Details of the Target

General Information of Target

Target ID LDTP06084
Target Name Protein NPAT (NPAT)
Gene Name NPAT
Gene ID 4863
Synonyms
CAND3; E14; Protein NPAT; Nuclear protein of the ataxia telangiectasia mutated locus; Nuclear protein of the ATM locus; p220
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLT
TILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEI
KRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQS
QDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAV
EKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLG
LPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVL
ADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQIS
TSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETE
MAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSL
TGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSC
LQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQ
EPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNT
DDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSP
TKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVT
PCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQ
PLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNN
FSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGC
HAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPN
HKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTT
IRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKS
IASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLA
DSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPAS
ETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERER
NSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
Target Bioclass
Other
Family
NPAT family
Subcellular location
Nucleus
Function
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Uniprot ID
Q14207
Ensemble ID
ENST00000278612.9
HGNC ID
HGNC:7896

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C517(2.01); C1316(2.58); C1065(2.36); C1020(2.46)  LDD0171  [2]
DBIA
 Probe Info  		C978(0.97)  LDD0547  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		C1020(0.00); C1059(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
Compound 10
 Probe Info  		C1059(0.00); C1065(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C551(0.00); C1172(0.00)  LDD0147  [8]
Phosphinate-6
 Probe Info  		C1059(0.00); C1172(0.00); C551(0.00); C978(0.00)  LDD0018  [9]
AOyne
 Probe Info  		12.60  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1172(3.11)  LDD0172  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C517(2.01); C1316(2.58); C1065(2.36); C1020(2.46)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C1172(1.04); C1002(1.18); C438(0.88); C1316(0.98)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C1172(1.03); C1002(1.09); C438(1.07); C682(1.08)  LDD1508  [11]
 LDCM0216  AC100 HEK-293T C978(0.96)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C978(0.99)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C978(0.95)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C978(0.96)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C978(1.02)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C978(1.03)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C978(0.81)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C978(0.94)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C978(0.93)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C978(0.97)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C1172(1.12); C438(1.01); C682(0.94); C517(1.14)  LDD1509  [11]
 LDCM0227  AC110 HEK-293T C978(0.93)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C978(0.87)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C978(0.95)  LDD0827  [3]
 LDCM0230  AC113 HCT 116 C978(0.97)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C978(0.88)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C978(1.05)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C978(1.11)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C978(1.38)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C978(1.14)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C978(0.96)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C1172(0.90); C1002(1.11); C551(0.99); C682(0.95)  LDD1510  [11]
 LDCM0238  AC120 HCT 116 C978(0.96)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C978(1.16)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C978(0.92)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C978(0.74)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C978(1.13)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C978(0.86)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C978(0.84)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C978(1.10)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C1172(1.05); C1002(1.05); C438(0.95); C682(1.00)  LDD1512  [11]
 LDCM0263  AC143 HCT 116 C978(1.38)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C978(1.52)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C978(0.85)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C978(1.05)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C978(1.33)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C978(1.81)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C978(1.75)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C1172(0.99); C1002(1.05); C551(1.04); C438(1.12)  LDD1513  [11]
 LDCM0271  AC150 HCT 116 C978(1.22)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C978(1.35)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C978(1.70)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C978(2.32)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C978(1.58)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C978(1.60)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C978(0.81)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C978(2.86)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C978(0.87)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C978(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C978(1.00)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C1172(0.99); C1002(1.02); C438(1.15); C682(1.03)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C978(0.84)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C978(0.93)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C978(0.95)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C978(0.84)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C978(0.79)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C978(1.21)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C978(1.34)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C978(1.15)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C978(1.62)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C978(1.14)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C1172(1.02); C438(1.23); C682(0.97); C517(0.95)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C978(1.41)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C978(1.14)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C978(1.57)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C978(1.12)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C978(0.79)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C978(1.03)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C978(0.92)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C978(0.89)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C978(0.87)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C978(1.16)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C1172(0.99); C1002(1.09); C551(0.97); C682(1.12)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C978(1.34)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C978(0.98)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C978(1.04)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C978(1.05)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C978(1.04)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C978(1.20)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C978(0.95)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C978(0.98)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C978(1.11)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C978(1.22)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C1172(0.97); C1002(0.93); C551(0.95); C438(1.07)  LDD1551  [11]
 LDCM0313  AC50 PaTu 8988t C978(1.23)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C978(0.76)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C978(1.15)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C978(1.51)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C978(1.53)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C978(1.14)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C978(1.28)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C978(1.35)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C978(0.99)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C978(1.18)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C1172(1.15); C1002(1.05); C438(1.01); C682(1.00)  LDD1562  [11]
