Details of the Target

General Information of Target

Target ID LDTP04768
Target Name 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)
Gene Name HSD17B7
Gene ID 51478
Synonyms
17HSD7; SDR37C1; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; EC 1.1.1.270; Dihydrotestosterone oxidoreductase; EC 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; EC 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family, ERG27 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis . Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol. Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation. Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase.; [Isoform 3]: Does not have enzymatic activities toward E1 and DHT.
Uniprot ID
P56937
Ensemble ID
ENST00000254521.8
HGNC ID
HGNC:5215
ChEMBL ID
CHEMBL5999

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C32(0.83); C35(0.83)  LDD0531  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C32(0.83); C35(0.83)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C32(0.47); C35(0.47)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C32(0.91)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C32(0.81)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C32(1.05)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C32(1.22)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C32(1.05)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C32(1.10)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C32(1.18)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C32(1.31)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C32(0.79)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C32(1.40)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C32(0.52); C35(0.52)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C32(1.19)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C32(1.58)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C32(1.09)  LDD0827  [1]
 LDCM0237  AC12 HCT 116 C32(0.90); C35(0.90)  LDD0554  [1]
 LDCM0246  AC128 HCT 116 C32(0.68); C35(0.68)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C32(1.29); C35(1.29)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C32(0.86); C35(0.86)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C32(1.66); C35(1.66)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C32(1.68); C35(1.68)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C32(1.04); C35(1.04)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C32(0.73); C35(0.73)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C32(0.75); C35(0.75)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C32(0.83); C35(0.83)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C32(0.94); C35(0.94)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C32(0.83); C35(0.83)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C32(1.16); C35(1.16)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C32(0.52); C35(0.52)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C32(0.80); C35(0.80)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C32(0.86); C35(0.86)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C32(1.04); C35(1.04)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C32(0.94); C35(0.94)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C32(0.39); C35(0.39)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C32(0.67); C35(0.67)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C32(0.52); C35(0.52)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C32(0.35); C35(0.35)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C32(0.26); C35(0.26)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C32(0.35); C35(0.35)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C32(0.60); C35(0.60)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C32(0.78); C35(0.78)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C32(1.49); C35(1.49)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C32(0.42); C35(0.42)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C32(0.31); C35(0.31)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C32(0.49); C35(0.49)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C32(0.57); C35(0.57)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C32(1.22); C35(1.22)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C32(1.17); C35(1.17)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C32(1.14); C35(1.14)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C32(0.54); C35(0.54)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C32(1.06); C35(1.06)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C32(1.05); C35(1.05)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C32(1.11); C35(1.11)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C32(1.07); C35(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C32(1.06); C35(1.06)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C32(1.37); C35(1.37)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C32(1.35); C35(1.35)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C32(1.23)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C32(1.39)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C32(1.13)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C32(1.26)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C32(1.43)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C32(0.83); C35(0.83)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C32(1.49)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C32(1.17)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C32(1.02)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C32(1.57)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C32(1.04)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C32(1.05); C35(1.05)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C32(1.01); C35(1.01)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C32(1.21); C35(1.21)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C32(1.21); C35(1.21)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C32(0.90); C35(0.90)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C32(1.05); C35(1.05)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C32(0.75); C35(0.75)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C32(0.85); C35(0.85)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C32(0.81); C35(0.81)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C32(0.95); C35(0.95)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C32(0.93); C35(0.93)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C32(0.67); C35(0.67)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C32(0.93); C35(0.93)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C32(0.66); C35(0.66)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C32(0.86); C35(0.86)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C32(0.53); C35(0.53)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C32(0.84); C35(0.84)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C32(0.59); C35(0.59)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C32(1.52); C35(1.52)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C32(0.78); C35(0.78)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C32(0.64); C35(0.64)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C32(0.66); C35(0.66)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C32(0.60); C35(0.60)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C32(0.61); C35(0.61)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C32(1.02); C35(1.02)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C32(0.99); C35(0.99)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C32(0.92); C35(0.92)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C32(0.47); C35(0.47)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C32(0.85); C35(0.85)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C32(0.84); C35(0.84)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C32(0.82); C35(0.82)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C32(0.83); C35(0.83)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C32(0.81); C35(0.81)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C32(1.04); C35(1.04)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C32(1.03); C35(1.03)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C32(0.64); C35(0.64)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C32(1.05); C35(1.05)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C32(0.94); C35(0.94)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C32(0.87); C35(0.87)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C32(0.89); C35(0.89)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C32(1.58); C35(1.58)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C32(1.60); C35(1.60)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C32(1.57); C35(1.57)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C32(1.39); C35(1.39)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C32(0.79); C35(0.79)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C32(0.88); C35(0.88)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C32(0.97); C35(0.97)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C32(1.16); C35(1.16)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C32(0.93); C35(0.93)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C32(0.55); C35(0.55)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C32(1.17); C35(1.17)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C32(1.16); C35(1.16)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C32(0.87); C35(0.87)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C32(0.66); C35(0.66)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C32(0.64); C35(0.64)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C32(0.87); C35(0.87)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C32(0.96); C35(0.96)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C32(0.92); C35(0.92)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C32(0.86); C35(0.86)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C32(1.10); C35(1.10)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C32(0.84); C35(0.84)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C32(0.56); C35(0.56)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C32(0.55); C35(0.55)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C32(0.82); C35(0.82)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C32(1.18); C35(1.18)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C32(1.25); C35(1.25)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C32(0.79); C35(0.79)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C32(0.73); C35(0.73)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C32(0.90)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C32(0.83)