Details of the Target

General Information of Target

Target ID LDTP07103
Target Name OTU domain-containing protein 3 (OTUD3)
Gene Name OTUD3
Gene ID 23252
Synonyms
KIAA0459; OTU domain-containing protein 3; EC 3.4.19.12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQL
QALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPF
EKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTEKSSVRELHIAYRYG
EHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVC
NATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGKRNNAEENLEPSGRVLKQCGPLWEE
GGSGARIFGNQGLNEGRTENNKAQASPSEENKANKNQLAKVTNKQRREQQWMEKKKRQEE
RHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination.
Uniprot ID
Q5T2D3
Ensemble ID
ENST00000375120.4
HGNC ID
HGNC:29038
ChEMBL ID
CHEMBL4630831

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C49(2.16)  LDD2157  [1]
AHL-Pu-1
 Probe Info  		C294(4.75)  LDD0169  [2]
DBIA
 Probe Info  		C49(2.22); C294(1.25)  LDD0080  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C49(3.07)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C294(4.75)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C76(1.11)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C294(0.96)  LDD1508  [6]
 LDCM0216  AC100 HCT 116 C76(0.71)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C76(0.64)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C76(0.59)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C76(0.42)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C76(0.44)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C76(0.43)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C76(0.48)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C76(0.49)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C76(0.63)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C76(0.60)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C76(1.04); C49(1.10); C294(1.33)  LDD1509  [6]
 LDCM0227  AC110 HCT 116 C76(0.61)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C76(0.66)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C76(0.54)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C76(1.05)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C76(1.00)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C76(1.12)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C76(1.00)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C76(1.10)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C76(0.91)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C76(0.92)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C76(1.02); C294(1.01)  LDD1510  [6]
 LDCM0238  AC120 HCT 116 C76(0.93)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C76(0.90)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C76(0.87)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C76(0.88)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C76(0.86)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C76(0.91)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C76(1.01)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C76(0.98)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C76(0.89)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C76(1.33)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C76(0.99)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C76(1.20)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C76(1.38)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C76(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C76(0.91)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C76(0.90)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C76(1.03)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C76(1.19)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C76(0.92)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C76(1.05)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C76(1.06); C49(1.06); C294(1.20)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C76(0.87)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C76(1.00)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C76(1.51)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C76(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C76(0.97)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C76(0.99)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C76(1.09)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C76(0.99)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C76(1.23)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C76(1.20)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C294(0.85)  LDD1513  [6]
 LDCM0271  AC150 HCT 116 C76(0.86)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C76(0.29)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C76(0.41)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C76(1.67)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C76(1.04)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C76(0.85)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C76(0.79)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C76(0.94)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C76(1.12)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C76(1.11)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C76(1.15)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C76(1.40)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C76(1.23)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C76(1.13)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C76(1.31)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C76(1.11)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C76(1.21)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C76(0.95)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C76(1.09)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C76(1.19)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C76(1.18)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C76(1.04)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C76(1.24)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C76(1.17)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C76(0.97)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C76(0.96)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C76(1.08)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C76(1.02)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C76(0.95)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C76(0.97)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C76(0.95)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C76(1.11)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C76(1.05)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C76(1.31)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C76(0.88)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C76(0.86)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C76(0.86)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C76(1.23)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C76(0.87)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C76(0.80)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C76(1.24)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C76(1.19)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C76(1.48)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C76(1.10)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C76(1.46)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C76(1.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C76(1.74)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C76(1.08)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C76(1.04)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C76(0.96)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C76(1.14)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C76(1.34)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C76(0.70)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C76(0.75)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C76(0.63)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C76(1.04); C49(1.13); C294(1.02)  LDD1562  [6]
 LDCM0324  AC60 HCT 116 C76(0.88)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C76(0.80)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C76(0.61)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C76(0.78)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C76(0.60)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C76(0.55)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C76(0.59)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C76(0.47)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C76(0.80)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C76(0.90)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C294(0.93)  LDD1568  [6]
 LDCM0335  AC70 HCT 116 C76(0.66)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C76(0.97)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C76(0.82)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C76(0.89)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C76(0.95)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C76(0.89)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C76(0.66)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C76(0.77)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C76(0.79)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C76(0.95)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C76(1.20); C49(0.96); C294(1.15)  LDD1569  [6]
