Details of the Target

General Information of Target

Target ID LDTP05645
Target Name Rho guanine nucleotide exchange factor 5 (ARHGEF5)
Gene Name ARHGEF5
Gene ID 7984
Synonyms
TIM; Rho guanine nucleotide exchange factor 5; Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ
QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA
PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT
RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF
RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL
NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE
DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD
LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEID
QNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVA
FPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQ
HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS
ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR
IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS
DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLP
PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPP
ATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHP
EAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSG
QAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMG
GFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESY
LQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHF
QLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDF
RRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL
KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECK
IFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVF
DHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMP
REELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGW
FPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration.
Uniprot ID
Q12774
Ensemble ID
ENST00000056217.10
HGNC ID
HGNC:13209

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R1519Ter .
NCIH2172 Substitution: p.M1538_V1539delinsIL .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C933(6.27)  LDD0168  [1]
IPM
 Probe Info  		C548(0.89)  LDD1701  [2]
DBIA
 Probe Info  		C548(1.30); C1509(0.70); C1517(0.70)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C933(6.27)  LDD0168  [1]
 LDCM0214  AC1 HCT 116 C548(1.30); C1509(0.70); C1517(0.70)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1301(0.92); C1355(1.01); C68(0.86)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C548(1.83); C1301(0.90); C1509(0.59); C1517(0.59)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C548(1.38); C1301(1.02); C1509(0.70); C1517(0.70)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C548(1.16); C1301(0.92); C1509(0.53); C1517(0.53)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C548(1.54); C1301(0.94); C1509(0.61); C1517(0.61)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C548(1.90); C1301(1.04); C1509(1.05); C1517(1.05)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C548(3.89); C1301(0.92); C1509(0.63); C1517(0.63)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C548(1.82); C1301(1.02); C1509(0.71); C1517(0.71)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C548(2.27); C1301(0.97); C1509(0.61); C1517(0.61)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C548(1.04); C1301(0.90); C1509(0.72); C1517(0.72)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C548(1.24); C1301(0.80); C1509(2.02); C1517(2.02)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1301(0.90); C1355(1.07); C68(1.01)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C548(1.25); C1301(1.04); C1509(0.65); C1517(0.65)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C548(1.72); C1301(0.97); C1509(0.68); C1517(0.68)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C548(1.65); C1301(0.97); C1509(0.85); C1517(0.85)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C548(1.20); C1355(1.12)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C548(1.84); C1355(0.78)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C548(1.70); C1355(1.09)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C548(3.38); C1355(1.17)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C548(1.81); C1355(0.93)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C548(1.36); C1355(0.88)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C548(2.39); C1355(1.27)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1301(1.04); C1355(1.04); C68(1.07)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C548(1.66); C1355(1.32)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C548(1.50); C1355(0.79)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C548(1.36); C1355(0.95)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C548(1.27); C1355(0.88)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C548(1.66); C1355(1.12)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C548(1.48); C1355(0.92)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C548(1.97); C1355(0.86)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C548(1.94); C1355(0.83)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1301(1.17); C1509(0.69); C1517(0.69)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1301(0.95); C1509(2.39); C1517(2.39)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1301(1.26); C1509(1.02); C1517(1.02)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1301(1.03); C1509(1.49); C1517(1.49)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1301(1.08); C1509(1.54); C1517(1.54)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1301(0.96); C1509(1.04); C1517(1.04)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1301(0.83); C1509(0.96); C1517(0.96)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1301(1.22); C1509(1.21); C1517(1.21)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1301(1.19); C1509(0.95); C1517(0.95)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1301(1.34); C1509(0.99); C1517(0.99)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1301(0.93); C1509(0.91); C1517(0.91)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1301(1.00); C1509(0.94); C1517(0.94)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1301(0.88); C1355(0.84); C68(0.91)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1301(1.11); C1509(0.84); C1517(0.84)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1301(1.27); C1509(1.25); C1517(1.25)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1301(1.14); C1509(1.43); C1517(1.43)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C548(1.20)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C548(2.12)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C548(1.96)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C548(1.85)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C548(1.81)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C548(