Details of the Target

General Information of Target

Target ID LDTP06260
Target Name UBX domain-containing protein 2B (UBXN2B)
Gene Name UBXN2B
Gene ID 137886
Synonyms
UBX domain-containing protein 2B; NSFL1 cofactor p37; p97 cofactor p37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTP
PQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGY
RLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEI
PLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEED
KSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFIL
VTSFPNKELTDESLTLLEADILNTVLLQQLK
Target Bioclass
Other
Family
NSFL1C family
Subcellular location
Nucleus
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Uniprot ID
Q14CS0
Ensemble ID
ENST00000399598.7
HGNC ID
HGNC:27035

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C127(48.14)  LDD0209  [1]
IA-alkyne
 Probe Info  		C127(8.16)  LDD1706  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Phosphinate-6
 Probe Info  		C127(0.00); C41(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C127(1.16)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C127(1.23)  LDD1508  [6]
 LDCM0216  AC100 PaTu 8988t C127(1.04)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C127(0.90)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C127(0.85)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C127(1.08)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C127(0.95)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C127(0.99)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C127(0.95)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C127(0.86)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C127(1.15)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C127(1.17)  LDD1104  [5]
 LDCM0226  AC11 HEK-293T C127(1.40)  LDD1509  [6]
 LDCM0227  AC110 PaTu 8988t C127(1.20)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C127(1.20)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C127(1.18)  LDD1108  [5]
 LDCM0237  AC12 HEK-293T C127(1.14)  LDD1510  [6]
 LDCM0246  AC128 HCT 116 C127(0.70)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C127(0.52)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C127(0.88)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C127(0.67)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C127(0.57)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C127(0.74)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C127(0.85)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C127(0.89)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C127(0.80)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C127(0.86)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C127(0.66)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C127(0.71)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C127(1.04)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C127(0.74)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C127(0.79)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C127(0.53)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C127(1.08)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C127(1.62)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C127(1.41)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C127(1.45)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C127(1.69)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C127(2.08)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C127(1.66)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C127(1.00)  LDD1513  [6]
 LDCM0271  AC150 HCT 116 C127(1.63)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C127(1.33)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C127(1.47)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C127(2.45)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C127(1.35)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C127(1.42)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C127(1.16)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C127(1.38)  LDD2161  [5]
 LDCM0276  AC17 PaTu 8988t C127(0.84)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C127(1.32)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C127(0.87)  LDD1157  [5]
 LDCM0279  AC2 HCT 116 C127(1.06)  LDD0596  [5]
 LDCM0280  AC20 PaTu 8988t C127(0.98)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C127(0.86)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C127(1.30)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C127(1.49)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C127(0.88)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C127(0.86)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C127(0.84)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C127(1.04)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C127(1.21)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C127(1.07)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C127(1.45)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C127(0.82)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C127(1.11)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C127(0.94)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C127(1.35)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C127(0.81)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C127(1.55)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C127(1.16)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C127(0.95)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C127(1.04)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C127(1.06)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C127(0.97)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C127(0.99)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C127(1.10)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C127(1.32)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C127(1.57)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C127(1.23)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C127(0.95)  LDD1546  [6]
 LDCM0308  AC46 PaTu 8988t C127(0.90)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C127(1.20)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C127(1.11)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C127(1.39)  LDD1190  [5]
 LDCM0312  AC5 HCT 116 C127(1.09)  LDD0629  [5]
 LDCM0313  AC50 PaTu 8988t C127(1.40)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C127(0.75)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C127(0.89)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C127(1.44)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C127(1.59)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C127(1.16)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C127(1.48)  LDD1198  [5]
 LDCM0320  AC57 HCT 116 C127(1.41)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C127(0.91)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C127(1.21)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C127(1.06)  LDD1562  [6]
 LDCM0324  AC60 HCT 116 C127(1.14)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C127(1.00)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C127(1.12)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C127(1.05)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C127(1.39)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C127(0.91)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C127(0.80)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C127(0.89)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C127(1.04)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C127(1.17)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C127(1.03)  LDD1568  [6]
 LDCM0335  AC70 HCT 116 C127(1.34)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C127(1.14)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C127(1.29)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C127(1.47)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C127(1.55)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C127(2.07)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C127(1.23)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C127(1.16)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C127(1.11)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C127(1.09)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C127(1.06)  LDD1569  [6]
 LDCM0346  AC80 HCT 116 C127(1.16)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C127(1.46)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C127(1.81)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C127(1.35)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C127(1.20)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C127(1.31)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C127(1.06)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C127(1.60)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C127(1.06)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C127(1.25)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C127(0.98)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C127(1.68)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C127(1.25)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C127(1.04)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C127(1.02)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C127(1.11)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C127(1.33)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C127(1.54)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C127(0.99)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C127(0.96)  LDD1245  [5]