 LDCM0324  AC60 HCT 116 C978(1.30)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C978(1.12)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C978(1.42)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C978(1.28)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C978(1.34)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C978(1.19)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C978(1.09)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C978(1.41)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C978(0.85)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C978(0.77)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C1172(0.93); C1002(1.02); C551(1.00); C438(1.03)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C978(0.89)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C978(0.85)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C978(1.05)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C978(1.12)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C978(1.08)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C978(0.99)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C978(0.93)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C978(0.91)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C978(1.02)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C978(1.02)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C1002(1.00); C551(0.95); C682(1.08)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C978(1.19)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C978(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C978(0.98)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C978(1.29)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C978(1.23)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C978(1.35)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C978(1.23)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C978(1.25)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C978(1.41)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C978(1.32)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C978(0.97)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C978(1.40)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C978(1.37)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C978(1.07)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C978(1.49)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C978(1.36)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C978(1.04)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C978(1.45)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C978(0.87)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C978(0.86)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C1172(0.95); C1002(0.99); C551(0.88); C438(1.13)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C1172(1.16); C1002(1.13); C438(1.10); C1316(1.00)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C1002(0.99); C551(0.89); C682(1.08)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 11.77  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C978(0.81)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C978(1.61)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C1172(1.07); C551(1.16); C438(1.08); C1316(0.78)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C1172(0.96); C1002(1.04); C551(1.10); C438(1.03)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C1172(0.95); C1002(1.20); C438(1.03); C682(1.00)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C1172(1.06); C1002(1.13); C682(1.03); C517(1.17)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C1172(1.11); C551(1.02); C438(0.97); C1316(1.15)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C978(0.99)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C978(0.99)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C978(0.96)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C978(0.97)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C978(0.97)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C978(1.17)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C978(0.83)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C978(0.82)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C978(1.38)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C978(1.17)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C978(1.05)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C978(1.05)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C978(1.08)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C978(1.36)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C978(1.04)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C978(1.03)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C978(1.26)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C978(1.06)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C978(0.97)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C978(1.26)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C978(1.29)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C978(1.25)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C978(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C978(1.00)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C978(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C978(1.14)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C978(1.29)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C978(0.76)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C978(1.30)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C978(1.17)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C978(1.19)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C978(1.09)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C978(0.92)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C978(0.74)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C978(1.09)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C978(1.16)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C978(1.20)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C978(1.64)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C978(1.15)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C978(1.42)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C978(1.59)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C978(1.66)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C978(1.23)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C978(1.17)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C978(0.77)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C978(1.21)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C978(0.94)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C978(1.17)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C978(1.18)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C978(1.00)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C978(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C978(1.11)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C978(1.14)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C978(0.84)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C978(0.87)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C978(1.18)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C978(0.88)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C978(0.90)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C978(0.98)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C978(0.94)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C978(1.09)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C978(0.76)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C978(0.92)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C978(0.85)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C978(0.94)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C978(0.87)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C978(0.89)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C978(0.84)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C978(0.90)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C978(0.92)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C978(0.84)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C978(0.86)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C978(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C978(1.00)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C978(0.81)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C978(0.88)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C978(1.11)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C978(0.92)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C978(0.99)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C978(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C978(1.04)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C978(1.09)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C978(0.93)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C978(1.10)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C978(0.95)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C978(1.02)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C978(1.24)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C978(0.96)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C978(0.97)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C978(0.89)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C978(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C978(1.05)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C978(0.94)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C978(1.13)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C978(1.07)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C978(1.26)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C978(1.48)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C978(1.89)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C978(1.33)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C978(1.23)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C978(1.50)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C978(1.44)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C978(1.30)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C978(1.27)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C978(1.39)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C978(1.48)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C978(1.63)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C978(1.18)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C978(1.27)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C978(1.90)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C1172(1.04); C438(1.06); C682(1.00); C517(1.05)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C1172(0.98); C1002(0.98); C551(0.83); C682(1.27)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C1172(0.90); C1002(0.94); C551(1.13); C438(0.86)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C1172(1.04); C1002(0.94); C438(0.99); C682(1.03)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C1172(0.98); C1002(1.03); C551(0.69); C438(0.90)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C1002(0.83); C551(0.90); C682(1.02)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C1172(0.98); C1002(1.01); C551(0.70); C438(1.05)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C1172(0.97); C1002(1.15); C438(0.93); C682(0.92)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C1172(0.91); C1002(1.05); C682(1.05); C517(1.02)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C1172(1.04); C1002(1.12); C682(1.02); C517(1.20)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1065(1.53); C1002(0.91)  LDD1702  [12]
 LDCM0468  Fragment33 HCT 116 C978(1.07)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C978(0.79)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C1172(0.95); C978(1.00); C387(1.18)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C1172(0.96); C978(1.00); C387(1.05)  LDD1497  [11]
 LDCM0024  KB05 OCUG-1 C978(3.26)  LDD3373  [13]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840