Details of the Target

General Information of Target

Target ID LDTP04604
Target Name Ataxin-3 (ATXN3)
Gene Name ATXN3
Gene ID 4287
Synonyms
ATX3; MJD; MJD1; SCA3; Ataxin-3; EC 3.4.19.12; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRT
FLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHW
FTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQM
IRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEI
DMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQ
QQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGK
K
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Nucleus matrix
Function
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates . Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription. Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex. Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1.
TTD ID
T63161
Uniprot ID
P54252
DrugMap ID
TT6A17J
Ensemble ID
ENST00000340660.10
HGNC ID
HGNC:7106
ChEMBL ID
CHEMBL4523240

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y58(22.42)  LDD3495  [2]
IPM
 Probe Info  		C316(1.25)  LDD1701  [3]
DBIA
 Probe Info  		C114(2.59)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C114(0.00); C14(0.00)  LDD0166  [6]
Lodoacetamide azide
 Probe Info  		C172(0.00); C114(0.00); C18(0.00); C14(0.00)  LDD0037  [5]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C114(0.60)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C316(1.41); C14(1.13)  LDD1508  [10]
 LDCM0216  AC100 PaTu 8988t C114(1.08)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C114(1.45)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C114(0.91)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C114(1.04)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C114(1.06)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C114(1.41)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C114(0.97)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C114(0.90)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C114(1.10)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C114(1.01)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C172(1.17); C14(1.12)  LDD1509  [10]
 LDCM0227  AC110 PaTu 8988t C114(0.91)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C114(1.20)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C114(0.92)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C114(1.03)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C114(1.05)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C114(0.92)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C114(0.96)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C114(1.34)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C114(0.92)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C114(1.17)  LDD1115  [4]
 LDCM0237  AC12 HEK-293T C172(1.17); C14(0.95)  LDD1510  [10]
 LDCM0238  AC120 PaTu 8988t C114(1.22)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C114(1.41)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C114(1.07)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C114(1.17)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C114(1.32)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C114(0.94)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C114(1.00)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C114(1.14)  LDD1124  [4]
 LDCM0259  AC14 HEK-293T C172(1.03); C14(1.14)  LDD1512  [10]
 LDCM0263  AC143 PaTu 8988t C114(0.62)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C114(0.74)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C114(0.98)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C114(0.50)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C114(0.76)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C114(0.99)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C114(0.92)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C172(0.73); C14(1.00)  LDD1513  [10]
 LDCM0271  AC150 PaTu 8988t C114(0.72)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C114(0.99)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C114(0.80)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C114(0.85)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C114(0.84)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C114(0.76)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C114(0.61)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C114(0.89)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C114(0.94)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C114(1.38)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C114(1.01)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C114(0.50)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C114(0.99)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C114(0.89)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C114(0.96)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C114(0.94)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C114(0.96)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C114(1.18)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C114(1.03)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C114(0.96)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C114(1.21)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C114(1.13)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C114(0.49)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C114(1.16)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C114(1.12)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C114(1.22)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C114(1.26)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C114(1.13)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C114(1.28)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C114(1.43)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C114(1.50)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C114(1.26)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C114(1.47)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C114(0.60)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C114(1.35)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C114(1.37)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C114(1.27)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C114(1.35)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C114(1.29)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C114(1.76)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C114(0.97)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C114(1.07)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C114(0.84)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C114(1.15)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C114(0.55)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C114(1.01)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C114(1.02)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C114(0.96)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C114(0.97)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C114(1.01)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C114(1.03)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C114(1.13)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C114(1.02)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C114(1.00)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C114(0.86)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C172(1.12); C14(1.29)  LDD1562  [10]
