Details of the Target

General Information of Target

Target ID LDTP04745
Target Name C-terminal-binding protein 2 (CTBP2)
Gene Name CTBP2
Gene ID 1488
Synonyms
C-terminal-binding protein 2; CtBP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFC
DAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELG
IAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRG
ETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVS
LHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHES
EPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKE
FFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTV
AHPSQAPSPNQPTKHGDNREHPNEQ
Target Bioclass
Enzyme
Family
D-isomer specific 2-hydroxyacid dehydrogenase family
Subcellular location
Nucleus
Function Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation.; Isoform 2 probably acts as a scaffold for specialized synapses.
Uniprot ID
P56545
Ensemble ID
ENST00000309035.11
HGNC ID
HGNC:2495
ChEMBL ID
CHEMBL3797016

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y325(12.49); Y108(5.38)  LDD0257  [2]
Probe 1
 Probe Info  		Y108(53.62)  LDD3495  [3]
BTD
 Probe Info  		C60(1.00)  LDD2107  [4]
AHL-Pu-1
 Probe Info  		C44(20.00)  LDD0168  [5]
HHS-475
 Probe Info  		Y153(1.04); Y385(1.08)  LDD0264  [6]
DBIA
 Probe Info  		C44(1.13)  LDD0080  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
NHS
 Probe Info  		N.A.  LDD0010  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C44(0.00); C60(0.00); C318(0.00); C356(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		Y153(0.00); Y385(0.00)  LDD2240  [17]
HHS-482
 Probe Info  		Y212(1.42)  LDD2239  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C44(20.00)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C44(11.23)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C44(1.47)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C44(1.26); C60(0.98)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C44(0.45); C60(0.88)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C44(0.49); C60(0.73)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C44(0.61); C60(0.73)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C44(0.42); C60(0.91)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C44(0.77); C60(0.80)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C44(0.45); C60(0.91)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C44(0.43); C60(1.00)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C44(0.50); C60(0.76)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C44(0.45); C60(1.03)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C44(0.91); C60(0.83)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C44(1.38); C60(1.04)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C44(0.45); C60(1.00)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C44(0.47); C60(0.88)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C44(0.45); C60(1.18)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C44(1.14); C60(1.19)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C44(1.08); C60(1.05)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C44(0.91); C60(1.13)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C44(1.25); C60(1.19)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C44(1.12); C60(1.09)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C44(1.20); C60(1.22)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C44(1.14); C60(1.09)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C44(1.45); C60(1.07)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C44(1.33); C60(1.32)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C44(1.03); C60(1.06)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C44(1.23); C60(1.46)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C44(1.15); C60(1.34)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C44(1.19); C60(0.95)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C44(1.42); C60(1.34)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C44(1.22); C60(1.48)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C44(1.27); C60(1.46)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C44(1.63); C60(1.83)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C44(1.46); C60(1.60)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C44(1.19); C60(1.22)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C44(1.24); C60(1.88)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C44(0.98); C60(0.84)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C44(1.08); C60(1.40)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C44(0.91); C60(1.26)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C44(1.17); C60(1.15)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C44(0.93); C60(1.00)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C44(1.03); C60(1.03)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C44(0.67); C60(0.80)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C44(0.77); C60(0.75)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C44(1.35); C60(1.14)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C44(0.67); C60(0.66)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C44(0.67); C60(0.91)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C44(0.88); C60(0.95)  LDD0579  [7]
 LDCM0263  AC143 HEK-293T C18(1.12)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C18(1.01)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C18(1.40)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C18(1.14)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C18(0.98)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C18(1.02)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C18(0.96)  LDD0867  [7]
 LDCM0270  AC15 HCT 116 C44(1.10); C60(1.21)  LDD0587  [7]
 LDCM0271  AC150 HEK-293T C18(0.93)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C18(1.18)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C18(0.89)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C18(1.04)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C18(0.93)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C18(1.02)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C18(1.06)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C18(0.95)  LDD2165  [7]
 LDCM0276  AC17 HCT 116 C44(1.00)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C44(1.33)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C44(1.21)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C44(1.06)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C44(0.94)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C44(1.20)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C44(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C44(1.14)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C44(1.08)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C44(1.02); C60(1.04)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C44(0.82); C60(1.10)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C44(0.84); C60(0.95)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C44(0.85); C60(1.38)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C44(0.57); C60(0.93)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C44(1.32)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C44(0.54); C60(0.90)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C44(0.70); C60(1.04)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C44(0.55); C60(0.95)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C44(0.91); C60(0.99)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C44(0.85); C60(1.18)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C44(1.36)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C44(0.92)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C44(1.51)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C44(0.92)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C44(1.02)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C44(1.40)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C44(1.26)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C44(1.19)