Details of the Target

General Information of Target

Target ID LDTP05707
Target Name Transcription initiation factor TFIID subunit 10 (TAF10)
Gene Name TAF10
Gene ID 6881
Synonyms
TAF2A; TAF2H; TAFII30; Transcription initiation factor TFIID subunit 10; STAF28; Transcription initiation factor TFIID 30 kDa subunit; TAF(II)30; TAFII-30; TAFII30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGG
TGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFL
MQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTA
SGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
Target Bioclass
Other
Family
TAF10 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex. May regulate cyclin E expression.
Uniprot ID
Q12962
Ensemble ID
ENST00000299424.9
HGNC ID
HGNC:11543

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K177(1.55); K213(10.00)  LDD0277  [1]
BTD
 Probe Info  		C174(1.82)  LDD2094  [2]
HHS-475
 Probe Info  		Y193(0.99)  LDD0264  [3]
DBIA
 Probe Info  		C174(0.85)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
1d-yne
 Probe Info  		N.A.  LDD0356  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [7]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C174(0.81)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C174(1.15)  LDD2112  [2]
 LDCM0214  AC1 HCT 116 C174(0.95)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C174(1.26)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C174(1.14)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C174(1.10)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C174(1.09)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C174(1.12)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C174(1.00)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C174(1.14)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C174(1.40)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C174(1.19)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C174(1.22)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C174(1.35)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C174(1.14)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C174(1.34)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C174(1.54)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C174(1.13)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C174(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C174(0.90)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C174(0.94)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C174(1.05)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C174(1.01)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C174(1.15)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C174(1.10)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C174(0.96)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C174(0.89)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C174(0.92)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C174(0.95)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C174(0.98)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C174(0.98)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C174(1.03)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C174(1.10)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C174(0.99)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C174(1.26)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C174(0.87)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C174(0.95)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C174(0.81)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C174(0.77)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C174(0.97)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C174(0.98)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C174(0.96)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C174(1.12)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C174(0.94)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C174(0.94)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C174(1.05)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C174(1.12)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C174(1.07)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C174(0.96)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C174(0.79)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C174(1.07)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C174(1.26)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C174(1.05)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C174(1.17)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C174(1.35)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C174(1.61)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C174(1.33)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C174(1.18)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C174(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C174(0.95)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C174(1.19)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C174(1.71)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C174(1.18)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C174(1.22)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C174(0.97)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C174(0.94)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C174(0.93)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C174(0.85)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C174(1.00)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C174(0.98)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C174(1.29)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C174(1.23)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C174(1.04)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C174(1.13)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C174(1.06)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C174(1.04)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C174(0.92)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C174(1.00)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C174(1.07)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C174(0.85)  LDD1528  [13]
 LDCM0290  AC3 HCT 116 C174(0.96)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C174(0.89)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C174(1.01)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C174(1.11)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C174(1.23)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C174(1.11)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C174(1.20)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C174(1.19)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C174(0.87)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C174(1.08)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C174(1.20)  LDD1539  [13]
 LDCM0301  AC4 HCT 116 C174(1.02)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C174(1.20)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C174(1.30)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C174(0.94)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C174(1.28)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C174(1.16)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C174(0.99)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C174(1.11)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C174(1.12)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C174(1.23)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C174(1.13)  LDD1550  [13]
 LDCM0312  AC5 HCT 116 C174(0.95)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C174(1.01)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C174(1.19)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C174(1.11)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C174(1.07)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C174(1.21)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C174(1.24)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C174(1.22)  LDD1558  [13]
 LDCM0320  AC57 HCT 116 C174(0.79)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C174(1.06)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C174(0.84)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C174(1.09)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C174(0.94)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C174(0.72)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C174(0.74)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C174(0.70)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C174(0.98)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C174(0.81)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C174(0.78)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C174(0.74)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C174(0.98)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C174(1.18)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C174(1.58)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C174(1.52)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C174(1.13)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C174(1.23)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C174(1.13)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C174(1.24)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C174(1.34)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C174(1.04)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C174(1.62)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C174(1.67)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C174(1.24)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C174(1.27)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C174(1.04)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C174(1.52)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C174(1.47)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C174(1.39)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C174(1.10)  LDD1245  [4]
