Details of the Target

General Information of Target

Target ID LDTP06229
Target Name Dr1-associated corepressor (DRAP1)
Gene Name DRAP1
Gene ID 10589
Synonyms
Dr1-associated corepressor; Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSR
NAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRK
NGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFA
STLPLPPAPPGPSAPDEEDEEDYDS
Target Bioclass
Transcription factor
Family
NC2 alpha/DRAP1 family
Subcellular location
Nucleus
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Uniprot ID
Q14919
Ensemble ID
ENST00000312515.7
HGNC ID
HGNC:3019

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.I27V DBIA    Probe Info 
HT SNV: p.M124V DBIA    Probe Info 
MOLT4 SNV: p.S48L IA-alkyne    Probe Info 
TOV21G SNV: p.R60W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.98  LDD0402  [1]
C-Sul
 Probe Info  		2.52  LDD0066  [2]
STPyne
 Probe Info  		K52(10.00); K63(4.41)  LDD0277  [3]
ONAyne
 Probe Info  		K52(7.62)  LDD0275  [3]
DBIA
 Probe Info  		C54(3.07)  LDD3311  [4]
BTD
 Probe Info  		C54(2.44)  LDD1700  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C54(0.00); C73(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C73(0.00); C54(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		12.10  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C54(0.47)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C54(0.53)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C54(0.94)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C54(0.91)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C54(1.85)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C54(0.77)  LDD2103  [5]
 LDCM0214  AC1 HEK-293T C73(1.21); C54(1.11)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C73(1.13); C54(0.92)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C73(1.11); C54(0.98)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C73(1.06)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C73(1.11); C54(0.99)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C73(1.13)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C73(1.19); C54(1.06)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C73(1.03); C54(0.93)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C73(1.50); C54(1.22)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C73(1.10); C54(1.01)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C73(1.03)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C73(1.08)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C73(0.96); C54(1.06)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C73(1.10)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C73(1.13); C54(0.92)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C73(1.23); C54(0.97)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C73(1.10); C54(0.93)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C73(1.08); C54(0.91)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C73(1.06)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C73(1.21)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C73(1.20); C54(1.00)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C73(1.03); C54(0.98)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C73(1.01)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C73(1.19); C54(0.89)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C73(1.20); C54(1.09)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C73(1.06); C54(0.94)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C73(1.13); C54(1.05)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C73(0.96)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C73(1.16)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C73(1.01); C54(0.92)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C73(1.08)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C73(1.04)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C73(1.10); C54(0.88)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C73(1.19); C54(1.10)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C73(1.24); C54(0.92)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C73(1.09); C54(1.04)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C73(1.01)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C73(1.13)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C73(1.15); C54(0.97)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C73(1.13)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C73(1.06); C54(0.89)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C73(1.19); C54(1.04)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C73(1.21)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C73(1.12); C54(0.95)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C73(1.17); C54(1.14)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C73(1.06)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C73(1.17)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C73(1.07); C54(0.98)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C73(1.10)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C73(1.09); C54(0.88)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C73(1.19); C54(0.99)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C73(1.16); C54(0.99)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C73(1.12); C54(1.06)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C73(1.05); C54(1.04)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C73(1.02)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C73(1.17)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C73(1.07); C54(0.98)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C73(1.08)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C73(1.04); C54(0.98)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C73(1.05)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C73(1.07); C54(1.04)  LDD1569  [14]
 LDCM0545  Acetamide MDA-MB-231 C54(0.19)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C54(0.73)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C73(1.20)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C73(1.24); C54(1.08)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C73(1.12); C54(1.00)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C54(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C73(1.34)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C73(1.09); C54(0.84)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C73(1.16)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C73(1.21)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C73(1.02)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C73(0.96)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C73(1.08)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C73(1.13)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C73(1.13)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C73(0.91)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C73(1.15)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C73(1.12)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C73(0.93)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C73(1.08)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C73(1.06)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C73(1.14)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C73(1.22)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C73(1.09)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C73(0.94)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C73(1.14)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C73(1.12)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C73(1.18)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C73(1.00)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C73(0.90); C54(0.88)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C73(1.13)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C73(1.15)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C73(0.91)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C73(1.04)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C73(1.10)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C73(1.23)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C73(0.99)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C73(1.06)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C73(1.22)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C73(1.30)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C73(1.01)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C73(1.08)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C73(1.27)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C73(1.28); C54(1.04)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C73(1.13); C54(0.87)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C73(1.15); C54(0.99)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C73(1.04)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C73(1.02)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C73(1.04)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C73(0.99); C54(0.98)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C73(0.92)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C73(0.86); C54(0.84)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C73(1.25)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C73(1.02)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C73(1.02)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C73(1.09)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C73(1.17); C54(1.08)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C73(0.99)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C73(1.13); C54(0.92)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C73(1.11); C54(0.93)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C73(0.96)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C73(1.12)