Details of the Target

General Information of Target

Target ID LDTP04523
Target Name Zinc finger protein 131 (ZNF131)
Gene Name ZNF131
Gene ID 7690
Synonyms
Zinc finger protein 131
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY
KFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKA
LEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVE
DEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPT
SKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRE
SAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFECPN
CHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPN
HCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHV
LPLLQVQVDSAQVTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHV
EELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLET
KPTVDSEAEKAENEDRTALPVLE
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
Uniprot ID
P52739
Ensemble ID
ENST00000306938.8
HGNC ID
HGNC:12915
ChEMBL ID
CHEMBL5069380

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.R145GfsTer26 .
HCT15 SNV: p.R547Q .
LNCaP clone FGC SNV: p.A193D DBIA    Probe Info 
NCIH1155 SNV: p.R222C DBIA    Probe Info 
NCIH23 SNV: p.N420S .
SNU5 SNV: p.E134G .
TOV21G Deletion: p.I327FfsTer45 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C373(0.00); C378(0.00); C235(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C235(1.46)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C235(0.96); C358(1.44); C361(1.44)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C358(0.69); C361(0.69)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C235(1.27)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C235(1.08)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C235(1.02)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C235(1.32)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C235(1.09)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C235(1.26)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C235(1.38)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C235(1.06)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C235(1.08)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C235(0.88)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C358(0.82); C361(0.82)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C235(1.10)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C235(0.95)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C235(1.14)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C358(1.03); C361(1.03)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C358(0.77); C361(0.77)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C358(1.23); C361(1.23)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C358(1.39); C361(1.39)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C358(0.94); C361(0.94)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C358(0.68); C361(0.68)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C358(0.75); C361(0.75)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C358(0.94); C361(0.94)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C358(0.92); C361(0.92)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C358(0.73); C361(0.73)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C358(0.81); C361(0.81)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C358(0.88); C361(0.88)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C358(1.09); C361(1.09)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C358(1.02); C361(1.02)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C358(0.90); C361(0.90)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C358(0.61); C361(0.61)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C235(0.58); C358(1.08); C361(1.08)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C235(0.67); C358(1.06); C361(1.06)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C235(0.76); C358(1.32); C361(1.32)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C235(0.69); C358(0.93); C361(0.93)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C235(0.82); C358(1.21); C361(1.21)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C235(0.75); C358(1.13); C361(1.13)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C235(0.77); C358(1.12); C361(1.12)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C235(0.69); C358(0.98); C361(0.98)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C235(0.78); C358(1.15); C361(1.15)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C235(0.82); C358(1.13); C361(1.13)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C235(0.80); C358(1.31); C361(1.31)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C235(0.85); C358(1.13); C361(1.13)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C358(0.91); C361(0.91)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C235(0.92); C358(1.27); C361(1.27)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C235(0.74); C358(1.27); C361(1.27)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C235(0.74); C358(1.10); C361(1.10)  LDD0579  [2]
 LDCM0270  AC15 HEK-293T C358(0.69); C361(0.69)  LDD0868  [2]
 LDCM0276  AC17 HCT 116 C235(0.84)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C235(1.04)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C235(0.88)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C235(0.93); C358(1.47); C361(1.47)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C235(0.84)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C235(0.94)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C235(0.90)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C235(0.89)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C235(0.87)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C235(0.89)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C235(1.31)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C235(1.28)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C235(1.35)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C235(1.54)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C235(1.11); C358(1.41); C361(1.41)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C235(1.56)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C235(1.25)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C235(1.67)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C235(1.10)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C235(1.24)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C55(0.92)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C55(0.93)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C309(1.15)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C55(0.94); C309(1.12); C235(0.82)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C55(0.97)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C235(0.99); C358(1.19); C361(1.19)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C373(1.00)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C55(0.99)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C55(1.08); C309(1.05)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C55(0.90)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C55(0.94)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C309(1.14)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C358(0.77); C361(0.70)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C358(0.70); C361(0.52)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C358(0.84); C361(0.47)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C358(0.81); C361(0.61)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C235(0.98); C358(1.29); C361(1.29)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C358(0.89); C361(0.71)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C358(1.22); C361(0.70)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C358(1.12); C361(0.66)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C358(1.06); C361(0.73)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C358(1.04); C361(0.62)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C358(0.84); C361(0.53)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C358(0.80); C361(0.54)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C358(1.33); C361(1.33)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C358(1.09); C361(1.09)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C358(1.28); C361(1.28)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C358(0.90); C361(0.90)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C358(1.06); C361(1.06)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C358(1.17); C361(1.17)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C358(1.42); C361(1.42)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C358(1.19); C361(1.19)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C358(1.22); C361(1.22)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C358(1.21); C361(1.21)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C358(0.85); C361(0.85)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C358(1.57); C361(1.57)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C358(1.14); C361(1.14)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C358(1.17); C361(1.17)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C358(0.93); C361(0.93)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C358(1.37); C361(1.37)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C358(1.13); C361(1.13)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C358(1.08); C361(1.08)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C358(0.81); C361(0.81)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C358(0.97); C361(0.97)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C358(0.69); C361(0.69)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C358(1.10); C361(1.10)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C358(1.13); C361(1.13)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C358(1.03); C361(1.03)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C358(0.86); C361(0.86)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C358(0.86); C361(0.86)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C358(0.99); C361(0.99)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C358(1.10); C361(1.10)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C358(1.00); C361(1.00)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C235(1.82