Details of the Target

General Information of Target

Target ID LDTP07536
Target Name WD repeat-containing protein 73 (WDR73)
Gene Name WDR73
Gene ID 84942
Synonyms
WD repeat-containing protein 73
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPGDDWLVESLRLYQDFYAFDLSGATRVLEWIDDKGVFVAGYESLKKNEILHLKLPLRL
SVKENKGLFPERDFKVRHGGFSDRSIFDLKHVPHTRLLVTSGLPGCYLQVWQVAEDSDVI
KAVSTIAVHEKEESLWPRVAVFSTLAPGVLHGARLRSLQVVDLESRKTTYTSDVSDSEEL
SSLQVLDADTFAFCCASGRLGLVDTRQKWAPLENRSPGPGSGGERWCAEVGSWGQGPGPS
IASLGSDGRLCLLDPRDLCHPVSSVQCPVSVPSPDPELLRVTWAPGLKNCLAISGFDGTV
QVYDATSWDGTRSQDGTRSQVEPLFTHRGHIFLDGNGMDPAPLVTTHTWHPCRPRTLLSA
TNDASLHVWDWVDLCAPR
Target Bioclass
Other
Family
WD repeat WDR73 family
Subcellular location
Cytoplasm, cytosol
Function May play a role in the regulation of microtubule organization and dynamics.
Uniprot ID
Q6P4I2
Ensemble ID
ENST00000434634.7
HGNC ID
HGNC:25928

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C227(0.96); C251(0.97)  LDD0531  [1]
CY4
 Probe Info  		N.A.  LDD0247  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C375(0.00); C251(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C251(0.00); C106(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C227(0.00); C251(0.00); C106(0.00); C375(0.00)  LDD0037  [3]
IPM
 Probe Info  		C259(0.00); C251(0.00); C106(0.00)  LDD2156  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C227(0.96); C251(0.97)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C352(0.86)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C106(0.87); C227(1.39)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C106(1.21); C227(1.42)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C106(1.11); C227(1.10)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C106(1.26); C227(1.14)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C106(1.37); C227(1.52)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C106(1.49); C227(1.66)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C106(1.03); C227(1.24)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C106(0.80); C227(1.26)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C106(0.88); C227(1.62)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C106(1.37); C227(1.69)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C352(1.11)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C106(0.79); C227(1.43)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C106(1.00); C227(1.49)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C106(1.18); C227(1.43)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C106(0.94); C227(0.71)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C106(1.06); C227(0.99)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C106(1.24); C227(1.25)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C106(1.34); C227(1.11)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C106(1.09); C227(1.13)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C106(1.20); C227(1.09)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C106(0.96); C227(1.11)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C352(0.93)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C106(1.09); C227(1.30)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C106(0.92); C227(0.90)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C106(1.02); C227(1.11)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C106(1.10); C227(1.22)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C106(1.16); C227(1.04)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C106(1.15); C227(0.93)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C106(1.31); C227(1.13)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C106(1.18); C227(0.98)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C106(1.56); C352(0.86)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C106(1.15); C352(1.11)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C106(1.31); C352(1.16)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C106(0.96); C352(1.18)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C106(1.19); C352(1.13)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C106(1.37); C352(1.18)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C106(1.49); C352(1.36)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C106(1.44); C352(1.19)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C106(1.12); C352(1.00)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C106(1.12); C352(0.99)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C106(1.42); C352(1.13)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C106(1.24); C352(1.52)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C352(0.96)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C106(1.30); C352(1.18)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C106(1.31); C352(1.13)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C106(1.12); C352(1.27)  LDD0579  [1]
 LDCM0263  AC143 HEK-293T C251(1.00); C259(1.13); C267(1.13); C352(1.44)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C251(1.03); C259(1.08); C267(1.08); C352(1.26)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C251(1.12); C259(1.30); C267(1.30); C352(1.30)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C251(1.16); C259(1.07); C267(1.07); C352(1.36)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C251(0.93); C259(1.12); C267(1.12); C352(1.64)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C251(1.11); C259(0.93); C267(0.93); C352(1.54)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C251(1.11); C259(0.98); C267(0.98); C352(0.99)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C352(1.01)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C251(0.99); C259(1.12); C267(1.12); C352(1.04)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C251(0.99); C259(1.06); C267(1.06); C352(1.18)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C251(1.01); C259(0.96); C267(0.96); C352(1.17)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C251(1.01); C259(1.04); C267(1.04); C352(1.15)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C251(0.97); C259(0.99); C267(0.99); C352(0.99)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C251(1.07); C259(0.95); C267(0.95); C352(1.18)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C251(1.11); C259(0.97); C267(0.97); C352(1.46)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C251(0.92); C259(0.92); C267(0.92); C352(1.91)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C352(1.16)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C352(0.94)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C352(1.17)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C251(1.06); C227(1.26)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C352(1.08)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C352(1.01)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C352(0.91)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C352(1.03)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C352(1.23)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C251(0.85); C259(1.27); C267(1.27); C352(0.86)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C251(0.92); C259(1.56); C267(1.56); C352(0.77)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C251(1.07); C259(1.56); C267(1.56); C352(0.76)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C251(0.86); C259(1.43); C267(1.43); C352(0.66)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C251(0.95); C259(1.33); C267(1.33); C352(0.78)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C251(0.93); C227(1.04)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C251(0.87); C259(1.43); C267(1.43); C352(0.75)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C251(0.86); C259(1.47); C267(1.47); C352(0.83)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C251(0.84); C259(1.54); C267(1.54); C352(0.77)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C251(1.06); C259(1.20); C267(1.20); C352(0.76)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C251(