Details of the Target

General Information of Target

Target ID LDTP07501
Target Name Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
Gene Name MAST2
Gene ID 23139
Synonyms
KIAA0807; MAST205; Microtubule-associated serine/threonine-protein kinase 2; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQD
VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVH
SSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTS
STSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYG
TNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSL
SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHH
QVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIII
ARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLS
SCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAM
KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATL
LKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG
LMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV
GCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVK
QHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIR
QFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGS
PEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWV
LTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISD
LAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQS
SNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHV
EDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGP
ARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGES
GPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH
GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHL
SPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKE
LPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIRE
VDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVP
SLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQ
HLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGL
ANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPA
LSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT
Target Bioclass
Enzyme
Family
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Subcellular location
Cytoplasm, cytoskeleton
Function
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
Uniprot ID
Q6P0Q8
Ensemble ID
ENST00000361297.7
HGNC ID
HGNC:19035
ChEMBL ID
CHEMBL2417355

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P306S .
COLO678 SNV: p.L1031V .
G402 SNV: p.S404Ter .
HT1197 Deletion: p.V926AfsTer18; p.R928PfsTer12 .
JURKAT SNV: p.Q255Ter .
KMS11 SNV: p.P1190S .
KMS12BM SNV: p.C930R .
KMS27 SNV: p.I673L .
KYSE150 SNV: p.K1197E .
LS180 Deletion: p.F726LfsTer12 .
MDAMB453 SNV: p.K174N .
MDST8 SNV: p.P1190S .
MFE296 Substitution: p.L156E .
MFE319 SNV: p.P150S .
NCIH1048 SNV: p.R24W .
PF382 SNV: p.S356G .
SAOS2 SNV: p.L1411R .
SNU1196 Deletion: p.P344QfsTer12 .
SUDHL4 SNV: p.D1093H .
TOV21G SNV: p.S1007Ter .
UACC257 SNV: p.G1310S .
VMRCRCW SNV: p.S1225T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C930(10.95)  LDD0209  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C845(0.62)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C845(1.39)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C845(1.24)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C845(1.33)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C845(0.92)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C845(1.18)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C845(1.04)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C845(1.56)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C845(1.24)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C845(1.32)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C845(1.19)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C845(1.00)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C845(1.35)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C845(1.39)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C845(1.13)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C845(1.15)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C845(1.03)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C845(1.44)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C845(1.48)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C845(1.67)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C845(1.46)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C845(1.29)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C845(1.11)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C845(1.06)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C845(1.20)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C845(1.06)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C845(1.32)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C845(1.06)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C845(1.14)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C845(1.34)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C845(1.50)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C845(1.34)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C845(1.11)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C845(0.97)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C845(1.09)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C845(1.07)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C845(0.93)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C845(1.00)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C845(1.39)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C845(0.95)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C845(1.09)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C845(0.99)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C845(1.15)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C845(1.17)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C845(1.14)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C845(1.17)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C845(1.15)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C845(1.07)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C845(0.94)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C845(1.05)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C845(1.01)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C845(1.41)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C845(1.26)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C845(1.24)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C845(1.17)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C845(1.30)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C845(1.26)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C845(1.23)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C845(1.32)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C845(1.70)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C845(1.37)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C845(1.41)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C845(1.54)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C845(1.59)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C845(0.80)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C845(0.66)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C845(0.96)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C845(0.65)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C845(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C845(1.16)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C845(1.07)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C845(0.83)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C845(0.89)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C845(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C845(1.14)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C845(1.09)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C845(1.23)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C845(0.99)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C845(0.84)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C845(1.39)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C845(1.28)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C845(1.47)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C845(1.22)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C845(1.34)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C845(1.07)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C845(1.18)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C845(1.04)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C845(1.28)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C845(1.13)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C845(0.65)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C845(1.48)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C845(0.80)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C845(1.05)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C845(1.05)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C845(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C845(1.33)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C845(1.39)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C845(1.44)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C845(1.61)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C845(1.60)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C845(0.58)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C845(2.