Details of the Target

General Information of Target

Target ID LDTP06904
Target Name Kelch-like protein 22 (KLHL22)
Gene Name KLHL22
Gene ID 84861
Synonyms
Kelch-like protein 22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH
IEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNV
QETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFV
AFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKL
LETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCV
VGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNV
QGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD
PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGP
VRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIA
VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE
PPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
Uniprot ID
Q53GT1
Ensemble ID
ENST00000328879.9
HGNC ID
HGNC:25888

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 Substitution: p.R157W DBIA    Probe Info 
HCC1937 SNV: p.V436A .
HEC1 SNV: p.V429M DBIA    Probe Info 
HEC1B SNV: p.V429M .
IGROV1 SNV: p.R603H .
KPL1 SNV: p.K260N DBIA    Probe Info 
MCC13 SNV: p.P192L DBIA    Probe Info 
NCIH1155 SNV: p.R508K .
SKMEL28 Insertion: p.A217delinsGP DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C22(2.36)  LDD0169  [1]
DBIA
 Probe Info  		C72(1.03)  LDD0580  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
PF-06672131
 Probe Info  		N.A.  LDD0017  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		11.50  LDD0443  [7]
NAIA_5
 Probe Info  		C22(0.00); C11(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C22(2.36)  LDD0169  [1]
 LDCM0214  AC1 PaTu 8988t C72(0.69)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C72(0.92)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C22(0.95); C72(0.92)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C22(0.99); C72(1.10)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C22(1.00); C72(1.06)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C22(1.07); C72(1.07)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C22(1.24); C72(0.94)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C22(0.93); C72(1.17)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C22(0.93); C72(1.21)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C22(1.06); C72(1.07)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C22(0.93); C72(0.91)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C22(0.97); C72(0.99)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C72(0.90)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C22(1.46); C72(1.18)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C22(1.71); C72(0.92)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C22(1.41); C72(0.98)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C72(1.02)  LDD0835  [2]
 LDCM0246  AC128 HEK-293T C72(0.79)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C72(0.72)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C72(0.84)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C72(1.14)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C72(0.61)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C72(0.87)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C72(0.92)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C72(1.03)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C72(1.19)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C72(0.75)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C72(0.83)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C72(0.78)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C72(0.90)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C72(0.83)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C72(0.86)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C72(0.78)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C72(1.03)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C72(0.94)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C72(0.85)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C72(0.86)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C72(0.85)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C72(0.98)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C72(0.89)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C72(0.91)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C72(0.86)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C72(0.85)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C72(0.96)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C72(1.07)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C72(0.82)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C72(0.86)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C72(1.00)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C72(0.96)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C72(0.80)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C72(0.92)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C72(0.73)  LDD0876  [2]
 LDCM0279  AC2 PaTu 8988t C72(0.78)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C72(0.86)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C72(0.83)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C72(0.86)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C72(0.89)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C72(0.92)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C72(0.53)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C72(0.55)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C72(0.90)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C72(0.73)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C72(0.95)  LDD0606  [2]
 LDCM0290  AC3 PaTu 8988t C72(0.79)  LDD1169  [2]
 LDCM0291  AC30 HCT 116 C72(0.64)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C72(0.57)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C72(0.65)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C72(0.85)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C72(0.78)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C72(0.98)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C72(1.20)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C72(0.99)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C72(1.03)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C72(0.85)  LDD0898  [2]
 LDCM0301  AC4 PaTu 8988t C72(0.78)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C72(1.02)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C72(1.02)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C72(0.89)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C72(0.87)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C72(1.09)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C72(0.95)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C72(1.07)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C72(1.08)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C72(1.31)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C72(1.20)  LDD0909  [2]
 LDCM0312  AC5 PaTu 8988t C72(0.80)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C72(0.97)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C72(1.02)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C72(0.91)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C72(0.99)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C72(0.84)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C72(0.92)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C72(1.23)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C72(1.05)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C72(1.03)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C72(1.10)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C72(0.98)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C72(1.17)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C72(1.08)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C72(1.13)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C72(1.12)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C72(0.98)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C72(1.06)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C72(1.31)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C72(1.00)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C72(0.75)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C72(1.33)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C72(0.88)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C72(1.26)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C72(1.02)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C72(0.88)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C72(0.85)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C72(1.18)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C72(0.90)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C72(0.88)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C72(0.94)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C72(0.67)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C72(0.72)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C72(1.13)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C72(0.63)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C72(0.61)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C72(0.96)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C22(0.98)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C22(1.03)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C22(0.94)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C22(1.06)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C22(1.07)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C22(1.01)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C22(1.03)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C22(1.07)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C22(0.98)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C22(1.05)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C22(1.25)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C22(1.13)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C22(1.06)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C22(1.05)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C22(1.58)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C22(0.98); C72(1.01)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C22(0.89); C72(0.91)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C72(0.96)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C72(0.99)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C72(0.87)  LDD0873  [2]