0.82); C259(1.47); C267(1.47); C352(0.78)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C251(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C251(0.97)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C251(1.05)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C251(1.02)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C251(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C251(1.01); C227(1.03)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C251(1.04)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C251(1.11)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C251(1.10)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C251(1.11)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C251(1.15)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C251(1.20)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C352(0.97)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C352(1.05)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C352(1.14)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C352(1.55)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C227(0.94); C251(1.12)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C352(1.44)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C352(0.63)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C352(1.47)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C352(1.47)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C352(1.45)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C352(1.58)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C352(1.66)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C251(0.92); C259(0.87); C267(0.87); C352(0.94)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C251(0.89); C259(0.70); C267(0.70); C352(0.82)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C251(0.89); C259(0.90); C267(0.90); C352(0.97)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C352(1.16)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C251(1.01); C259(1.20); C267(1.20); C352(0.89)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C251(1.03); C259(0.93); C267(0.93); C352(0.69)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C251(1.10); C259(1.02); C267(1.02); C352(0.74)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C251(0.93); C259(0.91); C267(0.91); C352(0.68)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C251(1.03); C259(0.76); C267(0.76); C352(0.80)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C251(1.00); C259(0.82); C267(0.82); C352(0.61)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C251(1.03); C259(0.86); C267(0.86); C352(0.87)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C251(1.01); C259(0.92); C267(0.92); C352(0.79)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C227(0.89)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C227(0.81)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C352(0.95)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C227(0.57)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C227(0.70)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C227(0.77)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C227(0.73)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C227(0.63)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C227(0.58)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C227(0.81)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C227(0.63)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C227(0.69)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C227(0.71)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C352(1.03)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C227(0.70)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C227(0.90)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C227(0.87)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C251(0.99); C259(1.27); C267(1.27); C352(1.22)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C251(1.28); C259(1.41); C267(1.41); C352(1.12)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C251(1.24); C259(1.13); C267(1.13); C352(1.12)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C251(1.24); C259(1.02); C267(1.02); C352(1.13)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C251(1.13); C259(1.13); C267(1.13); C352(1.18)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C251(1.29); C259(1.14); C267(1.14); C352(1.07)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C251(1.32); C259(1.35); C267(1.35); C352(1.24)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C251(1.17); C259(1.18); C267(1.18); C352(1.17)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C251(1.10); C259(1.23); C267(1.23); C352(1.05)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C251(0.88); C259(1.25); C267(1.25); C352(1.00)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C251(0.98); C259(1.79); C267(1.79); C352(1.08)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C251(1.00); C259(1.06); C267(1.06); C352(1.12)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C251(0.96); C259(1.10); C267(1.10); C352(1.07)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C251(0.87); C259(1.31); C267(1.31); C352(1.15)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C251(1.05); C259(1.54); C267(1.54); C352(1.09)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C106(0.94); C227(1.33)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C106(0.77); C227(1.63)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C352(0.84)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C352(0.97)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C352(1.05)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C259(1.18); C267(1.18)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C259(1.29); C267(1.29)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C251(1.14); C227(1.28)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C352(0.87)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C352(0.78)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C352(0.87)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C352(1.17)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C352(1.13)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C352(1.29)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C352(1.23)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C352(1.09)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C352(1.30)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C259(1.00); C267(1.00)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C352(1.24)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C352(1.03)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C251(0.93); C259(1.05); C267(1.05); C352(0.73)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C251(0.93); C259(1.22); C267(1.22); C352(0.77)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C251(1.21); C259(1.51); C267(1.51); C352(0.60)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C251(0.95); C259(1.34); C267(1.34); C352(0.77)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C251(1.05); C259(1.53); C267(1.53); C352(0.71)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C251(1.06)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C251(1.03)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C251(1.04)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C259(0.89); C267(0.89)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C251(1.10)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C352(1.26)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C352(1.34)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C352(1.25)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C352(1.43)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C251(0.87); C259(0.85); C267(0.85); C352(0.80)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C251(0.98); C259(0.77); C267(0.77); C352(1.01)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C251(1.07); C259(0.78); C267(0.78); C352(1.05)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