96); C644(1.11)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C670(0.89); C637(1.00)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C670(0.92); C637(0.98)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C637(1.33)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C670(0.82); C637(0.96)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C670(0.80); C637(1.12)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C670(0.94); C637(1.02)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C670(0.83); C637(1.17)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C670(0.80); C637(1.22)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C670(1.05); C637(1.21)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C670(0.92); C637(0.98)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C670(0.76); C637(0.96)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C637(1.00); C670(1.03)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C670(1.09); C637(1.19)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C637(1.39)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C670(1.05); C637(1.08)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C637(1.03); C670(1.05)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C670(1.33); C637(1.39)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C670(0.78)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C670(0.73)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C670(0.80)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C670(0.85)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C670(1.04)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C670(0.71)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C670(0.81)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C670(1.34)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C670(0.79)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C670(0.68)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C670(0.90)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C670(0.70)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C670(0.88)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C670(0.84)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C670(0.92)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C637(0.59)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C637(0.64)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C637(1.16)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C637(1.33)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C637(1.09)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C50(1.40); C53(1.40); C56(1.40); C77(1.44)  LDD2171  [1]
 LDCM0367  CL1 HEK-293T C442(1.59); C444(0.83); C670(1.38)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C442(2.38); C444(0.63); C670(2.99)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C644(1.07)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C637(1.26)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C637(1.37)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C637(1.65)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C637(1.28)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C637(0.78); C670(0.88); C644(1.03)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C670(0.71); C637(0.74); C644(1.15)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C670(0.74); C637(0.89); C644(1.10)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C670(0.75); C637(0.77); C644(1.04)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C670(0.75); C637(0.89); C644(1.35)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C442(2.15); C444(0.56); C670(2.13)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C670(0.67); C637(0.74); C644(1.24)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C637(0.86); C670(1.02); C644(1.04)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C670(0.82)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C670(0.70)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C670(0.59)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C670(0.89)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C670(0.70)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C670(1.03); C644(1.09)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C670(0.87); C644(1.11)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C670(1.14); C644(1.17)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C442(1.11); C444(0.59); C670(1.67)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C644(1.02); C670(1.15)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C637(0.74); C670(0.85)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C670(0.87); C637(1.11)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C670(1.00); C637(1.11)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C670(0.95); C637(1.23)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C670(0.83); C644(1.06); C637(1.19)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C670(0.74); C637(0.94); C644(1.06)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C670(0.80); C637(0.92); C644(1.12)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C637(0.91); C670(0.95); C644(1.08)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C442(1.10); C444(0.65); C670(2.28)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C442(1.28); C444(0.65); C670(1.89)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C442(1.56); C444(0.58); C670(1.71)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C637(0.91)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C637(0.87)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C637(0.73)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C637(0.84)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C442(1.23); C444(0.58); C670(1.59)  LDD1005  [1]
 LDCM0408  CL20 HCT 116 C637(0.89)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C637(0.85)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C637(1.05)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C637(0.79)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C637(0.96)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C637(0.94)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C637(0.95)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C637(0.83)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C637(0.81)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C637(0.84)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C442(1.57); C444(0.61); C670(2.37)  LDD1016  [1]
 LDCM0419  CL30 HCT 116 C637(0.91)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C644(1.06)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C644(1.09)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C644(1.10)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C644(1.09)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C644(1.09)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C644(0.96)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C644(0.95)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C644(1.10)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C442(1.23); C444(0.67); C670(2.05)  LDD1027  [1]
 LDCM0430  CL40 HCT 116 C644(0.93)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C644(1.09)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C644(0.85)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C644(1.24)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C644(0.97)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C644(0.92)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C637(0.99); C644(0.80)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C637(0.87); C644(0.75)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C637(0.97); C644(0.64)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C637(0.92); C644(0.84)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C442(1.43); C444(0.55); C670(1.57)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C637(0.93); C644(0.79)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C637(0.97); C644(0.95)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C637(1.04); C644(0.79)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C637(0.97); C644(0.82)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C637(0.94); C644(0.80)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C637(1.02); C644(0.78)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C637(0.94); C644(0.79)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C637(0.88); C644(0.83)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C637(0.95); C644(0.71)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C637(1.26); C644(0.96)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C442(1.35); C444(0.80); C670(1.75)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C637(0.97); C644(0.73)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C637(1.00)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C637(0.96)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C637(0.85)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C637(0.82)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C637(1.08)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C637(0.88)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C637(0.91)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C637(0.91)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C637(0.87)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C442(1.54); C444(0.51); C670(2.08)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C637(0.98)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C637(0.99)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C637(1.01)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C637(0.87)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C637(0.90)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C442(1.19); C444(0.87); C670(0.84)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C442(1.53); C444(0.93); C670(0.78)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C442(1.64); C444(0.69); C670(0.82)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C442(1.89); C444(0.73); C670(0.82)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C444(1.12)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C442(1.22); C444(0.71); C670(0.91)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C442(1.19); C444(0.89); C670(0.93)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C442(0.77); C444(0.94); C670(1.02)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C442(0.96); C444(1.03); C670(1.26)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C442(1.49); C444(0.71); C670(0.84)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C442(1.48); C444(0.68); C670(1.10)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C442(1.99); C444(0.56); C670(0.80)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C442(1.59); C444(0.72); C670(1.05)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C442(1.22); C444(0.74); C670(0.89)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C442(1.70); C444(0.79); C670(1.10)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C444(1.16)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C442(1.46); C444(0.87); C670(0.99)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C644(0.97)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C644(0.98)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C644(0.90)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C644(0.93)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C644(1.01)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C644(1.02)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C644(0.98)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C644(1.03)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C644(1.10)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C246(1.15)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C637(0.86)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C644(0.61)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C50(2.28); C56(2.28); C53(2.28); C142(1.14)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C50(2.09); C56(2.09); C53(2.09); C142(1.19)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C50(1.29); C56(1.29); C53(1.29); C142(1.07)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C50(1.40); C53(1.40); C56(1.40); C77(1.44)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Protein reprimo (RPRM) Reprimo family Q9NS64
Cytoplasmic protein NCK2 (NCK2) . O43639
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Vinexin (SORBS3) . O60504

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402