 LDCM0632  CL-Sc Hep-G2 C11(2.73); C22(0.33)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C22(1.01); C72(1.11)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C22(1.30); C72(2.08)  LDD0966  [2]
 LDCM0369  CL100 PaTu 8988t C72(0.72)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C72(1.05)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C72(0.93)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C72(1.19)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C72(1.02)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C72(0.87)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C72(0.80)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C72(0.98)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C72(0.70)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C72(0.83)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C22(1.24); C72(1.95)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C72(0.75)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C72(0.92)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C72(0.73)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C72(0.59)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C72(0.77)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C72(0.63)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C72(0.62)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C72(0.82)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C72(1.07)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C72(1.12)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C22(0.95); C72(1.43)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C72(1.02)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C72(0.89)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C72(1.10)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C72(0.88)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C72(1.11)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C72(0.94)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C72(1.09)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C72(0.77)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C72(1.14)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C22(0.93); C72(1.29)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C22(1.04); C72(1.50)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C22(1.07); C72(2.11)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C72(1.12)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C72(0.81)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C72(0.59)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C72(0.78)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C22(0.92); C72(1.40)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C72(1.08)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C72(0.90)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C72(1.08)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C72(0.98)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C72(0.94)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C72(0.96)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C72(0.80)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C72(1.08)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C72(0.74)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C72(0.87)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C22(0.86); C72(1.17)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C72(0.95)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C22(0.97)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C22(0.90)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C22(0.91)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C22(0.97)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C22(0.82)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C22(0.96)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C22(0.96)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C22(1.27)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C22(1.01); C72(1.43)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C22(1.02)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C22(1.15)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C22(1.04)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C22(1.09)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C22(0.83)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C22(1.05)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C22(1.00)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C22(0.99)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C22(0.93)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C22(1.16)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C22(1.05); C72(1.35)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C22(1.50)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C22(1.30)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C22(0.93)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C22(1.16)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C22(1.28)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C22(1.10)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C22(1.00)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C22(1.34)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C22(1.19)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C22(1.13)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C22(0.99); C72(1.39)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C22(1.28)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C22(0.73)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C22(0.76)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C22(0.84)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C22(0.89)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C22(0.80)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C22(0.82)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C22(0.87)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C22(0.91)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C22(0.90)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C22(0.99); C72(1.41)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C22(0.97)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C22(0.91)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C22(0.79)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C22(1.14)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C22(1.01)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C72(1.07)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C72(0.83)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C72(0.97)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C72(1.26)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C22(1.16)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C72(1.31)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C72(1.16)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C72(1.34)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C72(1.18)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C72(1.41)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C72(1.20)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C72(1.07)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C72(1.18)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C72(1.19)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C72(1.35)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C22(1.25)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C72(0.98)  LDD0802  [2]
 LDCM0486  CL91 PaTu 8988t C72(0.79)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C72(0.73)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C72(0.73)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C72(0.79)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C72(0.68)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C72(0.70)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C72(0.70)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C72(0.67)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C72(0.75)  LDD1373  [2]
 LDCM0634  CY-0357 Hep-G2 C11(0.52)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C22(0.95)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C22(1.02)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C22(0.83)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C22(1.10)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C22(0.95)  LDD1497  [9]
 LDCM0024  KB05 HMCB C22(1.79)  LDD3312  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NudC domain-containing protein 3 (NUDCD3) . Q8IVD9
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840