Details of the Target

General Information of Target

Target ID LDTP06101
Target Name Fas-activated serine/threonine kinase (FASTK)
Gene Name FASTK
Gene ID 10922
Synonyms
Fas-activated serine/threonine kinase; FAST kinase; EC 2.7.11.1; EC 2.7.11.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP
CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR
LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL
EQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVM
VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL
ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL
LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ
DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV
LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL
GLRWGPEGG
Target Bioclass
Enzyme
Family
FAST protein kinase family
Subcellular location
Mitochondrion matrix
Function
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.; [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
Uniprot ID
Q14296
Ensemble ID
ENST00000297532.11
HGNC ID
HGNC:24676

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Insertion: p.S338FfsTer70 DBIA    Probe Info 
EFO27 SNV: p.R2M DBIA    Probe Info 
HEC1B SNV: p.P46T .
IGROV1 Deletion: p.V424AfsTer43 DBIA    Probe Info 
U118MG SNV: p.G51S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C459(0.77)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C459(0.77)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C459(0.94)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C459(0.86)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C459(0.96)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C459(0.90)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C459(1.71)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C459(1.27)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C459(1.08)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C459(1.12)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C459(1.10)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C459(0.90)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C459(1.07)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C459(1.14)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C459(1.14)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C459(0.82)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C459(0.93)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C459(1.41)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C459(1.16)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C459(1.16)  LDD0562  [1]
 LDCM0246  AC128 PaTu 8988t C459(1.23)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C459(1.20)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C459(1.04)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C459(0.94)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C459(0.92)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C459(1.40)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C459(1.40)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C459(1.50)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C459(1.32)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C459(1.59)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C459(1.48)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C459(1.30)  LDD1137  [1]
 LDCM0259  AC14 HCT 116 C459(0.96)  LDD0576  [1]
 LDCM0260  AC140 PaTu 8988t C459(0.93)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C459(0.92)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C459(1.51)  LDD1141  [1]
 LDCM0270  AC15 HCT 116 C459(0.90)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C459(1.10)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C459(1.38)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C459(1.11)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C459(1.07)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C459(1.01)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C459(1.03)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C459(1.11)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C459(1.18)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C459(0.96)  LDD0601  [1]
 LDCM0286  AC26 HEK-293T C459(1.11)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C212(0.96)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C212(0.94)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C459(0.94); C212(1.02)  LDD1528  [4]
 LDCM0290  AC3 HCT 116 C459(0.88)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C459(0.84); C212(1.06)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C459(1.03)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C459(1.13)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C459(1.09)  LDD1534  [4]
 LDCM0296  AC35 HCT 116 C459(0.84)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C459(0.82)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C459(0.82)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C459(1.09)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C459(0.95)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C459(0.85)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C459(0.78)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C459(1.07)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C459(0.81)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C459(0.98)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C459(0.95)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C459(0.81)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C459(1.11)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C459(0.89)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C459(1.19)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C459(1.14)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C459(0.84)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C459(1.17)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C459(1.18)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C459(0.99)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C459(1.17)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C459(1.32)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C459(0.90)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C459(1.21)  LDD0636  [1]
 LDCM0321  AC58 HEK-293T C459(1.00)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C212(1.14)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C459(1.17)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C212(1.05)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C459(1.03); C212(1.13)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C459(0.84); C212(1.00)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C459(1.10)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C459(1.01)  LDD1567  [4]
 LDCM0334  AC7 HCT 116 C459(1.17)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C459(1.01)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C459(1.03)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C459(1.09)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C459(1.24)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C459(1.24)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C459(1.13)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C459(1.27)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C459(1.01)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C459(1.38)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C459(1.15)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C459(0.99)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C459(1.05)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C459(1.43)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C459(0.99)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C459(1.40)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C459(1.30)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C459(0.97)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C459(0.80)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C459(1.22)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C459(1.04)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C459(1.05)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C459(1.06)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C459(0.99)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C459(1.25)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C459(0.93)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C459(0.96)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C459(1.29)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C459(1.41)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C459(1.43)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C459(1.49)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C459(1.28)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C459(0.96)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C459(1.59)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C459(1.35)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C212(0.98)  LDD1586  [4]
 LDCM0385  CL115 HEK-293T C459(1.25)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C212(1.00)  LDD1590  [4]
 LDCM0387  CL117 HCT 116 C459(0.94)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C459(1.05)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C459(0.96)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C459(1.09)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C459(0.91)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C459(1.19)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C459(1.14)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C459(1.52)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C459(1.35)  LDD0712  [1]
 LDCM0398  CL127 HEK-293T C459(1.36)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C212(1.01)  LDD1603  [4]
 LDCM0400  CL13 HCT 116 C459(1.03)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C459(0.99)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C459(1.77)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C459(1.01)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C459(1.19)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C459(1.17)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C459(1.08)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C459(1.13)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C459(1.13)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C459(2.47)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C459(2.22)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C459(1.14)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C459(1.40)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C459(1.22)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C459(1.11)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C459(1.16)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C459(1.32)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C459(1.13)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C459(1.09)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C459(1.19)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C459(1.08)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C459(1.23)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C459(1.25)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C459(1.21)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C459(1.52)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C459(1.33)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C459(1.64)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C459(1.52)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C459(2.13)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C459(1.62)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C459(1.37)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C459(1.44)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C459(1.53)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C459(1.90)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C459(1.55)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C459(0.71)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C459(0.68)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C459(0.69)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C459(0.98)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C459(0.98)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C459(1.00)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C459(0.75)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C459(0.82)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C459(1.14)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C459(1.01)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C459(0.75)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C459(0.13)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C459(1.68)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C459(1.14)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C459(1.54)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C459(1.04)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C459(1.03)  LDD1331  [1]
 LDCM0453  CL61 HCT 116 C459(1.22)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C459(1.12)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C459(1.20)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C459(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C459(1.13)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C459(1.61)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C459(1.38)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C459(1.41)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C459(1.27)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C459(1.05)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C459(1.10)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C459(1.34)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C459(1.29)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C459(1.20)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C459(1.33)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C459(1.11)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C459(1.09)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C459(1.19)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C459(1.27)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C459(1.06)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C459(1.21)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C459(1.23)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C459(1.29)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C459(1.45)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C459(1.50)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C459(1.28)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C459(1.08)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C459(1.47)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C459(1.21)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C459(1.60)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C459(1.24)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C459(1.60)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C459(1.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C459(1.12)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C459(0.90)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C459(0.92)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C459(1.09)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C459(1.01)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C459(1.13)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C459(0.95)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C459(0.95)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C459(1.25)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C459(1.17)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C459(1.31)  LDD0744  [1]
 LDCM0149  GA MCF-7 C212(2.42)  LDD0379  [5]
 LDCM0022  KB02 HEK-293T C459(0.93)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C459(0.94)  LDD1497  [4]
 LDCM0024  KB05 WM115 C459(1.05)  LDD3327  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
Calcium homeostasis endoplasmic reticulum protein (CHERP) . Q8IWX8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840