Details of the Target

General Information of Target

Target ID LDTP06613
Target Name Alpha-mannosidase 2 (MAN2A1)
Gene Name MAN2A1
Gene ID 4124
Synonyms
MANA2; Alpha-mannosidase 2; EC 3.2.1.114; Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR
Target Type
Discontinued
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 38 family
Subcellular location
Golgi apparatus membrane
Function Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
TTD ID
T68668
Uniprot ID
Q16706
DrugMap ID
TT34DCN
Ensemble ID
ENST00000261483.5
HGNC ID
HGNC:6824
ChEMBL ID
CHEMBL4056

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K191(6.25)  LDD0277  [1]
BTD
 Probe Info  		C1088(1.13)  LDD2099  [2]
IPM
 Probe Info  		C1077(2.12)  LDD1701  [2]
DBIA
 Probe Info  		C430(0.87)  LDD0531  [3]
IA-alkyne
 Probe Info  		C1077(0.00); C1088(0.00)  LDD0162  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
W1
 Probe Info  		D961(0.00); D962(0.00)  LDD0236  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C368(1.24)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C430(0.87)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C367(1.22); C430(1.21); C368(1.22)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C430(0.78)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C430(0.89)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C430(0.94)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C430(0.80)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C430(0.95)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C430(0.82)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C430(0.87)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C430(0.70)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C430(0.66)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C430(1.00)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C367(1.08); C430(1.14); C368(1.08)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C430(0.94)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C430(0.81)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C430(0.52)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C430(0.94)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C430(1.07)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C430(1.18)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C430(1.12)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C430(1.02)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C430(1.26)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C430(1.20)  LDD0553  [3]
 LDCM0237  AC12 PaTu 8988t C367(1.08); C430(1.27); C368(1.08)  LDD1116  [3]
 LDCM0238  AC120 HCT 116 C430(1.26)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C430(1.07)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C430(1.05)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C430(1.02)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C430(1.07)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C430(1.07)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C430(1.18)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C430(1.16)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C367(1.27); C368(1.27)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C367(0.88); C368(0.88)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C367(1.05); C368(1.05)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C367(0.84); C368(0.84)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C367(1.07); C368(1.07)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C367(1.14); C368(1.14)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C367(1.14); C368(1.14)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C367(0.96); C368(0.96)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C367(1.04); C368(1.04)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C367(1.02); C368(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C367(1.00); C368(1.00)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C367(1.28); C368(1.28)  LDD0575  [3]
 LDCM0259  AC14 PaTu 8988t C367(1.11); C430(0.98); C368(1.11)  LDD1138  [3]
 LDCM0260  AC140 HCT 116 C367(1.16); C368(1.16)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C367(1.11); C368(1.11)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C367(0.92); C368(0.92)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C430(0.98)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C430(1.18)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C430(0.99)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C430(1.15)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C430(1.23)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C430(1.15)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C430(1.20)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C367(1.19); C430(1.13); C368(1.19)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C430(1.04)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C430(1.05)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C430(1.28)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C430(1.10)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C430(1.19)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C430(1.16)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C430(0.93)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C430(0.82)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C430(1.01)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C430(1.10)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C430(1.05)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C430(0.87)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C430(1.08)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C430(0.97)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C430(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C430(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C430(0.99)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C430(0.96)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C430(1.02)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C430(1.09)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C430(1.16)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C430(1.10)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C430(0.96)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C430(1.19)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C430(1.13)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C430(1.23)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C430(1.17)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C430(1.17)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C430(0.95)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C430(0.90)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C430(1.06)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C430(1.10)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C430(1.08)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C430(0.89)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C430(1.15)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C430(1.07)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C430(1.06)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C430(0.99)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C430(1.10)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C430(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C430(0.98)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C430(1.01)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C430(1.10)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C430(1.15)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C