 LDCM0324  AC60 HCT 116 C114(0.90)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C114(1.02)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C114(0.94)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C114(0.98)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C114(0.98)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C114(1.07)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C114(1.06)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C114(1.00)  LDD0648  [4]
 LDCM0334  AC7 HEK-293T C172(1.01); C14(1.04)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C172(0.96); C14(0.97)  LDD1569  [10]
 LDCM0349  AC83 HCT 116 C114(1.02)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C114(0.96)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C114(0.83)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C114(0.91)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C114(0.87)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C114(0.91)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C114(1.00)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C114(1.08)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C114(0.92)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C114(1.00)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C114(0.83)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C114(0.92)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C114(0.83)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C114(0.85)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C114(1.07)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C114(0.86)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C114(0.89)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C14(1.13)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C14(1.11)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C172(1.13); C14(1.07)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 12.94  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C114(1.03)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C114(0.86)  LDD1247  [4]
 LDCM0369  CL100 HCT 116 C114(0.56)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C114(0.99); C316(0.97); C172(1.05); C14(1.04)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C14(0.96)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C14(1.23)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C172(1.18); C14(1.09)  LDD1577  [10]
 LDCM0374  CL105 HCT 116 C114(0.93)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C114(0.95)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C114(0.97)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C114(1.00)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C114(0.93)  LDD0695  [4]
 LDCM0379  CL11 PaTu 8988t C114(0.87)  LDD1258  [4]
 LDCM0380  CL110 HCT 116 C114(0.95)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C114(0.95)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C114(1.63)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C114(1.34)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C114(1.04)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C114(1.06)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C114(1.61)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C114(1.53)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C114(1.45)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C114(1.53)  LDD0706  [4]
 LDCM0390  CL12 PaTu 8988t C114(0.94)  LDD1269  [4]
 LDCM0391  CL120 HCT 116 C114(1.78)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C114(0.94)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C114(0.90)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C114(1.00)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C114(1.01)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C114(1.01)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C114(0.89)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C114(0.87)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C114(1.24)  LDD0716  [4]
 LDCM0400  CL13 PaTu 8988t C114(1.08)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C114(1.03)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C114(0.97)  LDD1281  [4]
 LDCM0403  CL16 HEK-293T C172(1.12); C14(1.03)  LDD1607  [10]
 LDCM0404  CL17 HCT 116 C114(0.92)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C114(1.02)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C114(0.94)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C114(0.96)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C114(0.97)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C114(1.27)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C114(0.76)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C114(1.08)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C114(0.88)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C114(0.70)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C114(0.83)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C114(0.85)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C114(0.76)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C114(0.71)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C114(0.68)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C114(0.93)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C114(0.97)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C114(0.83)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C114(0.96)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C114(1.37)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C114(0.85)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C114(1.04)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C114(1.03)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C114(1.14)  LDD0745  [4]
 LDCM0429  CL4 PaTu 8988t C114(0.73)  LDD1308  [4]
 LDCM0430  CL40 HCT 116 C114(0.95)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C114(1.00)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C114(1.07)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C114(0.92)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C114(0.99)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C114(1.01)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C114(0.90)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C114(0.77)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C114(0.88)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C114(0.90)  LDD0756  [4]
 LDCM0440  CL5 PaTu 8988t C114(1.02)  LDD1319  [4]