C251(0.95); C259(0.98); C267(0.98); C352(0.93)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C259(0.82); C267(0.82)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C259(0.94); C267(0.94)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C259(1.26); C267(1.26)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C259(0.97); C267(0.97); C352(0.94)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C259(1.28); C267(1.28); C352(0.90)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C259(0.92); C267(0.92); C352(0.81)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C259(0.98); C267(0.98); C352(0.96)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C259(0.96); C267(0.96)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C259(1.12); C267(1.12); C352(0.90)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C259(1.24); C267(1.24); C352(0.82)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C259(1.56); C267(1.56); C352(0.80)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C259(1.34); C267(1.34); C352(0.83)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C259(1.27); C267(1.27); C352(0.86)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C259(1.26); C267(1.26); C352(0.86)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C259(1.28); C267(1.28); C352(1.04)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C259(1.25); C267(1.25); C352(0.88)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C259(1.08); C267(1.08); C352(0.89)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C259(1.04); C267(1.04); C352(0.88)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C259(1.05); C267(1.05)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C259(1.66); C267(1.66); C352(0.90)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C251(0.87)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C251(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C251(1.22)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C251(1.18)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C251(1.10)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C251(1.06)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C251(1.10)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C251(0.98)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C259(0.92); C267(0.92)  LDD1027  [1]
 LDCM0430  CL40 HCT 116 C251(0.87)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C251(0.93)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C251(0.93)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C251(1.16)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C251(1.04)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C251(1.11)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C259(1.13); C267(1.13); C352(0.75)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C259(1.05); C267(1.05); C352(0.77)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C259(0.96); C267(0.96); C352(0.86)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C259(1.11); C267(1.11); C352(0.86)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C259(1.24); C267(1.24)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C259(1.10); C267(1.10); C352(0.97)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C259(1.09); C267(1.09); C352(1.07)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C259(0.93); C267(0.93); C352(1.08)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C259(0.84); C267(0.84); C352(1.00)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C259(0.99); C267(0.99); C352(0.90)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C259(1.07); C267(1.07); C352(0.93)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C259(0.81); C267(0.81); C352(1.03)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C259(1.18); C267(1.18); C352(0.89)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C259(1.04); C267(1.04); C352(1.05)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C259(1.09); C267(1.09); C352(0.79)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C259(1.15); C267(1.15)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C259(1.07); C267(1.07); C352(1.07)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C106(0.96); C251(1.09)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C106(0.95); C251(1.01)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C106(1.12); C251(0.96)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C106(1.28); C251(0.97)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C106(1.00); C251(0.92)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C106(1.56); C251(1.10)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C106(1.31); C251(0.93)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C106(1.30); C251(0.93)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C106(1.22); C251(0.92)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C259(1.09); C267(1.09)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C106(1.08); C251(0.95)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C106(1.21); C251(0.94)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C106(1.06); C251(1.09)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C106(1.57); C251(1.08)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C106(1.32); C251(0.86)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C259(0.81); C267(0.81); C352(0.85)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C259(0.91); C267(0.91); C352(0.71)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C259(1.24); C267(1.24); C352(0.62)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C259(1.29); C267(1.29); C352(0.55)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C259(0.77); C267(0.88)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C259(1.17); C267(1.17); C352(0.72)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C259(1.27); C267(1.27); C352(0.57)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C259(0.86); C267(0.86); C352(0.84)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C259(1.16); C267(1.16); C352(0.89)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C259(1.24); C267(1.24); C352(0.58)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C259(0.94); C267(0.94); C352(0.63)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C259(1.53); C267(1.53); C352(0.46)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C259(1.05); C267(1.05); C352(0.57)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C259(1.19); C267(1.19); C352(0.66)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C259(0.83); C267(0.83); C352(0.63)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C259(1.64); C267(0.90)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C259(1.45); C267(1.45); C352(0.71)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C227(0.92); C251(0.99)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C227(1.04); C251(0.88)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C227(1.15); C251(0.85)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C227(1.00); C251(1.00)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C227(1.10); C251(0.78)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C227(1.07); C251(1.18)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C227(1.01); C251(1.15)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C227(1.13); C251(0.96)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C227(1.25); C251(0.97)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C106(1.38); C259(1.14)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C106(1.01); C251(1.09)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C251(0.83)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C375(0.98); C106(0.96); C251(1.00); C259(0.88)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C375(0.90); C106(0.95); C251(1.05); C259(1.01)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C251(1.35)  LDD3310  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C259(0.26)  LDD2206  [10]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.