 LDCM0346  AC80 HCT 116 C76(0.76)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C76(1.06)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C76(0.92)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C76(0.50)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C76(0.52)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C76(0.64)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C76(0.57)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C76(0.75)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C76(0.71)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C76(0.47)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C76(0.74)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C76(0.52)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C76(0.46)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C76(0.57)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C76(0.73)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C76(0.89)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C76(0.58)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C76(0.47)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C76(0.46)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C76(0.73)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C76(0.93); C294(1.15)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C76(1.08); C294(1.31)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C76(1.25); C49(1.07); C294(1.23)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C76(1.10)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C76(0.93); C49(0.56); C294(1.09)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C76(1.20)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C76(0.89)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C49(1.10)  LDD1575  [6]
 LDCM0373  CL104 HEK-293T C76(1.13); C294(1.03)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C76(0.90)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C76(0.98)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C76(1.04)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C76(0.98)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C76(1.41)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C294(0.91)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C76(1.34)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C76(0.89)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C76(0.95)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C76(1.18)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C76(1.01)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C76(1.10)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C76(1.01)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C76(0.99)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C76(0.89)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C76(0.91)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C76(1.24); C49(1.04); C294(1.16)  LDD1594  [6]
 LDCM0391  CL120 HCT 116 C76(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C76(0.54)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C76(1.04)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C76(0.98)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C76(0.90)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C76(0.84)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C76(0.69)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C76(0.84)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C76(0.65)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C76(0.97)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C49(1.18)  LDD1605  [6]
 LDCM0403  CL16 HCT 116 C76(0.87)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C76(0.72)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C76(1.10)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C76(0.76)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C49(0.73)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C76(0.74)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C76(0.74)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C76(0.90)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C76(0.81)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C76(0.85)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C76(0.65)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C76(0.89)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C76(0.98)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C76(0.79)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C76(0.94)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C76(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C76(0.89)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C76(0.94)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C76(0.82)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C76(0.47)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C76(0.60)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C76(0.59)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C76(0.54)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C76(0.69)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C76(1.15); C294(1.07)  LDD1633  [6]
 LDCM0430  CL40 HCT 116 C76(0.70)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C76(0.65)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C76(0.79)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C76(0.76)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C76(0.80)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C76(0.70)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C76(1.13); C49(1.04); C294(0.98)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C294(0.89)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C76(1.01); C49(0.95); C294(0.98)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C76(1.09)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C76(1.02); C294(1.25)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C49(1.30)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C76(1.14); C294(1.24)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C76(1.23); C294(0.98)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C294(1.12)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C76(1.11); C49(1.12); C294(1.34)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C76(1.01); C294(0.94)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C76(0.91); C294(1.05)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C76(1.29); C49(0.85); C294(0.94)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C294(0.85)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C294(0.93)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C76(1.00); C49(1.12); C294(0.98)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C76(1.22)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C49(0.84)  LDD1657  [6]
 LDCM0456  CL64 HEK-293T C76(1.02); C294(1.06)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C76(1.09); C294(1.09)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C294(1.07)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C76(1.08); C49(1.13); C294(1.29)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C76(1.11); C294(0.98)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C76(0.95); C294(1.13)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C76(1.17); C49(1.06); C294(1.13)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C76(0.97); C49(0.87); C294(1.02)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C294(0.93)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C76(0.96); C49(1.05); C294(0.96)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C76(1.06)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C49(1.39)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C76(1.07); C294(0.97)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C76(1.04); C294(1.25)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C294(1.02)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C76(1.13); C49(1.04); C294(1.35)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C76(0.98); C294(0.89)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C76(1.00); C294(0.88)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C76(0.86); C294(1.27)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C76(0.98); C49(0.86); C294(1.27)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C294(0.92)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C76(1.05); C49(1.15); C294(0.90)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C76(1.28)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C49(0.95)  LDD1683  [6]
 LDCM0482  CL88 HEK-293T C76(1.04); C294(1.05)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C76(1.34); C294(1.26)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C76(1.09); C294(1.10)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C294(0.97)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C76(1.11)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C76(1.14)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C76(0.99)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C76(1.30)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C76(1.17)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C76(1.17)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C76(1.07)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C76(1.16)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C76(1.21)  LDD1092  [3]
 LDCM0427  Fragment51 HCT 116 C76(0.85)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C49(2.22); C294(1.25)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C49(1.43); C294(1.11)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C49(1.79); C294(1.36)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402