Details of the Target

General Information of Target

Target ID LDTP06690
Target Name DNA-binding protein RFX7 (RFX7)
Gene Name RFX7
Gene ID 64864
Synonyms
RFXDC2; DNA-binding protein RFX7; Regulatory factor X 7; Regulatory factor X domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHKIKNSICKTVQSK
VDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSRAQQMHAFSWIRNTLEEHP
ETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLR
KKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDT
VLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGITQPSAFIPTAESNSFQPQVKTLPSP
IDAKQQLQRKIQKKQQEQKLQSPLPGESAAKKSESATSNGVTNLPNGNPSILSPQPIGIV
VAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQAPKTPQNVPASPG
GDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISL
TPSNSNTPLKHSASVSSATGTTEESRSVPQIKNGSVVSLQSPGSRSSSAGGTSAVEVKVE
PETSSDEHPVQCQENSDEAKAPQTPSALLGQKSNTDGALQKPSNEGVIEIKATKVCDQRT
KCKSRCNEMLPGTSTGNNQSTITLSVASQNLTFTSSSSPPNGDSINKDPKLCTKSPRKRL
SSTLQETQVPPVKKPIVEQLSAATIEGQKQGSVKKDQKVPHSGKTEGSTAGAQIPSKVSV
NVSSHIGANQPLNSSALVISDSALEQQTTPSSSPDIKVKLEGSVFLLDSDSKSVGSFNPN
GWQQITKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHSQIQ
ESSLNQIQAHSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSM
NNSHSYGNCLGMTLQSQSVTPGAPMSSHTSSTHFYHPIHSNGTPIHTPTPTPTPTPTPTP
TPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVEC
RNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGH
GILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNNTNKQ
EGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPV
TPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQANSKKITNVLLSKLDSD
NDDAVRGLGMNNLPSNYTARMNLTQILEPSTVFPSANPQNMIDSSTSVYEFQTPSYLTKS
NSTGQINFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDSLQTNQQLVGQGASDLTNTASDF
SSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSM
TSSGFEWIESKDHPTVEMLG
Target Bioclass
Transcription factor
Family
RFX family
Subcellular location
Nucleus
Function
Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure.
Uniprot ID
Q2KHR2
Ensemble ID
ENST00000559447.8
HGNC ID
HGNC:25777