430(0.90)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C430(1.07)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C430(0.82)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C430(0.97)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C430(1.09)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C430(1.12)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C430(1.19)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C430(0.86)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C367(0.98); C368(0.98); C430(0.99)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C367(0.93); C368(0.93); C430(0.95)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C430(1.07); C367(1.15); C368(1.15)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C367(1.08); C430(1.16); C368(1.08)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C430(1.02); C367(1.07); C368(1.07)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C430(1.04); C367(1.13); C368(1.13)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C367(1.11); C368(1.11); C430(1.23)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C430(1.04); C367(1.14); C368(1.14)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C430(1.15); C367(1.26); C368(1.26)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C430(0.94); C367(1.15); C368(1.15)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C430(0.95); C367(1.25); C368(1.25)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C367(0.99); C368(0.99); C430(1.16)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C430(0.79); C368(0.91); C367(0.96)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C430(0.88); C368(0.91); C367(0.99)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C367(0.98); C430(1.10); C368(0.98)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C430(0.87); C368(0.95); C367(0.96)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C430(0.83); C368(0.88); C367(0.92)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C430(0.85); C367(0.97); C368(1.01)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C430(0.86); C367(1.01); C368(1.02)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C367(0.86); C368(0.87); C430(0.89)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C430(0.80); C367(0.94); C368(0.97)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C430(0.83); C368(0.94); C367(0.95)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C430(0.82); C368(0.92); C367(0.97)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C430(0.84); C368(0.87); C367(0.91)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C430(0.85); C368(1.03); C367(1.08)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C367(0.94); C430(1.00); C368(0.94)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C430(0.80); C367(0.89); C368(0.89)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C430(0.82); C368(0.91); C367(0.97)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C430(0.68); C368(0.83); C367(0.85)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C367(0.89); C368(0.91)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C367(0.90); C368(0.93)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C367(0.89); C368(0.94)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C367(0.79); C368(0.83)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C368(0.92); C367(1.03)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C368(0.85); C367(0.88)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C368(0.78); C367(0.83)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C367(0.92); C368(0.93)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C368(0.93); C367(1.00)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C367(0.98); C368(1.01)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C367(0.98); C368(1.00)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C367(1.03); C368(1.08)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C367(0.96); C368(0.97)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C367(0.85); C368(1.01)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C367(0.96); C368(1.07)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C430(0.58)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C430(0.88)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C367(1.06); C430(1.05); C368(1.06)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C367(1.04); C430(1.21); C368(1.04)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C367(1.23); C430(1.20); C368(1.23)  LDD1154  [3]
 LDCM0367  CL1 HCT 116 C367(1.09)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C367(1.06)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C430(0.91)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C367(1.09); C430(1.03); C368(1.09)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C367(1.05); C430(1.14); C368(1.05)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C367(0.90); C430(1.23); C368(0.90)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C367(1.09); C430(1.16); C368(1.09)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C430(1.02)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C430(1.13)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C430(1.07)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C430(1.32)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C430(1.01)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C367(1.06)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C430(1.07)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C430(0.94)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C430(1.00)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C430(1.13)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C430(1.05)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C430(1.10)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C430(1.12)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C430(1.07)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C430(1.27)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C430(1.22)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C367(1.28)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C430(1.11)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C430(1.16)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C430(1.18)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C430(1.07)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C430(1.11)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C430(1.09); C367(1.17); C368(1.17)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C430(0.83); C367(0.91); C368(0.91)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C367(0.91); C368(0.91); C430(1.05)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C430(1.02); C367(1.27); C368(1.27)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C367(1.01)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C367(1.16)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C367(1.09)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C367(1.10); C368(1.10); C430(1.23)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C368(0.97); C367(1.07); C430(1.07)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C368(0.98); C367(0.99); C430(1.30)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C368(1.02); C367(1.05); C430(1.41)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C367(1.07)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C368(1.00); C367(1.01); C430(1.31)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C368(1.09); C367(1.11); C430(1.39)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C367(0.84); C368(0.87); C430