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C845(1.08)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C845(1.31)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C845(1.83)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C845(1.97)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C845(1.52)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C845(1.93)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C845(1.49)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C845(0.88)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C845(1.06)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C845(1.29)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C845(0.99)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C845(0.82)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C845(1.12)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C845(0.99)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C845(1.39)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C845(0.81)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C845(0.74)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C845(0.92)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C845(1.20)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C845(1.32)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C845(1.07)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C845(1.09)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C845(0.95)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C845(1.15)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C845(1.69)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C845(1.55)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C845(1.78)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C845(1.21)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C845(1.03)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C845(1.16)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C845(1.18)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C845(1.55)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C845(1.33)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C845(1.27)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C845(1.62)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C845(2.11)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C845(2.00)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C845(1.37)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C845(1.54)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C845(1.28)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C845(1.47)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C845(1.61)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C845(1.10)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C845(1.94)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C845(2.02)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C845(1.36)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C845(1.59)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C845(1.56)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C845(1.44)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C845(1.61)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C845(1.49)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C845(1.10)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C845(1.09)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C845(1.05)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C845(1.77)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C845(1.28)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C845(2.83)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C845(0.76)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C845(1.23)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C845(1.17)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C845(1.28)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C845(1.18)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C845(0.75)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C845(0.99)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C845(1.17)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C845(1.20)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C845(1.22)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C845(1.99)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C845(1.31)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C845(1.06)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C845(1.08)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C845(1.43)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C845(1.35)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C845(1.17)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C845(1.11)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C845(1.85)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C845(1.10)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C845(1.58)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C845(1.06)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C845(1.17)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C845(1.39)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C845(1.32)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C845(1.73)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C845(1.33)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C845(0.74)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C845(1.04)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C845(0.96)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C845(1.07)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C845(1.13)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C845(1.39)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C845(1.30)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C845(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C845(0.67)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C845(0.64)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C845(0.65)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C845(0.96)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C845(0.67)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C845(0.88)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C845(0.85)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C845(0.65)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C845(0.75)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C845(0.77)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C845(0.68)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C845(0.82)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C845(0.74)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C845(0.88)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C845(1.31)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C845(0.77)  LDD0736  [2]
 LDCM0421  CL32 HCT 116 C845(1.78)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C845(0.99)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C845(1.25)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C845(1.48)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C845(1.10)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C845(1.15)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C845(1.33)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C845(1.41)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C845(1.22)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C845(1.81)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C845(1.34)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C845(1.44)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C845(0.83)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C845(1.29)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C845(1.58)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C845(1.68)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C845(1.20)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C845(1.04)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C845(1.38)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C845(1.26)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C845(2.26)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C845(1.69)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C845(1.54)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C845(1.21)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C845(1.00)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C845(1.15)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C845(1.26)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C845(1.10)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C845(1.08)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C845(1.07)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C845(1.21)  LDD0769  [2]
 LDCM0453  CL61 PaTu 8988t C845(0.88)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C845(1.03)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C845(1.10)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C845(1.13)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C845(0.90)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C845(0.90)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C845(0.98)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C845(1.13)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C845(1.19)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C845(1.70)  LDD1060  [2]
 LDCM0463  CL70 PaTu 8988t C845(1.04)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C845(1.07)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C845(1.07)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C845(1.58)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C845(1.13)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C845(1.44)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C845(1.44)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C845(1.06)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C845(2.21)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C845(1.92)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C845(1.33)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C845(1.12)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C845(1.05)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C845(2.01)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C845(1.62)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C845(1.63)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C845(1.04)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C845(2.11)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C845(1.50)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C845(1.48)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C845(1.61)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C845(1.61)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C845(1.10)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C845(0.76)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C845(0.68)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C845(0.72)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C845(0.88)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C845(1.06)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C845(0.80)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C845(0.86)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C845(0.94)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C429(0.87)  LDD1698  [3]
 LDCM0468  Fragment33 PaTu 8988t C845(1.16)  LDD1347  [2]
 LDCM0427  Fragment51 HCT 116 C845(1.76)  LDD0744  [2]
 LDCM0022  KB02 Daoy C744(1.93)  LDD2314  [4]
 LDCM0023  KB03 Jurkat C930(10.95)  LDD0209  [1]
 LDCM0024  KB05 OCUG-1 C744(3.34)  LDD3373  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/hydrogen exchanger 3 (SLC9A3) Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family P48764
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cadherin-related family member 2 (CDHR2) . Q9BYE9

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840