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C44(1.13)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C44(0.94)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C44(1.59)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C44(1.70)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C44(0.62); C60(0.71)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C44(0.80); C60(0.83)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C44(0.65); C60(0.77)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C44(0.56); C60(0.70)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C44(1.41)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C44(0.56); C60(0.70)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C44(0.59); C60(0.78)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C44(0.63); C60(0.72)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C44(0.99); C60(1.07)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C44(0.68); C60(0.87)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C60(1.13); C44(1.16)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C44(0.68); C60(0.78)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C44(1.08)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C44(0.86)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C44(1.15)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C60(0.88); C44(0.88)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C44(1.21)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C44(1.09)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C44(1.37)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C44(1.50)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C44(1.82)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C44(0.90)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C44(0.90)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C44(1.12)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C44(0.79)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C44(0.80)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C60(0.95); C44(1.03)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C44(0.65)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C44(1.22)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C44(0.62)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C44(0.69)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C44(1.01)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C44(0.67)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C44(0.91)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C44(0.77)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C44(0.80)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C44(0.64)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C44(1.01); C60(1.26)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C44(1.07)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C44(0.87)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C44(1.01)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C44(0.76)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C44(0.83)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C44(0.84)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C44(0.68)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C44(0.70)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C44(0.67)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C44(0.71)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C44(0.66)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C44(0.92)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C44(0.82)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C44(0.71)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C44(1.00)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C44(0.70)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C44(1.37)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C44(0.77)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C44(0.40); C60(0.81)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C44(0.51); C60(1.15)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C44(1.23); C60(0.94)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C60(0.91); C44(1.33)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C44(0.92); C60(1.10)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.86  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C60(2.50)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C44(0.88)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C44(0.94)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C44(1.42)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C60(0.98); C44(1.11)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C60(0.85); C44(1.19)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C60(1.17); C44(1.44)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C60(1.02); C44(1.11)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C44(1.24)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C44(1.37)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C44(1.29)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C44(1.31)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C44(1.12)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C44(0.96)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C44(1.02)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C44(0.95)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C44(0.77); C60(0.90)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C44(0.53); C60(0.89)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C44(0.52); C60(0.99)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C44(0.62); C60(1.04)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C44(0.80); C60(1.14)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C44(0.88)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C44(0.96)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C44(1.00)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C44(0.99)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C44(1.08)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C44(0.84); C60(0.90)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C44(0.75); C60(0.94)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C60(0.62); C44(0.77)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C60(0.67); C44(0.72)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C44(0.93)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C44(0.79)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C44(0.94)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C44(0.93)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C44(1.04)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C44(0.95)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C44(0.94)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C18(0.91)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C18(1.45)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C18(0.77)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C18(0.87)  LDD1004  [7]
 LDCM0407  CL2 HCT 116 C44(0.91)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C18(1.04)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C18(1.33)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C18(1.10)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C18(0.78)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C18(0.82)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C18(1.11)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C18(0.98)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C18(0.80)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C18(1.16)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C18(1.00)  LDD1015  [7]
 LDCM0418  CL3 HCT 116 C44(1.28)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C18(0.99)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C44(0.95)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C44(0.88)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C44(0.72)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C44(0.95)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C44(0.87)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C44(0.93)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C44(0.93)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C44(0.85)  LDD1026  [7]