2.55)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C548(2.01)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1301(0.78); C68(0.94); C1355(1.01)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C548(1.49)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C548(1.93)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C548(1.62)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C548(2.77)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C548(2.14)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C548(2.12)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C548(1.32)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C548(1.83)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1509(0.73); C1517(0.73); C1301(1.14); C1355(1.15)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1509(0.78); C1517(0.78); C1355(1.23); C1301(1.36)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1509(0.97); C1517(0.97); C1301(1.27); C1355(1.31)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1509(0.79); C1517(0.79); C548(1.35)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1509(0.76); C1517(0.76); C1301(0.98); C1355(1.11)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1509(0.80); C1517(0.80); C1301(1.12); C1355(1.15)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1509(0.73); C1517(0.73); C1301(1.19); C1355(1.21)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1509(0.67); C1517(0.67); C1301(1.30); C1355(1.32)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1509(0.84); C1517(0.84); C1355(1.08); C1301(1.11)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1509(0.85); C1517(0.85); C548(1.09)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1509(0.72); C1517(0.72); C548(1.27)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1509(0.75); C1517(0.75); C548(1.65)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1509(0.71); C1517(0.71); C548(1.68)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1509(0.88); C1517(0.88); C548(1.27)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1509(0.73); C1517(0.73); C548(1.31)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1509(0.72); C1517(0.72); C548(2.07)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1509(0.77); C1517(0.77); C548(1.02)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1509(0.68); C1517(0.68); C548(1.83)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1509(0.70); C1517(0.70); C548(1.48)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1509(0.69); C1517(0.69); C548(1.13)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1301(1.04)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1301(0.85)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1301(1.04)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1301(1.03)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1301(1.08)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C1509(0.72); C1517(0.72); C548(1.96)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1301(1.13)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1301(0.98)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1301(1.11)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1301(1.05)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1301(1.01)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1301(1.04)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C548(0.82); C68(1.28)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C548(0.72); C68(1.19)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C548(0.75); C68(0.76)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C548(0.70); C68(0.86)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1509(0.70); C1517(0.70); C548(1.35)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C68(0.79); C548(1.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C68(0.76); C548(0.79)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C548(0.61); C68(0.77)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C548(0.89); C68(0.91)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C68(0.66); C548(0.69)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C548(0.82); C68(0.86)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C548(0.80); C68(1.16)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1509(0.75); C1517(0.75); C1355(0.92); C1301(1.11)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1509(0.80); C1517(0.80); C68(0.91); C1355(0.98)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1509(0.80); C1517(0.80); C1355(1.09); C68(1.17)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1301(0.84); C68(0.99); C1355(1.03)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1509(0.67); C1517(0.67); C1355(1.06); C1301(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1509(0.91); C1517(0.91); C1355(1.00); C1301(1.15)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1509(0.83); C1517(0.83); C1355(1.11); C68(1.55)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1509(0.74); C1517(0.74); C1301(1.05); C1355(1.13)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1509(0.74); C1517(0.74); C1355(1.16); C1301(1.35)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1509(0.76); C1517(0.76); C68(1.11); C1355(1.12)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1509(0.84); C1517(0.84); C68(0.97); C1355(1.13)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1509(0.75); C1517(0.75); C1355(0.93); C68(1.12)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C68(0.74); C548(1.09)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C68(0.70); C548(1.47)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1301(0.76); C1355(0.92); C68(0.97)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C68(1.08); C548(1.36)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C68(0.72); C548(1.14)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C68(1.17); C548(1.24)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C68(1.16); C548(1.87)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C68(0.91); C548(1.99)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C68(1.12); C548(2.13)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C68(1.18); C548(1.45)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C68(0.67); C548(1.31)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C68(0.81); C548(1.31)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C68(0.98); C548(1.14)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1301(0.76); C1355(0.95); C68(0.96)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C68(1.13); C548(1.36)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C68(0.83); C548(0.83)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C68(1.14); C548(2.41)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1509(0.73); C1517(0.73); C1301(1.08); C548(1