Details of the Target

General Information of Target

Target ID LDTP07226
Target Name Rho guanine nucleotide exchange factor 16 (ARHGEF16)
Gene Name ARHGEF16
Gene ID 27237
Synonyms
EPHEXIN4; NBR; Rho guanine nucleotide exchange factor 16; Ephexin-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRVRDDAAFQPQVPAPPQP
RPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARR
DPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQAL
AEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQERGLNTSQESDDDILDESSS
PEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQ
HSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDIS
DILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFL
ILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYT
LHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKK
KSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLL
SSDSASDRARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQ
QEDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLRVETDV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
Uniprot ID
Q5VV41
Ensemble ID
ENST00000378371.6
HGNC ID
HGNC:15515

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 Substitution: p.P267L .
A2780 SNV: p.A396T .
A431 SNV: p.E183Ter DBIA    Probe Info 
A498 SNV: p.S77R DBIA    Probe Info 
ABC1 SNV: p.W69R; p.A367T .
HEC1 Substitution: p.P267L .
L428 SNV: p.G223D; p.G677R .
MEWO Deletion: p.S606MfsTer212 .
MOLT4 SNV: p.P494S .
MV411 SNV: p.G143D .
SAOS2 SNV: p.K163N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y216(37.49)  LDD3495  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C438(0.79); C465(0.87)  LDD0531  [3]
IA-alkyne
 Probe Info  		C438(0.00); C411(0.00); C465(0.00)  LDD0162  [4]
NAIA_5
 Probe Info  		C438(0.00); C465(0.00); C411(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C438(0.79); C465(0.87)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C465(0.95)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C465(1.43)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C465(1.23)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C465(1.16)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C465(1.35)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C465(0.92)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C465(1.07)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C465(1.07)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C465(1.24)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C465(1.48)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C465(1.26)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C465(0.89)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C465(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C465(1.04)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C465(1.14)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C465(1.03)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C465(1.10)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C465(1.14)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C438(0.97)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C438(1.15)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C438(0.97)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C438(1.13)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C438(1.17)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C438(1.08)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C438(1.05)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C438(1.01)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C438(1.13)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C438(1.15)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C438(1.01)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C438(1.07)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C465(1.45)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C438(1.08)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C438(1.03)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C438(1.18)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C465(1.06)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C465(0.66)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C465(0.64)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C465(0.70)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C465(0.83); C438(0.90)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C465(0.76)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C465(0.74)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C465(0.85)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C465(0.76)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C465(0.88)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C465(0.92); C438(1.06)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C465(0.82); C438(1.15)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C465(0.72); C438(1.31)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C465(0.86); C438(1.16)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C465(0.96); C438(1.14)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C438(0.90); C465(1.13)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C465(0.92); C438(1.15)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C465(0.73); C438(1.23)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C465(0.83); C438(1.29)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C465(0.83); C438(1.36)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C465(0.71); C438(1.23)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C465(1.28)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C465(1.18)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C465(1.22)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C465(1.08)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C465(1.04)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C465(0.74); C438(0.79)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C465(0.88)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C465(1.13)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C465(0.96)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C465(1.00)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C465(0.99)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C465(0.89)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C465(1.08)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C465(1.25)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C465(1.09)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C465(0.97)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C465(0.82); C438(0.84)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C465(0.90)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C465(1.29)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C465(1.01)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C465(0.94)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C465(0.80)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C465(0.94)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C465(1.10)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C465(0.58)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C465(0.56)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C465(0.48)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C465(1.10)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C465(0.56)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C465(0.52)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C465(0.47)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C465(0.53)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C465(0.54)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C465(0.61)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C465(0.71)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C465(0.58)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C465(0.87)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C465(0.86)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C465(1.33)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C465(0.87)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C465(1.03)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C465(0.83)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C465(1.00)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C465(1.03)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C465(1.07)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C465(0.96)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C465(0.90)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C465(0.98)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C465(1.06)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C465(0.97)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C465(0.91)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C465(1.18)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C465(1.07)  LDD0665  [3]
