Details of the Target

General Information of Target

Target ID LDTP06655
Target Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)
Gene Name PFKFB4
Gene ID 5210
Synonyms
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; PFK/FBPase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase; EC 2.7.1.105; Fructose-2,6-bisphosphatase; EC 3.1.3.46)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family
Function Synthesis and degradation of fructose 2,6-bisphosphate.
Uniprot ID
Q16877
Ensemble ID
ENST00000232375.8
HGNC ID
HGNC:8875
ChEMBL ID
CHEMBL3721311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.T301K DBIA    Probe Info 
IM95 SNV: p.L174P DBIA    Probe Info 
LNCaP clone FGC SNV: p.R80Q DBIA    Probe Info 
LS180 SNV: p.C106R DBIA    Probe Info 
MOLT4 Deletion: p.T70LfsTer31 .
NCIH2052 Deletion: p.N143RfsTer19 DBIA    Probe Info 
OCIAML2 SNV: p.G122V DBIA    Probe Info 
RKO SNV: p.N10I DBIA    Probe Info 
SKMEL30 Substitution: p.L324F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K104(3.31)  LDD0277  [1]
BTD
 Probe Info  		C106(0.42)  LDD2089  [2]
IA-alkyne
 Probe Info  		C159(10.28)  LDD1706  [3]
IPM
 Probe Info  		C430(0.90)  LDD1702  [2]
DBIA
 Probe Info  		C29(1.94)  LDD0080  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		12.90  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C106(0.95)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C106(0.88)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C106(1.03)  LDD2103  [2]
 LDCM0214  AC1 HCT 116 C29(0.78)  LDD0531  [4]
 LDCM0230  AC113 HCT 116 C29(0.93)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C29(0.99)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C29(1.00)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C29(1.03)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C29(0.81)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C29(1.02)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C29(0.89)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C29(1.00)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C29(0.89)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C29(0.96)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C29(0.89)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C29(0.85)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C29(0.89)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C29(0.97)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C29(1.04)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C29(0.98)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C29(0.75)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C29(0.83)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C29(0.90)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C29(0.80)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C29(1.04)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C29(0.96)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C29(1.00)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C29(0.87)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C29(0.88)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C29(1.00)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C29(0.99)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C29(1.10)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C29(0.98)  LDD1512  [9]
 LDCM0260  AC140 HCT 116 C29(1.10)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C29(1.25)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C29(0.84)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C29(1.19)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C29(1.11)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C29(1.16)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C29(1.06)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C29(0.97)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C29(1.32)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C29(1.19)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C159(0.89)  LDD1513  [9]
 LDCM0271  AC150 HCT 116 C29(1.17)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C29(1.21)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C29(1.16)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C29(1.42)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C29(1.16)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C29(1.23)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C29(1.15)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C29(1.22)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C29(1.07)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C29(0.93)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C29(0.90)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C29(0.92)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C29(0.99)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C29(0.96)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C29(1.15)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C29(0.90)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C29(1.09)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C29(0.85)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C29(1.04)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C29(0.84)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C29(1.05)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C29(0.80)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C29(0.82)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C29(0.89)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C29(0.82)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C29(0.92)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C29(0.96)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C29(0.93)  LDD0893  [4]
 LDCM0297  AC36 HEK-293T C29(1.10)  LDD1536  [9]
 LDCM0299  AC38 HEK-293T C29(1.03)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C159(1.02)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C29(0.74)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C159(1.06); C29(1.06)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C159(1.05)  LDD1542  [9]
 LDCM0306  AC44 HEK-293T C29(1.07)  LDD1545  [9]
 LDCM0308  AC46 HEK-293T C29(1.13)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C29(0.94)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C29(1.07)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C29(1.53)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C29(0.66)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C29(0.91)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C29(0.77)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C29(0.94)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C29(1.14)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C29(1.15)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C29(1.07)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C29(0.95)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C29(0.91)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C29(1.15)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C29(0.58)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C29(1.00)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C29(0.66)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C29(0.82)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C29(0.70)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C29(0.69)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C29(0.84)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C29(0.63)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C29(0.61)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C29(0.66)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C29(0.74)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C29(0.93)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C159(1.09)  LDD1568  [9]
 LDCM0335  AC70 HEK-293T C29(0.72)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C29(0.71)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C29(0.74)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C29(0.72)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C29(0.65)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C29(0.70)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C29(0.73)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C29(0.62)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C29(0.63)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C29(0.68)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C159(1.11); C29(1.12)  LDD1569  [9]
 LDCM0346  AC80 HEK-293T C29(0.78)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C29(0.84)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C29(0.68)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C29(1.11)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C29(1.23)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C29(1.07)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C29(1.31)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C29(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C29(1.43)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C29(1.17)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C29(1.23)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C29(1.03)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C29(1.13)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C29(1.20)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C29(0.86)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C29(1.19)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C29(0.81)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C29(1.32)  LDD0681  [4]
 LDCM0356  AKOS034007680 HEK-293T C159(0.91)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C159(1.09); C29(1.03)  LDD1514  [9]
 LDCM0367  CL1 HCT 116 C29(0.95)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C29(0.82)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C29(0.99)  LDD0686  [4]