.91)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1509(0.72); C1517(0.72); C1301(1.02); C548(1.60)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1509(0.61); C1517(0.61); C1301(0.76); C548(1.24)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1509(0.70); C1517(0.70); C1301(0.78); C548(1.33)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1301(0.73); C1509(0.75); C1517(0.75); C548(1.35)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1509(0.73); C1517(0.73); C1301(0.95); C548(1.08)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1301(0.65); C1509(0.71); C1517(0.71); C548(1.12)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1301(0.83); C1509(1.19); C1517(1.19); C548(1.55)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1509(0.70); C1517(0.70); C548(1.23); C1301(1.36)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1509(0.71); C1517(0.71); C548(0.86); C1301(0.88)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1509(0.60); C1517(0.60); C1301(0.69); C548(1.11)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1301(0.63); C1509(0.66); C1517(0.66); C548(0.75)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1509(0.79); C1517(0.79); C1301(0.80); C548(0.94)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1509(0.65); C1517(0.65); C1301(0.67); C548(1.17)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1509(0.64); C1517(0.64); C1301(0.82); C548(1.28)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1509(0.79); C1517(0.79); C1301(0.97); C548(4.64)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1509(0.78); C1517(0.78); C1301(0.82); C548(1.22)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1301(1.26); C1355(1.11); C68(0.90)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1355(0.94); C68(1.04); C1301(1.06)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1301(0.90); C68(0.95); C1355(0.99)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C548(0.82); C68(0.93); C1301(1.27)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C68(0.78); C548(1.22); C1301(1.81)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1509(0.63); C1517(0.63); C548(1.93)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C68(0.84); C1301(0.84); C1355(0.86)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C68(0.61); C1301(0.91); C1355(1.05)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C68(0.82); C1355(0.97); C1301(1.02)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C68(0.82); C1355(0.83); C1301(0.89)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1509(0.62); C1517(0.62); C1355(0.95); C1301(1.10)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1509(0.57); C1517(0.57); C1355(0.93); C1301(1.41)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1509(0.53); C1517(0.53); C1355(0.96); C1301(1.33)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1509(0.56); C1517(0.56); C1355(0.98); C1301(1.21)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1509(0.71); C1517(0.71); C1355(1.02); C1301(1.03)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C68(0.54); C1301(1.17); C548(1.50)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C1509(0.67); C1517(0.67); C1355(1.12); C1301(1.29)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1509(0.74); C1517(0.74); C1355(1.06); C1301(1.31)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1509(0.84); C1517(0.84); C548(1.46)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1509(0.64); C1517(0.64); C548(1.39)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1509(0.78); C1517(0.78); C548(1.16)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1509(0.76); C1517(0.76); C548(1.55)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1509(0.75); C1517(0.75); C548(1.67)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1301(1.20)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1301(0.98)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1301(1.10)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C68(0.97); C1301(1.13); C548(2.17)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1301(1.02)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C68(0.82); C548(1.11)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C548(0.89); C68(1.05)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C548(0.47); C68(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C548(0.39); C68(0.84)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C1509(0.95); C1517(0.95); C1355(1.09); C1301(1.18)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1355(0.87); C1301(1.04); C1509(1.04); C1517(1.04)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1355(0.92); C1509(0.97); C1517(0.97); C68(1.02)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1509(0.78); C1517(0.78); C1355(0.95); C1301(1.41)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C68(1.10); C548(1.37); C1301(1.90)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1301(1.05); C68(1.19); C548(1.50)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C548(1.08); C68(1.26); C1301(1.93)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1355(1.02); C1509(1.11); C1517(1.11); C68(1.67)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1355(0.95); C1509(1.05); C1517(1.05); C548(1.06)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1509(0.85); C1517(0.85); C68(0.90); C1355(0.97)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1509(0.93); C1517(0.93); C1355(1.03); C68(1.23)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C548(0.96); C68(1.09); C1301(1.28)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1509(0.83); C1517(0.83); C68(0.91); C1355(0.97)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C68(0.89); C1509(1.00); C1517(1.00); C548(1.22)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1509(1.01); C1517(1.01); C68(1.34); C548(1.44)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1509(0.88); C1517(0.88); C1355(0.89); C548(1.05)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1509(0.79); C1517(0.79); C1355(1.00); C68(1.13)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C548(1.12); C1355(1.13); C1509(0.80); C1517(0.80)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C548(1.65); C1355(1.00); C1509(1.18); C1517(1.18)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C548(1.63); C1355(1.06); C1509(0.82); C1517(0.82)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C548(1.45); C1355(0.97); C1509(0.92); C1517(0.92)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C548(1.65); C1355(1.05); C1509(0.96); C1517(0.96)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C548(1.14); C1301(1.49); C68(1.16)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C548(2.34); C1355(1.22); C1509(1.13); C1517(1.13)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C1301(0.80); C1509(0.76); C1517(0.76)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C1301(0.78); C1509(0.66); C1517(0.66)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C1301(0.74); C1509(0.60); C1517(0.60)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C1301(0.80); C1509(0.55); C1517(0.55)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C1301(1.10); C1509(0.53); C1517(0.53)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C1301(0.26); C1509(0.65); C1517(0.65)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C1301(0.88); C1509(0.58); C1517(0.58)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C1301(0.72); C1509(0.63); C1517(0.63)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C548(1.68); C1301(0.91); C68(0.95)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C1301(0.67); C1509(0.85); C1517(0.85)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C1301(0.79); C1509(0.50); C1517(0.50)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C1301(0.91); C1509(0.49); C1517(0.49)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C1301(1.10); C1509(0.58); C1517(0.58)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C1301(0.68); C1509(0.55); C1517(0.55)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C1301(0.84); C1509(0.49); C1517(0.49)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C1301(1.03)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C1301(0.88)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C1301(1.04)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C1301(0.80)  LDD1318  [3]
 LDCM0440  CL5 HCT 116 C548(1.19); C1301(1.95); C68(1.38)  LDD0757  [3]
 LDCM0441  CL50 PaTu 8988t C1301(0.86)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C1301(0.81)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C1301(0.83)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C1301(0.80)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C1301(0.70)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C1301(0.84)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C1301(0.35)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C1301(1.08)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C1301(0.84)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C1301(1.13)  LDD1329  [3]
 LDCM0451  CL6 HCT 116 C548(0.96); C1301(1.44); C68(1.34)  LDD0768  [3]
 LDCM0452  CL60 PaTu 8988t C1301(0.90)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C1301(0.81); C1509(0.99); C1517(0.99)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1301(0.93); C1509(0.74); C1517(0.74)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1301(0.76); C1509(0.79); C1517(0.79)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1301(0.82); C1509(0.76); C1517(0.76)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1301(0.85); C1509(0.85); C1517(0.85)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1301(0.81); C1509(0.73); C1517(0.73)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1301(0.89); C1509(0.73); C1517(0.73)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1301(0.84); C1509(0.75); C1517(0.75)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1301(0.85); C1509(0.91); C1517(0.91)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C548(1.78); C1301(1.93); C68(0.94)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1301(0.71); C1509(0.79); C1517(0.79)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1301(0.67); C1509(0.81); C1517(0.81)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1301(0.69); C1509(0.88); C1517(0.88)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1301(0.73); C1509(0.88); C1517(0.88)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1301(0.82); C1509(0.77); C1517(0.77)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1509(0.81); C1517(0.81)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1509(1.05); C1517(1.05)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1509(0.74); C1517(0.74)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1509(0.78); C1517(0.78)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C548(3.37); C1301(1.70); C68(0.87)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1509(0.86); C1517(0.86)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1509(0.97); C1517(0.97)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1509(0.71); C1517(0.71)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1509(0.62); C1517(0.62)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1509(0.75); C1517(0.75)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1509(0.68); C1517(0.68)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1509(0.85); C1517(0.85)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1509(0.96); C1517(0.96)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1509(0.92); C1517(0.92)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1509(0.65); C1517(0.65)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C548(1.68); C1301(2.26); C68(0.84)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1509(0.78); C1517(0.78)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C548(1.38); C1509(0.75); C1517(0.75)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C548(1.66); C1509(0.92); C1517(0.92)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C548(1.49); C1509(0.81); C1517(0.81)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C548(2.77); C1509(0.68); C1517(0.68)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C548(2.32); C1509(0.59); C1517(0.59)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C548(1.32); C1509(0.85); C1517(0.85)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C548(1.20); C1509(0.76); C1517(0.76)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C548(2.08); C1509(0.73); C1517(0.73)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C548(1.38); C1509(0.62); C1517(0.62)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C548(0.91)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1301(0.81); C1509(0.83); C1517(0.83)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C1301(0.83); C1509(0.68); C1517(0.68)  LDD1306  [3]
 LDCM0022  KB02 786-O C68(1.49)  LDD2247  [7]
 LDCM0023  KB03 MDA-MB-231 C548(0.89)  LDD1701  [2]
 LDCM0024  KB05 MEL167 C277(1.93)  LDD3316  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Nucleotidyltransferase MB21D2 (MB21D2) Mab-21 family Q8IYB1
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
HSPB1-associated protein 1 (HSPBAP1) . Q96EW2
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein LRATD1 (LRATD1) LRATD family Q96KN4
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Heat shock factor 2-binding protein (HSF2BP) . O75031
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7
TBC1 domain family member 13 (TBC1D13) . Q9NVG8

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840