)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C235(1.55)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C235(1.19)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C235(1.06)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C235(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C235(1.33)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C235(1.30)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C235(0.90)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C235(1.57)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C235(1.53)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C235(1.27)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C235(1.16)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C235(1.07)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C235(1.27)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C235(1.46)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C235(1.60)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C235(1.19)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C358(0.93); C361(0.93)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C358(0.89); C361(0.89)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C358(0.67); C361(0.67)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C235(1.06)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C235(1.06)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C235(0.93); C358(1.23); C361(1.23)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C358(1.15); C361(1.15)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C358(1.32); C361(1.32)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C358(1.10); C361(1.10)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C358(1.12); C361(1.12)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C235(1.10)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C235(0.99)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C235(1.10)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C235(0.96)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C235(1.17)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C235(0.85)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C235(0.90)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C235(0.91)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C235(1.22)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C235(1.29)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C235(1.30)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C235(1.28)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C235(1.22)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C55(0.93)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C55(1.14); C309(1.20)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C55(0.96)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C235(1.05)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C55(0.95); C309(1.11)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C358(0.67); C361(0.47)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C358(0.82); C361(0.59)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C358(1.17); C361(1.05)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C358(0.90); C361(0.71)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C358(1.26); C361(1.26)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C358(0.88); C361(0.88)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C358(1.07); C361(1.07)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C358(1.22); C361(1.22)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C235(0.97)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C235(0.90)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C235(0.81)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C235(1.00)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C235(0.79)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C235(0.90)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C235(0.80)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C235(0.95)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C235(0.85)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C235(0.77)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C235(0.83)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C235(0.94)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C235(1.10)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C235(0.85)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C235(1.19)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C235(0.91)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C235(0.91)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C235(0.97)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C235(0.99)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C235(0.99)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C235(1.13)  LDD1299  [2]
 LDCM0421  CL32 HCT 116 C235(1.22)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C235(1.06)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C235(0.93)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C235(1.02)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C235(0.76)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C235(1.02)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C235(1.29)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C235(0.98)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C235(0.92)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C235(0.93)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C235(0.78)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C235(0.94)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C235(0.92)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C235(0.96)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C358(0.78); C361(0.78)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C358(0.76); C361(0.76)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C358(0.97); C361(0.97)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C358(1.02); C361(1.02)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C235(0.89)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C358(0.82); C361(0.82)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C358(0.94); C361(0.94)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C358(0.85); C361(0.85)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C358(1.00); C361(1.00)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C358(0.72); C361(0.72)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C358(0.72); C361(0.72)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C358(0.70); C361(0.70)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C358(0.97); C361(0.97)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C358(0.80); C361(0.80)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C358(0.92); C361(0.92)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C235(0.91)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C358(0.77); C361(0.77)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C55(0.97)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C55(1.37); C309(1.02)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C55(0.89)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C55(1.15); C309(1.10)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C55(0.99)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C55(0.99); C309(1.03)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C55(1.00)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C55(1.12)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C309(1.00)  LDD1664  [8]
 LDCM0462  CL7 HCT 116 C235(0.91)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C55(1.01); C309(1.00); C235(1.88)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C55(1.11)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C373(1.04)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C55(0.89)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C55(1.18); C309(1.04)  LDD1670  [8]
 LDCM0469  CL76 HCT 116 C235(0.84)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C235(0.97)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C235(0.93)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C235(1.00)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C235(1.04)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C235(1.07)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C235(1.09)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C235(0.82)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C235(1.12)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C235(1.03)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C235(1.03)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C235(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C235(1.22)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C235(1.06)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C235(1.01)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C235(1.03)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C235(0.87)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C235(1.00); C358(1.03); C361(1.03)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C235(0.81); C358(0.97); C361(0.97)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C235(0.77); C358(0.97); C361(0.97)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C235(0.97); C358(0.92); C361(0.92)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C235(0.87); C358(1.14); C361(1.14)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C235(1.06); C358(1.07); C361(1.07)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C235(0.94); C358(0.93); C361(0.93)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C235(1.10); C358(1.52); C361(1.52)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C235(0.87); C358(1.22); C361(1.22)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C55(0.96)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C55(1.00)  LDD1671  [8]
 LDCM0427  Fragment51 HCT 116 C235(0.97)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C235(1.46)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C235(1.28)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C235(1.39)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
MORN repeat-containing protein 4 (MORN4) . Q8NDC4

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402