 LDCM0371  CL102 HEK-293T C159(0.95)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C159(1.04)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C159(0.91)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C29(0.95)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C29(0.86)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C29(0.96)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C29(0.84)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C29(1.04)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C29(0.82)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C29(1.09)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C29(0.98)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C29(0.88)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C29(0.96)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C29(0.99)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C29(0.75)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C29(0.71)  LDD0984  [4]
 LDCM0388  CL118 HEK-293T C159(1.01)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C159(1.02)  LDD1593  [9]
 LDCM0390  CL12 HCT 116 C29(0.87)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C159(0.99)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C29(1.32)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C29(1.08)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C29(1.17)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C29(1.13)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C29(1.13)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C29(0.85)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C29(1.01)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C29(0.98)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C29(0.91)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C29(0.80)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C29(1.04)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C29(1.35)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C29(1.18)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C29(1.04)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C29(1.17)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C29(1.25)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C29(1.19)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C29(1.21)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C29(0.91)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C29(0.88)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C29(1.08)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C29(1.07)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C29(1.00)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C29(1.07)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C29(1.13)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C29(1.15)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C29(0.96)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C29(0.94)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C29(1.04)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C29(1.36)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C29(1.32)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C29(1.34)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C29(1.03)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C29(1.24)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C29(1.06)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C29(1.14)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C29(1.12)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C29(1.30)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C29(0.96)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C29(1.17)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C29(1.10)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C29(1.11)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C29(1.30)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C29(0.75)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C29(0.46)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C29(0.50)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C29(0.57)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C29(0.94)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C29(0.71)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C29(0.69)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C29(0.61)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C29(0.57)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C29(0.48)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C29(0.67)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C29(0.66)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C29(0.67)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C29(0.70)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C29(1.00)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C29(1.05)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C29(0.84)  LDD0769  [4]
 LDCM0454  CL62 HEK-293T C159(0.98)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C159(0.96)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C159(0.99)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C159(1.06)  LDD1660  [9]
 LDCM0460  CL68 HEK-293T C29(1.29)  LDD1663  [9]
 LDCM0462  CL7 HCT 116 C29(1.02)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C29(1.01)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C159(1.01)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C159(1.25); C29(0.98)  LDD1668  [9]
 LDCM0467  CL74 HEK-293T C159(1.00)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C159(1.22)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C159(1.14)  LDD1673  [9]
 LDCM0473  CL8 HCT 116 C29(1.11)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C29(1.18)  LDD1677  [9]
 LDCM0476  CL82 HEK-293T C29(1.04)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C159(0.90)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C159(1.01); C29(0.99)  LDD1681  [9]
 LDCM0480  CL86 HEK-293T C159(1.11)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C159(1.10)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C159(0.82)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C159(1.10)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C29(1.00)  LDD0801  [4]
 LDCM0486  CL91 HCT 116 C29(1.11)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C29(1.25)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C29(0.94)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C29(0.76)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C29(0.99)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C29(0.91)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C29(0.88)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C29(0.83)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C29(0.91)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C159(1.00)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C430(0.90)  LDD1702  [2]
 LDCM0625  F8 Ramos C430(1.26)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C430(0.85)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C106(0.25)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C430(1.27)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C430(0.73)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C430(0.71); C106(0.13)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C430(1.29)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C430(0.93)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C430(1.05)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C430(0.89)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C430(0.66)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C430(0.98)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C430(0.94)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C430(0.80)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C159(0.97)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C430(0.82)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C430(1.03)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C29(1.45)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C430(0.97)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C430(1.07)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C430(1.01)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C430(0.96)  LDD2188  [10]
 LDCM0022  KB02 HCT 116 C29(1.94)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C29(1.17)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C29(1.28)  LDD0082  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C106(1.10)  LDD2102  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C106(0.42)  LDD2089  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C106(0.93)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C106(1.04)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C106(0.45)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C106(0.89)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C106(1.35)  LDD2105  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C106(0.95)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C430(0.62)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C106(0.89)  LDD2111  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C106(0.87)  LDD2116  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C106(0.78)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C106(0.63)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C106(0.85)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C106(0.83)  LDD2128  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C106(0.63)  LDD2137  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C106(0.32)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) Phosphoglycerate mutase family P16118
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Leucine-rich repeat protein 1 (LRR1) . Q96L50

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fructose-6-phosphate Small molecular drug DB04493
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578