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C32(1.02); C35(1.02)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C32(0.61); C35(0.61)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C32(0.23); C35(0.23)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C32(1.47); C35(1.47)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C32(0.58); C35(0.58)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C32(0.97); C35(0.97)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C32(0.46); C35(0.46)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C32(0.78); C35(0.78)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C32(1.11); C35(1.11)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C32(0.57); C35(0.57)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C32(0.73); C35(0.73)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C32(0.43); C35(0.43)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C32(0.44); C35(0.44)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C32(0.38); C35(0.38)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C32(0.86); C35(0.86)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C32(0.54); C35(0.54)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C32(0.59); C35(0.59)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C32(1.02); C35(1.02)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C32(1.10)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C32(1.20)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C32(1.41)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C32(1.30)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C32(1.24)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C32(0.64); C35(0.64)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C32(0.86); C35(0.86)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C32(0.82); C35(0.82)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C32(0.48); C35(0.48)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C32(1.14); C35(1.14)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C32(1.34); C35(1.34)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C32(0.77); C35(0.77)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C32(0.63); C35(0.63)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C32(0.57); C35(0.57)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C32(1.03); C35(1.03)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C32(1.01); C35(1.01)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C32(1.11); C35(1.11)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C32(1.02); C35(1.02)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C32(0.74); C35(0.74)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C32(0.95); C35(0.95)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C32(0.77); C35(0.77)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C32(0.90)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C32(0.92)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C32(0.84)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C32(0.97)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C32(1.41); C35(1.41)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C32(0.95)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C32(1.07)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C32(0.69)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C32(0.71)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C32(0.75)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C32(0.92)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C32(1.00)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C32(0.92)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C32(1.24)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C32(0.94)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C32(1.08); C35(1.08)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C32(1.04)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C32(1.41); C35(1.41)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C32(1.60); C35(1.60)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C32(1.63); C35(1.63)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C32(1.26); C35(1.26)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C32(1.66); C35(1.66)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C32(1.19); C35(1.19)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C32(1.18); C35(1.18)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C32(1.31); C35(1.31)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C32(0.94); C35(0.94)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C32(1.92); C35(1.92)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C32(1.11); C35(1.11)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C32(1.28); C35(1.28)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C32(1.24); C35(1.24)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C32(1.20); C35(1.20)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C32(1.71); C35(1.71)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C32(1.23); C35(1.23)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C32(1.00); C35(1.00)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C32(1.14); C35(1.14)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C32(1.08); C35(1.08)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C32(0.88); C35(0.88)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C32(1.19); C35(1.19)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C32(1.26); C35(1.26)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C32(1.03); C35(1.03)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C32(0.85); C35(0.85)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C32(1.21); C35(1.21)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C32(1.09); C35(1.09)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C32(0.88); C35(0.88)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C32(1.07); C35(1.07)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C32(1.12); C35(1.12)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C32(1.14); C35(1.14)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C32(0.82); C35(0.82)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C32(1.27); C35(1.27)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C32(0.84); C35(0.84)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C32(0.75); C35(0.75)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C32(0.91); C35(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C32(0.91); C35(0.91)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C32(0.90); C35(0.90)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C32(1.01); C35(1.01)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C32(1.06); C35(1.06)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C32(0.82); C35(0.82)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C32(0.80); C35(0.80)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C32(0.54); C35(0.54)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C32(0.96); C35(0.96)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C32(0.88); C35(0.88)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C32(0.86); C35(0.86)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C32(0.92); C35(0.92)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C32(0.89); C35(0.89)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C32(0.87)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C32(0.86)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C32(0.70)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C32(0.89)  LDD1070  [1]
 LDCM0473  CL8 HCT 116 C32(0.46); C35(0.46)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C32(0.89)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C32(0.99)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C32(1.20)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C32(2.12)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C32(0.89)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C32(1.03)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C32(1.02)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C32(1.01)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C32(0.95)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C32(1.19)  LDD1081  [1]
 LDCM0484  CL9 HCT 116 C32(0.72); C35(0.72)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C32(1.13)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C32(1.01); C35(1.01)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C32(1.21); C35(1.21)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C32(1.15); C35(1.15)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C32(1.22); C35(1.22)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C32(1.19); C35(1.19)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C32(1.02); C35(1.02)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C32(0.86); C35(0.86)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C32(0.96); C35(0.96)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C32(0.95); C35(0.95)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C86(0.92); C19(1.00); C45(0.89); C158(1.04)  LDD1698  [7]
 LDCM0625  F8 Ramos C158(1.96)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C158(1.08)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C158(0.38)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C158(1.19)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C158(1.00)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C158(1.17)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C158(1.47)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C158(0.95)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C158(1.27)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C158(1.08)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C158(0.72)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C158(1.11)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C158(1.16)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C158(0.86)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C32(0.92); C35(0.92)  LDD0785  [1]
 LDCM0596  Fragment38 Ramos C158(1.24)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C158(1.12)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C32(1.24); C35(1.24)  LDD0744  [1]
 LDCM0610  Fragment52 Ramos C158(1.04)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C158(0.90)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C158(0.76)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C158(1.32)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C158(0.99); C86(0.98); C35(0.95)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C158(0.94); C86(0.95); C35(0.94)  LDD1497  [7]
 LDCM0024  KB05 HMCB C158(1.41)  LDD3312  [9]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840