 LDCM0248  AKOS034007472 HCT 116 C465(1.46)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C465(1.24)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C465(1.45)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C438(1.33); C438(0.76)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C438(1.19)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C438(0.71)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C465(0.82); C438(0.87)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C465(1.07)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C465(1.04)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C465(1.60)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C465(1.76)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C465(0.60)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C465(0.56)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C465(0.64)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C465(0.56)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C465(0.65)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C438(0.71)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C465(0.62)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C465(0.67)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C465(1.02); C438(1.05)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C465(0.80); C438(1.11)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C465(0.84); C438(1.03)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C465(0.83); C438(1.09)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C465(0.92); C438(1.30)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C465(1.01)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C465(1.08)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C465(0.99)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C438(0.72)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C465(1.07)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C465(0.93)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C465(0.90)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C465(0.96)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C465(0.96)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C465(0.79)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C465(0.66)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C465(0.68)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C465(0.52)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C438(0.76)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C438(0.90)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C438(0.76)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C465(0.86)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C465(0.73)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C465(0.67)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C465(0.71)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C438(1.13)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C465(0.74)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C465(0.56)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C465(0.64)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C465(0.61)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C465(0.51)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C465(0.63)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C465(0.93)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C465(0.65)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C465(1.00)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C465(0.71)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C438(0.93)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C465(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C438(0.75); C465(0.93)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C438(0.59); C465(0.87)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C438(0.56); C465(0.65)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C438(0.60); C465(1.32)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C438(0.53); C465(0.71)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C438(0.59); C465(0.80)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C438(0.54); C465(0.68)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C438(0.56); C465(0.88)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C438(1.02)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C438(0.57); C465(0.76)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C438(0.63); C465(0.93)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C438(0.61); C465(0.88)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C438(0.55); C465(1.02)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C438(0.57); C465(0.78)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C438(0.56); C465(0.80)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C438(0.97)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C438(0.93)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C438(1.03)  LDD1643  [6]
 LDCM0440  CL5 HCT 116 C438(0.96)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C438(0.28); C465(0.99)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C438(1.02)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C438(1.08)  LDD1647  [6]
 LDCM0446  CL55 HEK-293T C438(0.95)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C438(1.11)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C438(1.00)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C438(1.03)  LDD1652  [6]
 LDCM0451  CL6 HCT 116 C438(0.81)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C438(1.06)  LDD1655  [6]
 LDCM0453  CL61 HCT 116 C438(0.88); C465(0.92)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C438(0.91); C465(0.93)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C438(0.74); C465(0.82)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C438(0.78); C465(0.75)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C438(0.84); C465(0.95)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C438(0.67); C465(0.78)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C438(0.73); C465(0.85)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C438(0.74); C465(0.75)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C438(0.68); C465(0.66)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C438(0.81)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C438(0.71); C465(0.78)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C438(0.75); C465(0.80)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C438(0.91); C465(0.87)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C438(0.77); C465(0.80)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C438(0.75); C465(0.76)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C438(0.78)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C438(0.94)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C438(0.80)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C438(0.71)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C438(0.71)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C438(0.78)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C438(0.79)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C438(0.65)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C438(0.72)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C438(0.74)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C438(0.79)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C438(0.94)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C438(0.76)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C438(0.68)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C438(0.85)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C438(0.89)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C438(1.14)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C438(0.91); C465(0.98)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C438(1.07); C465(1.30)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C438(0.95); C465(0.83)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C438(0.84); C465(0.76)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C438(0.78); C465(0.75)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C438(0.86); C465(0.84)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C438(0.82); C465(0.57)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C438(0.80); C465(0.82)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C438(0.76); C465(1.01)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C438(1.15)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C438(0.74); C465(0.80)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C438(0.55); C465(0.76)  LDD0744  [3]
 LDCM0022  KB02 22RV1 C438(2.69); C465(3.48)  LDD2243  [7]
 LDCM0023  KB03 22RV1 C438(5.02); C465(9.75)  LDD2660  [7]
 LDCM0024  KB05 COLO792 C465(2.53)  LDD3310  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Disks large homolog 1 (DLG1) MAGUK family Q12959
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein scribble homolog (SCRIB) LAP (LRR and PDZ) protein family Q14160
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Protein TFG (TFG) . Q92734

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840