 LDCM0429  CL4 HCT 116 C44(0.86)  LDD0746  [7]
 LDCM0430  CL40 HEK-293T C44(0.98)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C44(0.86)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C44(0.90)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C44(0.93)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C44(0.80)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C44(0.97)  LDD1033  [7]
 LDCM0436  CL46 HCT 116 C44(0.92); C60(0.87)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C44(0.90); C60(1.10)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C44(1.05); C60(1.28)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C44(1.22); C60(1.26)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C44(1.08)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C44(0.99); C60(0.92)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C44(0.97); C60(0.73)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C44(0.76); C60(0.94)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C44(0.76); C60(0.91)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C44(0.88); C60(1.23)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C44(0.96); C60(0.93)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C44(0.88); C60(0.95)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C44(0.90); C60(0.90)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C44(1.03); C60(1.03)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C44(1.04); C60(1.14)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C44(1.04)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C44(1.00); C60(1.19)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C44(0.91)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C44(0.93)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C44(0.82)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C44(1.04)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C44(1.00)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C44(0.97)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C44(0.94)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C44(0.76)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C44(0.69)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C44(1.12)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C44(0.79)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C44(0.80)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C44(0.63)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C44(0.74)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C44(0.79)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C44(0.81)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C44(0.77)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C44(0.99)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C44(0.88)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C44(1.12)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C44(1.02)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C44(0.92)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C44(0.92)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C44(0.87)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C44(0.84)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C44(0.73)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C44(0.88)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C44(0.93)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C44(0.92)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C44(0.95)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C44(0.88)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C44(0.67)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C44(0.81)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C44(0.82)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C44(1.06)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C44(1.27)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C44(0.82)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C44(0.89)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C44(0.83)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C44(1.16)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C44(1.30)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C18(1.65); C44(1.02); C60(0.97); C318(0.92)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C44(1.82)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C44(0.77)  LDD0785  [7]
 LDCM0427  Fragment51 HEK-293T C44(1.09)  LDD1025  [7]
 LDCM0116  HHS-0101 DM93 Y153(1.04); Y385(1.08)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y385(0.85); Y153(1.21)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y153(0.92); Y385(0.95)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y153(1.39); Y385(1.54)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y153(1.10); Y385(1.23)  LDD0268  [6]
 LDCM0107  IAA HeLa C60(0.00); H69(0.00)  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C44(1.13)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C44(1.25)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C44(1.08)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0225  [15]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C60(1.00)  LDD2107  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C60(0.87)  LDD2207  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
Dual specificity protein phosphatase 21 (DUSP21) Protein-tyrosine phosphatase family Q9H596
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) . Q9NQ66
E3 ubiquitin-protein ligase RNF135 (RNF135) . Q8IUD6
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) Calcium channel beta subunit family Q02641
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) Calcium channel beta subunit family Q08289
Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) Calcium channel beta subunit family P54284
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) Calcium channel beta subunit family O00305
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Huntingtin (HTT) Huntingtin family P42858
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A5 (HOXA5) Antp homeobox family P20719
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Friend leukemia integration 1 transcription factor (FLI1) ETS family Q01543
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein Helios (IKZF2) Ikaros C2H2-type zinc-finger protein family Q9UKS7
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Zinc finger protein 516 (ZNF516) Krueppel C2H2-type zinc-finger protein family Q92618
Hypermethylated in cancer 1 protein (HIC1) Krueppel C2H2-type zinc-finger protein family Q14526
Zinc finger and BTB domain-containing protein 18 (ZBTB18) Krueppel C2H2-type zinc-finger protein family Q99592
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Prospero homeobox protein 1 (PROX1) Prospero homeodomain family Q92786
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
B-cell lymphoma 3 protein (BCL3) . P20749
Forkhead box protein P2 (FOXP2) . O15409
Ligand-dependent corepressor (LCOR) . Q96JN0
Transcription factor SOX-13 (SOX13) . Q9UN79
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
BCAS3 microtubule associated cell migration factor (BCAS3) BCAS3 family Q9H6U6
Cyclin-H (CCNH) Cyclin family P51946
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) PPP1R15 family O75807
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Vertnin (VRTN) Vertnin family Q9H8Y1
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) WAL family Q9UIF8
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Four and a half LIM domains protein 3 (FHL3) . Q13643
LIM domain transcription factor LMO4 (LMO4) . P61968
Nucleolar protein 4-like (NOL4L) . Q96MY1
RBBP8 N-terminal-like protein (RBBP8NL) . Q8NC74
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Zinc finger protein 750 (ZNF750) . Q32MQ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.