 LDCM0441  CL50 HCT 116 C114(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C114(0.73)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C114(0.77)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C114(0.66)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C114(0.74)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C114(1.08)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C114(0.79)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C114(0.97)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C114(0.97)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C114(0.71)  LDD0767  [4]
 LDCM0451  CL6 PaTu 8988t C114(0.98)  LDD1330  [4]
 LDCM0452  CL60 HCT 116 C114(0.86)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C114(0.87)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C114(0.86)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C114(0.84)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C114(1.01)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C114(0.89)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C114(0.88)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C114(0.98)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C114(0.75)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C114(0.74)  LDD0778  [4]
 LDCM0462  CL7 PaTu 8988t C114(1.04)  LDD1341  [4]
 LDCM0463  CL70 HCT 116 C114(0.81)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C114(0.83)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C114(0.86)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C114(0.77)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C114(0.82)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C114(0.78)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C114(0.94)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C114(0.89)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C114(1.22)  LDD0789  [4]
 LDCM0473  CL8 PaTu 8988t C114(0.74)  LDD1352  [4]
 LDCM0474  CL80 HCT 116 C114(0.71)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C114(1.07)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C114(0.98)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C114(0.86)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C114(1.07)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C114(0.73)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C114(1.03)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C114(0.98)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C114(0.86)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C114(1.22)  LDD0800  [4]
 LDCM0484  CL9 PaTu 8988t C114(0.93)  LDD1363  [4]
 LDCM0485  CL90 HCT 116 C114(0.81)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C114(1.05)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C114(0.90)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C114(0.94)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C114(0.95)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C114(0.74)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C114(0.72)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C114(0.67)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C114(0.70)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C114(0.65)  LDD0811  [4]
 LDCM0634  CY-0357 Hep-G2 C316(0.62)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C14(1.19)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C316(1.48)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C114(0.79)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C114(0.98)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C114(2.59)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C114(3.38)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C114(2.72)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) ABHD17 family Q6PCB6
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Aldo/keto reductase family O43488
Tyrosyl-DNA phosphodiesterase 2 (TDP2) CCR4/nocturin family O95551
5' exonuclease Apollo (DCLRE1B) DNA repair metallo-beta-lactamase (DRMBL) family Q9H816
Polyamine deacetylase HDAC10 (HDAC10) Histone deacetylase family Q969S8
L-lactate dehydrogenase A-like 6B (LDHAL6B) LDH family Q9BYZ2
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) Methylthiotransferase family Q5VV42
Thiol S-methyltransferase TMT1A (TMT1A) Methyltransferase superfamily Q9H8H3
[F-actin]-monooxygenase MICAL2 (MICAL2) Mical family O94851
Caspase-3 (CASP3) Peptidase C14A family P42574
Ubiquitin carboxyl-terminal hydrolase 13 (USP13) Peptidase C19 family Q92995
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) Peptidase M67A family P51665
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) PI3/PI4-kinase family P42336
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Serine/threonine-protein kinase 36 (STK36) Ser/Thr protein kinase family Q9NRP7
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
E3 ubiquitin-protein ligase RNF31 (RNF31) RBR family Q96EP0
E3 ubiquitin-protein ligase parkin (PRKN) RBR family, Parkin subfamily O60260
Cholinesterase (BCHE) Type-B carboxylesterase/lipase family P06276
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) . Q9H0M0
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
MICOS complex subunit MIC60 (IMMT) MICOS complex subunit Mic60 family Q16891
Solute carrier family 52, riboflavin transporter, member 3 (SLC52A3) Riboflavin transporter family Q9NQ40
Nucleoporin Nup43 (NUP43) . Q8NFH3
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 0 group B member 2 (NR0B2) Nuclear hormone receptor family Q15466
Forkhead box protein D4-like 6 (FOXD4L6) . Q3SYB3
LIM/homeobox protein Lhx6 (LHX6) . Q9UPM6
T-box transcription factor TBX22 (TBX22) . Q9Y458
Transcription factor SOX-14 (SOX14) . O95416
Zinc finger protein 366 (ZNF366) . Q8N895
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mth938 domain-containing protein (AAMDC) AAMDC family Q9H7C9
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Protein PALS1 (PALS1) MAGUK family Q8N3R9
Alpha-parvin (PARVA) Parvin family Q9NVD7
Phagosome assembly factor 1 (PHAF1) PHAF1 family Q9BSU1
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
E-selectin (SELE) Selectin/LECAM family P16581
Serpin H1 (SERPINH1) Serpin family P50454
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
T-complex protein 1 subunit zeta (CCT6A) TCP-1 chaperonin family P40227
Telomere length regulation protein TEL2 homolog (TELO2) TEL2 family Q9Y4R8
Toll-like receptor 10 (TLR10) Toll-like receptor family Q9BXR5
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
POC1 centriolar protein homolog A (POC1A) WD repeat POC1 family Q8NBT0
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
Erythroid differentiation-related factor 1 (EDRF1) . Q3B7T1
Fanconi anemia group G protein (FANCG) . O15287
Huntingtin-associated protein 1 (HAP1) . P54257
Huntingtin-interacting protein M (H2AP) . O75409
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1) . Q66K80
Rho GTPase-activating protein 19 (ARHGAP19) . Q14CB8
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Testis-expressed protein 19 (TEX19) . Q8NA77
Transmembrane protein C16orf54 (C16orf54) . Q6UWD8
Ubiquilin-1 (UBQLN1) . Q9UMX0
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402