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
Johansson_61
 Probe Info  		_(15.32)  LDD1489  [2]
DBIA
 Probe Info  		C78(1.04)  LDD0531  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		C499(0.00); C1118(0.00)  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C78(1.04)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C78(0.88)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C78(1.23)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C78(1.25)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C78(0.93)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C78(1.05)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C78(1.34)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C78(1.03)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C78(1.17)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C78(1.07)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C78(1.02)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C78(1.13)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C78(1.00)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C78(1.28)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C78(1.23)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C78(0.99)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C78(1.18)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C78(0.89)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C78(1.02)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C78(0.80)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C78(0.91)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C78(0.81)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C78(0.96)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C78(0.98)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C78(0.82)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C78(0.98)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C78(0.81)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C78(0.72)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C78(0.87)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C78(0.79)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C78(0.75)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C78(0.81)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C78(0.59)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C78(0.58)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C78(0.50)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C78(0.75)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C78(0.62)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C78(0.72)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C78(0.77)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C78(0.69)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C78(0.66)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C78(0.59)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C78(0.55)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C78(0.73)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C78(0.83)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C78(0.79)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C78(0.79)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C78(0.71)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C78(0.97)  LDD0587  [3]
 LDCM0276  AC17 HEK-293T C130(0.96); C78(1.01)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C130(1.07)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C130(1.56); C78(0.98)  LDD1517  [8]
 LDCM0279  AC2 HCT 116 C78(1.40)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C130(0.93); C455(1.25); C78(1.07)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C130(0.92); C78(0.89)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C130(0.98); C78(0.91)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C130(0.91); C78(0.92)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C130(0.98); C1118(0.89)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C130(0.93); C78(1.01)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C130(0.95)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C130(0.88); C78(1.01)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C130(0.96); C455(1.01); C78(1.04)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C130(0.92); C78(1.03)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C78(1.07)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C130(1.01); C78(0.97)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C130(0.94); C78(0.98)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C130(0.93); C1118(0.97)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C130(1.01); C78(0.91)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C130(1.07)  LDD1534  [8]
 LDCM0296  AC35 HCT 116 C78(1.24)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C78(1.25)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C78(1.22)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C78(1.38)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C78(1.51)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C78(1.32)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C78(1.12)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C78(1.32)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C78(1.13)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C78(1.26)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C78(1.24)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C78(1.37)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C78(1.56)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C78(1.10)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C78(1.56)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C78(0.98)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C78(1.08)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C78(1.47)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C78(1.23)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C78(1.28)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C78(1.39)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C78(1.37)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C78(1.56)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C78(1.62)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C130(0.95); C78(1.10)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C130(1.08)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C130(0.96); C78(1.03)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C78(0.98)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C130(0.95); C455(1.07); C78(1.12)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C130(0.89); C78(1.05)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C130(1.10); C78(1.07)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C130(0.95); C78(1.15)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C130(0.96); C1118(1.03)  LDD1567  [8]
 LDCM0332  AC68 HCT 116 C78(1.08)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C78(0.76)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C78(1.15)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C78(0.82)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C78(0.86)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C78(1.12)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C78(0.90)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C78(0.87)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C78(1.04)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C78(0.94)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C78(0.79)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C78(1.03)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C78(0.81)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C78(1.45)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C78(0.91)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C78(0.89)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C78(1.07)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C78(1.19)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C78(1.27)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C78(1.24)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C78(1.28)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C78(1.16)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C78(1.20)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C78(1.24)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C78(1.35)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C78(1.22)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C78(1.21)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C78(1.29)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C78(1.37)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C78(1.45)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C78(1.61)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C78(1.54)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C78(1.49)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C78(1.14)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C78(0.75)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C78(0.87)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C78(0.91)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C130(1.05)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C130(1.29); C78(0.80)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C78(1.83)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C78(0.95)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C78(0.79)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C78(1.71)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C78(1.08)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C130(1.03)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C130(1.04); C78(0.97)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C130(1.03); C78(1.03); C699(0.96)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C130(0.92)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C130(0.74)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C130(1.02); C78(0.93)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C130(1.01); C78(1.02)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C130(0.97); C78(1.06); C699(1.03)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C130(0.98)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C130(1.05)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C130(1.05); C78(1.19)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C130(0.99); C78(1.03); C699(0.92)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C130(1.04)  LDD1590  [8]
 LDCM0387  CL117 HCT 116 C78(1.13)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C78(1.19)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C78(1.37)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C130(1.00); C1118(0.92)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C78(1.22)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C78(1.27)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C78(1.34)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C78(0.81)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C78(1.38)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C130(0.94)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C130(1.00); C78(1.21)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C130(0.95); C78(1.08); C699(1.07)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C130(1.01)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C130(1.07)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C130(1.00); C78(1.19)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C130(1.03); C78(1.08); C699(1.00)  LDD1606  [8]
 LDCM0403  CL16 HCT 116 C78(1.45)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C78(1.19)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C78(1.25)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C78(1.02)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C130(0.97); C78(1.02)  LDD1611  [8]
 LDCM0408  CL20 HCT 116 C78(1.33)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C78(1.16)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C78(1.06)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C78(1.47)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C78(1.29)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C78(1.04)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C78(1.57)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C78(1.11)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C78(1.34)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C78(1.42)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C130(1.01); C78(0.86); C699(1.20)  LDD1622  [8]
 LDCM0419  CL30 HCT 116 C78(1.02)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C78(0.90)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C78(1.37)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C78(2.17)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C78(2.02)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C78(0.87)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C78(0.90)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C78(1.47)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C78(1.31)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C130(1.02)  LDD1633  [8]
 LDCM0430  CL40 HCT 116 C78(1.21)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C78(1.71)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C78(1.85)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C78(1.25)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C78(1.44)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C78(1.55)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C130(1.06); C78(1.00)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C130(0.98); C78(0.98)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C130(1.06); C1118(0.93)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C130(1.05)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C130(0.96); C78(1.05)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C130(1.07); C78(1.08)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C130(1.03)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C130(1.00); C78(1.04)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C130(1.22)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C130(1.00); C78(0.95)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C130(0.97); C455(1.12); C78(1.08)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C130(1.16); C78(0.95)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C130(1.07); C78(1.04)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C130(1.00); C78(1.01)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C130(1.11)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C130(1.01); C1118(0.98)  LDD1655  [8]
 LDCM0453  CL61 HCT 116 C78(0.62)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C78(0.80)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C78(0.97)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C78(1.12)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C78(0.70)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C78(1.03)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C78(1.13)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C78(1.25)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C78(1.21)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C130(0.95); C78(1.09)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C78(1.31)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C78(1.63)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C78(1.31)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C78(1.21)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C78(1.28)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C130(0.99)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C130(1.01); C78(0.96)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C130(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C130(0.94); C78(1.05)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C130(3.88); C455(0.99); C78(1.15)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C130(1.01); C455(1.17); C78(1.03)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C130(0.99); C78(0.86)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C130(1.17); C78(0.92)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C130(1.00); C78(0.95)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C130(0.98); C1118(0.92)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C130(0.94)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C130(1.05); C78(1.12)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C130(0.96); C78(1.18); C699(1.04)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C130(1.03)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C130(0.99); C78(1.07)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C130(1.00); C78(0.88)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C130(1.62)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C78(0.80)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C78(0.98)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C78(1.27)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C78(1.44)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C78(0.99)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C78(1.77)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C78(1.21)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C78(1.03)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C78(1.19)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C130(1.00); C78(0.94); C699(1.14)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C78(5.53)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C78(2.64)  LDD0744  [3]
 LDCM0616  Fragment61 Jurkat _(15.32)  LDD1489  [2]
 LDCM0022  KB02 HEK-293T C78(0.93); C455(0.94)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C78(0.94); C455(0.91)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C78(0.96); C455(0.96)  LDD1502  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein RFXANK (RFXANK) . O14593
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat family A protein 2 (ANKRA2) . Q9H9E1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402