 LDCM0248  AKOS034007472 HCT 116 C174(1.15)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C174(1.15)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C174(1.74)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C174(0.85)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C174(2.51)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C174(0.89)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C174(1.02)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C174(0.93)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C174(1.13)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C174(1.08)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C174(1.13)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C174(1.14)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C174(0.92)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C174(0.85)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C174(0.83)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C174(0.96)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C174(0.98)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C174(1.13)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C174(0.90)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C174(0.89)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C174(0.87)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C174(1.19)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C174(1.39)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C174(0.96)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C174(1.07)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C174(1.22)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C174(1.02)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C174(0.96)  LDD1593  [13]
 LDCM0390  CL12 HCT 116 C174(1.35)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C174(1.01)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C174(1.27)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C174(1.24)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C174(1.46)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C174(1.15)  LDD1599  [13]
 LDCM0396  CL125 HCT 116 C174(0.67)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C174(0.67)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C174(0.80)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C174(0.57)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C174(1.10)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C174(1.12)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C174(0.89)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C174(0.70)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C174(1.04)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C174(0.82)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C174(0.77)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C174(0.88)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C174(0.66)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C174(0.69)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C174(0.56)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C174(0.98)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C174(0.80)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C174(0.89)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C174(0.77)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C174(0.78)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C174(0.69)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C174(0.64)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C174(0.82)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C174(0.66)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C174(0.84)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C174(1.03)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C174(1.23)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C174(1.01)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C174(1.01)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C174(1.18)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C174(1.19)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C174(1.26)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C174(0.88)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C174(1.30)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C174(0.96)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C174(1.26)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C174(1.05)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C174(1.24)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C174(0.99)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C174(1.17)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C174(1.22)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C174(1.43)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C174(1.06)  LDD1643  [13]
 LDCM0440  CL5 HCT 116 C174(1.09)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C174(1.33)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C174(0.98)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C174(1.56)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C174(1.31)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C174(1.26)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C174(1.22)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C174(1.46)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C174(1.08)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C174(1.19)  LDD1653  [13]
 LDCM0451  CL6 HCT 116 C174(1.18)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C174(1.32)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C174(1.25)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C174(1.14)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C174(1.24)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C174(1.39)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C174(1.36)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C174(1.16)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C174(1.05)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C174(1.16)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C174(1.23)  LDD1664  [13]
 LDCM0462  CL7 HCT 116 C174(1.36)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C174(1.17)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C174(1.15)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C174(1.54)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C174(1.12)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C174(0.94)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C174(0.95)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C174(1.28)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C174(0.93)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C174(0.99)  LDD1675  [13]
 LDCM0473  CL8 HCT 116 C174(1.33)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C174(0.88)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C174(1.07)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C174(0.91)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C174(1.05)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C174(1.33)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C174(1.17)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C174(1.12)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C174(1.13)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C174(1.17)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C174(1.27)  LDD1686  [13]
 LDCM0484  CL9 HCT 116 C174(0.99)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C174(2.19)  LDD1688  [13]
 LDCM0486  CL91 HCT 116 C174(1.04)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C174(1.02)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C174(1.00)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C174(1.01)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C174(1.03)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C174(0.99)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C174(1.01)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C174(1.09)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C174(1.01)  LDD0811  [4]
 LDCM0634  CY-0357 Hep-G2 C3(0.42)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C174(1.40)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C174(0.93)  LDD1702  [2]
 LDCM0625  F8 Ramos C174(0.75)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C174(3.07)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C174(0.70)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C174(2.56)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C174(1.14)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C174(1.80)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C174(4.11)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C174(1.08)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C174(1.10)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C174(0.80)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C174(0.74)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C174(1.42)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C174(1.33)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C174(2.21)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C174(0.99)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C174(1.02)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C174(1.88)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C174(1.14)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C174(1.21)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C174(1.01)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C174(2.16)  LDD2186  [14]
 LDCM0116  HHS-0101 DM93 Y193(0.99)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y193(1.28)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y193(1.00)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y193(1.39)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y193(0.85)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C174(0.87)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C174(1.04)  LDD1497  [13]
 LDCM0024  KB05 HEK-293T C174(0.56)  LDD1502  [13]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C174(1.82)  LDD2094  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C174(1.63)  LDD2105  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C174(1.06)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C174(1.78)  LDD2110  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C174(1.68)  LDD2123  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C174(0.84)  LDD2141  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C174(0.59)  LDD2206  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SETD7 (SETD7) Histone-lysine methyltransferase family Q8WTS6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-7 (ATXN7) Ataxin-7 family O15265

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.