 LDCM0248  AKOS034007472 HEK-293T C127(0.97)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C127(1.08)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C127(1.05)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C127(0.98)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C127(1.19)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C127(1.30)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C127(1.01)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C127(1.02)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C127(0.95)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C127(1.14)  LDD1577  [6]
 LDCM0374  CL105 PaTu 8988t C127(1.06)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C127(1.10)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C127(0.98)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C127(1.01)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C127(1.07)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C127(0.99)  LDD1583  [6]
 LDCM0380  CL110 PaTu 8988t C127(0.93)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C127(1.38)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C127(0.88)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C127(0.89)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C127(0.92)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C127(0.83)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C127(1.19)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C127(1.07)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C127(1.13)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C127(0.90)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C127(1.01)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C127(1.16)  LDD1595  [6]
 LDCM0392  CL121 PaTu 8988t C127(1.04)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C127(1.38)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C127(1.35)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C127(1.47)  LDD1274  [5]
 LDCM0396  CL125 HCT 116 C127(0.91)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C127(0.97)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C127(0.97)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C127(1.03)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C127(1.15)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C127(1.01)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C127(1.01)  LDD1606  [6]
 LDCM0403  CL16 HCT 116 C127(1.18)  LDD0720  [5]
 LDCM0404  CL17 PaTu 8988t C127(1.47)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C127(1.49)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C127(1.66)  LDD1285  [5]
 LDCM0407  CL2 HEK-293T C127(1.01)  LDD1611  [6]
 LDCM0408  CL20 PaTu 8988t C127(1.99)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C127(2.53)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C127(1.84)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C127(1.33)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C127(1.05)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C127(1.29)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C127(1.63)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C127(1.11)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C127(1.90)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C127(1.77)  LDD1296  [5]
 LDCM0418  CL3 HEK-293T C127(0.94)  LDD1622  [6]
 LDCM0419  CL30 PaTu 8988t C127(1.43)  LDD1298  [5]
 LDCM0420  CL31 HEK-293T C127(1.36)  LDD1624  [6]
 LDCM0421  CL32 HCT 116 C127(1.11)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C127(0.58)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C127(1.17)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C127(1.23)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C127(1.11)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C127(1.16)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C127(0.85)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C127(1.18)  LDD1633  [6]
 LDCM0430  CL40 HCT 116 C127(0.91)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C127(1.00)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C127(0.60)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C127(0.77)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C127(0.99)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C127(0.78)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C127(1.04)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C127(0.88)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C127(0.94)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C127(0.84)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C127(1.08)  LDD1644  [6]
 LDCM0441  CL50 HCT 116 C127(0.93)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C127(0.90)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C127(0.99)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C127(1.01)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C127(1.01)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C127(1.00)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C127(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C127(0.84)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C127(1.04)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C127(0.85)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C127(1.25)  LDD1654  [6]
 LDCM0452  CL60 HCT 116 C127(0.90)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C127(0.97)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C127(1.04)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C127(0.88)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C127(1.00)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C127(1.15)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C127(1.12)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C127(1.37)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C127(1.16)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C127(0.96)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C127(1.48)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C127(0.98)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C127(1.02)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C127(1.02)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C127(0.88)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C127(1.00)  LDD1670  [6]
 LDCM0469  CL76 HCT 116 C127(0.91)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C127(0.85)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C127(1.07)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C127(0.87)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C127(1.20)  LDD1676  [6]
 LDCM0474  CL80 HCT 116 C127(0.88)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C127(0.81)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C127(0.76)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C127(0.90)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C127(0.98)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C127(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C127(0.89)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C127(0.79)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C127(0.84)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C127(0.85)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C127(0.95)  LDD1687  [6]
 LDCM0485  CL90 HCT 116 C127(1.09)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C127(1.39)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C127(1.15)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C127(1.10)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C127(1.27)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C127(1.33)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C127(1.22)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C127(1.21)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C127(1.19)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C127(1.22)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C127(1.10)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C127(0.95)  LDD1671  [6]
 LDCM0427  Fragment51 HCT 116 C127(1.03)  LDD0744  [5]
 LDCM0023  KB03 Jurkat C127(48.14)  LDD0209  [1]
 LDCM0024  KB05 T cell-activated C127(8.16)  LDD1706  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) PNGase family Q96IV0
Synaptic vesicle membrane protein VAT-1 homolog-like (VAT1L) Zinc-containing alcohol dehydrogenase family Q9HCJ6
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein MOX-1 (MEOX1) . P50221
Paired box protein Pax-5 (PAX5) . Q02548
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein VCF1 (VCF1) FAM104 family Q969W3
Protein INCA1 (INCA1) INCA family Q0VD86
UBX domain-containing protein 6 (UBXN6) . Q9BZV1
XIAP-associated factor 1 (XAF1) . Q6GPH4

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402