(1.07)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C368(1.03); C367(1.03); C430(1.40)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C367(0.88); C368(0.94); C430(1.35)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C367(0.98); C368(0.84); C430(1.30)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C367(1.00); C368(0.96); C430(1.19)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C367(0.99); C368(1.05); C430(1.13)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C367(0.99); C368(0.91); C430(1.31)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C367(0.85); C368(0.84); C430(1.26)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C367(0.99)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C367(1.09); C368(0.90); C430(1.16)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C367(1.01); C368(0.96); C430(1.10)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C367(0.93); C368(0.93); C430(1.08)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C367(1.28); C368(1.28); C430(1.05)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C367(0.92); C368(0.92); C430(1.09)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C367(0.95); C368(0.95); C430(1.01)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C367(1.01); C368(1.01); C430(1.06)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C367(1.05); C368(1.05); C430(1.03)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C367(1.11); C368(1.11); C430(1.00)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C367(0.98)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C367(0.92); C368(0.92); C430(0.88)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C367(0.80); C368(0.80); C430(1.03)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C367(1.09); C368(1.09); C430(0.95)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C367(1.14); C368(1.14); C430(1.10)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C367(1.02); C368(1.02); C430(1.00)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C367(0.96); C368(0.96); C430(1.20)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C367(1.09); C368(1.09); C430(1.00)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C367(1.03); C368(1.03); C430(1.02)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C367(0.90); C368(0.90); C430(0.98)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C367(0.98); C368(0.98); C430(0.97)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C367(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C367(0.83); C368(0.83); C430(0.94)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C367(0.96); C368(0.96); C430(1.00)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C367(0.99); C368(0.99); C430(1.03)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C367(0.96); C368(0.96); C430(0.80)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C367(0.92); C368(0.92); C430(0.90)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C367(0.99); C368(0.99); C430(0.93)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C367(0.91); C368(0.91); C430(1.05)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C367(0.96); C368(0.96); C430(0.88)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C367(0.91); C368(0.91); C430(0.97)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C367(0.95); C368(0.95); C430(1.02)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C367(1.09)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C367(0.91); C368(0.91); C430(1.09)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C367(1.15); C368(1.15)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C367(1.14); C368(1.14)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C367(1.16); C368(1.16)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C367(1.09); C368(1.09)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C367(1.02); C368(1.02)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C367(1.17); C368(1.17)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C367(1.30); C368(1.30)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C367(1.17); C368(1.17)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C367(1.26); C368(1.26)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C367(1.14)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C367(1.31); C368(1.31)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C367(1.05); C368(1.05)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C367(0.98); C368(0.98)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C367(1.37); C368(1.37)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C367(1.24); C368(1.24)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C430(1.15); C368(0.97)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C430(1.23); C368(0.98)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C430(1.44); C368(1.12)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C430(1.34); C368(1.24)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C367(1.16)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C430(1.36); C368(1.24)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C430(1.44); C368(1.14)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C430(1.36); C368(1.21)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C430(1.50); C368(1.19)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C430(1.27); C368(1.05)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C430(1.17); C368(1.06)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C430(1.32); C368(1.10)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C430(1.51); C368(1.21)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C430(1.47); C368(1.29)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C430(1.27); C368(1.11)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C367(1.08)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C430(1.40); C368(1.03)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C430(0.85)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C430(0.72)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C430(1.05)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C430(0.84)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C430(0.78)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C430(0.81)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C430(0.89)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C430(0.94)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C430(0.73)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C367(1.19)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C367(1.23); C368(1.23)  LDD1347  [3]
 LDCM0427  Fragment51 HCT 116 C367(1.20); C368(1.20); C430(0.87)  LDD0744  [3]
 LDCM0022  KB02 786-O C430(1.22)  LDD2247  [9]
 LDCM0023  KB03 MDA-MB-231 C1077(2.12)  LDD1701  [2]
 LDCM0024  KB05 COLO792 C1088(2.45)  LDD3310  [9]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1088(1.13)  LDD2099  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C382(0.70)  LDD2123  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C368(0.90)  LDD2137  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(1s2s3r6r)-4-(Hydroxymethyl)-6-(Octylamino)Cyclohex-4-ene-123-triol Small molecular drug DB08321
(1r2r3r4s5r)-4-(Benzylamino)-5-(Methylthio)Cyclopentane-123-triol . DB06984
1-deoxymannojirimycin . DB03955
2-deoxy-2-fluoro-alpha-d-mannosyl Fluoride . DB02318
5-fluoro-beta-l-gulosyl Fluoride . DB03008
5-thio-a/B-d-mannopyranosylamine . DB03414
Ghavamiol . DB02492
Kifunensine . DB02742
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tridolgosir Small molecular drug D0S1AD

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840