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C73(0.94); C54(0.92)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C73(0.92)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C73(0.86); C54(0.97)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C73(1.11)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C73(0.84)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C73(1.27)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C73(1.14)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C73(1.25); C54(0.98)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C73(1.15); C54(0.94)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C73(1.10); C54(0.87)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C73(0.93)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C73(1.03)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C73(0.91); C54(1.02)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C73(0.91)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C73(0.99); C54(0.93)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C73(1.26)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C73(1.38); C54(1.00)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C73(0.98)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C73(1.16)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C73(1.22); C54(1.14)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C73(1.15); C54(0.97)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C73(1.09); C54(1.04)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C73(0.97)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C73(1.02)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C73(0.94); C54(0.96)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C73(0.93)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C73(1.21); C54(0.88)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C73(0.91); C54(0.90)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C73(1.31)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C73(0.99)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C73(1.09)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C73(1.17)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C73(1.08); C54(0.96)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C73(1.14); C54(0.99)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C73(1.15); C54(1.07)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C73(1.00)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C73(1.01)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C73(1.24); C54(1.17)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C73(1.04); C54(1.06)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C73(0.84)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C73(0.95); C54(0.97)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C73(1.25)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C73(1.05)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C73(1.24)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C73(1.53); C54(1.01)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C73(1.05); C54(0.95)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C73(1.03); C54(0.98)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C73(1.44)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C73(0.98)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C73(1.00)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C73(1.02); C54(0.93)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C73(0.89)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C73(0.92); C54(0.82)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C73(1.28)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C73(1.09)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C73(1.02)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C73(1.12)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C73(1.30); C54(1.11)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C73(1.14)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C73(1.23); C54(1.07)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C73(1.19); C54(1.12)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C73(0.99)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C73(1.04)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C73(1.05); C54(0.93)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C73(1.33)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C73(0.97); C54(0.96)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C73(1.17)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C73(1.03)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C73(1.05)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C73(0.94)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C54(2.98)  LDD1702  [5]
 LDCM0625  F8 Ramos C54(1.19)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C54(0.85)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C54(0.17)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C54(0.67)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C54(0.92)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C54(1.00)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C54(0.64)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C54(0.94)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C54(0.70)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C54(1.01)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C54(0.65)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C54(1.23)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C54(0.89)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C54(0.85)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C73(1.09)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C54(1.01)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C54(0.75)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C73(1.07)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C54(1.21)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C54(1.60)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C54(0.61)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C54(0.67)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C54(1.00)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C54(0.99)  LDD1497  [14]
 LDCM0024  KB05 G361 C54(3.07)  LDD3311  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C54(0.87)  LDD2102  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C54(0.33)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C54(1.17)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C54(1.33)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C54(0.85)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C54(1.02)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C54(0.96)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C54(1.01)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C54(0.58)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C54(0.90)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C54(0.38)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C54(1.23)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C54(1.06)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C54(0.42)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C54(0.70)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C54(1.11)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C54(0.55)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C54(0.40)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C54(1.07)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C54(1.37)  LDD2118  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C54(0.82)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C54(1.10)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C54(0.78)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C54(0.95)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C54(0.79)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C54(0.98)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C54(1.10)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C54(0.76)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C54(0.75)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C54(0.66)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C54(0.69)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C54(1.02)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C54(1.41)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C54(0.97)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C54(2.44)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C54(1.00)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C54(0.58)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C54(1.01)  LDD2143  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C54(0.87)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C54(2.97)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C54(0.36)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C54(1.24)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C54(0.34)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C54(1.09)  LDD2151  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C54(0.86)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C54(0.49)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Nuclear transcription factor Y subunit beta (NFYB) NFYB/HAP3 subunit family P25208
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Transcription initiation factor TFIID subunit 9 (TAF9) TAF9 family Q16594
Transcription initiation factor TFIID subunit 9B (TAF9B) TAF9 family Q9HBM6
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Cytoplasmic protein NCK2 (NCK2) . O43639
DNA polymerase epsilon subunit 3 (POLE3) . Q9NRF9
Microspherule protein 1 (MCRS1) . Q96EZ8
PRKCA-binding protein (PICK1) . Q9NRD5
Rhombotin-2 (LMO2) . P25791

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.